scholarly journals Erythropoiesis, serum erythropoietin, and serum IGF-I in rats during accelerated growth

1990 ◽  
Vol 122 (3) ◽  
pp. 323-328 ◽  
Author(s):  
Armin Kurtz ◽  
Robert Matter ◽  
Kai-Uwe Eckardt ◽  
Jürgen Zapf
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Total Iron ◽  
Female Rats ◽  
Time Interval ◽  
Iron Incorporation ◽  
Male And Female Rats ◽  
Igf I ◽  
Accelerated Growth ◽  
Serum Erythropoietin

Abstract In this study we have examined the correlation between activity of erythropoiesis and serum concentrations of erythropoietin and insulin-like growth factor I in male and female rats during accelerated growth (day 30-90). We found that fractional incorporation of iron into newly formed red blood cells was linearily correlated with body weight gain. Total iron incorporation into newly formed red blood cells reflecting total daily red cell formation increased almost linearily between day 25 and 80 after birth in both sexes. While serum erythropoietin concentrations decreased in the time interval investigated (25–120 days), serum IGF-I levels increased in both sexes between day 25 and 55. In this period, individual values of total iron incorporation into red blood cells and serum IGF-I concentrations were linearily correlated. Our observations support the concept that IGF-I rather than erythropoietin modulates erythropoiesis during accelerated growth and thus manages a proportional increase in body mass and oxygen transport capacity.

scholarly journals Influence of a hyperlipidic diet on the composition of the non-membrane lipid pool of red blood cells of male and female rats

PeerJ ◽  
2015 ◽  
Vol 3 ◽  
pp. e1083 ◽  
Author(s):  
Xavier Remesar ◽  
Arantxa Antelo ◽  
Clàudia Llivina ◽  
Emma Albà ◽  
Lourdes Berdié ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Membrane Lipid ◽  
Female Rats ◽  
Male And Female ◽  
Lipid Pool ◽  
Male And Female Rats ◽  
Hyperlipidic Diet

scholarly journals Altered IGF-I and IGFBPs in Senescent Male and Female Rats

1999 ◽  
Vol 54 (3) ◽  
pp. B111-B115 ◽  
Author(s):  
S. Severgnini ◽  
D. T. Lowenthal ◽  
W. J. Millard ◽  
F. A. Simmen ◽  
B. H. Pollock ◽  
...  
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Igf I

Nandrolone decanoate does not enhance training effects but increases IGF-I mRNA in rat diaphragm

2000 ◽  
Vol 88 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Ghislaine Gayan-Ramirez ◽  
Hélène Rollier ◽  
Frank Vanderhoydonc ◽  
Guido Verhoeven ◽  
Rik Gosselink ◽  
...  
Keyword(s):  
Female Rats ◽  
Diaphragm Muscle ◽  
High Dose ◽  
Type I ◽  
Mrna Levels ◽  
Rat Diaphragm ◽  
Nandrolone Decanoate ◽  
Training Effects ◽  
Male And Female Rats ◽  
Igf I

To examine whether concomitant anabolic steroid treatment combined with training might enhance previously observed training effects (A. Bisschop, G. Gayan-Ramirez, H. Rollier, R. Gosselink, R. Dom, V. de Bock, and M. Decramer. Am. J. Respir. Crit. Care Med. 155: 1583–1589, 1997) and whether insulin-like growth factor I (IGF-I) was involved in these changes, male and female rats were submitted to inspiratory muscle training (IMT) for 8 wk (30 min/day, 5 times/wk) and were compared with untrained controls. During the last 5 wk of training, trained rats were divided to receive weekly either low-dose (LD; 1.5 mg/kg) or high-dose (HD; 7.5 mg/kg) nandrolone decanoate or saline for the IMT and control rats. In both sexes, diaphragm muscle mass and contractile properties were unchanged with treatment. In males, HD resulted in decreased diaphragm type I cross-sectional area (−15%; P < 0.05, HD vs. IMT), whereas no changes were observed in females. Finally, an increase in IGF-I mRNA levels was present in HD male (+73%; P < 0.05, HD vs. IMT) and female treated rats [LD (+58%) and HD (+96%) vs. IMT; P < 0.001]. We conclude that administration of nandrolone decanoate did not enhance the previously observed training effects in rat diaphragm, although it increased the IGF-I mRNA expression levels.

scholarly journals The impact of fetal load of biologically active substances of Hirudo verbana saline extract antigens on the morphometric and hematologic parameters of rats in the early stages of post-embryonic development

2016 ◽  
pp. 6-11
Author(s):  
R. Aminov ◽  
A. Frolov ◽  
Y. Fedotov
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Color Index ◽  
White Blood Cells ◽  
Medicinal Leech ◽  
Morphometric Parameters ◽  
The Body ◽  
Female Rats ◽  
Saline Extract ◽  
The Impact

