Calcification of the coronary arteries among the males with coronary heart disease and osteoporosis

2013 ◽  
Author(s):  
Elena Malyuta ◽  
Tatiana Raskina ◽  
Olga Barbarash ◽  
Alexandr Kokov
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries

CURRENT ASPECTS OF CORONARY HEART DISEASE DIAGNOSIS AND TREATMENT

2020 ◽  
pp. 5-10
Author(s):  
O. M. Korzh
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Drug Therapy ◽  
Coronary Arteries ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Disease Diagnosis ◽  
Percutaneous Coronary Angioplasty ◽  
Mortality And Morbidity ◽  
Intravascular Thrombosis

Among the cardiovascular diseases associated with atherosclerosis, chronic coronary heart disease, including angina, is the most common form. It is the myocardium lesion that develops as a result of an imbalance between the coronary circulation and metabolic needs of heart muscle. The presence of angina symptoms often indicates a pronounced narrowing of one or more coronary arteries, but also occurs in non−obstructive arterial impairment and even in normal coronary arteries. Factors of functional damage to the coronary arteries are spasm, temporary platelet aggregation and intravascular thrombosis. Today there are opportunities not only to use the therapy with proven effectiveness, aimed at reducing the risk of complications, including fatal, but also to treat angina (ischemia), which improves the patient's life quality. The drug protocol includes the ones with a proven positive effect on this disease prognosis, which are mandatory if there are no direct contraindications to use, as well as a large group of antianginal or anti−ischemic drugs. The choice of a particular drug or its combinations with other drugs is carried out in accordance with generally accepted recommendations: taking into account the individual approach, the severity of angina, hemodynamic parameters (heart rate and blood pressure, presence of comorbid conditions). If drug therapy is ineffective, the option of coronary myocardial revascularization (percutaneous coronary angioplasty or coronary artery bypass grafting) is considered. Due to the high mortality and morbidity rates of coronary heart disease worldwide, one of the priorities of practical health care is the prevention of diseases caused by atherosclerosis. Key words: coronary heart disease, angina, family physician, prognosis, drug therapy.

Intimal thickening in the coronary arteries of infants and children as an indicator of risk factors for coronary heart disease

1990 ◽  
Vol 11 (suppl E) ◽  
pp. 53-60 ◽  
Author(s):  
E. Pesonen ◽  
R. Norio ◽  
J. Hirvonen ◽  
K. Karkola ◽  
V. Kuusela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Infants And Children ◽  
Intimal Thickening

Circular RNA expression profiles and bioinformatic analysis in coronary heart disease

Epigenomics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 439-454 ◽  
Author(s):  
Fangpu Yu ◽  
Yuanyuan Tie ◽  
Ya Zhang ◽  
Zunzhe Wang ◽  
Liwen Yu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Expression Profiles ◽  
Peripheral Blood Mononuclear ◽  
Qrt Pcr ◽  
Blood Mononuclear Cells

Aim: We aimed to identify the expression profile and role of circular RNAs (circRNAs) in coronary heart disease (CHD). Materials & methods: We performed sequence analysis of circRNAs in peripheral blood mononuclear cells of 70 CHD patients and 30 controls. Eight selected circRNAs were validated using quantitative real-time polymerase chain reaction (qRT-PCR) in human atherosclerotic coronary arteries. Results: In total, 2283 downregulated and 85 upregulated circRNAs were identified in CHD. Parental genes of top 100 dysregulated-circRNAs are related to metabolism and protein modification, and 12 circRNAs might upregulate their CHD-related parental genes through miRNA sponges. Of the eight circRNAs validated in atherosclerotic coronary arteries by qRT-PCR, six were consistent with sequencing results of peripheral blood mononuclear cells. Conclusion: As potential ceRNAs, dysregulated circRNAs may be involved in CHD pathophysiology.

scholarly journals Results of holter monitoring in patients with coronary heart disease depending on the severity of atherosclerotic lesions of the coronary arteries

