The transcription factor Foxc1 controls endochondral ossification through the direct regulation of PTHrP and Cola10a1 expression under the partnership with Gli2 and Runx2

2014 ◽  
Author(s):  
Michiko Yoshida ◽  
Kenji Hata ◽  
Rikako Takashima ◽  
Sachiko Iseki ◽  
Teruko Yamamoto-Takano ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Endochondral Ossification ◽  
Direct Regulation

scholarly journals Direct Regulation by the Vibrio cholerae Regulator ToxT To Modulate Colonization and Anticolonization Pilus Expression

2009 ◽  
Vol 77 (4) ◽  
pp. 1383-1388 ◽  
Author(s):  
Ansel Hsiao ◽  
Xiao Xu ◽  
Biao Kan ◽  
Rahul V. Kulkarni ◽  
Jun Zhu
Keyword(s):  
Transcription Factor ◽  
Vibrio Cholerae ◽  
Transcriptional Repression ◽  
Type Iv Pili ◽  
Present Evidence ◽  
Type Iv ◽  
Transcriptional Regulatory ◽  
Environmental Reservoir ◽  
Target Promoters ◽  
Direct Regulation

ABSTRACT The pathogen Vibrio cholerae uses a large number of coordinated transcriptional regulatory events to transition from its environmental reservoir to the host and establish itself at its preferred colonization site at the host intestinal mucosa. The key regulator in this process is the AraC/XylS family transcription factor, ToxT, which plays critical roles in pathogenesis, including the regulation of two type IV pili, the anticolonization factor mannose-sensitive hemagglutinin and the toxin-coregulated pilus. Previously, it was thought ToxT required dimerization in order to effect transcriptional regulation at its cognate promoters. Here, we present evidence that ToxT directly represses transcription of the msh operon by binding to three promoters within this operon and that dimerization may not be required for transcriptional repression of target promoters by ToxT, suggesting that this regulator uses different mechanisms to modulate the transcriptional repertoire of V. cholerae.

scholarly journals Tomato SlBES1.8 influences leaf morphogenesis by mediating gibberellin metabolism and signaling

2021 ◽  
Author(s):  
Deding Su ◽  
Wei Xiang ◽  
Qin Liang ◽  
Ling Wen ◽  
Yuan Shi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Regulatory Mechanism ◽  
Tomato Leaf ◽  
Negative Regulator ◽  
The Other ◽  
Leaf Morphogenesis ◽  
Gibberellin Metabolism ◽  
Expression Studies ◽  
Ga Biosynthesis ◽  
Direct Regulation

Leaf morphogenetic activity determines its shape diversity. However, our knowledge to the regulatory mechanism in maintaining leaf morphogenetic capacity is still limited. In tomato, gibberellin (GA) negatively regulates leaf complexity by shortening the morphogenetic window. We here reported a tomato BRI1-EMS-SUPPRESSOR 1 (BES1) transcription factor, SlBES1.8, that promoted the simplification of leaf pattern in a similar manner as GA functions. Enhanced level of SlBES1.8 dramatically decreased the sensibility of tomato to GA whereas increased the sensibility to the GA biosynthesis inhibitor, PAC. In line with the phenotypic observation, the endogenous bioactive GA contents were increased in OE-SlBES1.8 lines, which certainly promoted the degradation of the GA signaling negative regulator, SlDELLA. Moreover, transcriptomic analysis uncovered a set of overlapping genomic targets of SlBES1.8 and GA, and most of them were regulated in the same way. Expression studies showed the repression of SlBES1.8 to the transcriptions of two GA deactivated genes, SlGA2ox2 and SlGA2ox6, and one GA receptor, SlGID1b-1. Further experiments confirmed the direct regulation of SlBES1.8 to their promoters. On the other hand, SlDELLA physically interacted with SlBES1.8 and further inhibited its transcriptional regulation activity by abolishing SlBES1.8-DNA binding. Conclusively, by mediating GA deactivation and signaling, SlBES1.8 greatly influenced tomato leaf morphogenesis.

scholarly journals Factores de diferenciación génica y su futuro en el tratamiento de la osteoporosis: de la adipogénesis a la osteoblastogénesis, ¿del mismo modo y en sentido contrario?

2018 ◽  
Vol 5 (4) ◽  
pp. 21-25
Author(s):  
Pedro Sánchez Márquez ◽  
Carlos Arturo Révérend Lizcano
Keyword(s):  
Transcription Factor ◽  
Bone Loss ◽  
Bone Formation ◽  
Endochondral Ossification ◽  
Related Factors ◽  
Senile Osteoporosis ◽  
Age Related ◽  
Post Traumatic

El presente artículo tiene como objetivo presentar de forma resumida los diferentes factores que están involucrados en la diferenciación y el mantenimiento del fenotipo óseo, en contraste con los factores adipogénicos, cuya expresión determina procesos de diferenciación mutuamente excluyentes. Por otro lado, se propone el posible uso terapéutico para distintas patologías óseas como la osteoporosis. Los datos fueron obtenidos de estudios clínicos aleatorizados y de revisión, en idioma español e inglés, de los últimos 15 años, que incluyeran los términos Mesh: Osteoporosis; Osteoporoses; Osteoporosis, Post-Traumatic; Osteoporosis, Senile; Osteoporosis, Age-Related; Bone Loss, Age-Related; Factors, Transcription; Transcription Factor; Adipogeneses; Bone Formation; Osteoclastogenesis; Endochondral Ossification; Endochondral Ossifications; Ossification, Endochondral; Ossification, Physiological; Ossification, Physiologic.

scholarly journals The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0150263 ◽  
Author(s):  
Lindsay E. Laurie ◽  
Hiroki Kokubo ◽  
Masataka Nakamura ◽  
Yumiko Saga ◽  
Noriko Funato
Keyword(s):  
Transcription Factor ◽  
Endochondral Ossification

scholarly journals MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2

2017 ◽  
Vol 8 (1) ◽  
pp. e2572-e2572 ◽  
Author(s):  
Melissa Colden ◽  
Altaf A Dar ◽  
Sharanjot Saini ◽  
Priya V Dahiya ◽  
Varahram Shahryari ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transcription Factor ◽  
Bone Metastasis ◽  
Tumor Growth ◽  
Direct Regulation

scholarly journals The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1

2021 ◽  
Vol 1868 (5) ◽  
pp. 118974
Author(s):  
Nuria Pujol-Carrion ◽  
Mónica Pavón-Vergés ◽  
Javier Arroyo ◽  
Maria Angeles de la Torre-Ruiz
Keyword(s):  
Transcription Factor ◽  
Iron Homeostasis ◽  
Direct Regulation
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