Maternal calcium supplementation in a rural Gambian population associated with reduced blood pressure among adolescent female, but not male, offspring

2017 ◽  
Author(s):  
Simon Schoenbuchner ◽  
Sophie Moore ◽  
Landing Jarjou ◽  
Kate Ward ◽  
Ann Prentice
Keyword(s):  
Blood Pressure ◽  
Calcium Supplementation ◽  
Male Offspring ◽  
Adolescent Female

Sex differences in prenatal programming of hypertension by dexamethasone

2021 ◽  
pp. 153537022110032
Author(s):  
Issa Alhamoud ◽  
Susan K Legan ◽  
Jyothsna Gattineni ◽  
Michel Baum
Keyword(s):  
Blood Pressure ◽  
Plasma Renin ◽  
Female Offspring ◽  
Male Offspring ◽  
Thick Ascending Limb ◽  
Protein Abundance ◽  
Female Rat ◽  
Prenatal Programming ◽  
Transporter Protein ◽  
Renal Tubular

Prenatal dexamethasone has been shown to increase blood pressure in male offspring but the mechanism for the increase in blood pressure is unclear. The present study examined if prenatal programming by maternal injection of dexamethasone on days 15 and 16 of gestation affected the blood pressure comparably in female and male offspring. Our hypothesis was that males would be affected by prenatal dexamethasone to a greater extent than females and that either an increase in renal tubular transporter abundance or an increase in renin or aldosterone system would be associated with hypertension with prenatal programming. Prenatal dexamethasone increased blood pressure at two months and six months of age and resulted in proteinuria and albuminuria at six months in male but not female rat offspring. There was no effect of prenatal dexamethasone on blood pressure and proteinuria at one month in male and in female offspring. While prenatal dexamethasone increased male renal thick ascending limb sodium potassium two chloride cotransporter protein abundance at two months, prenatal dexamethasone on days 15 and 16 of gestation did not affect transporter abundance in males at other ages, nor did it affect proximal tubule sodium/hydrogen exchanger or distal convoluted tubule sodium chloride cotransporter protein abundance at any age. There was no difference in systemic renin or aldosterone in the prenatal dexamethasone group compared to same sex controls. In conclusion, male but not female offspring have an increase in blood pressure and urinary protein excretion with prenatal dexamethasone. The increase in blood pressure with prenatal programming was not associated with a consistent increase in renal tubular transporter protein abundance, nor plasma renin activity and serum aldosterone.

scholarly journals Long-Term Effects of Maternal Diabetes on Blood Pressure and Renal Function in Rat Male Offspring

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88269 ◽  
Author(s):  
Jie Yan ◽  
Xin Li ◽  
Rina Su ◽  
Kai Zhang ◽  
Huixia Yang
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Maternal Diabetes ◽  
Male Offspring ◽  
Long Term Effects

Does Oral Calcium Supplementation Lower High Blood Pressure? A Double Blind Study

1987 ◽  
Vol 5 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Francesco P. Cappuccio ◽  
Nirmala D. Markandu ◽  
Donald R.J. Singer ◽  
Stephen J. Smith ◽  
Angela C. Shore ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Calcium Supplementation ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Oral Calcium

scholarly journals Intrauterine growth restriction programs an accelerated age-related increase in cardiovascular risk in male offspring

2016 ◽  
Vol 311 (2) ◽  
pp. F312-F319 ◽  
Author(s):  
John Henry Dasinger ◽  
Suttira Intapad ◽  
Miles A. Backstrom ◽  
Anthony J. Carter ◽  
Barbara T. Alexander
Keyword(s):  
Blood Pressure ◽  
Intrauterine Growth Restriction ◽  
Renin Angiotensin System ◽  
Positive Association ◽  
Serum Testosterone ◽  
Growth Restriction ◽  
Male Offspring ◽  
Intrauterine Growth ◽  
Age Related ◽  
Related Increase

Placental insufficiency programs an increase in blood pressure associated with a twofold increase in serum testosterone in male growth-restricted offspring at 4 mo of age. Population studies indicate that the inverse relationship between birth weight and blood pressure is amplified with age. Thus, we tested the hypothesis that intrauterine growth restriction programs an age-related increase in blood pressure in male offspring. Growth-restricted offspring retained a significantly higher blood pressure at 12 but not at 18 mo of age compared with age-matched controls. Blood pressure was significantly increased in control offspring at 18 mo of age relative to control counterparts at 12 mo; however, blood pressure was not increased in growth-restricted at 18 mo relative to growth-restricted counterparts at 12 mo. Serum testosterone levels were not elevated in growth-restricted offspring relative to control at 12 mo of age. Thus, male growth-restricted offspring no longer exhibited a positive association between blood pressure and testosterone at 12 mo of age. Unlike hypertension in male growth-restricted offspring at 4 mo of age, inhibition of the renin-angiotensin system with enalapril (250 mg/l for 2 wk) did not abolish the difference in blood pressure in growth-restricted offspring relative to control counterparts at 12 mo of age. Therefore, these data suggest that intrauterine growth restriction programs an accelerated age-related increase in blood pressure in growth-restricted offspring. Furthermore, this study suggests that the etiology of increased blood pressure in male growth-restricted offspring at 12 mo of age differs from that at 4 mo of age.

Excessive maternal salt intake gives rise to vasopressin-dependent salt sensitivity of blood pressure in male offspring

2021 ◽  
Vol 150 ◽  
pp. 12-22 ◽  
Author(s):  
Young-Beom Kim ◽  
Won Woo Jung ◽  
Seung Won Lee ◽  
Xiangyan Jin ◽  
Hyung Kyung Kang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Salt Intake ◽  
Salt Sensitivity ◽  
Male Offspring
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