Influence of vitamin D deficiency to structural and functional state of bone tissue in schoolchildren

2014 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Olena Tyazhka ◽  
Nataliya Balatska ◽  
Tetyana Budnik ◽  
Inga Kubey ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Functional State

Vitamin D deficiency and structural and functional state of bone tissue in schoolchildren of Ukraine

2013 ◽  
Author(s):  
Povoroznyuk Vladyslav ◽  
Tyazhka O ◽  
Balatska Nataliya ◽  
Budnik T ◽  
Kubey I ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Functional State

scholarly journals High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state

2013 ◽  
Vol 95 (8) ◽  
pp. 569-572 ◽  
Author(s):  
JA Jansen ◽  
FS Haddad
Keyword(s):  
Vitamin D ◽  
Total Knee Replacement ◽  
Elderly Patients ◽  
Knee Osteoarthritis ◽  
Vitamin D Deficiency ◽  
Knee Replacement ◽  
Functional State ◽  
High Prevalence ◽  
Outcome Scores ◽  
Total Knee

Vitamin D deficiency has been reported previously in patients with osteoarthritis undergoing total hip arthroplasty. We found a high prevalence of vitamin D deficiency in elderly patients with advanced knee osteoarthritis scheduled for total knee replacement and also a significant association with a lower preoperative functional state. A review of the literature is given on vitamin D deficiency in patients with knee osteoarthritis and the association with lower outcome scores after arthroplasty is discussed.

scholarly journals STUDY OF BIOCHEMICAL MARKERS’ CONTENT OF BONE TISSUE METABOLISM IN THE ORAL LIQUID OF PATIENTS WITH GENERALIZED PERIODONTITIS

2020 ◽  
pp. 10-15
Author(s):  
I.V. Vozna ◽  
A.V. Samoilenko ◽  
S.V. Pavlov
Keyword(s):  
Vitamin D ◽  
Periodontal Disease ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Biochemical Markers ◽  
Oral Fluid ◽  
Comparison Group ◽  
Study Group ◽  
Periodontal Tissue ◽  
Tissue Metabolism

The study aims to determine the concentration of vitamin D in the oral fluid, markers of bone destruction as well as to assess the diagnostic value of these indicators to optimize special programs for diagnostics and prevention of major dental diseases in the industrial region’s residents. The object and research methods. There were examined 178 patients. The study group consisted of 126 patients with generalized periodontitis of initial (8), I (32), II (68), and III (18) severity levels, chronic course who are working in hazardous conditions of the "Dniprospetsstal" plant in Zaporizhzhya. The comparison group included 32 patients with periodontitis of initial (5), I (10), II (11), and III (6) severity degrees, which do not have occupational health risks. The control group consisted of 20 relatively healthy individuals without signs of periodontal tissue disease. The level of vitamin D, VDBP, MMP-8, and osteocalcin was determined by enzyme-linked immunosorbent assay. Research results. It is established, that the patients with the initial severity of periodontal disease have minor vitamin D deficiency and as the severity progresses, the vitamin D deficiency increases. Therefore, in the third severity of the inflammatory process, there is a severe deficiency of vitamin D. It should be noted that in the study group patients who were working in hazardous production conditions, the decrease of vitamin D content in the oral fluid was more pronounced relative to the patients in the comparison group with periodontal disease and no occupational hazards. Vitamin D deficiency depends on the severity of periodontitis, which is confirmed by the established strong feedback of the comparison group (γ = -0.790, p <0.05), and that of the study group (γ = -0.778, p <0.05). Periodontitis was accompanied by a significant loss of vitamin D and was associated with a sharp decrease of VDBP protein. That is, not only the concentration of vitamin D changes but so does the protein responsible for the transfer and utilization of this vitamin. We have found a correlation between the VDBP presence in the sample and the severity of periodontitis. Strong feedback of the comparison group (γ = -0.962, p <0.05) and that of the study group (γ = -0.966, p <0.05) was detected. The patients had impaired bone tissue metabolism, which was accompanied by the bone destruction marker MMP-8 increase. The obtained data show a significant increase of MMP-8 content in the oral fluid in periodontitis patients, compared to the individuals with clinically intact periodontium, and reliably reflects the severity of the disease. We have established a direct strong connection between the level of MMP-8 in the oral fluid and the degree of the disease using the method of mathematical analysis. The correlation coefficient was (γ = 0.892, p <0.05) in the comparison group and (γ = 0.965, p <0.05) in the study group. The results of studying bone tissue formation activity considering the level of osteocalcin have shown that osteocalcin decreases with increasing severity of the disease. The correlation between osteocalcin levels and disease severity in the patient groups had strong feedback both in the comparison group (γ = -0.919, p <0.05) and in the study group (γ = -0.987, p <0.05). Conclusions. Biochemical markers allow detecting disorders of bone tissue metabolism and their level of concentration depends on the severity of periodontal tissue disease. The vitamin D deficiency, the concentration of VDBP, MMP-8, osteocalcin are more pronounced in the patients with periodontal disease experiencing occupational hazards compared to the patients who are not exposed to such conditions. The obtained results substantiate the feasibility of enzyme-linked immunosorbent assay introducing vitamin D, VDBP, MMP-8, osteocalcin in laboratory screening of periodontal tissue diseases as highly informative biochemical markers used for diagnostics and prognosis.

