The effect of a met-enkephalin analogue on growth hormone, prolactin, gonadotropins, cortisol and thyroid stimulating hormone in healthy elderly men

1992 ◽  
Vol 127 (3) ◽  
pp. 205-209 ◽  
Author(s):  
M Giusti ◽  
G Delitala ◽  
G Marini ◽  
B Uggias ◽  
P Sessarego ◽  
...  
Keyword(s):  
Young Adults ◽  
Young Men ◽  
Thyroid Stimulating Hormone ◽  
Significant Rise ◽  
The Other ◽  
Cortisol Secretion ◽  
Placebo Administration ◽  
Elderly Men ◽  
Healthy Elderly ◽  
Pituitary Secretion

The aim of the study was to evaluate the effect of the guanyl derivative of the opioid analogue D-ala2,MePhe4-Met-enkephalin-(o)-ol (G-DAMME) on pituitary secretion in healthy elderly men. Nine healthy elderly men (65–88 years) and 10 young adults (20–30 years) were studied. GH, PRL, gonadotropins, cortisol (to evaluate the effect on ACTH) and TSH were measured after G-DAMME (0.25 mg iv) or placebo administration. In elderly men, the GH response to G-DAMME was reduced or absent, while prompt GH release was found in all young men. G-DAMME lowered LH levels in young men but not in elderly men. No significant variations in FSH levels after G-DAMME and placebo were noted in either group of subjects. A similar and significant rise in PRL and TSH, and a fall in cortisol, after G-DAMME was observed in both elderly and young adults. We have demonstrated that the sensitivity to opioid modulation by G-DAMME on PRL, TSH and cortisol secretion is unchanged with aging. On the other hand, the data indicate that LH and GH responsiveness to G-DAMME change with age.

Effect of aging on the metabolism of phosphorus and 1,25-dihydroxyvitamin D in healthy men

1996 ◽  
Vol 270 (3) ◽  
pp. E483-E490
Author(s):  
A. A. Portale ◽  
B. P. Halloran ◽  
R. C. Morris ◽  
E. T. Lonergan
Keyword(s):  
Time Course ◽  
Young Men ◽  
Normal Serum ◽  
Serum Phosphorus ◽  
Serum Concentrations ◽  
Elderly Men ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Healthy Elderly ◽  
Dietary Phosphorus

We tested the hypothesis that aging alters physiological regulation of the serum concentration of 1,25-dihydroxyvitamin D [1,25(OH)2D] by inorganic phosphorus. In seven elderly men [age 71 +/- 1 (SE) yr] and 9 young men (29 +/- 2 yr), dietary phosphorus was first normal, then increased and decreased within its normal range. At each intake of phosphorus, serum concentrations of 1,25(OH)2D in the elderly did not differ from those in young men, but fasting and 24-h mean serum concentrations of phosphorus were lower in elderly men. With phosphorus restriction, in each group serum 1,25(OH)2D increased by 47%, and 24-h mean serum phosphorus decreased by 0.6 +/- 0.1 mg/dl. Serum concentrations of 1,25(OH)2D varied inversely with 24-h mean serum phosphorus (R= -0.92, P<0.0001). Thus, in healthy elderly men in whom glomerular filtration rate is normal or near normal, serum concentrations of 1,25(OH)2D increase when dietary phosphorus is restricted; the magnitude of response at steady state is unaffected by aging, but the time course of response is delayed. At any level of serum phosphorus, serum 1,25(OH)2D is lower than that in young men, as reflected by a lower intercept of regression of serum 1,25(OH)2D on 24-h mean phosphorus.

scholarly journals Premature oral pre-shaping for feeding in elderly population with risk of aspiration pneumonia

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246804
Author(s):  
Yoshiki Tamaru ◽  
Akiyoshi Matsugi ◽  
Shinzo Masaki ◽  
Yoshihito Tsubouchi ◽  
Akiyoshi Yanagawa
Keyword(s):  
Young Adults ◽  
High Risk ◽  
Elderly People ◽  
Aspiration Pneumonia ◽  
Elderly Population ◽  
Movement Time ◽  
The Other ◽  
Feeding Time ◽  
Healthy Elderly ◽  
Risk Of Aspiration

