Longitudinal assessment of spinal bone mineral density in children with neurofibromatosis type 1 using dual energy absorptiometry and quantitative computed tomography

2013 ◽  
Author(s):  
Eelloo Judith ◽  
Ward Kate ◽  
M Huson Susan ◽  
E Adams Judith ◽  
Russell Sarah ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Neurofibromatosis Type 1 ◽  
Quantitative Computed Tomography ◽  
Neurofibromatosis Type ◽  
Dual Energy ◽  
Spinal Bone Mineral Density ◽  
Longitudinal Assessment ◽  
Mineral Density

scholarly journals Bone densitometry measurements in children with neurofibromatosis Type 1 using quantitative computed tomography

2021 ◽  
Author(s):  
O Tezol ◽  
Y Balcı ◽  
M Alakaya ◽  
B Gundogan ◽  
EC Cıtak
Keyword(s):  
Computed Tomography ◽  
Neurofibromatosis Type 1 ◽  
Quantitative Computed Tomography ◽  
Neurofibromatosis Type ◽  
Significant Negative Correlation ◽  
Urinary Calcium ◽  
Volumetric Bone Mineral Density ◽  
Z Score ◽  
Mineral Density

Introduction: Neurofibromatosis type 1 (NF 1) is an autosomal dominant neurocutaneous disease characterised by multisystemic involvement, including bone tissue. Deformities and reduced bone mass are the main bone manifestations in NF1. Quantitative computed tomography (QCT) provides true volumetric bone mineral density (BMD) measurement. This study aimed to evaluate bone metabolism parameters and BMD in children with NF1 using QCT. Methods: The data of 52 paediatric NF1 patients (23 female, 29 male) was evaluated retrospectively. We investigated anthropometric measurements, biochemical parameters like total calcium, phosphate, magnesium, alkaline phosphatase, 25-hydroxyvitamin D (25OHD), parathyroid hormone, calcitonin, urinary calcium/creatinine ratio, and QCT parameters like lumbar trabecular and cortical BMD, trabecular area and cortical thickness. Comparisons of gender and puberty status were performed. Results: 25% of patients had skeletal deformities and 42.3% had 25OHD inadequacy (< 20 ng/mL). The frequency of 25OHD inadequacy was significantly higher in pubertal/postpubertal patients than prepubertal patients (61.9% vs. 29.0%, p = 0.019). Trabecular BMD Z-score was < −2.0 in 11.5% of patients; all with low BMD were at the pubertal/postpubertal stage. There was a significant negative correlation between age and trabecular Z-score (r = −0.41, p = 0.003). Mean cortical BMD was statistically similar between the genders and puberty groups. Puberty status, anthropometric Z-scores, and biochemical and QCT parameters were statistically similar between the genders (p > 0.05). Conclusion: Paediatric NF1 patients may present with low BMD and 25OHD inadequacy, especially at puberty. QCT may be a useful tool to evaluate trabecular and cortical bone separately in NF1 patients.

Reduced spinal bone mineral density (BMD) in pre-pubertal children with neurofibromatosis type 1 (NF1)

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S68-S69
Author(s):  
J.A. Eelloo ◽  
S.M. Huson ◽  
K.A. Ward ◽  
J.E. Adams ◽  
S.A. Russell ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Spinal Bone Mineral Density ◽  
Mineral Density

scholarly journals Bone mineral density in children and young adults with neurofibromatosis type 1

2012 ◽  
Vol 19 (6) ◽  
pp. 817-825 ◽  
Author(s):  
Maya B Lodish ◽  
Urania Dagalakis ◽  
Ninet Sinaii ◽  
Ethan Bornstein ◽  
AeRang Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Plexiform Neurofibroma ◽  
Neurofibromatosis Type ◽  
Whole Body ◽  
Mineral Density ◽  
Bone Mineral Apparent Density ◽  
Total Body

Concern for impaired bone health in children with neurofibromatosis type 1 (NF-1) has led to increased interest in bone densitometry in this population. Our study assessed bone mineral apparent density (BMAD) and whole-body bone mineral content (BMC)/height in pediatric patients with NF-1 with a high plexiform neurofibroma burden. Sixty-nine patients with NF-1 (age range 5.2–24.8; mean 13.7±4.8 years) were studied. Hologic dual-energy X-ray absorptiometry scans (Hologic, Inc., Bedford, MA, USA) were performed on all patients. BMD was normalized to derive a reference volume by correcting for height through the use of the BMAD, as well as the BMC. BMAD of the lumbar spine (LS 2–4), femoral neck (FN), and total body BMC/height were measured and Z-scores were calculated. Impaired bone mineral density was defined as a Z-score ≤−2. Forty-seven percent of patients exhibited impaired bone mineral density at any bone site, with 36% at the LS, 18% at the FN, and 20% total BMC/height. BMAD Z-scores of the LS (−1.60±1.26) were more impaired compared with both the FN (−0.54±1.58; P=0.0003) and the whole-body BMC/height Z-scores (−1.16±0.90; P=0.036). Plexiform neurofibroma burden was negatively correlated with LS BMAD (rs=−0.36, P=0.01). In pediatric and young adult patients with NF-1, LS BMAD was more severely affected than the FN BMAD or whole-body BMC/height.

scholarly journals Modern approaches and possibilities for assessing bone mineral density by quantitative computed tomography (literature review)

2021 ◽  
Vol 23 (4) ◽  
pp. 372-381
Author(s):  
Aleksandr A. Melnikov ◽  
◽  
Viktor V. Diachenko ◽  
Igor V. Shubin ◽  
Aleksei E. Nikitin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Dual Energy ◽  
Mineral Density ◽  
Diagnosis Of Osteoporosis ◽  
X Ray ◽  
Clinically Significant

The review provides the literature data on the basal issues of bone remodeling and the applied use of medical imaging techniques for the prevention of clinically significant consequences of osteoporosis. The article discusses the role and prospects of using the method of quantitative computed tomography and its modifications for the diagnosis of osteoporosis and osteopenic syndrome. It considers the advantages of quantitative computed tomography over widely used medical techniques for assessing bone mineral density (mono- and dual-energy X-ray absorptiometry, mono- and dual-energy isotope absorptiometry).

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