scholarly journals Effects of ascorbic acid on the skeletal response of chicks to vitamin D deficiency

1968 ◽  
Vol 22 (1) ◽  
pp. 77-82 ◽  
Author(s):  
P. A. Thornton
Keyword(s):  
Vitamin D ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Compact Bone ◽  
Significant Degree ◽  
Plasma Ascorbic Acid ◽  
Bone Ash ◽  
Plate Width

1. The skeletal response of vitamin D-deficient chicks to dietary ascorbic acid was tested.2. The epiphyseal cartilaginous plate width, which was increased by the vitamin D deficiency, was further increased when ascorbic acid was added and the effect appeared sooner.3. Absence of vitamin D was associated with a reduction in the relative amount of cancellous to compact bone ash in the tibia. Dietary ascorbic acid intensified this effect to a significant degree.4. Plasma ascorbic acid levels in rachitic chicks were approximately 25% less than in controls. This observation may explain the skeletal response to added vitamin C and suggests that avian bone tissue has a particularly high requirement for this vitamin.

scholarly journals The action of vitamin D on the degree of mineralization of bone tissue in rats given adequate amounts of calcium and phosphorus in the diet

1970 ◽  
Vol 24 (1) ◽  
pp. 29-38 ◽  
Author(s):  
P. Rasmussen
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cortical Bone ◽  
Bone Tissue ◽  
Bone Matrix ◽  
Serum Analysis ◽  
Epiphyseal Plate ◽  
Degree Of Mineralization ◽  
Normal Degree ◽  
Calcium And Phosphorus

1. The action of vitamin D on the degree of mineralization of the bone tissue of rats given a diet containing adequate amounts of calcium and phosphorus for 8 weeks has been investigated by quantitative microradiography. The method is described.2. There was a significant reduction in the growth of the vitamin D-deficient rats; the reduction was most marked in the females.3. Serum analysis showed a reduction in Ca, but P was unchanged. However, the Ca × P product was considered to be high enough to permit normal mineralization.4. The degree of mineralization of the cortical bone tissue increased significantly according to the distance from the epiphyseal plate. However, there were no significant differences between vitamin D-treated and vitamin D-deficient animals.5. It is concluded that vitamin D deficiency in rats does not prevent the formation of a bone matrix which can attain a normal degree of mineralization.

scholarly journals Bone condition in children with juvenile idiopathic arthritis

2021 ◽  
pp. 45-52
Author(s):  
N.S. Shevchenko ◽  
◽  
L.F. Bogmat ◽  
Yu.V. Khadzhinova ◽  
◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Juvenile Idiopathic Arthritis ◽  
Parathyroid Hormone ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Control Group ◽  
Mineral Density ◽  
Calcium And Phosphorus