The aim of this study was to determine the abnormal hand and mouth behavior before actual swallowing for eating in elderly people with high risk of aspiration pneumonia. Ten elderly people with a diagnosis of aspiration pneumonia (EAP), 15 healthy elderly (HE) people, and 21 young adults (YA) were enrolled. The feeding time and the timing of the maximum distance between the upper and lower lips were extracted using a motion analyzer during self-feeding and assisted-feeding. The results showed that feeding time in EAP was significantly longer than that for the other groups in self- and assisted-feeding. In self-feeding, the timing of mouth-preparation in the EAP group was significantly earlier than that in the other groups; conversely, in assisted-feeding, the timing in EAP was significantly delayed. Our results indicate that abnormal preparation of mouth-shape and movement time of hand before actual swallowing in both self- and assisted-feeding may exist in elderly people with previous experience of aspiration pneumonia.

scholarly journals Hypothalamus-Pituitary-Adrenal Hyperactivity in Human Aging Is Partially Refractory to Stimulation by Mineralocorticoid Receptor Blockade

2005 ◽  
Vol 90 (10) ◽  
pp. 5656-5662 ◽  
Author(s):  
Roberta Giordano ◽  
Mario Bo ◽  
Micaela Pellegrino ◽  
Marco Vezzari ◽  
Matteo Baldi ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Mineralocorticoid Receptor ◽  
Elderly Subjects ◽  
Cortisol Secretion ◽  
Mineralocorticoid Receptors ◽  
Placebo Administration ◽  
Healthy Elderly ◽  
Age Related ◽  
Young Subjects ◽  
Mineralocorticoid Antagonists

Context: The hypothalamus-pituitary-adrenal (HPA) axis is mainly regulated by CRH, arginine vasopressin, and glucocorticoid feedback. Hippocampal mineralocorticoid receptors mediate proactive glucocorticoid feedback and mineralocorticoid antagonists, accordingly, stimulate HPA axis. Age-related HPA hyperactivity reflects impaired glucocorticoid feedback at the suprapituitary level. Design: ACTH, cortisol, and dehydroepiandrosterone (DHEA) secretion were studied in eight healthy elderly (75.1 ± 3.2 yr) and eight young (25.0 ± 4.6 yr) subjects during placebo or canrenoate (CAN) administration (200 mg iv bolus followed by 200 mg infused over 4 h). Results: During placebo administration, ACTH and cortisol areas under the curve (AUCs) in elderly subjects were higher than in young subjects (P ≤ 0.01); conversely, DHEA AUCs in elderly subjects were lower than in young subjects (P = 0.002). CAN increased ACTH, cortisol, and DHEA levels in both groups. In young subjects, ACTH, cortisol, and DHEA levels at the end of CAN infusion were higher (P ≤ 0.05) than after placebo. In elderly subjects, at the end of CAN infusion, ACTH, cortisol, and DHEA levels were higher (P = 0.01) than after placebo. Under CAN, ACTH and cortisol AUCs were persistently higher (P ≤ 0.01) and DHEA AUCs lower (P = 0.006) in elderly than in young subjects. Cortisol AUCs after CAN in young subjects did not become significantly different from those in elderly subjects after placebo. Conclusions: 1) Evening-time ACTH and cortisol secretion in elderly subjects is higher than in young subjects; 2) ACTH and cortisol secretion in elderly subjects is enhanced by CAN but less than that in young subjects; and 3) DHEA hyposecretion in elderly subjects is partially restored by mineralocorticoid antagonism. Age-related variations of HPA activity may be determined by some derangement in mineralocorticoid receptors function at the hippocampal level.

scholarly journals The Effect Of Marital Status On The Standard Of Living Of Young Men And Women

