Targeted gene therapy

2016 ◽  
Author(s):  
Angelo Lombardo
Keyword(s):  
Gene Therapy ◽  
Targeted Gene Therapy

Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

2020 ◽  
Vol 20 (3) ◽  
pp. 195-206 ◽  
Author(s):  
Shriya Agarwal ◽  
Vinayak Agarwal ◽  
Mugdha Agarwal ◽  
Manisha Singh
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Immune Responses ◽  
Biological Membrane ◽  
Gene Isolation ◽  
Delivery Vehicle ◽  
Scientific Communities ◽  
Therapeutic Regime ◽  
Targeted Gene Therapy ◽  
Delivery Mechanism

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

Optimizing Polyplexes into Synthetic Viruses for Tumor-Targeted Gene Therapy

2006 ◽  
pp. 237-245
Author(s):  
Ernst Wagner ◽  
Julia Kloeckner ◽  
Manfred Ogris
Keyword(s):  
Gene Therapy ◽  
Targeted Gene Therapy

scholarly journals Computational Design and Application of Endogenous Promoters for Transcriptionally Targeted Gene Therapy for Rheumatoid Arthritis

2009 ◽  
Vol 17 (11) ◽  
pp. 1877-1887 ◽  
Author(s):  
Jeroen Geurts ◽  
Leo AB Joosten ◽  
Nozomi Takahashi ◽  
Onno J Arntz ◽  
Anton Glück ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Therapy ◽  
Computational Design ◽  
Targeted Gene Therapy ◽  
Design And Application

scholarly journals Tumor-targeted gene therapy using Adv-AFP-HRPC/IAA prodrug system suppresses growth of hepatoma xenografted in mice

2011 ◽  
Vol 19 (2) ◽  
pp. 77-83 ◽  
Author(s):  
M Dai ◽  
J Liu ◽  
D-E Chen ◽  
Y Rao ◽  
Z-J Tang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Targeted Gene Therapy

Advances in Liposome-Based Targeted Gene Therapy of Cancer

2012 ◽  
pp. 113-133 ◽  
Author(s):  
Jennifer L. Hsu ◽  
Chi-Hong Chao ◽  
Xiaoming Xie ◽  
Mien-Chie Hung
Keyword(s):  
Gene Therapy ◽  
Targeted Gene Therapy

Antibody-Targeted Gene Therapy

2002 ◽  
pp. 81-94
Author(s):  
C. LAMPERT ◽  
A.M. McCALL ◽  
L.M. WEINER
Keyword(s):  
Gene Therapy ◽  
Targeted Gene Therapy
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