Failure of GnRH analogue to inhibit serum concentrations of testosterone and 17α-hydroxyprogesterone in hCG-substituted hypogonadotropic hypogonadism

1986 ◽  
Vol 113 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Enzo Vicari ◽  
Alessandro Mongioi ◽  
Domenico Recupero ◽  
Francesca Coniglione ◽  
Maria Macchi ◽  
...  
Keyword(s):  
Hypogonadotropic Hypogonadism ◽  
Serum Testosterone ◽  
Gonadotropin Releasing Hormone ◽  
Gnrh Analogue ◽  
Testicular Function ◽  
Androgen Deficiency ◽  
Serum Concentrations ◽  
Experimental Conditions ◽  
Similar Treatment ◽  
Hcg Therapy

Abstract. Gonadotropin-releasing hormone analogues (GnRH-A) induce inhibition of testicular function and reduction of serum testosterone (T) in man, but the mechanism involved is still debatable. To elucidate it we studied six patients with hypogonadotropic hypogonadism (HH) in chronic substitution with hCG for correction of androgen deficiency symptoms, and evaluated the effect of addition of GnRH-A to the hCG therapy on plasma levels of T and 17α-hydroxyprogesterone (17 OHP). All patients were treated with 1000 U of hCG im every 3rd day for 24 weeks. After 8 weeks of this regimen, GnRH-A, Buserelin (D-Ser-TBU-EA-LHRH), 200 μg per day sc, was added and given for 8 weeks. After cessation of analogue administration patients were followed for 8 further weeks. The levels of the two steroids did not differ markedly in the pre- and post-GnRH-A period. GnRH-A given for two months did not lower T or 17 OHP levels as in eugonadal men after similar treatment. The median T concentrations during GnRH-A tended to be increased, with plasma values higher (P < 0.025) than the peak values observed during hCG alone. Since administration of Buserelin did not inhibit hCG-sustained steroid levels in these HH patients, it is conceivable that GnRH-A may have lacked a direct inhibitory gonadal effect in such experimental conditions.

scholarly journals Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes

2015 ◽  
Vol 8 ◽  
pp. CMED.S27700 ◽  
Author(s):  
Entesar O.A. El Saghier ◽  
Salah E. Shebl ◽  
Olfat A. Fawzy ◽  
lhab M. Eltayeb ◽  
Lamya M.A. Bekhet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Erectile Dysfunction ◽  
Hypogonadotropic Hypogonadism ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Testosterone ◽  
Total Serum ◽  
Total Testosterone ◽  
Androgen Deficiency ◽  
Cross Sectional

Background The association between type 2 diabetes mellitus (T2DM) and low total serum testosterone (LST) has been identified in several cross-sectional studies. Objectives To assess the prevalence of androgen deficiency and erectile dysfunction (ED) and their relation to glycemic control within a sample of Egyptian men with T2DM. Research Design and Methods A cross-sectional study including 70 men having T2DM. Their ages ranged from 30 to 50 years. They were evaluated for symptoms of androgen deficiency and ED, using a validated Arabic-translated Androgen Deficiency in Aging Males questionnaire and five-items version of the International Index of Erectile Function-5, respectively. Total testosterone (TT), glycated hemoglobin (HbA1c), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured for all study subjects. Penile hemodynamics was assessed using penile duplex study for subjects who gave history of ED. Results LST was found in 40% of studied men, and 92.9% of them reported overt symptoms of androgen deficiency. ED was detected in 85.7% of those with LST, as opposed to 31.0% of those with normal TT ( P < 0.000). TT was lower in diabetic men with ED compared to those without ED (12.04 ± 5.36 vs 17.11 ± 7.11 nmol/L, P < 0.001). Significant negative correlation was found between TT and age, body mass index, waist circumference, systolic and diastolic blood pressures, and HBA1c ( P < 0.00). FSH, LH, and prolactin levels were within the normal reference range in all subjects. HbA1c was higher in patients who had LST with ED, compared to those with normal TT and without ED. However, multivariate logistic regression analysis did not reveal a significant association between HBA1c and LST levels. Conclusion LST, symptoms of androgen deficiency, and ED are common in the studied sample of Egyptian men with T2DM. Inappropriately normal FSH and LH in face of LST may denote a state of hypogonadotropic hypogonadism. HBA1c was found to be more significantly associated with ED than with LST.

