scholarly journals Preliminary evidence of the association between DNAm and orbital volumetry in GO

2020 ◽  
Vol 9 (7) ◽  
pp. 617-626
Author(s):  
Ya-Fen Hu ◽  
Lin Hua ◽  
Xiu Tuo ◽  
Ting-Ting Shi ◽  
Yi-Lin Yang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Preliminary Evidence ◽  
Chinese Patients ◽  
Cross Sectional ◽  
Partial Least Squares Analysis ◽  
Targeted Bisulfite Sequencing ◽  
Total Cross Sectional Area ◽  
Graves Orbitopathy

Background The pathogenesis underlying the alterations of orbital architecture in Graves’ orbitopathy (GO) is not yet fully understood. The present study aimed to investigate the association of DNA methylation in peripheral blood and orbital volumetry in Chinese patients with GO. Methods A total of 35 GO subjects (70 orbits) were subjected to CT scan. The total cross-sectional area of the extraocular muscles (orbital muscles, OM), total orbit area (TOA), and the exophthalmometry were measured and OM/TOA ratio was calculated. Targeted bisulfite sequencing was performed on seven candidate genes. Results No significant correlation was established between the DNA methylation levels of these genes and exophthalmometry. The MBP methylation level was found to be correlated with OM/TOA ratio (P < 0.05). Multiple linear regression analysis on parameters including age, sex, TRAb, duration of GO, and DNA methylation levels of seven genes with OM/TOA ratio confirmed that MBP and OM/TOA ratio had a significant correlation (P < 0.05). The partial least squares analysis showed that the top three genes with the highest loadings were MBP, BOLL, and BECN1 and that OM/TOA ratio affected the DNA methylation block than exophthalmometry. Conclusions This study provided preliminary evidence that MBP is a potential gene associated with OM enlargement in GO patients according to the combination of DNA methylation sequencing and orbital CT measurement.

scholarly journals The relationship between the atherogenic index of plasma and arterial stiffness in essential hypertensive patients from China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Juan Yin ◽  
Minghui Li ◽  
Lingling Yu ◽  
Feng Hu ◽  
Yu Yu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Arterial Stiffness ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Chinese Patients ◽  
Multivariate Linear Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma

Abstract Background The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypertensive patient populations. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in Chinese patients diagnosed with arterial hypertension. Methods This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides to high-density lipoprotein cholesterol levels indicated in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results Data were adjusted for potential confounding variables, and multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, the same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05). Conclusion AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2. Clinical trial registration ChiCTR1800017274.

Association Between Lower Trapezius Isometric Strength and Y-Balance Test Upper Quarter Performance in College Volleyball Players

2021 ◽  
pp. 1-6
Author(s):  
Guillermo Mendez-Rebolledo ◽  
Ann M. Cools ◽  
Rodrigo Ramirez-Campillo ◽  
Elias Quiroz-Aldea ◽  
Fernanda A.P. Habechian
Keyword(s):  
Upper Limb ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Isometric Strength ◽  
Serratus Anterior ◽  
Balance Test ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Volleyball Players ◽  
Lower Trapezius

Context: Knowing the possible association between the isometric strength of the shoulder rotators, scapular muscles, and the Y-balance test upper quarter (YBT-UQ) performance could help identify which indicators of shoulder stability should be considered in this field test. This study aimed to determine whether the isometric strength of the shoulder rotators and scapular muscles is associated with the YBT-UQ performance of the dominant upper limb in amateur volleyball players. Design: Cross-sectional study. Methods: A convenience sample of 22 male and 18 female volleyball players (≥12 h of training/week) between 18 and 26 years of age. The isometric strength of the middle trapezius, lower trapezius, serratus anterior, internal, and external rotator muscles was assessed with a handheld dynamometer. Participants performed the YBT-UQ in the superolateral, medial, and inferolateral directions. The absolute isometric peak force (in Newtons) was normalized to body weight (in Newtons per kilogram) for each muscle test. For each YBT-UQ direction, the distance (in centimeters) was normalized for upper limb length (in percentage). A backward multiple linear regression analysis was used to determine the associations between variables. Results: The analysis revealed that the isometric strength of the lower trapezius (β = 26.82; 95% confidence interval, 21.24–32.40) is associated with inferolateral YBT-UQ performance (adjusted R2 = .706; P < .001). This factor explains 70% of the variability of the YBT-UQ in the inferolateral direction. Conclusions: Lower trapezius isometric strength is associated with inferolateral YBT-UQ performance of the dominant upper limb in amateur volleyball players. These findings could help in the development of more specific training programs and rehabilitation goals according to the performance of the athletes in the test.

