Dendritic glycopolymers as efficient drug delivery systems for retarded release of bortezomib from calcium phosphate cements

2016 ◽  
Author(s):  
Bettina Mamitzsch ◽  
Christin Striegler ◽  
Matthias Schumacher ◽  
Michael Gelinsky ◽  
Martin Muller ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Calcium Phosphate Cements

Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release

2012 ◽  
Vol 32 (11) ◽  
pp. 2679-2690 ◽  
Author(s):  
Hiva Baradari ◽  
Chantal Damia ◽  
Maggy Dutreih-Colas ◽  
Etienne Laborde ◽  
Nathalie Pécout ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

The Application of Energetic SHS Reactions in the Synthesis of Multi-functional Bone Tissue Engineering and Drug Delivery Systems

2005 ◽  
Vol 896 ◽  
Author(s):  
Reed Ayers ◽  
Doug Burkes ◽  
Guglielmo Gottoli ◽  
H.C. Yi ◽  
Jaque Guigné ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Combustion Synthesis ◽  
Bone Tissue ◽  
Drug Delivery Systems ◽  
Exothermic Reaction ◽  
Functional Materials ◽  
Delivery Systems

AbstractThe term combustion synthesis, or self-propagating high temperature synthesis (SHS), refers to an exothermic chemical reaction process that utilizes the heat generated by the exothermic reaction to ignite and sustain a propagating combustion wave through the reactants to produce the desired product(s). The products of combustion synthesis normally are extremely porous: typically 50 percent of theoretical densityAdvantages of combustion synthesis over traditional processing routes, e.g., sintering, in the production of advanced materials such as ceramics, intermetallic compounds and composites include process economics, simplicity of operation, and low energy requirements. However, the high exothermicity and rapid combustion propagation rates necessitate a high degree of control of these reactions.One research area being conducted in the Institute for Space Resources (ISR) at the Colorado School of Mines (CSM) is the application of combustion synthesis (SHS) to synthesize advanced, engineered porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems. Such material systems require a complex combination of properties that can be truly classified as multi-functional materials. The range of properties includes: an overall porosity of 40-60% with a pore size of 200-500 μm; mechanical properties (compression strength and Young’s modulus) that match those of natural bone to avoid ‘stress shielding’; and a surface chemistry that is capable of facilitating bone growth and mineralization.The paper will discuss the synthesis of porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems.

Calcium phosphate biomaterials as bone drug delivery systems: a review

2010 ◽  
Vol 15 (13-14) ◽  
pp. 547-552 ◽  
Author(s):  
Elise Verron ◽  
Ibrahim Khairoun ◽  
Jerome Guicheux ◽  
Jean-Michel Bouler
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Delivery Systems

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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