Insulin-like growth factor I responses to recombinant bovine growth hormone during feed restriction in heifers

1989 ◽  
Vol 120 (6) ◽  
pp. 735-744 ◽  
Author(s):  
H. Ronge ◽  
J. Blum
Keyword(s):  
Growth Factor ◽  
Feed Intake ◽  
Feed Restriction ◽  
Insulin Like Growth Factor ◽  
Urea Nitrogen ◽  
Blood Concentrations ◽  
Factor I ◽  
Esterified Fatty Acids ◽  
Low Glucose ◽  
Growth Factor I

Abstract. Insulin-like growth factor I, other hormones and blood metabolites were measured in growing heifers before, during and after a 3-day period of normal feed intake and a corresponding period of reduced feed intake. In addition, 0.1 or 0.5 mg recombinant bovine GH/kg was injected daily for 5 days during normal or during and following reduced feed intake. During reduced feed intake blood concentrations of insulin-like growth factor I, insulin, T4, T3, glucose and urea-nitrogen decreased, whereas those of non-esterified fatty acids, albumin and protein increased (P< 0.05). GH, insulin-like growth factor I and insulin increased, whereas urea-nitrogen decreased in response to exogenous GH when heifers were adequately fed (P< 0.05). In contrast, insulin-like growth factor I did not change during GH injections while heifers received reduced amounts of feed. Therefore, during insufficient energy and (or) protein intake, characterized by low glucose, insulin and thyroid hormone levels and increased non-esterified fatty acid concentrations, insulin-like growth factor I concentrations and responses to GH administration were markedly reduced.

Ovarian and hepatic insulin-like growth factor-I gene expression and associated metabolic responses in prepubertal gilts subjected to feed restriction and refeeding

1993 ◽  
Vol 139 (1) ◽  
pp. 143-152 ◽  
Author(s):  
S. T. Charlton ◽  
J. R. Cosgrove ◽  
D. R. Glimm ◽  
G. R. Foxcroft
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Follicular Fluid ◽  
Feed Restriction ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Plasma Gh ◽  
I Gene

ABSTRACT The effects of feed restriction and refeeding on ovarian and hepatic insulin-like growth factor-I (IGF-I) gene expression, systemic and ovarian IGF-I concentrations and on associated metabolic changes were measured in prepubertal gilts. Eleven pairs of littermate gilts (70·7 ± 4·7 kg) were placed on a maintenance level of feeding for 7 days (days 1–7). On day 8, littermates were either fed at a maintenance level of energy or fed to appetite for a further 6 days. Blood samples were taken on day 13 (07.00–16.00 h) to determine plasma insulin and IGF-I, and on day 14 (02.00–06.00 h) to determine plasma GH levels. Following slaughter on day 14, one ovary from each animal was retained to measure follicular fluid IGF-I and oestradiol concentrations. The remaining ovary and a sample of liver were retained for IGF-I mRNA analysis using a ribonuclease protection assay. Six days of refeeding significantly increased plasma IGF-I (P<0·005) and basal insulin (P<0·05) but there was no effect on plasma GH. Ovarian follicular volume and diameter were significantly larger after refeeding (P<0·05), with no effect on follicular fluid oestradiol concentrations. Mean follicular fluid IGF-I concentrations were unaffected by treatment. However, the relationships between individual follicular IGF-I concentrations, absolute follicular fluid IGF-I contents and follicle volume were affected by feeding level (P<0·05). Regression analysis of the same data also revealed that at this stage of maturity, small follicles had greater follicular fluid concentrations of IGF-I than larger follicles. Refeeding increased the amount of IGF-I mRNA in hepatic but not ovarian tissue. We conclude that there is differential regulation of the IGF-I gene in porcine hepatic and ovarian tissues, and that ovarian factors other than, or as well as, IGF-I are involved in the regulation of ovarian responses to refeeding. Journal of Endocrinology (1993) 139, 143–152

Effects of dietary recombinant human insulin-like growth factor-I on concentrations of hormones and growth factors in the blood of newborn calves

1994 ◽  
Vol 140 (1) ◽  
pp. 15-21 ◽  
Author(s):  
C R Baumrucker ◽  
J W Blum
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Milk Replacer ◽  
Insulin Like Growth Factor ◽  
Recombinant Human Insulin ◽  
Blood Concentrations ◽  
Factor I ◽  
First Feeding ◽  
Igf I ◽  
Growth Factor I

Abstract Colostrum is rich in insulin-like growth factor-I (IGF-I) and IGF-II and the dietary effects of recombinant human IGF-I (rhIGF-I) on the newborn are of interest. The objective of this study was to examine the effects of dietary rhIGF-I upon selected hormones and growth factors in the blood. Calves were fed for the first 2 days of life with one of three experimental diets: (1) milk replacer plus isolated colostrum-derived globulin (MR−), (2) as (1) plus 98 μmol rhIGF-I/l (MR+) or (3) pooled cow colostrum. Thereafter, all animals received only milk replacer at 5% of body weight/feeding twice a day with only treatment 2 having the continued addition of 98 μmol rhIGF-I/l until completion of the experiment 7 days after birth. Radioimmunoassays for insulin, prolactin, IGF-I, IGF-II, GH, l-thyroxine, 3,5,3′-l-triiodothyroline and cortisol were conducted. With the exception of GH, all hormones and growth factors examined showed some form of dietary effect, but many were transient, changing only with the first feeding. Both insulin and prolactin concentrations exhibited a transient increase in blood at the first feeding, but insulin increased with the MR− treatment whereas prolactin increased with the MR+ treatment. Total IGF-I concentration in blood did not show any diet-induced changes for the first 4 days, but thereafter a rise in blood concentrations of IGF-I was observed. These data indirectly support the hypothesis that dietary IGF-I may be absorbed and causes transient systemic effects in the newborn calf. Journal of Endocrinology (1994) 140, 15–21

scholarly journals The Association between Newborn Regional Body Composition and Cord Blood Concentrations of C-Peptide and Insulin-Like Growth Factor I

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0121350 ◽  
Author(s):  
Emma M. Carlsen ◽  
Kristina M. Renault ◽  
Rikke B. Jensen ◽  
Kirsten Nørgaard ◽  
Jens-Erik B. Jensen ◽  
...  
Keyword(s):  
Body Composition ◽  
Growth Factor ◽  
Cord Blood ◽  
Insulin Like Growth Factor ◽  
Blood Concentrations ◽  
C Peptide ◽  
Factor I ◽  
Regional Body Composition ◽  
Growth Factor I

Effect of feed intake on antimicrobially induced increases in porcine serum insulin-like growth factor I.

1999 ◽  
Vol 77 (12) ◽  
pp. 3208 ◽  
Author(s):  
M R Hathaway ◽  
W R Dayton ◽  
M E White ◽  
T L Henderson ◽  
D A Young ◽  
...  
Keyword(s):  
Growth Factor ◽  
Feed Intake ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Porcine Serum ◽  
Factor I ◽  
Growth Factor I
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