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Michael C. Seeborg
Keyword(s):  
Young Adults ◽  
Regression Analysis ◽  
Marital Status ◽  
Young Women ◽  
Young Men ◽  
Longitudinal Survey ◽  
The Other ◽  
Standard Of Living ◽  
Font Size ◽  
Men And Women

<p class="MsoBlockText" style="text-align: justify; margin: 0in 0.5in 0pt;"><span style="font-style: normal; mso-bidi-font-style: italic;"><span style="font-size: x-small;"><span style="font-family: Times New Roman;">The National Longitudinal Survey of Youth data base is used to explore the effects of changes in marital status on the standard of living of a sample of young adults. OLS regression analysis indicates that changes in marital status have very different effects on young women and young men.<span style="mso-spacerun: yes;">&nbsp; </span>Women receive large increases in their income-to-needs ratios when they marry, and they incur large declines in their income-to-needs ratios after experiencing a divorce or separation.<span style="mso-spacerun: yes;">&nbsp; </span>Men, on the other hand, do not experience significant changes in their income-to-needs ratios when their marital status changes.</span></span></span></p>

Changes in pituitary secretion induced by an agonist-antagonist opioid drug, buprenorphine

1983 ◽  
Vol 104 (3) ◽  
pp. 257-260 ◽  
Author(s):  
Ermanno Rolandi ◽  
Alessandra Marabini ◽  
Roberto Franceschini ◽  
Valeria Messina ◽  
Patrizia Bongera ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Serum Cortisol ◽  
Serum Levels ◽  
Significant Rise ◽  
The Other ◽  
Opiate Antagonist ◽  
Pituitary Secretion ◽  
Serum Gh ◽  
Opiate Agonist ◽  
Antagonist Effect

Abstract. The im administration in 6 healthy subjects of buprenorphine, a derivative of the morphine alkaloid thebaine with agonist-antagonist properties, resulted in a significant rise of serum Prl within 45–240 min, a small and transient increase in serum GH and a significant fall in serum cortisol values. Conversely, no appreciable changes in the serum levels of the other hormones studied were found. The observed hormonal effects indicate that, in man, buprenorphine exerts an opiate agonist rather than an opiate antagonist effect.

The aging Leydig cell: VI. Response of testosterone precursors to gonadotrophin in men

1982 ◽  
Vol 100 (3) ◽  
pp. 455-461 ◽  
Author(s):  
E. P. Murono ◽  
H. R. Nankin ◽  
T. Lin ◽  
J. Osterman
Keyword(s):  
Young Adults ◽  
Leydig Cell ◽  
Young Men ◽  
Significant Rise ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Aged Population ◽  
Small Peak ◽  
Early Peak ◽  
Old Men

Abstract. The effects of a single im injection of human chorionic gonadotrophin (hCG) on circulating testosterone precursor levels at 0, 1–6, 24, 48 and 72 h were examined in normal young adults (mean age 34 years) and normal aged men (mean age 74 years). Basal 08.30–09.00 h concentrations of androstenedione and dehydroepiandrosterone were lower in aged men while progesterone levels were not significantly different from young men. A significant biphasic increase of circulating progesterone was observed in young men, characterized by an early peak at 2 h (33% above basal) and a secondary peak at 24 h (49% above basal). In old men there were no increases in circulating progesterone levels following hCG treatment during the early (1–6 h) or late (24–72 h) periods. There were not discernable increases in circulating dehydroepiandrosterone levels following hCG administration in both groups of men. Androstenedione levels in young men did not change during the first 6 h following hCG but increased significantly at 48 and 72 h, while in old men there was a small peak at 4 h (which was not statistically significant) and a secondary significant rise at 48 and 72 h. However, early and late stimulated absolute levels for androstenedione were lower in the aged population. Thus, there are differences in precursor concentrations in the basal state and in response to hCG in aged men.

