Hip fractures and bone mineral density of the elderly: importance of serum 25-hydroxy vitamin D

2013 ◽  
Author(s):  
Laufey Steingrimsdottir ◽  
Thorhallur Halldorsson ◽  
Kristin Siggeirsdottir ◽  
Mary Frances Cotch ◽  
Gudny Eiriksdottir ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Hip Fractures ◽  
The Elderly ◽  
Mineral Density ◽  
25 Hydroxy Vitamin D

Serum 25‐hydroxy‐vitamin D status and incident hip fractures in elderly adults: Looking beyond bone mineral density

2021 ◽  
Author(s):  
Sigrun S Skuladottir ◽  
Alfons Ramel ◽  
Hrafnhildur Eymundsdottir ◽  
Ingibjorg Hjaltadottir ◽  
Lenore J Launer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Hip Fractures ◽  
Vitamin D Status ◽  
Elderly Adults ◽  
Mineral Density ◽  
25 Hydroxy Vitamin D

scholarly journals The contribution of the endocrine system to the development of osteoporosis in the elderly and senile (review)

2021 ◽  
Vol 7 (3) ◽  
pp. 308-321
Author(s):  
Svetlana V. Bulgakova ◽  
◽  
Dmitriy P. Kurmaev ◽  
Marina V. Silyutina ◽  
Elena A. Voronina ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Loss ◽  
Bone Mineral ◽  
Endocrine System ◽  
The Elderly ◽  
Published Data ◽  
Social Significance ◽  
Mineral Density ◽  
Stimulating Hormone

Osteoporosis is increasingly found in the elderly and senile, maintaining its enormous medical and social significance. The effect of hormones on bone metabolism is beyond doubt. However, currently the data on the effect of sex hormones on bone tissue prevails. As for the other hormones, sometimes, there are conflicting opinions. The aim of the study: Based on published data, to study the contribution of the endocrine system to the development of osteoporosis in the elderly. Materials and methods: Literature data was analyzed using the following search words: osteoporosis, bone mineral density, FSH, estrogens, testosterone, cortisol, vitamin D, IGF1 for 1998-2020 in computer databases PubMed, Scopus, Medical- Science, Elibrary, Web of Science, Ceeol. Results: Analysis of the literature showed that the increase of levels of thyroid stimulating hormone (TSH) plays an osteoprotective role; the decrease of levels of estrogen, testosterone, insulin-like growth factor 1 (IGF1) and vitamin D, as well as the increase in the levels of cortisol, parathyroid hormone and follicle-stimulating hormone (FSH) contribute to bone loss in the elderly and senile. In addition, the FSH receptor (FSHR) genotype AA rs6166 is associated with low bone mineral density, regardless of estrogen level. A polyclonal antibody with an FSHR-binding sequence against mouse β-subunit of FSH is likely to be an effective tool for reducing bone loss in mice subjected to ovariectomy. Conclusion: A comprehensive assessment of the hormonal profile in the elderly and senile is needed to identify the causes of osteoporosis and the formation of an individual program of medical diagnostic and rehabilitation measures. Currently, there are all prerequisites for the development of new diagnostic and therapeutic interventions for the correction of low bone density.

The relationship between serum 25-hydroxy vitamin D, parathormone and bone mineral density in Indian population

2013 ◽  
Vol 80 (1) ◽  
pp. 41-46 ◽  
Author(s):  
M. K. Garg ◽  
N. Tandon ◽  
R. K. Marwaha ◽  
A. S. Menon ◽  
N. Mahalle
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Indian Population ◽  
Mineral Density ◽  
25 Hydroxy Vitamin D ◽  
The Relationship

25-hydroxy vitamin D levels in healthy premenopausal women: Association with bone turnover markers and bone mineral density

Bone ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 423-426 ◽  
Author(s):  
Silvano Adami ◽  
Francesco Bertoldo ◽  
Vania Braga ◽  
Elena Fracassi ◽  
Davide Gatti ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Turnover Markers

scholarly journals Calcium and vitamin D supplementation in children with frequently relapsing and steroid-dependent nephrotic syndrome

2012 ◽  
Vol 52 (1) ◽  
pp. 16
Author(s):  
Ayi Dilla Septarini ◽  
Taralan Tambunan ◽  
Pustika Amalia
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Vitamin D Supplementation ◽  
Ionized Calcium ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Before And After ◽  
25 Hydroxy Vitamin D ◽  
Serum Ionized Calcium

