Bone metabolism in patients with anorexia nervosa and amenorrhea

2016 ◽  
Author(s):  
Davide Gatti ◽  
Luca Idolazzi ◽  
Ghoch Marwan el ◽  
Ombretta Viapiana ◽  
Simona Calugi ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Bone Metabolism

Bone metabolism in anorexia nervosa and hypothalamic amenorrhea

Metabolism ◽  
2018 ◽  
Vol 80 ◽  
pp. 91-104 ◽  
Author(s):  
Sharon H. Chou ◽  
Christos Mantzoros
Keyword(s):  
Anorexia Nervosa ◽  
Bone Metabolism ◽  
Hypothalamic Amenorrhea

Bone metabolism in patients with anorexia nervosa and amenorrhoea

2016 ◽  
Vol 23 (2) ◽  
pp. 255-261 ◽  
Author(s):  
L. Idolazzi ◽  
M. El Ghoch ◽  
R. Dalle Grave ◽  
P. V. Bazzani ◽  
S. Calugi ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Bone Metabolism

scholarly journals Bone Metabolism in Anorexia Nervosa

2014 ◽  
Vol 12 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Pouneh K. Fazeli ◽  
Anne Klibanski
Keyword(s):  
Anorexia Nervosa ◽  
Bone Metabolism

scholarly journals Clinical and Biochemical Determinants of Bone Metabolism and Bone Mass in Adolescent Female Patients with Anorexia Nervosa

2002 ◽  
Vol 51 (4) ◽  
pp. 497-504 ◽  
Author(s):  
Laura Audí ◽  
Deisi M Vargas ◽  
Miquel Gussinyé ◽  
Diego Yeste ◽  
Gertrudis Martí ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Bone Mass ◽  
Bone Metabolism ◽  
Adolescent Female ◽  
Female Patients

scholarly journals Bone metabolism in adolescents with anorexia nervosa

2011 ◽  
Vol 34 (4) ◽  
pp. 324-332 ◽  
Author(s):  
M. Misra ◽  
A. Klibanski
Keyword(s):  
Anorexia Nervosa ◽  
Bone Metabolism

scholarly journals Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels

2019 ◽  
Vol 25 (5) ◽  
pp. 1387-1397
Author(s):  
Christina Patlaka ◽  
Bojan Tubic ◽  
Pernilla Lång ◽  
Staffan Paulie ◽  
Diana Swolin-Eide ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Acid Phosphatase ◽  
Bone Resorption ◽  
Bone Metabolism ◽  
High Energy ◽  
Tartrate Resistant Acid Phosphatase ◽  
Protein Levels ◽  
Serum Trap ◽  
Trap 5B

Abstract Aim Tartrate-resistant acid phosphatase (TRAP) exists as isoforms 5a and 5b. TRAP 5a is a biomarker of chronic inflammation and influences adipose tissue and 5b associates with bone metabolism/pathologies. The aim was to investigate the association of serum TRAP 5a/5b isoforms with fat and bone markers and anthropometric parameters in patients with anorexia nervosa (AN) during weight gain therapy. Methods Twenty-five Swedish female AN patients, age 16–24 years, were treated for 12 weeks with a high-energy diet with six meals daily. Serum TRAP 5a/5b, markers of fat/glucose metabolism, markers of bone resorption and formation were measured. Parameters of bone and body composition were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Results BMI increased from median 15.4 kg/m2 to 19.0 kg/m2, p < 0.0001. TRAP 5a and 5a/5b ratio increased but TRAP 5b decreased during the study. TRAP Δ5a and Δ5b correlated with Δinsulin and Δadiponectin, respectively. TRAP 5b correlated with trabecular density at start but not at week 12. At 12 weeks, TRAP 5b correlated with CTX, and Δ decrease in TRAP 5b correlated to Δ increase in bone-specific alkaline phosphatase. Conclusions This clinical interventional study resulted in increased BMI in patients with AN. The decreased TRAP 5b protein levels confirm a role for TRAP 5b as a marker of bone resorption, whereas increased TRAP 5a seemed to derive from systemic changes in bone as well as metabolic changes. The combined detection of TRAP 5a and TRAP 5b in serum could be an indicator of improved bone metabolism. Level of evidence Level III, prospective interventional cohort study.

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