Kinetics of steroid responsiveness to hCG during chronic inhibition of testicular function by GnRH analogue

1984 ◽  
Vol 107 (4) ◽  
pp. 544-549
Author(s):  
Enzo Vicari ◽  
Alessandro Mongioi ◽  
Antonia Aliffi ◽  
Salvatore Gulizia ◽  
Rosario D'Agata
Keyword(s):  
Biosynthetic Pathway ◽  
Serum Testosterone ◽  
Gnrh Analogue ◽  
Testicular Function ◽  
Term Administration ◽  
Significant Release ◽  
Prepubertal Boys ◽  
Steroid Responsiveness ◽  
Kinetics Of

Abstract. The effect of daily injections of D-Ser-(TBU)6-LRH-EA10 (GnRH analogue (GnRH-A) 100 μg sc) on serum testosterone (T),17α-hydroxyprogesterone (17OHP) and oestradiol-17β (E2) was studied in 4 men. During GnRH-A therapy T, 17OHP and E2 were markedly decreased by the end of the second month. Continuous long-term administration of GnRh-A inhibited testicular function. To test whether the biosynthetic pathway was affected by the regimen, a bolus of 2000 U hCG was given to each subject after 10 months of therapy. Evaluation of the kinetics of steroid responsiveness showed a significant release of T in response to the trophic stimulus, with little or nor elevation of serum 17OHP and E2. The response seen in these treated men appeared similar to that found in hypogonadotrophic men and prepubertal boys.

Semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant

2016 ◽  
Vol 19 (2) ◽  
pp. 194-199 ◽  
Author(s):  
Stefano Romagnoli ◽  
Anna Baldan ◽  
Camilla Righetti ◽  
Chiara Milani ◽  
Antonio Mollo ◽  
...  
Keyword(s):  
Intramuscular Injection ◽  
Healthy Adult ◽  
Semen Quality ◽  
Serum Testosterone ◽  
Reproductive Behaviour ◽  
Gonadotropin Releasing Hormone ◽  
Gnrh Agonists ◽  
Progressive Motility ◽  
Semen Collection ◽  
Very High

Objectives Gonadotropin-releasing hormone (GnRH) agonists like deslorelin are being increasingly used in tom cats for their efficacy in controlling reproductive behaviour and fertility. Deslorelin implants have been widely available in Europe since 2008. Little, if anything, is known about the interval between treatment and onset of sterility, as well as semen quality, after treatment in tom cats. The purpose of this study was to investigate semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant. Methods Fifteen healthy adult tom cats were treated with a 9.4 mg deslorelin implant (Suprelorin 12). For each cat, semen collection and a GnRH stimulation test (intramuscular administration of 50 μg gonadorelin [Fertagyl], followed by blood sampling 1 h later, to assay serum testosterone) were performed on the first consultation and then repeated every 15 days until complete sterility was achieved. Semen collection was performed by introducing a 14 cm, open-end feline catheter (Argyle) 9 cm into the distal urethra 10 mins after sedation by intramuscular injection of 100 μg/kg medetomidine (Domitor). Results Semen collection was not successful in all cats at each attempt. In the first month after treatment, the semen of only four cats could be evaluated, while the semen of eight cats could be evaluated during the second and third months of the study. Semen quality (ejaculate volume, progressive motility and morphological abnormalities) improved slightly during the first 19–25 days in 2/4 cats, and in 1/4 cats motility was still very high (80%) 25 days post-treatment (PT), but we have no data regarding fertility prior to treatment in this cat. The last cat never produced spermatozoa. Subsequently, semen quality gradually worsened in all cats from 30 days onwards. At 70 days PT, one cat was still potentially fertile. After 72 days all cats were sterile. Conclusions and relevance Semen quality increased slightly in treated cats during the first month after treatment, and then gradually decreased over the following months. Complete sterility was reached within 40–72 days following implantation.

SUPRESSION OF TESTICULAR FUNCTION IN A MALE ASIAN ELEPHANT (ELEPHAS MAXIMUS) TREATED WITH GONADOTROPIN-RELEASING HORMONE VACCINES

2014 ◽  
Vol 45 (3) ◽  
pp. 611-619 ◽  
Author(s):  
Imke Lueders ◽  
Thomas Bernd Hildebrandt ◽  
Charles Gray ◽  
Stephan Botha ◽  
Peter Rich ◽  
...  
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Asian Elephant ◽  
Elephas Maximus ◽  
Testicular Function ◽  
Releasing Hormone

Effect of pinealectomy on the testicular response of the freshwater snake Natrix piscator to different environmental factors