Background Children with frequently relapsing and steroiddependentnephrotic syndrome (FRNS/SDNS) are at riskfor osteoporosis due to impaired metabolism of calcium andvitamin D.Objective To determine the effect of calcium and vitamin Dsupplementation on bone mineral density, serum ionized calciumlevels and serum 25-hydroxy-vitamin D levels in children withFRNS and SDNS.Methods A clinical trial with a before and after design wasperformed. Subjects were SDNS or FRNS pediatric patients 2: 5years of age. Subjects received 800 mg elemental calcium and 400IU vitamin D supplementation for 8 weeks. Serum ionized calcium,serum 25-hydroxy-vitamin D [25(0H)D], and bone mineral density(BMD) were determined before and after the supplementation.Results Of the 30 subjects, 28 completed the study. However,only 20 subjects underwent BMD determination before and aftersupplementation. Of the 28 subjects, 22 had hypocalcemia and 26had low vitamin D levels. Osteopenia was found in 14/20 subjects andosteoporosis was in 2/20 subjects. After 8 weeks of supplementation,mean serum ionized calcium increased from low [1.15 mmol/L (SDO.oJ)] to normal [1.18 mmol/L (SD 0.04)] (P< 0.001) levels, butmean serum 25(0H)D only increased from vitamin D deficiencycategory [20 ng/mL (SD 7 .7)] to vitamin D insufficiency category[25.5 ng/mL (7.7)] (P=0.010). Mean z-score BMD increased from-1.1 (SD 0.9) to -0.7 (SD 0.2) after supplementation (P<0.001).Conclusion Calcium vitamin D supplementation effectively increasedserum ionized calcium, serum 25 (OH)D, and BMD in subjectswith FRNS and SDNS. [Paediatr lndones. 2012;52:16-21].

scholarly journals Management of Fragility Hip Fractures: Our Institutional Experience

2019 ◽  
Vol 10 ◽  
pp. 215145931982861
Author(s):  
Glenn E. Lee ◽  
Scott Muffly ◽  
Gregory J. Golladay
Keyword(s):  
Bone Mineral Density ◽  
Primary Care ◽  
Vitamin D ◽  
Bone Mineral ◽  
Hip Fractures ◽  
The United States ◽  
Primary Care Doctor ◽  
Mineral Density ◽  
Osteoporosis Screening ◽  
Bone Mineral Density Testing

Introduction: Approximately 320 000 fragility hip fractures are sustained in the United States annually, resulting in substantial morbidity and mortality as well as significant economic burden on the health-care system. Nevertheless, a majority of these patients are not screened and do not receive treatment for osteoporosis. The objective of this study was to evaluate rates of osteoporosis screening and treatment in our institution and compare them to those reported in the literature. Methods: This was a retrospective cohort study of 191 patients ages 50 and older who sustained osteoporotic hip fractures. Primary outcome measures were percentage of patients who (1) underwent bone health laboratory workup during admission, (2) were started on vitamin D, calcium, and/or a bisphosphonate, (3) received bone mineral density testing, and (4) followed up with a primary care doctor or endocrinologist. Secondary outcomes measures were (1) whether gender, race, or age influenced our primary outcomes and (2) whether obtaining in-hospital laboratory workup led to increased rates of further screening and treatment. Results: Fifty-six (29.3%) patients received full laboratory workup, 48 (25.1%) were prescribed vitamin D and calcium, 11 (5.7%) were prescribed a bisphosphonate, 13 (6.8%) underwent bone mineral density testing, and 41 (21.5%) followed up with primary care or endocrinology. Discussion: Women were more likely to be treated with vitamin D and calcium. Outcomes were similar regardless of race. Younger patients were more likely to undergo laboratory testing, bisphosphonate therapy, and bone mineral density testing. Initiating workup during admission did not lead to increased rates of outpatient treatment. Conclusion: Despite nationwide efforts to improve, rates of osteoporosis screening and treatment following hip fracture are suboptimal. Rates at our institution are similar to those reported in previous studies. There were disparities between gender and age groups. Future studies are needed to evaluate whether more recently implemented policies lead to better osteoporosis screening and management.

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