Potential association between vitamin D deficiency and hypertension in adolescents: a Pilot study

2013 ◽  
Author(s):  
Babinska-Malec Edyta ◽  
Konstantynowicz Jerzy ◽  
Abramowicz Pawel ◽  
Werpachowska Irena ◽  
Bazyluk-Muszynska Malgorzata ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Deficiency ◽  
Potential Association

scholarly journals Serum Parathormone Levels as a Sign for Vitamin D Deficiency During Anti-Tuberculosis Therapy (Pilot Study)

2013 ◽  
Vol 8 (3) ◽  
Author(s):  
Shahram Habibzadeh ◽  
Ahmad Ghasemi ◽  
Nava Soleimani ◽  
Saeedeh Bagherbandi ◽  
Nahid Pourmohammadjan
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Deficiency ◽  
Tuberculosis Therapy

scholarly journals Vitamin D in schizophrenia and depression: a clinical review

2019 ◽  
Vol 25 (4) ◽  
pp. 240-248 ◽  
Author(s):  
John Lally ◽  
Fiona Gaughran
Keyword(s):  
Vitamin D ◽  
Mental Disorders ◽  
Physical Health ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Research Centre ◽  
List Type ◽  
Potential Association ◽  
Health And Social Care ◽  
Randomised Controlled

SUMMARYEvidence from preclinical and clinical studies supports a role for vitamin D deficiency in many mental disorders. In this review, we discuss the role of vitamin D in the aetiology and treatment of schizophrenia and depression and their physical health comorbidities. Although observational studies support a potential association between vitamin D and schizophrenia and depression, sufficient high-quality evidence from clinical trials does not yet exist to establish a place for vitamin D supplementation in optimising clinical response or promoting physical health. Completed randomised controlled trials are needed to provide insights into the efficacy and safety of vitamin D in the management of mental disorders.LEARNING OBJECTIVESAfter reading this article you will be able to: •outline the epidemiology of vitamin D deficiency in schizophrenia•describe the associations of vitamin D with schizophrenia and depression•know how to assess, and consider treatment for, vitamin D deficiency.DECLARATION OF INTERESTF.G. has received support or honoraria for CME, advisory work and lectures from Bristol-Myers Squibb, Janssen, Lundbeck, Otsuka, Roche and Sunovion, and has a family member with professional links to Lilly and GSK, including shares. She is in part funded by the National Institute for Health Research's (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London and the South London Collaboration for Leadership in Applied Health Research & Care Funding scheme, and by the Maudsley Charity. The views expressed in this article are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.

The effect of vitamin D deficiency on the developing brain: a pilot study

2012 ◽  
Vol 97 (Suppl 1) ◽  
pp. A16.1-A16
Author(s):  
V Kyriakopoulou ◽  
D Vatansever ◽  
SK Dhodhia ◽  
JM Allsop ◽  
M Fox ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Deficiency ◽  
Developing Brain