1989 ◽  
Vol 67 (10) ◽  
pp. 2352-2357 ◽  
Author(s):  
C. Haldar ◽  
R. Pandey
Keyword(s):  
High Temperature ◽  
Pineal Gland ◽  
High Humidity ◽  
Testicular Function ◽  
Experimental Conditions ◽  
Gland Weight ◽  
Tropical Water ◽  
Water Snake ◽  
Temperature Regimes ◽  
Testicular Weight

The effects of different humidity, photoperiod, and temperature regimes on the testicular function of the tropical water snake Natrix piscator were investigated in both sham-operated and pinealectomized snakes. Moderate humidity (50 ± 5%) had no effect on the testis, but high humidity (85 ± 5%) increased the testicular weight and activity of sham-operated snakes after 3, 6, and 9 weeks. Exposures to 14L:10D or 24L:0D and high temperature (42 ± 2 °C) inhibited testicular weight and activity in sham-operated snakes, whereas exposure to 10L:14D or 0L:24D and a low temperature (20 ± 2 °C) had no effect. Pinealectomized snakes did not respond to any of these experimental conditions, but their testicular weight remained the same as that of the pinealectomized controls under natural environmental conditions. The pineal gland showed an opposite response to that of the testes. Pineal gland weight decreased under high humidity and increased under 14L:10D, 24L:0D, and high temperature. These findings suggest that the ecofactors humidity, photoperiod, and temperature play a role in the regulation of testicular function in this snake, and that the pineal gland is implicated in the mediation of these factors.

scholarly journals AN ADULT MALE CASE OF CRYPTORCHIDISM CONCOMITANT WITH HYPOGONADOTROPIC HYPOGONADISM WHO UNDERWENT hCG THERAPY AND SHOWED A SPONTANEOUS DESCENT OF THE TESTIS

2020 ◽  
Vol 111 (1) ◽  
pp. 30-33
Author(s):  
Soichi Matsumura ◽  
Akira Nagahara ◽  
Shinichiro Fukuhara ◽  
Kazutoshi Fujita ◽  
Motohide Uemura ◽  
...  
Keyword(s):  
Adult Male ◽  
Hypogonadotropic Hypogonadism ◽  
Hcg Therapy

scholarly journals Role of Kisspeptin in Puberty in Humans

2020 ◽  
pp. 92-97
Author(s):  
Ravi Kant ◽  
Mahendra Kumar Meena
Keyword(s):  
Reproductive Biology ◽  
Conventional Treatment ◽  
Hypogonadotropic Hypogonadism ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Pilot Studies ◽  
Releasing Hormone ◽  
Infertile Couples ◽  
Stimulating Hormone

Kisspeptin or GPR-54 is a product of KISS 1 gene regulating the production of gonadotropin releasing hormone (GnRH), luteinizing (LH) as well follicle stimulating hormone (FSH). Both LH and FSH are important hormones for reproduction in animals as well in humans. The recognition of Kisspeptin has a landmark bearing in reproductive biology. Few recent pilot studies have convincingly proven it to be a promising molecule in treating infertile couples especially those having hypogonadotropic hypogonadism not responding to conventional treatment.

scholarly journals Severe hyperandrogenism due to ovarian hyperthecosis in a young woman

2019 ◽  
Vol 12 (12) ◽  
pp. e232783 ◽  
Author(s):  
Alpesh Goyal ◽  
Rakhi Malhotra ◽  
Vidushi Kulshrestha ◽  
Garima Kachhawa
Keyword(s):  
Young Woman ◽  
Serum Testosterone ◽  
Clinical Problem ◽  
Gnrh Analogue ◽  
Rare Presentation ◽  
Presumptive Diagnosis ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Ovarian Hyperandrogenism ◽  
Two Sides

Hyperandrogenism is a relatively common clinical problem. However, severe hyperandrogenism causing virilisation is rare. A 27-year-old woman presented with generalised hirsutism, clitoromegaly, breast atrophy and secondary amenorrhoea. She had serum testosterone levels elevated to the adult male range. Administration of gonadotropin-releasing hormone (GnRH) analogue resulted in >50% suppression of serum testosterone which was suggestive of luteinising hormone-dependent ovarian hyperandrogenism. Imaging studies of abdomen and pelvis were normal, and ovarian venous sampling failed to show a gradient between the two sides. A presumptive diagnosis of ovarian hyperthecosis was, therefore, considered. Medical treatment with GnRH analogue and combined oral contraceptive pills was initiated to which an excellent clinical and biochemical response was noted. This case highlights a rare presentation of ovarian hyperthecosis in a young woman with severe hyperandrogenism mimicking a virilising neoplasm.

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