Osteopenia (osteopenic syndrome) and osteoporosis (OP) are among the frequent and highly disabling conditions that accompany the development of rheumatic diseases (RD), including juvenile idiopathic arthritis (JIA). Changes in the requirements for the diagnosis and treatment of children with JIA according to the treatment strategy to achieve the goal (treat to target) have led to a decrease in the frequency of development and manifestations of OP in patients with RD. The condition of bone tissue in children with JIA, against the background of modern therapy and in conditions of widespread vitamin D deficiency requires further study. Purpose — to study bone mineral density (BMD) in children with JIA in modern disease management and to identify adverse factors for the development of OP among clinical signs. Materials and methods. We examined 35 children with JIA aged 7 to 17 years, mostly female (77.1%), with oligo (25.7)%, poly (60.0%) and undifferentiated (14.3%) option, 53.4% of whom have not yet received basic therapy. All patients underwent BMD by dual-energy X-ray absorptiometry on a bone densitometer Explorer QD W (Hologic), parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], total and ionized calcium and phosphorus in syvo. The control group consisted of 12 healthy children of the same age with a normal level of 25(OH)D. Results. The mean level of vitamin D in the serum of children in the main group was 20.41±1.35 ng/ml, which was significantly lower than in the control group (30.03±2.53 ng/ml, p<0.05); the frequency of low levels of vitamin D reached 88.57%. The content of calcium and phosphorus in the blood did not deviate from the normative values, despite the widespread deficiency of vitamin D. 98.37% of patients had normal PTH values, the average level in the blood was 30.43±0.90 pg/ml. The content of PTH was the highest in non-differential arthritis (34.33±1.80 pg/ml), the lowest in the oligoarticular variant (28.36±1.43 pg/ml, p<0.05). PTH concentrations correlated with vitamin D levels (r=-0.41; p<0.05) and were independent of patient gender and disease activity. The frequency of decreased BMD was 28.57% of the surveyed children. The prevalence of osteopenia was the same in different variants of arthritis and did not depend on the sex and age of patients, positivity in the RF. Osteopenic syndrome was significantly more common in ANA-positive JIA than in ANA-negative variant (46.15% vs. 18.18%; pϕ<0.05). The condition of bone tissue (Z-criteria) depended on BMI (r=0.33; p<0.05), disease activity on the JADAS scale (r=0.35; p<0.04), the number of active joints (r=0.34; p<0.05); ANA level (r=-0.34; p<0.05). In the group of children with osteopenic syndrome, BMD correlated with the duration of the disease (r=-0.67; p<0.05), the number of active joints (r=-0.62; p<0.05), the level of blood phosphorus 0.74; p<0.05) and the sum of points on the JADAS scale (r=0.59; p<0.05). In the group of children with preserved BMD, the spectrum of correlations was supplemented by indicators of vitamin D status (r=-0.33; p<0.05) and BMI (r=-0.40; p<0.05). Conclusions. In children with JIA, the incidence of osteopenia is 28.57% with vitamin D deficiency in 88.57% of patients, preserved levels of total calcium, phosphorus and PTH in the blood. Decreased BMD in the early stages of JIA is associated with a younger age of patients and the age of onset of the disease, increased prevalence of joint syndrome, inflammatory and serological activity of the disease, ionized calcium and blood phosphorus, PTH levels and decreased vitamin D (р<0,001). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: bone mineral density; juvenile idiopathic arthritis; osteopenia; 25-OH-vitamin D; parathyroid hormone.

scholarly journals MANDIBULAR OSTEOMETRIC INDEXES IN PATIENTS WITH PERIODONTITIS DEPENDING ON THE LEVEL OF VITAMIN D

2017 ◽  
Vol 4 (1) ◽  
pp. 42-44
Author(s):  
V. E. Novoshytskyy ◽  
I.P. Mazur
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Alveolar Bone ◽  
Body Height ◽  
Hydroxyvitamin D ◽  
Mandibular Body ◽  
25 Hydroxyvitamin D ◽  
Bone Height