scholarly journals The Clinical Investigation of Disparity of Utility Values Associated with Gallstone Disease: A Pilot Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Chung-Te Hsu ◽  
Yi Liao ◽  
Jorn-Hon Liu ◽  
Tao-Hsin Tung
Keyword(s):  
Clinical Investigation ◽  
Gallstone Disease ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Older Age ◽  
Outpatient Clinics ◽  
Cross Sectional ◽  
Utility Values ◽  
Utility Evaluation

Purpose. The utility evaluation was an effective method to incorporate all of the contributing variables for multiple diseases into one outcome measure. A cross-sectional study was conducted to assess the utility values associated with varying states of gallstone disease among outpatient clinics participants at a teaching hospital in Taipei, Taiwan.Methods. The utility values were measured by using time trade-off method. A total of 120 outpatient clinics participants (30 subjects with no gallstone disease, 30 subjects with single stone, 30 subjects with multiple stones, and 30 subjects with cholecystectomy) evaluated utility values from January 1, 2006 to December 31, 2006. The diagnosis of gallstone disease was performed by a panel of specialists using ultrasound sonography.Results. The overall mean utility value was0.89±0.13(95% CI: 0.87–0.91) indicating that study participants were willing to trade about 11% (95% CI: 9–13%) of their remaining life in return for being free of gallstone disease perpetually. The significant associated factors of utility values based on the multiple linear regression analysis were older age and different degrees of gallstone disease.Conclusion. Our results found that in addition to older age, multiple stones and cholecystectomy could influence utility values from the patient’s preference-based viewpoint.

Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running

2001 ◽  
Vol 90 (4) ◽  
pp. 1334-1341 ◽  
Author(s):  
R. C. Hickner ◽  
P. M. Mehta ◽  
D. Dyck ◽  
P. Devita ◽  
J. A. Houmard ◽  
...  
Keyword(s):  
Body Mass ◽  
Muscle Glycogen ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Fat Free Mass ◽  
Mass Ratio ◽  
Low Fat ◽  
Cross Sectional ◽  
Leg Strength ◽  
Downhill Running

The purpose of this study was to determine whether greater body fat mass (FM) relative to lean mass would result in more severe muscle damage and greater decrements in leg strength after downhill running. The relationship between the FM-to-fat-free mass ratio (FM/FFM) and the strength decline resulting from downhill running (−11% grade) was investigated in 24 male runners [age 23.4 ± 0.7 (SE) yr]. The runners were divided into two groups on the basis of FM/FFM: low fat (FM/FFM = 0.100 ± 0.008, body mass = 68.4 ± 1.3 kg) and normal fat (FM/FFM = 0.233 ± 0.020, body mass = 76.5 ± 3.3 kg, P < 0.05). Leg strength was reduced less in the low-fat (−0.7 ± 1.3%) than in the normal-fat individuals (−10.3 ± 1.5%) 48 h after, compared with before, downhill running ( P < 0.01). Multiple linear regression analysis revealed that the decline in strength could be predicted best by FM/FFM ( r2= 0.44, P < 0.05) and FM-to-thigh lean tissue cross-sectional area ratio ( r2= 0.53, P < 0.05), with no additional variables enhancing the prediction equation. There were no differences in muscle glycogen, creatine phosphate, ATP, or total creatine 48 h after, compared with before, downhill running; however, the change in muscle glycogen after downhill running was associated with a higher FM/FFM ( r = −0.56, P < 0.05). These data suggest that FM/FFM is a major determinant of losses in muscle strength after downhill running.

scholarly journals Characteristics of Brain Structure in HIV Male Patients with Syphilis Co-Infection: A Cross-Sectional Study.

