A genetic polymorphism of osteocalcin is associated with BMI but not with parameters of glucose and lipid metabolism in women with polycystic ovary syndrome

2013 ◽  
Author(s):  
Verena Schwetz ◽  
Olivia Trummer ◽  
Albrecht Giuliani ◽  
Thomas R Pieber ◽  
Barbara Obermayer-Pietsch ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Genetic Polymorphism ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Glucose And Lipid Metabolism

scholarly journals miR-141-3p is Poorly Expressed in Polycystic Ovary Syndrome and Correlates with Glucose and Lipid Metabolism

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Lingye Fan ◽  
Chunyan Wang ◽  
Ping Zhan ◽  
Yaofang Liu
Keyword(s):  
Lipid Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Diagnostic Value ◽  
Obese Patients ◽  
Ovary Syndrome ◽  
Glucose And Lipid Metabolism ◽  
Fat Reduction ◽  
High Prevalence ◽  
Area Under Roc Curve

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with high prevalence. miR-141-3p downregulation was reported in PCOS rats. This study intended to investigate miR-141-3p expression in serum of PCOS patients and its correlation with glucose and lipid metabolism. A total of 100 PCOS patients and 100 healthy controls were enrolled in this study. Clinical parameters and glucose and lipid indexes were analyzed. A 3-month fat reduction intervention was conducted to PCOS-obese patients. Expressions of miR-141-3p and PTEN were detected. WHR and levels of TG, HDL-C, FBG, FINS, HOMA-β, and HOMA-IR showed significant differences in PCOS patients. miR-141-3p was downregulated in PCOS patients. Area under ROC curve of miR-141-3p diagnosing PCOS-obese patients was 0.985 with specificity 95.35% and flexibility 93.33%. Levels of glucose and lipid metabolism indexes were increased while HDL-C level was decreased in miR-141-3p low expression group. Indexes of PCOS-obese patients were improved and miR-141-3p was upregulated after fat reduction intervention. PTEN was upregulated in PCOS patients and negatively correlated with miR-141-3p. In conclusion, miR-141-3p was downregulated in PCOS patients and had higher diagnostic value on PCOS and associated with glucose and lipid metabolism. miR-141-3p might play a role in glucose and lipid metabolism in PCOS-obese patients by targeting PTEN.

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