2021 ◽  
pp. 15-19
Author(s):  
Tetiana Pylova
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Comparative Analysis ◽  
Myocardial Ischemia ◽  
Coronary Arteries ◽  
Holter Monitoring ◽  
Group I ◽  
St Segment ◽  
Stable Coronary Heart Disease ◽  
Group Ii

The aim – to conduct a comparative analysis of the presence, frequency and duration of episodes of myocardial ischemia and arrhythmias based on the results of Holter monitoring in patients with coronary heart disease depending on the condition of the coronary arteries. Materials and methods. We examined 53 patients (group I) with stable coronary heart disease (CHD) and slightly altered coronary arteries (INOCA), who were hospitalized in the period from October 2018 to February 2021 at the “City Clinical Hospital № 8” of Kharkiv City Council. Group II included 52 patients with a diagnosis of stable coronary heart disease, and according to coronary angiography (CAG) had stenosis of coronary arteries (CA) more than 50 %. Results. According to the results of comparative analysis, it was found that in group I there were signs of myocardial ischemia – depression of the ST segment in 62.3 % (n=33) and elevation of the ST segment in 11.3 % (n=6), compared with group II -73 % (n=38) and 5.66 % (n=3), respectively. Ventricular arrhythmias (VA) have been reported in 52 patients of group I, and in 44 patients of group II. VA 4 and 5 type according to Laun, was significantly higher in group II compared with group I (p=0.0324). The occurrence of ventricular tachycardia was recorded in 5.7 % (n=3) of patients in group I and 9.3 % (n=5) patients of group II (p=0.347). In group II, there was a tendency to more episodes of ischemia compared with group I (p=0.072). The duration of ischemia was significantly longer in group I, compared with group II (p=0.042). Conclusions. The results of the study did not show significant differences in the development of the number of episodes of myocardial ischemia according to Holter monitoring depending on the condition of the coronary arteries. The duration of episodes of ischemia in patients with INOCA is significantly longer than in patients with obstructive atherosclerosis. In patients with coronary heart disease with obstructive coronary arteries, ventricular arrhythmia was statistically significantly more severe according to Lown

scholarly journals Multi-center randomized trial on the impact of “CONFIDENCE” communication program aimed at evaluating therapy adherence of patients with registered myocardial infarction who underwent successful revascularization by stenting or thrombolysis after discharg

2017 ◽  
Vol 21 (1) ◽  
pp. 31 ◽  
Author(s):  
A. R. Tarkova ◽  
V. D. Anisimova ◽  
I. O. Grazhdankin ◽  
V. I. Baystrukov ◽  
D. D. Zubarev ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Conflict Of Interest ◽  
Total Duration ◽  
Therapy Adherence ◽  
Communication Program ◽  
Parallel Group ◽  
The Impact

<p><strong>Aim.</strong> The article looks at the effect of the program "Confidence" to increase the proportion of patients’ therapy in patients with coronary heart disease for two years after successful revascularization using thrombolytic or stenting of the coronary arteries on the myocardial infarction.<br /><strong>Methods.</strong> This is a prospective, randomized, controlled, parallel-group trial including 4.000 patients. They will be divided into two groups: patients receiving standard outpatient observation (n=2000) and those enrolled for the program "Confidence" (n=2000). The total duration is 24 months. The trial will take place in two stages. In the first stage (0-12 months) the impact of the program "Confidence" on therapy adherence and outcomes of cardiovascular diseases will be assessed. In the second stage (after the change of groups in 12 months, 12-24 months) the effect of changing the way to remind patients of therapy adherence will be evaluated.<br /><strong>Conclusion.</strong> The trial was designed in such a way as to show that the proposed program "Confidence" increases the proportion of patients who adhere to therapy in the cohort of those with coronary heart disease for two years after successful revascularization by using thrombolytic or stenting of the coronary arteries against the background of myocardial infarction.</p><p>Received 13 February 2017. Accepted 9 March 2017.</p><p><strong>Financing:</strong> KRKA company’s grant. Sponsorship had no effect on data acquisition, analysis and interpretation.</p><p><strong>Conflict of interest:</strong> Kretov E.I. served as executive editor of “Endovascular surgery” section. All other authors declare no conflict of interest.</p><p><strong>Author contributions</strong><br />Study conception and design: Kretov E.I., Grazhdankin I.O., Baystrukov V.I., Zubarev D.D. <br />Statistical data processing: Krestyaninov O.V., Kozyr K.V., Obedinskiy A.A., Prokhorikhin A.A.<br />Drafting the article: Tarkova A.R., Anisimova V.D.<br />Critical revision: Tarkova A.R., Anisimova V.D., Kretov E.I.</p>