2021 ◽  
Author(s):  
Yu Qi ◽  
Yuan-Yuan Wang ◽  
Wei Wang ◽  
Xu-Ze Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Infected Male ◽  
Syphilis Infection ◽  
Cross Sectional ◽  
Corona Radiata ◽  
Male Patients ◽  
The Right

Abstract Background To investigate the effect of syphilis infection on the microstructure of white matter (WM) in HIV-infected male patients through comparing the differences of WM between HIV-infected male patients with and without syphilitic infection using diffusion tensor imaging (DTI).Methods 27 HIV-infected male patients with current syphilis or a history of syphilis (HIV+/syphilis+) and 29 HIV-infected male patients without syphilis co-infection history (HIV+/syphilis-) were enrolled. All patients received DTI and comprehensive neuropsychological assessment. Clinical data were compared between the two groups with T-test, Mann-Whitney U Test and Chi-square Test. Tract-based spatial statistics (TBSS) was adopted to analyze the DTI metrics. Multiple linear regression analysis was conducted to investigate the relationships between DTI metrics and clinical variables and cognitive performance. Results In the HIV+/syphilis+ group, decreased AD was found in the right superior corona radiata (SCR-R) and body of corpus callosum (BCC); increased RD was found in the bilateral posterior corona radiata (PCR), the right posterior thalamic radiation (PTR-R), the left SCR (SCR-L), splenium of corpus callosum (SCC) and BCC; decreased FA was found in multiple regions. AD in BCC was negatively correlated with CD4/CD8 ratios. AD in SCR-R was positively correlated with CD4/CD8 ratios. Patients in HIV+/syphilis+ group had a lower score in complex motor skills (CMS). RD in SCC and SCR-L was negatively correlated with CMS; RD in PTR-R was positively correlated with CMS. AD in SCR-R was positively correlated with CMS. Conclusions Compared with patients simply infected with HIV, the integrity of WM is more seriously impaired in HIV-infected patients with syphilis co-infection, and it may accelerate the impairment of cognitive function.

scholarly journals Oxidative stress and gut-derived lipopolysaccharides in children affected by Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections.

2020 ◽  
Author(s):  
Lorenzo Loffredo ◽  
Alberto Spalice ◽  
Francesca Salvatori ◽  
De Castro Giovanna ◽  
Cristiana Alessia Guido ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Prostaglandin F2α ◽  
Neuropsychiatric Disorders ◽  
Serum Levels ◽  
Multiple Linear Regression Analysis ◽  
Tic Disorders ◽  
Streptococcal Infections ◽  
Cross Sectional

Abstract Background: pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) identifies patients with acute onset of obsessive-compulsive and tic disorders. The objective of this study was to assess NOX2 levels, as well as serum 8-iso-prostaglandin F2α (iso-PGF2α) and lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut of patients with PANDAS. Methods: a cross sectional study was performed to compare serum levels of soluble NOX2-dp (sNOX-2-dp), isoprostanes and LPS in 60 consecutive subjects, including 30 children affected by PANDAS and 30 controls (CT) matched for age and gender. Serum zonulin was used to assess gut permeability. Results: compared with CT, PANDAS children had higher values of sNOX-2-dp, 8-iso-PGF2-alpha and LPS. Simple linear regression analysis showed that sNOX2-dp was significantly correlated with serum LPS (Rs=0.359; p=0.005), zonulin (Rs=0.444; p<0.001) and iso-PGF2α (Rs=0.704; p<0.001). LPS significantly correlated with serum zonulin (Rs=0.610; p<0.001), and iso-PGF2α (Rs=0.591; p=0.001). A multiple linear regression analysis was performed to define the independent predictors of sNOX-2-dp. Isoprostanes and zonulin emerged as the only independent predictive variables associated with sNOX2-dp (R2=68%). Conclusion: this study provides evidences that children affected by PANDAS have high circulating levels of sNOX2-dp, isoprostanes and of LPS that could be potentially implicated in the process of neuroinflammation.

