Early-life vitamin D status and bone mass at five years in a prospective birth cohort study

2017 ◽  
Author(s):  
Carol ni Chaoimh ◽  
Deirdre Murray ◽  
Louise Kenny ◽  
Alan Irvine ◽  
Jonathan Hourihane ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Bone Mass ◽  
Birth Cohort ◽  
Early Life ◽  
Birth Cohort Study ◽  
Vitamin D Status ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

scholarly journals The role of early life variables on the risk of fractures from birth to early adolescence: a prospective birth cohort study

2009 ◽  
Vol 20 (11) ◽  
pp. 1873-1879 ◽  
Author(s):  
P. C. Hallal ◽  
F. V. Siqueira ◽  
A. M. B. Menezes ◽  
C. L. P. Araújo ◽  
S. A. Norris ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Early Adolescence ◽  
Early Life ◽  
Birth Cohort Study ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

scholarly journals CD4+T Cell Responses to Cytomegalovirus in Early Life: A Prospective Birth Cohort Study

2008 ◽  
Vol 197 (5) ◽  
pp. 658-662 ◽  
Author(s):  
David J. C. Miles ◽  
Marianne van der Sande ◽  
Steve Kaye ◽  
Sarah Crozier ◽  
Olubukola Ojuola ◽  
...  
Keyword(s):  
Cohort Study ◽  
T Cell ◽  
Birth Cohort ◽  
Early Life ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Birth Cohort Study ◽  
Cell Responses ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

scholarly journals The association of vitamin D status and supplementation during pregnancy with gestational diabetes mellitus: a Chinese prospective birth cohort study

2019 ◽  
Author(s):  
Wan-jun Yin ◽  
Rui-xue Tao ◽  
Hong-lin Hu ◽  
Ying Zhang ◽  
Xiao-min Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Cohort Study ◽  
Glucose Metabolism ◽  
Pregnant Women ◽  
Vitamin D Supplementation ◽  
Birth Cohort Study ◽  
Vitamin D Status ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

ABSTRACT Background Previous studies have shown conflicting findings regarding the relation of vitamin D status and supplementation during pregnancy with gestational diabetes mellitus (GDM). Most of these studies hypothesized that 25-hydroxyvitamin D [25(OH)D] concentrations were associated with GDM risk and glucose metabolism based on linear association models. Objectives We aimed to estimate the associations of 25(OH)D concentrations and vitamin D supplementation with GDM risk and glucose metabolism and determine the threshold concentrations of 25(OH)D that could significantly affect glucose metabolism and GDM risk. Methods In a prospective birth cohort study, we collected information about sociodemographic characteristics, health status, and lifestyle from 4984 pregnant women. Vitamin D supplementation and 25(OH)D concentrations were assessed in the second trimester. Data from the 75-g oral-glucose-tolerance test were obtained at 24–28 weeks of gestation. Results A total of 922 (18.5%) women were diagnosed with GDM. Compared with women with 25(OH)D concentrations <25 nmol/L, the GDM risk was significantly lower in women with 25(OH)D concentrations ranging from 50 to 75 nmol/L (RR: 0.74; 95% CI: 0.58, 0.95) and >75 nmol/L (RR: 0.40; 95% CI: 0.22, 0.70). The curve-fitting models suggested a significant large reduction in GDM risk, fasting plasma glucose, and area under the curve of glucose with increasing 25(OH)D concentrations only for concentrations >50 nmol/L. Consistently, GDM risk was significantly reduced only in women who took 400–600 IU vitamin D/d (RR: 0.83; 95% CI: 0.70, 0.97) with a mean 25(OH)D concentration of 50 nmol/L but not in women taking vitamin D sometimes with a mean 25(OH)D concentration of 40 nmol/L. Conclusions GDM risk was significantly reduced only in pregnant women with 25(OH)D concentrations >50 nmol/L. Pregnant women taking 400–600 IU vitamin D/d with mean 25(OH)D concentrations of 50 nmol/L had a lower risk of GDM.

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