scholarly journals Impact of ranolazine on exercise tolerance and arrhythmias in patients with INOCA

2021 ◽  
pp. 10-15
Author(s):  
Vira Tseluyko ◽  
Tetyana Pylova
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Exercise Test ◽  
Exercise Tolerance ◽  
Ventricular Arrhythmias ◽  
Ecg Monitoring ◽  
Holter Ecg ◽  
Group I ◽  
Group Ii

The aim of the study to evaluate the effect of supplementation of basic therapy by ranolazine in patients with INOCA on exercise test parameters and Holter ECG monitoring. Materials and methods. 53 patients with stable coronary heart disease were examined, including 18 men (33.9 %) and 35 (66 %) women, the average age of patients was 57 (±9.68) years. According to the results of coronary angiography all patients had non-obstructive coronary arteries. In addition to physical and laboratory examination, bicycle ergometry, Holter ECG monitoring and echocardiography were included in the examination of patients. Patients were divided into 2 groups: group I - patients who in addition to standard therapy received ranolazine at a dose of 1000 mg twice a day for 6 months, and group II patients with standard coronary heart disease therapy. After 6 months from the beginning of the observation an objective examination, echocardiography, exercise test, Holter ECG monitoring were repeated. Results. The study found that patients receiving ranolazine in addition to standard therapy had a statistically significant increase in exercise duration after 6 months compared with baseline and group II. Before treatment in group I, the duration of the exercise test was 356.51±180.24s, and after treatment 414.32±142.10s (p=0.03). In group II, the duration of the test before treatment was 361.4±160.24 c, and after 380.5±152.2 s (p=0.15). It was also found that the duration of the test differed significantly in group I after treatment of patients from group II after treatment of patients with a standard treatment regimen (p=0.04). According to the results of Holter ECG monitoring in group I found a positive effect of ranolazine on the frequency of ventricular arrhythmias: before treatment n=1142 [30; 2012], after treatment n=729 [23; 1420], while in group II a significant difference between the number of extrasystoles before treatment and after not detected (n=1026 [17; 1920], n=985 [15; 1680], respectively) p=0.18. Conclusions. The addition of ranolazine to the basic therapy of patients with non-obstructive coronary arteries disease helps to increase exercise tolerance (according to the loading stress test) and contributes to a significant reduction in the number of ventricular arrhythmias (according to Holter-ECG) compared with both baseline and group II

scholarly journals Olahraga sebagai Pencegahan Penyakit Jantung Koroner

2019 ◽  
Author(s):  
Matthew Aldo Wijayanto
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Moderate Intensity ◽  
Lower Blood Pressure ◽  
Moderate Intensity Exercise ◽  
Cholesterol Levels ◽  
Lower Blood ◽  
Heart Blood ◽  
Main Factors

Coronary heart disease (CHD) is a heart disease that is mainly caused by narrowing of the coronary arteries due to the process of atherosclerosis or spasm or a combination of both. CHD is a very frightening disease that is still a problem in both developed and developing countries. One of the most effective way to reduce the risk of coronary heart disease is to exercise. Through regular exercise such as aerobic (walking, running, swimming, riding a bicycle) can increase the ability of the heart and lungs. This allows the person not to feel tired and helps dilate the heart blood vessels (coronary arteries) thus the blood flow more smoothly, reduce cholesterol levels in the blood, lower blood pressure, which are the main factors in CHD. Thus, further research is conducted on the effectiveness of exercise to reduce the risk of coronary heart disease. The purpose of this paper is to describe exercise as a prevention and their effectiveness to reduce the risk of coronary heart disease. The research method is carried out by studying literature from various research journals and textbooks relating to the topic taken and interview. The result obtained from the literature studies and interview show a significant effect on how exercise can reduce the risk of coronary heart disease. Good exercise is done according to the needs of each individual, but the standard of good exercise is moderate intensity exercise performed 3 times a week for at least 30 minutes.