MANDIBULAR OSTEOMETRIC INDEXES IN PATIENTS WITH PERIODONTITIS DEPENDING ON THE LEVEL OF VITAMIN DNovoshytskyy V. E., Mazur I. P. Recent studies have reported a relationship between vitamin D level, bone tissue and periodontitis. The aim of study was to determine mandibular osteometric indices in patients with periodontitis depending on the level of vitamin D. We have examined 95 patients with periodontitis. Patients were divided into 3 groups according to 25-hydroxyvitamin-D concentration in plasma. All patients were examined to determine vitamin D level and mandibular osteometric indices. Mandibular height in the canine area in patients with vitamin D sufficiency was the lowest and was 27.33(25.15-29.02)mm. Mandibular height in patients with vitamin D deficiency and insufficiency was 28.04(25.91-29.78)mm and 29.03(26.70-31.21)mm, respectively. Mandibular body height in the canine area in patients with GP and vitamin D deficiency, insufficiency and sufficiency was 16.68(14.95-18.45)mm, 17.34(15.74-19.42)mm and 15.93(14.65-17.23)mm, respectively and alveolar bone height in canine area was 11.55(9.53-12.85)mm, 11.21(10.00-13.81)mm and 11.21(9.69-12.75)mm, respectively. Thus, the increase of mandibular height in patients with periodontitis who had vitamin D deficiency and insufficiency occurred by the increase of mandibular body height.KeyWords:  periodontitis, vitamin D, bone tissue, mandible, osteometric indices. ОСТЕОМЕТРИЧНІ ПОКАЗНИКИ НИЖНЬОЇ ЩЕЛЕПИ У ПАЦІЄНТІВ ІЗ ГЕНЕРАЛІЗОВАНИМ ПАРОДОНТИТОМ В ЗАЛЕЖНОСТІ ВІД РІВНЯ ВІТАМІНУ DНовошицький В. Є., Мазур І. П.Останнім часом повідомляється про взаємозв’язок між рівнем вітаміну D, кістковою тканиною та генералізованим пародонтитом (ГП). Метою дослідження було визначити остеометричні показники нижньої щелепи (НЩ) у пацієнтів із ГП в залежності від рівня вітаміну D. В дослідження були включені 95 пацієнтів із ГП віком від 25 до 68 років. Пацієнти були розподілені на 3 групи в залежності від рівня вітаміну D. Всім пацієнтам було проведено визначення рівня вітаміну D та остеометричних показників НЩ. Висота НЩ в ділянці ікол була найнижча у пацієнтів із ГП, які мають достатній рівень вітаміну D та становила 27,33(25,15-29,02)мм. А висота НЩ при дефіциті та недостатності становила 28,04(25,91-29,78)мм та 29,03(26,70-31,21)мм відповідно. Висота тіла НЩ в ділянці ікол у пацієнтів із ГП при дефіциті, недостатності та достатності вітаміну D становила 16,68(14,95-18,45)мм, 17,34(15,74-19,42)мм та 15,93(14,65-17,23)мм відповідно, а висота альвеолярного відростка НЩ в ділянці ікол становила 11,55(9,53-12,85)мм, 11,21(10,00-13,81)мм та 11,21(9,69-12,75)мм відповідно. Отже, збільшення висоти НЩ у пацієнтів із ГП при дефіциті та недостатності вітаміну D відбувається за рахунок збільшення висоти тіла НЩ.Ключові слова: генералізований пародонтит, вітамін D, кісткова тканина, нижня щелепа, остеометричні індекси  ОСТЕОМЕТРИЧЕСКИЕ ПОКАЗАТЕЛИ НИЖНЕЙ ЧЕЛЮСТИ У ПАЦИЕНТОВ С ГЕНЕРАЛИЗОВАННЫМ ПАРОДОНТИТОМ В ЗАВИСИМОСТИ ОТ УРОВНЯ ВИТАМИНА DНовошицкий В. Е.,  Мазур И. П.В последнее время сообщается о взаимосвязи между уровнем витамина D, костной тканью и генерализованным пародонтитом (ГП). Целью исследования было определение остеометрических показателей нижней челюсти (НЧ) у пациентов с ГП в зависимости от уровня витамина D. В исследование были включены 95 пациентов с ГП в возрасте от 25 до 68 лет. Пациенты были разделены на 3 группы в зависимости от уровня витамина D. Всем пациентам было проведено определение уровня витамина D и остеометрических показателей НЧ. Высота НЧ в области клыков была самая низкая у пациентов с ГП, которые имеют достаточный уровень витамина D и составила 27,33(25,15-29,02)мм. Высота НЧ при дефиците и недостаточности составляла 28,04(25,91-29,78)мм и 29,03(26,70-31,21)мм, соответственно. Высота тела НЧ в области клыков у пациентов с ГП при дефиците, недостаточности и достаточности витамина D составляла 16,68(14,95-18,45)мм, 17,34(15,74-19,42)мм и 15,93(14,65-17,23)мм, соответственно. Высота альвеолярного отростка НЧ в области клыков составляла 11,55(9,53-12,85) мм, 11,21(10,00-13,81)мм и 11,21(9,69-12,75) мм соответственно. Таким образом, увеличение высоты НЧ у пациентов с ГП при дефиците и недостаточности витамина D происходит за счет увеличения высоты тела НЧ.Ключевые слова: генерализованный пародонтит, витамин D, костная ткань, нижняя челюсть, остеометрические индексы

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