scholarly journals Losartan reduces circulating TGFb and CTX and increases vertebral bone mass in the OIM mouse

2019 ◽  
Author(s):  
Nick Bishop ◽  
Ivo Kalajzic ◽  
Fawaz Arshad ◽  
Diane Lefley ◽  
Fatma Gossiel ◽  
...  
Keyword(s):  
Bone Mass ◽  
Vertebral Bone ◽  
Vertebral Bone Mass

scholarly journals Neutralization of CD40 ligand costimulation promotes bone formation and accretion of vertebral bone mass in mice

Rheumatology ◽  
2018 ◽  
Vol 57 (6) ◽  
pp. 1105-1114 ◽  
Author(s):  
Susanne Roser-Page ◽  
Tatyana Vikulina ◽  
Kanglun Yu ◽  
Meghan E McGee-Lawrence ◽  
M Neale Weitzmann
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Cd40 Ligand ◽  
Vertebral Bone ◽  
Vertebral Bone Mass

Subclinical Vitamin D Deficiency in Postmenopausal Women with Low Vertebral Bone Mass*

1991 ◽  
Vol 72 (3) ◽  
pp. 628-634 ◽  
Author(s):  
DENNIS T. VILLAREAL ◽  
ROBERTO CIVITELLI ◽  
ARKADI CHINES ◽  
LOUIS V. AVIOLI
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Vertebral Bone ◽  
Subclinical Vitamin ◽  
Vertebral Bone Mass

scholarly journals Age- and Gender-Related Differences in Vertebral Bone Mass, Density, and Strength

1999 ◽  
Vol 14 (8) ◽  
pp. 1394-1403 ◽  
Author(s):  
Ebbe N. Ebbesen ◽  
Jesper S. Thomsen ◽  
Henning Beck-Nielsen ◽  
Hans J. Nepper-Rasmussen ◽  
Lis Mosekilde
Keyword(s):  
Bone Mass ◽  
Mass Density ◽  
Bone Mass Density ◽  
Age And Gender ◽  
Vertebral Bone ◽  
And Gender ◽  
Vertebral Bone Mass

scholarly journals Sequential Treatment with Basic Fibroblast Growth Factor and PTH Is More Efficacious than Treatment with PTH Alone for Increasing Vertebral Bone Mass and Strength in Osteopenic Ovariectomized Rats

Endocrinology ◽  
2002 ◽  
Vol 143 (7) ◽  
pp. 2515-2526 ◽  
Author(s):  
U. T. Iwaniec ◽  
Li. Mosekilde ◽  
N. G. Mitova-Caneva ◽  
J. S. Thomsen ◽  
T. J. Wronski
Keyword(s):  
Bone Mass ◽  
Cancellous Bone ◽  
Sequential Treatment ◽  
Ovariectomized Rats ◽  
Concurrent Administration ◽  
Trabecular Microarchitecture ◽  
Trabecular Thickness ◽  
Vertebral Bone ◽  
Ovx Rats ◽  
Vertebral Bone Mass

Abstract The study was designed 1) to determine whether treatment with basic fibroblast growth factor (bFGF) and PTH is more efficacious than treatment with PTH alone for increasing bone mass and strength and improving trabecular microarchitecture in osteopenic ovariectomized rats, and 2) to assess whether prior and concurrent administration of the antiresorptive agents estrogen and risedronate suppresses the bone anabolic response to treatment with bFGF alone and sequential treatment with bFGF and PTH. Three-month-old female Sprague Dawley rats were ovariectomized (OVX) or sham-operated (sham) and maintained untreated for 1 yr. Baseline sham and OVX rats were killed at this time (15 months of age). Groups of rats were injected sc with estrogen (10 μg/kg, 4 d/wk), risedronate (5 μg/kg, 2 d/wk), or vehicle. At the end of the second week of antiresorptive treatment, catheters were inserted into the jugular veins of all rats, and vehicle or bFGF at a dose of 250 μg/kg was injected daily for 14 d. Three groups of rats were killed at the end of bFGF treatment. The remaining rats were continued on their respective antiresorptive therapy and injected sc with vehicle or synthetic human PTH-(1–34) at a dose of 80 μg/kg, 5 d/wk, for 8 wk. Lumbar vertebrae were processed for cancellous bone histomorphometry and biomechanical testing. Ovariectomy resulted in a decrease in vertebral bone mass and strength. Treatment of OVX rats for 14 d with bFGF markedly increased osteoblast surface, osteoid surface, and osteoid volume compared with vehicle treatment of sham and OVX rats. Furthermore, osteoid bridges were observed extending between preexisting trabeculae in bFGF-treated OVX rats. Prior and concurrent administration of estrogen and risedronate did not suppress these bone anabolic effects of bFGF. Treatment of OVX rats with PTH alone increased vertebral cancellous bone mass and strength to the level of vehicle-treated sham rats. Sequential treatment of OVX rats with bFGF and PTH further augmented vertebral bone mass and strength to a level above that observed in OVX rats treated with PTH alone. The improvements in bone mass and strength were associated with an increase in trabecular thickness in OVX rats treated with PTH alone and with an increase in trabecular thickness and node to terminus ratio, an index of trabecular connectivity, in OVX rats treated sequentially with bFGF and PTH. Cotreatment with estrogen and risedronate did not suppress the anabolic response of bone to bFGF and PTH. In fact, a trend for an even greater increase in cancellous bone mass and node to terminus ratio was observed in OVX rats treated with risedronate, bFGF, and PTH. These findings indicate that sequential treatment with bFGF and PTH is more efficacious than treatment with PTH alone for increasing bone mass and strength and improving trabecular microarchitecture in osteopenic OVX rats.

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