scholarly journals Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Jiahui Chen ◽  
Yating Tang ◽  
Qinghe Jing ◽  
Yi Lu ◽  
Yongxiang Jiang
Keyword(s):  
Spherical Aberration ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Individual Measurement ◽  
Ectopia Lentis ◽  
Corneal Asphericity ◽  
Optical Zone ◽  
Anterior Posterior

Purpose: To analyze the anterior, posterior, and total corneal spherical aberrations (ASA, PSA, and TSA) in patients with Chinese bilateral ectopia lentis (EL).Methods: A cross-sectional study was conducted to evaluate corneal spherical aberration (CSA) using a Pentacam system at the 6-mm optical zone. Axial length, keratometry, astigmatism, and corneal asphericity were also determined.Results: This study included 247 patients (420 eyes) with a mean age of 18.1 years. The values of ASA, PSA, and TSA were 0.136 ± 0.100 μm, −0.118 ± 0.030 μm, and 0.095 ± 0.095 μm, respectively. In the EL patients with Marfan syndrome (MFS), ASA and TSA were significantly lower than in the non-MFS patients (0.126 ± 0.094 μm vs. 0.155 ± 0.107 μm, P = 0.004 for ASA; 0.085 ± 0.091 μm vs. 0.114 ± 0.099 μm, P = 0.003 for TSA), whereas PSA was not significantly different (P = 0.061). The values of ASA and TSA were significantly higher in the patients with EL aged ≥ 40 years old than in younger patients, whereas ASA and PSA were lower in patients aged &lt;10 years old than in older patients (all P &lt; 0.05). In the multiple linear regression analysis, age, keratometry, astigmatism, anterior asphericity, higher-order aberration (HOA), and lower-order aberration (LOA) were positively or negatively correlated with TSA in the patients with EL (r = 0.681, P &lt; 0.001).Conclusions: Corneal spherical aberration was low in the patients with EL especially for MFS and tended to increase with aging. Preoperatively, individual measurement of CSA was necessary for bilateral EL patients with MFS.

scholarly journals Association of Salivary Statherin, Calcium, and Proline-Rich Proteins on Oral Hygiene: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Deepak Gowda Sadashivappa Pateel ◽  
Shilpa Gunjal ◽  
Liew Fong Fong ◽  
Nur Sulwana Mohd Hanapi
Keyword(s):  
Oral Health ◽  
Negative Correlation ◽  
Oral Hygiene ◽  
Linear Regression Analysis ◽  
Rank Correlation ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Background. Saliva, as a complex biofluid, plays a pivotal role in maintaining oral health and tooth integrity. There has been inconsistent data available on the relationship between salivary parameters and oral health. This study aims to investigate the association between salivary statherin, acidic proline-rich proteins (aPRP), and calcium with oral hygiene status. Methods. One hundred and eighty-eight healthy subjects aged between 18 and 50 years with varying oral hygiene status who gave consent to participate were included in this cross-sectional study. The subjects were recruited from primary oral health care of MAHSA University. Oral hygiene of all the participants was measured using Oral Hygiene Index–Simplified (OHI-S). Stimulated saliva collected using paraffin wax was analyzed for salivary statherin, aPRP, and calcium. The relationship between salivary statherin, aPRP, and calcium levels with OHI-S was assessed using Spearman’s Rank correlation coefficient; the strength of relationship was assessed by multiple linear regression analysis. Results. The study found a weak positive correlation (r = 0.179, p  = 0.014) between salivary statherin and OHI-S; weak negative correlation (r = −0.187, p  = 0.010) between salivary aPRP and OHI-S; and moderate negative correlation between salivary statherin and salivary aPRP levels (r = −0.50, p  < 0.001) which were statistically significant. Conclusion. Poor oral hygiene is associated with increased statherin and reduced aPRP levels in saliva. Thus, these salivary components may have a role in predicting oral hygiene status.