scholarly journals PROFIL PENYAKIT JANTUNG KORONER DI IRINA F JANTUNG RSUP PROF. Dr. R. D. KANDOU MANADO

e-CliniC ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Andi Eka Dharma Putra Syukri
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Communicable Disease ◽  
Cardiovascular Disorder ◽  
Industrial Country ◽  
Unhealthy Lifestyle ◽  
Old Myocardial Infarction

Abstract: Heart and Blood Vessels Disease is the leading cause of cardiovascular disorder that mostly happened in developed or industrial country, related to new communicable disease or “infection” caused by imitation of unhealthy lifestyle.1 The cardiovascular disease divided into several type of heart disease such as; coronary heart disease (CHD) that caused by narrowing of of the coronary arteries due to deposition of fat gathering in and around the cells lining the walls of the coronary arteries and blocking of the blood flow. This research aimed to know the  CHD Profile in Irina F Jantung of RSUP Prof.Dr. R.D Kandou Manado in period of January-December 2010. This was retrospective-descriptive study that used medical records in Irina F Jantung of RSUP. Prof. Dr. R.D Kandou Manado. During this period of this research reported 230 cases of CHD; 69 cases (30%) byage groups 61-70 years old, 159 cases (69,13%) by gender and 86 cases were accompanied disease with the greatest proportion of Hypertension 52 cases (55,32%), and Old Myocardial Infarction (OMI) 71 cases (30,87%) as being the most clinical symptom. The frequency of Cardiovascular disease will be increasing every year if there’s no change of diet and unhealthy lifestyle by people in both urban and rural environments and other degenerative diseases are caused. Key words: Heart Disease, Coronary Heart Disease, Old Myocardial Infarction   ABSTRAK : Penyakit Jantung dan Pembuluh Darah (PJPD) adalah penyakit yang mengakibatkan gangguan jantung dan pembuluh darah, paling sering terjadi di negara maju atau negara industri akibat ‘penularan’ yang disebabkan peniruan gaya hidup kurang sehat.1 Penyakit Jantung ini terbagi dalam beberapa jenis penyakit jantung lainnya diantaranya adalah Penyakit Jantung Koroner (PJK) penyakit jantung yang disebabkan oleh penyempitan arteri koroner akibat dari berkumpulnya endapan lemak di dalam dan sekitar sel yang melapisi dinding arteri koroner sehingga menyumbat aliran darah. Tujuan penelitian ini adalah untuk mengetahui Profil PJK di Irina F Jantung Rsup Prof. Dr. R. D Kandou Manado Periode Januari 2010 - Desember 2010. Penelitian ini bersifat deskriptif dengan metoderetrospektif menggunakan buku register di Irina F Jantung RSUP. Prof. Dr. R.D Kandou Manado periode Januari 2010 sampai Desember 2010. Selama periode Januari 2010 sampai Desember 2010 di Irina F Jantung Rsup Prof. Dr. R. D Kandou Manado tercatat 230 kasus PJK. Berdasarkan kelompok Umur 61-70 tahun sebanyak 69 kasus (30%), Jenis Kelamin sebanyak 159 kasus (69,13%), 86 kasus disertai penyakit penyerta yang terbanyak diantaranya Hipertensi 52 kasus (55,32%), dan manifestasi klinis yang didapat adalah Old Myocardial Infarction (OMI) sebanyak 71 kasus (30,87%). Setiap tahun frekuensi penyakit ini akan terus meningkat jika tidak di atur pola makan atau gaya hidup masyarakat yang kurang sehat, baik di lingkungan urban maupun rural dan disebabkan penyakit degeneratif lainnya. Kata kunci: Penyakit Jantung, Jantung Koroner, Old infark miokard

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