scholarly journals Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis

2017 ◽  
Vol 6 (3) ◽  
pp. 159-171 ◽  
Author(s):  
Ozlem Atan Sahin ◽  
Damla Goksen ◽  
Aysel Ozpinar ◽  
Muhittin Serdar ◽  
Huseyin Onay
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Vdr Gene ◽  
Increased Risk ◽  
Funnel Plots ◽  
Type 1 Dm ◽  
Study Inclusion

Background There have been studies focused on FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor (VDR) gene and susceptibility to type 1 diabetes mellitus with controversial results. Methods This present study is a meta-analysis investigating the association between FokI, ApaI, TaqI and BsmI polymorphisms of VDR gene and type 1 DM in children. A literature search was performed using Medline, EMBASE, Cochrane and PubMed. Any study was considered eligible for inclusion if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined, and outcome was type 1 DM at pediatric age. Results A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios (ORs) of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the OR value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB (P < 0.05), BsmIBb, (P < 0.05), BsmIbb (P < 0.05), TaqITT (P < 0.05) and TaqItt (P < 0.05) in children. Conclusion The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of type 1 DM, whereas BsmIbb and TaqITT had protective effect for type 1 DM in children.

scholarly journals Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

2020 ◽  
Author(s):  
Masoud Hassanzadeh Makoui ◽  
Saeed Aslani ◽  
Payam Mohammadi ◽  
Bahman Razi ◽  
danyal imani
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms

Abstract Objective The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of Type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to July 2019 were identified by comprehensive systematic database search in web of science, Scopus, and PubMed. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted.Results A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI genes polymorphism and T1DM in African and American populations, respectively.Conclusions This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

scholarly journals Association of Vitamin D Receptor Ggene Ppolymorphisms and Type 1 diabetes in Egyptian Population.

2015 ◽  
Vol 9 (2) ◽  
pp. 23-28
Author(s):  
Ali Salim Al-shehmany Al-shehmany ◽  
*Ahmad A. El- Kafoury El- Kafoury ◽  
*Ahmad A. El- Kafoury * El- Kafoury ◽  
Amira M. Embaby Embaby
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Chi Square ◽  
Vdr Gene ◽  
Egyptian Population ◽  
Specific Pcr ◽  
Increased Risk ◽  
Allele Specific

The human vitamin D receptor (VDR) gene is located on chromosome 12q12–q14, and four commonnucleotide polymorphisms have been identified. Several studies have found a relationship betweenpolymorphisms of the (VDR) gene and development of type 1 diabetes (T1DM). The association ofVDR polymorphisms and susceptibility to T1DM in the Egyptian population were examined in 60individuals with type 1 diabetes and compared with healthy 60 persons. Single nucleotidepolymorphisms (SNP) genotyping was performed using PCR and BsmI and FokI, by using twotechniques, allele specific PCR technique and restriction fragment length polymorphism – PCR(RFLP-PCR). Data were analyzed using the chi square. The result approved that the genotype TA inSNP FokI was risk factor among type 1 diabetes mellitus patients combination which conferredstrongest susceptibility to T1DM (P=0.004) while the SNP BsmI did not showed any significancebetween cases as compared with control (P=0.493). The results of the current study indicated that VDRpolymorphisms are associated with increased risk of T1DM in the Egyptian population. The differencein the association of the aforementioned SNPs variants with T1DM among different populations maybe attributed to the presence of multiple susceptibility alleles.

scholarly journals Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

2020 ◽  
Author(s):  
Na Zhai ◽  
Ramtin Bidares ◽  
Masoud Hassanzadeh Makoui ◽  
Saeed Aslani ◽  
Payam Mohammadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms

Abstract Background: The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM. Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to March 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in African and American populations, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

scholarly journals Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

2020 ◽  
Author(s):  
Na Zhai ◽  
Ramtin Bidares ◽  
Masoud Hassanzadeh Makoui ◽  
Saeed Aslani ◽  
Payam Mohammadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Subgroup Analysis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Case Control ◽  
Case Control Studies

Abstract Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

scholarly journals Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies

2006 ◽  
Vol 164 (8) ◽  
pp. 711-724 ◽  
Author(s):  
Sun-Wei Guo ◽  
Victoria L. Magnuson ◽  
Jennifer J. Schiller ◽  
Xujing Wang ◽  
Yan Wu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Genetic Association ◽  
Vitamin D Receptor ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies

scholarly journals A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Mohammed Y. Areeshi ◽  
Raju K. Mandal ◽  
Sajad A. Dar ◽  
Abdulrahman M. Alshahrani ◽  
Aqeel Ahmad ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Genetic Models ◽  
Wild Type ◽  
Vdr Gene ◽  
Bsmi Polymorphism ◽  
Increased Risk ◽  
Tuberculosis Risk

BsmI (rs1544410) polymorphism located in intron 8 at the 3′-end of the vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. A total of 19 studies comprising 3644 controls and 2635 cases were included in the present study. Overall no association of PTB in allelic contrast (b compared with B: P=0.285; OR =0.909, 95% CI =0.762–1.083), homozygous (bb compared with BB: P=0.881; OR =0.975, 95% CI =0.700–1.359), heterozygous (bB compared with BB: P=0.834; OR =1.017, 95% CI =0.872–1.185), dominant (bb compared with BB + Bb: P=0.451; OR =0.954, 95% CI =0.843–1.079) and recessive (bb + Bb compared with BB: P=0.983; OR =1.002, 95% CI =0.868–1.156) genetic models in comparison with wild-type allele and genotype BB were observed. However, variant allele (b compared with B: P=0.001; OR =2.289, 95% CI =1.661–3.154) showed increased risk of PTB in Asians. In conclusion, VDR BsmI polymorphism is not a risk factor for PTB in overall population. However, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.

Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus

Autoimmunity ◽  
2013 ◽  
Vol 46 (6) ◽  
pp. 382-387 ◽  
Author(s):  
Jaqueline De Azevêdo Silva ◽  
Rafael Lima Guimarães ◽  
Lucas André Cavalcanti Brandão ◽  
Jacqueline Araujo ◽  
Ludovica Segat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms
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