scholarly journals Network ties and transactive memory systems: leadership as an enabler

2017 ◽  
Vol 38 (1) ◽  
pp. 56-73 ◽  
Author(s):  
Dainelis Cabeza Pulles ◽  
Francisco Javier LLorens Montes ◽  
Leopoldo Gutierrez-Gutierrrez
Keyword(s):  
Linear Regression Analysis ◽  
Memory Systems ◽  
Multiple Linear Regression Analysis ◽  
Transactive Memory ◽  
Moderating Effect ◽  
Three Dimensions ◽  
Network Ties ◽  
Cross Sectional ◽  
Transactive Memory Systems ◽  
Content Type

Purpose The purpose of this paper is to study the relationship between network ties (NT) and transactive memory systems (TMS), observed through three dimensions – specialization (TMSS), credibility (TMSCR), and coordination (TMSCO) – in the presence of leadership (LDR) as a moderating variable, in university research-and-development (R&D) groups. Design/methodology/approach The data are composed of 257 university R&D groups. To confirm the hypotheses, the authors use multiple linear regression analysis with a moderating effect. Findings The conclusions show that the relationships between NT and two of the three dimensions of TMS (TMSCR and TMSCO) are significant when LDR is included as a moderating variable. Although the effect of TMSS is positive, it is not significant. Including the interaction element enables better explanation of two of the dimensions of TMS in the sector analyzed. Thus, LDR is perfectly applicable to the university R&D environment. Research limitations/implications This research has several limitations that suggest further possibilities for empirical research. The limitations include the cross-sectional nature of the research and the judgment of a single manager as the basis of the perception analyzed for each group. Practical implications The authors provide several implications for R&D practitioners. The results of this study could be validated in other universities in other geographic areas, enabling better generalization and applicability of the results. The results described may serve as a guide for group leaders of university R&D. This research helps us to see the importance of LDR in forming internal research networks that help researchers to perform common projects in order to obtain better results in the group. Thus, the groups provided better results to society. Originality/value No studies have tested the moderating effect of LDR in university R&D empirically. The results provide information to fill this gap and demonstrate the applicability of LDR as a key element in the organization, improvement, and cohesion of R&D groups.

Abstract T P337: Asymmetric Dimethylarginine Is Related to the Predicted Stroke Risk in Middle-aged Japanese Men

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
yasuhiro nishiyama ◽  
Masayuki Ueda ◽  
Yasuo Katayama ◽  
Toshiaki Otsuka
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Stroke Risk ◽  
Smoking Status ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cerebrovascular Diseases ◽  
Adma Level ◽  
Middle Aged ◽  
Cross Sectional ◽  
Japanese Men

Background: Asymmetric dimethylarginine (ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it remains unclear whether ADMA levels are related to the risk of stroke in the general Japanese population. Methods and Results: In this cross-sectional study, we examined 769 Japanese men (mean, 47 ± 5 years) who underwent health examinations. Each patient’s ADMA level and various vascular risk factors were assessed, and the predicted 10-year risk of stroke was calculated using the point-based prediction model for incident total stroke for Japanese from the Japan Public Health Center Study. In a multiple linear regression analysis, age, body mass index, estimated glomerular filtration rate, and current smoking status were significant independent determinants of the ADMA level. A significant odds ratio (OR) for high predicted stroke risk (10-year risk ≥ 5%) was noted in the highest quartile of ADMA level (OR, 2.47; 95% CI, 1.00-6.07) as compared to the lowest quartile, even after adjusting for potential confounding factors. A significant OR for high predicted stroke risk was also found for each standard-deviation increment in ADMA level (adjusted OR, 1.46; 95% CI, 1.10-1.92). Conclusions: An elevated ADMA level was significantly associated with an increase in predicted stroke risk, suggesting that the measurement of ADMA level may be useful for identifying middle-aged Japanese men at high risk for stroke.

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