Assessment of insulin action "in vivo": role of the prevailing plasma glucose level

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S182
Author(s):  
E. MARTENS ◽  
R. ZICK ◽  
H. J. MITZKAT ◽  
A. VON ZUR MÜHLEN ◽  
M. J. MÜLLER
Keyword(s):  
Glucose Level ◽  
Plasma Glucose ◽  
Insulin Action ◽  
Plasma Glucose Level

Assessment of insulin action in man: role of hyperglycemia

1988 ◽  
Vol 119 (2) ◽  
pp. 213-222 ◽  
Author(s):  
E. Martens ◽  
R. Zick ◽  
H. J. Mitzkat ◽  
A. von zur Mühlen ◽  
M. J. Müller
Keyword(s):  
Glucose Level ◽  
Plasma Glucose ◽  
Insulin Action ◽  
Plasma Insulin ◽  
Plasma Glucose Level ◽  
Insulin Level ◽  
Maximum Effect ◽  
Insulin Responsiveness ◽  
Sensitivity Data

Abstract. The effect of hyperglycemia on insulin-induced glucose metabolism (M) was investigated in healthy subjects using sequential clamp protocols at constant insulin + somatostatin infusions and varying plasma glucose. During euglycemia (4.8 mmol/l) M increased from 5.6 to 12.5 mg·kg−1·min−1 with increasing plasma insulin (0.34-3.00 nmol/l). At increasing glucose (6.7 mmol/l), M further increased (9.7 to 19.2 mg·kg−1·min−1) with the plasma insulin level (0.41 to 2.99 nmol/l). At a plasma glucose level of 9.8 mmol/l insulin (0.42 to 3.17 nmol/l) was still effective to increase M (13.7 to 25.2 mg·kg−1·min−1). Regression analysis showed that hyperglycemia does not only increase the maximal insulin-stimulated M, but also decreases the insulin concentration causing a half maximum effect. During prolonged clamp studies M increased by about 10% per h, independent by the plasma glucose level. We conclude that hyperglycemia increases M by increasing insulin responsiveness as well as insulin sensitivity. Data derived from euglycemic clamp studies alone are of limited value with respect to the assessment of insulin action.

Validity of the operational equation of the 14C-deoxyglucose method modified for changing arterial plasma glucose level.

1987 ◽  
Vol 36 (2) ◽  
pp. 217-222
Author(s):  
Kortaro Tanaka ◽  
Fumio Gotoh ◽  
Shintaro Gomi ◽  
Shutaro Takashima ◽  
Ban Mihara
Keyword(s):  
Glucose Level ◽  
Plasma Glucose ◽  
Plasma Glucose Level ◽  
Operational Equation ◽  
Arterial Plasma ◽  
Deoxyglucose Method
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