scholarly journals Nutritional Status and Micro Nutrient Deficiencies Among adolescents: A Pilot Study from Northern India (P18-101-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ankita Kankaria ◽  
Mona Duggal ◽  
Parul Chawla Gupta ◽  
Limalemla Jamir ◽  
Akash Kumar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Nutritional Status ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Folate Deficiency ◽  
Serum Folate ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract Objectives To study the nutritional status and prevalence of RBC folate, Serum folate and vitamin D deficiency among adolescents. Methods A cross sectional pilot study was carried out among 96 adolescents visiting outpatient department for refraction at tertiary care hospital in North India. Anthropometric data was obtained for height in centimetres and weight in kilograms. A pretested questionnaire was used to capture quantitative data. Venous blood samples were collected where red blood cell (RBC), serum folate and serum Vitamin D concentrations were measured. Anaemia was defined as normal, mild, moderate and severe as Hb > 12gm/dl, 11–11.9 gm/dl, 8–10.9 gm/dl and < 8 gm/dl respectively. Serum folate deficiency was defined as serum folate < 7 nmol/l, and RBC folate deficiency and insufficiency were defined as RBC folate < 305 nmol/l and & < 748 nmol/l, respectively. Vitamin D deficiency, insufficiency and sufficiency was defined as 25(OH)D < 20 ng/ml, 20–29 ng/ml and ≥ 30 ng/ml respectively. Descriptive statistics and inferential statistics were used. Results Almost 46% of adolescents were malnourished (10.4% were underweight, 35.4% were overweight or obese) and mean BMI was 19.7 kg/meter2 however it did not differ significantly across gender. As compared to boys more girls were vegetarian by diet. The mean concentrations for Hb, serum folate and RBC folate were 12.7 (95% CI: 12.4, 13.0) gm/dl, 15.1 (95% CI 12.5, 17.7) nmol/L and 492.9 (95% CI 431.9, 553.9) nmol/L, respectively. Mean concentration for Hb was significantly different across gender (p – 0.0). Around 17% of adolescents were anaemic, 60% were deficient for serum folate and 79% were deficient for RBC folate. Mean serum vitamin D levels were 18 ng/dl (95% CI: 17.0, 22.3) no significant difference found across gender. A total of 62.5% were deficient and 28% were insufficient for vitamin D (ng/ml). Around 50% of the adolescents lack adequate sleep (<8 hours) and increase vitamin D levels were associated with increase sleep duration (r-0.02, p-0.02). Conclusions The nutritional status of adolescents in this study is poor and reflects a need to conduct a community-based study which can help in planning strategies to improve nutritional status during critical period of adolescence Funding Sources nil. Supporting Tables, Images and/or Graphs

Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study

2012 ◽  
Vol 24 (1) ◽  
pp. 131-133 ◽  
Author(s):  
András Holló ◽  
Zsófia Clemens ◽  
Anita Kamondi ◽  
Péter Lakatos ◽  
Anna Szűcs
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Deficiency ◽  
Seizure Control

scholarly journals Association of Gut Microbiome and Vitamin D Deficiency in Knee Osteoarthritis Patients: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1272
Author(s):  
Boopalan Ramasamy ◽  
Fabien Magne ◽  
Sujit Kumar Tripathy ◽  
Giriprasad Venugopal ◽  
Diptasree Mukherjee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Knee Osteoarthritis ◽  
Vitamin D Deficiency ◽  
Gut Microbiome ◽  
Bacterial Species ◽  
Serum Vitamin ◽  
Core Microbiome ◽  
Serum Vitamin D ◽  
Significant Difference

Background: Few preclinical studies have shown that Knee osteoarthritis (KOA) is linked to gut microbiome dysbiosis and chronic inflammation. This pilot study was designed to look at the gut microbiome composition in KOA patients and normal individuals with or without vitamin D deficiency (VDD, serum vitamin D <30 ng/mL). Methods: This pilot study was conducted prospectively in 24 participants. The faecal samples of all the participants were taken for DNA extraction. The V3-V4 region of 16s rRNA was amplified, and the library was prepared and sequenced on the Illumina Miseq platform. Results: The mean (±SD) age was 45.5 (±10.2) years with no defined comorbidities. Of 447 total Operational Taxonomic Units (OTUs), a differential abundance of 16 nominally significant OTUs between the groups was observed. Linear discriminate analysis (LEfSe) revealed a significant difference in bacteria among the study groups. Pseudobutyrivibrio and Odoribacter were specific for VDD, while Parabacteroides, Butyricimonas and Gordonibacter were abundant in the KOA_VDD group, and Peptococcus, Intestimonas, Delftia and Oribacterium were abundant in the KOA group. About 80% of bacterial species were common among different groups and hence labelled as core bacterial species. However, the core microbiome of KOA and VDD groups were not seen in the KOA_VDD group, suggesting that these bacterial groups were affected by the interaction of the KOA and VDD factors. Conclusion: Parabacteroides, Butyricimonas, Pseudobutyrivibrio, Odoribacter and Gordonibacter are the predominant bacteria in vitamin D deficient patients with or without KOA. Together these results indicate an association between the gut microbiome, vitamin D and knee osteoarthritis.

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