The female rats of wild type 2 weeks before and 2 weeks after mating were administered intraperitoneally medicinal leech saline extract antigens (4 injection). Studied females after feeding the offspring and the offspring itself in dynamics at 1, 15, 30, 60 days. All animals were decapitated under anesthesia after measuring morphometric parameters of the body. Then we did the autopsy animals and studied morphometric parameters of immunogenic organs (spleen and thymus), laboratory parameters: total white blood cells count, red blood cells count, hemoglobin, color index, leukocyte formula. As a result of our investigations was found an immunostimulatory effect of antigens from saline extract of the medicinal leech on morphometric parameters of the body and major immunogenic organs of rats. Under the influence of medical leeches’ antigens from the first day increased the number of white blood cells, increased the number of red blood cells, increased hemoglobin, color index was in the normal range. Changes of morphological and hematological parameters indicate the immune-stimulating impact of medical leeches’ antigens on leucopoiesis, erythropoiesis and morphogenesis.

scholarly journals Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

Aging Cell ◽  
2013 ◽  
Vol 12 (2) ◽  
pp. 280-291 ◽  
Author(s):  
Wen Guo ◽  
Eric Bachman ◽  
Michelle Li ◽  
Cindy N. Roy ◽  
Jerzy Blusztajn ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Iron Incorporation ◽  
Testosterone Administration

scholarly journals Erythropoietin Production in the Anephric Rat. I. Relationship Between Nephrectomy, Time of Hypoxic Exposure, and Erythropoietin Production

Blood ◽  
1972 ◽  
Vol 39 (1) ◽  
pp. 31-38 ◽  
Author(s):  
J. C. Schooley ◽  
L. J. Mahlmann
Keyword(s):  
Adult Female ◽  
Actinomycin D ◽  
Female Rats ◽  
Male Rats ◽  
Hypoxic Exposure ◽  
Simulated Altitude ◽  
Male And Female ◽  
Erythropoietin Production ◽  
Male And Female Rats ◽  
Serum Erythropoietin

Abstract The serum erythropoietin levels of adult male and female rats exposed immediately after nephrectomy to a simulated altitude of 22,000 ft for 5 hr is measurable but decreased to about l5% of normal. Erythropoietin is not detected in the serum of adult female and male rats when the interval between nephrectomy and the beginning of the hypoxic exposure is increased to 8 and 16 rr, respectively. The ability of an anephric rat to respond to this hypoxic stimulus progressively decreases with increasing time after nephrectomy. The ability of young anephric rats to increase their serum erythropoietin levels is little altered if the rats are exposed to hypoxia immediately after nephrectomy, but exposure to the same hypoxic stimulus 24 hr later results in a significant reduction in erythropoietin production. The ability of both normal and anephric rats to produce erythropoietin is reduced or abolished by actinomycin D. The serum erythropoietin produced in hypoxic anephric rats is immunologically indistinguishable from normal erythropoietin.

scholarly journals Effect of diabetes mellitus on levels of insulin-like growth factors and their carrier proteins in Guerin’s carcinoma and it’s perifocal tissue in rats

2021 ◽  
Vol 8 (4) ◽  
pp. 44-52
Author(s):  
E. M. Frantsiyants ◽  
V. A. Bandovkina ◽  
I. V. Kaplieva ◽  
E. I. Surikova ◽  
I. V. Neskubina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Growth Dynamics ◽  
Female Rats ◽  
Carrier Proteins ◽  
Male And Female ◽  
Male And Female Rats ◽  
Igf I ◽  
Guerin’S Carcinoma ◽  
Insulin Like Growth Factors

Purpose of the study. Diabetes mellitus (DM) is considered an independent risk factor for higher cancer incidence and death rates. The system of insulin-like growth factors and their carrier proteins (IGF and IGFBP) and hyperglycemia create favorable conditions for the proliferation and metastasis of cancer cells.Materials and methods. Outbred male and female rats were divided into groups (n = 8 each): controls - with Guerin's carcinoma; main group - Guerin's carcinoma growing in presence of DM. Experimental DM was reproduces in animals by the single intraperitoneal alloxan injection (150 mg/kg body weight). After 10 days of the carcinoma growth, levels of IGF and IGFBP in the tumor and in it's perifocal area were measured using ELISA.Results. DM in females upregulated levels of glucose both in the tumor and in perifocal tissues by 1.8 (p < 0.05) and 8.1 times, respectively, but caused opposite changes in IGF-I - it's increase by 6.3 times in the tumor and decrease by 3.2 times in the perifocal area; as a result, such tumors with small primary nodes were more "aggressive" and actively metastasized. In males, induced DM downregulated levels of glucose, IGF-II and IGFBP2 in the carcinoma by 8.4, 3.1 and 1.7 (p < 0.05) times, respectively, and increased levels of IGF-I and IGFBP2 by 1.4 and 1.3 times (p < 0.05) in the perifocal area without changing glucose levels; as a result, tumor volumes exceeded the values in the standard growth, without metastasizing into visceral organs.Conclusion. We revealed gender differences in changing levels of glucose and IGF both in the tumor and in it's perifocal tissue in rats with Guerin's carcinoma growing in presence of DM; these differences could determine different tumor growth dynamics in male and female rats.

Sign in / Sign up

Export Citation Format

Share Document