CLINICAL EVALUATION OF THE THYROID STIMULATING HORMONE ACTIVITY IN EXOPHTHALMOS

1961 ◽  
Vol 38 (4) ◽  
pp. 577-584 ◽  
Author(s):  
Sven Erik Björkman ◽  
Torsten Denneberg ◽  
Inge Hedenskog
Keyword(s):  
Clinical Evaluation ◽  
Thyroid Stimulating Hormone ◽  
Significant Rise ◽  
Hormone Activity ◽  
Control Subjects ◽  
Long Duration ◽  
Stimulating Factor ◽  
Stimulating Hormone

ABSTRACT A method for demonstrating the presence of a thyroid stimulating factor in the blood of patients with progressive exophthalmos after thyroidectomy or after treatment with radioiodine is described. The method consists of transfusing freshly drawn blood from the patients to euthyroid recipients and subsequently following the PBI level of the recipients at regular intervals. Six exophthalmic patients tested in this manner were found to have such a factor in their circulating blood. After transfusion of their blood a significant rise in the PBI level of the recipients could be demonstrated. Two other patients, one with exophthalmos of long duration did not show this response nor did it occur after transfusion of blood from two control subjects. In one case the action of this factor was compared with that of animal thyrotrophin and found to be of the same magnitude.

Methods of Countering Cyber Recruitment (Iraq Model)

2019 ◽  
pp. 196
Author(s):  
Hind Mohammed Abdul Jabbar Ali
Keyword(s):  
Social Justice ◽  
Young People ◽  
Young Men ◽  
The Other ◽  
The Internet ◽  
Information Network ◽  
Political Repression ◽  
Electronic Information ◽  
Terrorist Organizations ◽  
Other Hand

Connecting to the  electronic information network (internet) became the most characteristic that distinguish this era However , the long hours which young men daily spend on the internet On the other hand ,there are many people who are waiting for the chance to talk and convince them with their views This will lead the young people to be part in the project of the “cyber armies “that involved with states and terrorist organizations  This project has been able  to recruitment hundreds of people every day to work in its rank . It is very difficult to control these websites because we can see the terrorist presence in all its forms in the internet   In addition there are many incubation environments that feed in particular the young people minds                                                                                         Because they are suffering from the lack of social justice Also the unemployment, deprivation , social and political repression So , that terrorist organizations can attract young people through the internet by convincing them to their views and ideas . So these organizations will enable to be more  stronger.

“My Roommates Would Laugh at me”: Young Males Reveal Embarrassment over Lack of Food Skills

2020 ◽  
pp. 1-8
Author(s):  
Kristen Simonds ◽  
Lucy Yixuan Zhang ◽  
June I. Matthews
Keyword(s):  
Young Adults ◽  
Food Safety ◽  
Parental Influence ◽  
Comparative Method ◽  
Food Selection ◽  
Young Men ◽  
Structured Interviews ◽  
Young Males ◽  
Solid Foundation ◽  
And Storage

Purpose: This descriptive qualitative study explored young males’ perceptions of food skills in 3 domains: food selection and planning, food preparation, and food safety and storage. Methods: Semi-structured interviews were audio-recorded and transcribed verbatim. Data were analyzed using the constant comparative method. Results: Forty-four young men (aged 17–35) reported varying levels of food skills, from little/no confidence to very confident and skilled. Most participants learned food skills from their mothers. Greater involvement in food selection and planning at a young age appeared to be related to parental influence and encouragement, exposure to food skills at school, and interest in food-related activities, which, in turn, provided a solid foundation for being confident cooks as young adults. Most notable was the lack of knowledge about, or confidence in, food safety and storage. Young men with low self-perceived food skills were deeply embarrassed about this deficiency in front of peers who had higher levels of confidence and skills. Conclusions: Future interventions or curricula should emphasize food safety and storage. This research also illustrates the importance of the home environment in teaching food skills to youth and ensuring that food skills are taught well before young adults begin living independently.

Sign in / Sign up

Export Citation Format

Share Document