Bisphosphonate treatment and the characteristics of femoral fractures in children with osteogenesis imperfecta

2015 ◽  
Author(s):  
Ilkka Vuorimies ◽  
Mervi Mayranpaa ◽  
Helena Valta ◽  
Heikki Kroger ◽  
Sanna Toiviainen-Salo ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Femoral Fractures ◽  
Bisphosphonate Treatment ◽  
Fractures In Children

scholarly journals Bisphosphonate Treatment and the Characteristics of Femoral Fractures in Children With Osteogenesis Imperfecta

2017 ◽  
Vol 102 (4) ◽  
pp. 1333-1339 ◽  
Author(s):  
Ilkka Vuorimies ◽  
Mervi K. Mäyränpää ◽  
Helena Valta ◽  
Heikki Kröger ◽  
Sanna Toiviainen-Salo ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Femoral Fractures ◽  
University Hospital ◽  
Type I ◽  
Fracture Type ◽  
Long Term Effects ◽  
Fracture Characteristics ◽  
Fractures In Children ◽  
Distal Shaft ◽  
Almost All

Abstract Context: The short-term benefits of bisphosphonates (BPs) are evident in the treatment of children with osteogenesis imperfecta (OI), but some concerns related to long-term effects remain. Objective: To elucidate the effect of BPs on characteristics of femoral fractures in children with OI. Design and Setting: Retrospective cohort study at a university hospital. Patients and Main Outcome Measure: The study included 93 patients with OI. We recorded fracture histories and analyzed all femoral fractures for location and fracture type using radiographs obtained at fracture diagnosis. Effects of BPs were evaluated by comparing fracture characteristics in three groups: patients (1) naive to BPs, (2) receiving ongoing BP treatment, and (3) whose treatment was discontinued. Results: In total, 127 femoral fractures occurred in 24 patients. Of the fractures, 63 (50%) occurred in patients naive to BPs, 44 (35%) during BP treatment, and 20 (16%) after treatment discontinuation. Mid or distal shaft fractures were most common (41%), followed by subtrochanteric (33%) and distal (20%) fractures. Almost all fractures were transverse (65%) or oblique (28%). The pattern of femoral fractures was similar in all three BP treatment groups (P = 0.78 for location; P = 0.35 for fracture type) and was not related to cumulative BP dose. Instead, OI type correlated with fracture characteristics, and distal location and transverse configuration were more common in the more severe types III and IV compared with type I OI. Conclusion: Characteristics of femoral fractures in children with OI are affected by OI type but not by BP exposure.

scholarly journals Validating scoring systems for fracture healing in infants and young children: pilot study

2021 ◽  
Author(s):  
Samuel Crompton ◽  
Fabrizio Messina ◽  
Gillian Klafkowski ◽  
Christine Hall ◽  
Amaka C. Offiah
Keyword(s):  
Pilot Study ◽  
Young Children ◽  
Fracture Healing ◽  
Callus Formation ◽  
Femoral Fractures ◽  
Scoring Systems ◽  
Power Calculation ◽  
Small Pilot Study ◽  
Fractures In Children ◽  
Infants And Young Children

Abstract Background Recent studies have analysed birth-related clavicular fractures to propose time frames for healing that could be applied to dating of all fractures in cases of suspected child abuse. Objective To assess differences in healing rates between femoral fractures and birth-related clavicular fractures in infants and young children. Materials and methods A retrospective 5-year pilot study of femoral fractures in children younger than 3 years of age was performed. Anonymised radiographs were independently scored by two radiologists for stages of fracture healing. In cases of reader disagreement, radiographs were independently scored by a third radiologist. Results In total, 74 radiographs (30 children) met the inclusion criteria. Fracture healing evolved over time with subperiosteal new bone formation (SPNBF) appearing first, followed by callus then remodelling. A power calculation for a single proportion, with a level of confidence of 95% and a margin of error of 5%, showed that in a definitive study, 359 radiographs would be required. Conclusion Although the overall pattern of healing is similar, in this small pilot study, the earliest times for SPNBF and callus formation in femoral fractures appeared to lag behind healing of birth-related clavicular fractures. Remodelling appeared earlier than remodelling of clavicular fractures. A power calculation has determined numbers of femoral radiographs (359) required for a definitive study.

Atypical femoral fractures and bisphosphonate treatment

2012 ◽  
Vol 94-B (3) ◽  
pp. 385-390 ◽  
Author(s):  
R. N. Thompson ◽  
J. R. A. Phillips ◽  
S. H. J. McCauley ◽  
J. R. M. Elliott ◽  
C. G. Moran
Keyword(s):  
Femoral Fractures ◽  
Bisphosphonate Treatment ◽  
Atypical Femoral Fractures

Skin traction in hip spica casting for femoral fractures in children

2007 ◽  
Vol 12 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Cem Zeki Esenyel ◽  
Kahraman Öztürk ◽  
Oktay Adanir ◽  
Bulent Aksoy ◽  
Meltem Esenyel ◽  
...  
Keyword(s):  
Femoral Fractures ◽  
Spica Casting ◽  
Fractures In Children ◽  
Skin Traction

Nerve blocks for initial pain management of femoral fractures in children

2012 ◽  
Author(s):  
Karen JL Black ◽  
Nancy G Murphy ◽  
Kara Thompson ◽  
Catherine A Bevan ◽  
Jason J Howard
Keyword(s):  
Pain Management ◽  
Femoral Fractures ◽  
Nerve Blocks ◽  
Fractures In Children

Do femoral fractures in adult patients with osteogenesis imperfecta imitate atypical femoral fractures? A case series

2018 ◽  
Vol 30 (2) ◽  
pp. 513-517 ◽  
Author(s):  
J. D. Andersen ◽  
M. H. Bünger ◽  
O. Rahbek ◽  
J. D. Hald ◽  
T. Harsløf ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Case Series ◽  
Femoral Fractures ◽  
Adult Patients ◽  
Atypical Femoral Fractures

scholarly journals Observational study on titanium elastic nailing in femoral shaft fractures in children

2018 ◽  
Vol 5 (1) ◽  
pp. 32
Author(s):  
Jyotirtmayee Bahinipati ◽  
R. G. Asutosh Mohapatra
Keyword(s):  
Femoral Shaft Fracture ◽  
Femoral Fractures ◽  
Femoral Shaft ◽  
Limb Length Discrepancy ◽  
Shaft Fracture ◽  
Titanium Elastic Nailing ◽  
Fractures In Children ◽  
Group 5 ◽  
One Year ◽  
Prolonged Immobilization

<p class="abstract"><strong>Background:</strong> Nowadays femoral fractures in children are more commonly managed with operative fixation rather than conservative treatment because of more rapid recovery and avoidance of prolonged immobilization. Our aim of study was to assess the outcome of titanium elastic nailing in femoral shaft fracture in children.</p><p class="abstract"><strong>Methods:</strong> Twenty five children in age group 5-15 years with femoral shaft fracture were stabilized with two titanium nails. Children were followed up for one year. The operative outcome was evaluated using criteria of Flynn. Complications associated with procedure were recorded and analyzed.<strong></strong></p><p class="abstract"><strong>Results:</strong> The final outcome was excellent in 67% (19 of 25) of patients, satisfactory in 16% (4 of 25) of patients and poor in 8% (2 of 25) of patients. Poor outcome was due to limb length discrepancy, pain in the knee and angular misalignment.</p><p class="abstract"><strong>Conclusions:</strong> We concluded that titanium elastic nailing is an ideal method of femoral shaft fixation in children.</p>

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