Adrenocortical tumours in children: our experience with nine cases

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S264-S274 ◽  
Author(s):  
E. CACCIARI ◽  
A. CICOGNANI ◽  
P. PIRAZZOLI ◽  
G. PAOLUCCI ◽  
A. MANCINI ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Plasma Level ◽  
Hepatic Metastasis ◽  
Plasma Levels ◽  
The Other ◽  
Adrenocortical Tumor ◽  
Adrenal Androgens ◽  
Abdominal Sonography ◽  
Adrenocortical Tumours ◽  
Adrenocortical Tumour

Abstract Nine cases of adrenocortical tumor are presented, six were males. Four were less than three years and five were between 5 and 10 years of age. Clinical virilization was found in 8 children, one had only signs of hypercortisolism and another showed signs of virilization and hypercortisolism simultaneously. Urinary 17-KS and 17-OHCS were high in all patients. Plasma levels of testosterone and of the other adrenal androgens were high in all the cases tested. Plasma level of cortisol was elevated only in few cases. In two out of five cases steroids were only partially suppressed by dexamethasone. Computed tomography and abdominal sonography have been useful tods for the localization of the tumour. The resection of the tumour, indipendent of hystopathological diagnosis, led to a complete normalization of the clinical and hormonal picture in eight cases evaluated at a distance of 2 months 10 years after surgery. In one case a hepatic metastasis was observed and removed three years after surgery. Adrenocortical tumours are rare (Javadpour et al., 1980) and the vast majority of them are hormone secreting. Although cases have been described which showed feminilization and hyperaldosteronism (Bacon & Lowrey, 1965; Bhettay & Bormici, 1977; Crane et al., 1961; Gauguly et al., 1980), virilization and hypercortisolism are most commonly found (Hayles et al., 1966). This paper illustrates our experience with nine cases of adrenocortical tumour, eight of whom showed inappropriate virilization with or without hypercortisolism and one of whom was a classic case of Cushing's syndrome.

scholarly journals High doses of carbamazepine for refractory partial epilepsy

1996 ◽  
Vol 54 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Cristiana Borges Pereira ◽  
Carlos Otto Heise ◽  
Arthur Cukiert
Keyword(s):  
Side Effects ◽  
Plasma Level ◽  
Plasma Levels ◽  
Partial Epilepsy ◽  
The Other ◽  
Partial Seizures ◽  
High Doses ◽  
Higher Doses ◽  
Refractory Partial Epilepsy

Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and fifteen on polytherapy. The other drugs were kept unchanged in the patients on polytherapy. The dose of CBZ was increased if no control was observed and the patient had no side effects. The doses used ranged between 1200 and 1900 mg/day (1200 mg/day, n=18; 1300mg/day, n=1; 1400 mg/day, n=7; 1600 mg/day, n=9; 1700 mg/day, n=4; 1800 mg/day, n=8; 1900 mg/day, n=1). Anticonvulsant plasma levels were taken to confirm patient compliance. The average plasma level was 9.6 ug/mL. The period of follow up varied from 3 to 96 months (M=25.6). Seizure's control was observed in 7 (14.48%) patients taking 1200 mg/day and in 2 (4.16%) patients taking 1400 mg/day of CBZ. Thirty-nine patients did not show any control (81.21%). Ten patients (20.81%) had signs of intoxication. When patients have no improvement with 1400 mg/day, it is difficult to obtain any control despite the use of higher doses of CBZ, which frequently expose the patient to significant side effects.

EFFECTS OF CONTINUOUS DAILY ADMINISTRATION OF 0.5 MG OF NORETHINDRONE ON THE PLASMA LEVELS OF PROGESTERONE AND ON THE URINARY EXCRETION OF LUTEINIZING HORMONE, PREGNANEDIOL AND TOTAL OESTROGENS

1970 ◽  
Vol 63 (2) ◽  
pp. 216-224 ◽  
Author(s):  
U. Larsson-Cohn ◽  
E. D. B. Johansson ◽  
L. Wide ◽  
C. Gemzell
Keyword(s):  
Luteinizing Hormone ◽  
Plasma Level ◽  
Urinary Excretion ◽  
Plasma Levels ◽  
The Other ◽  
Daily Treatment ◽  
Daily Administration ◽  
Menstrual Bleeding ◽  
Biphasic Pattern

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of LH, total oestrogens and pregnanediol were performed in 4 subjects during one control cycle, immediately followed for 2 or 3 months of daily treatment with 0.5 mg of norethindrone continuously. The control cycles were ovulatory according to all the parameters investigated. During treatment the mid-cycle LH peak disappeared in all cases while the basal LH excretion showed considerable day to day variations. The excretion of total oestrogens was increased in all subjects but did not show the normal biphasic pattern. Periods of increased oestrogen excretion also appeared in the subjects with consistently low progesterone and pregnanediol levels during the treatment. In two cases, all signs of luteal activity immediately disappeared after the commencement of treatment. The other cases had one and three periods of increased progesterone and pregnanediol levels respectively. However, these periods were shorter than those of the control cycles. One of the subjects had regular menstrual bleeding while the other three had more or less irregular vaginal flows, often appearing during elevated but declining oestrogen excretion.

scholarly journals Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases

2021 ◽  
Vol 30 ◽  
pp. 096368972098545
Author(s):  
Tao Hu ◽  
Xiao Liu ◽  
Qinan Yin ◽  
Xingting Duan ◽  
Li Yan
Keyword(s):  
Computed Tomography ◽  
Nucleic Acid ◽  
Virus Infection ◽  
Severe Acute Respiratory Syndrome ◽  
The Other ◽  
Computed Tomography Scan ◽  
Health Authorities ◽  
History Of ◽  
Tomography Scan ◽  
Nucleic Acid Tests

In this work, we discovered a new phenomenon—asymptomatic COVID-19 infection, or covert case, during the pandemic. All the 3 patients had a history of exposure, with no symptoms, and no abnormalities were found in computed tomography scan or lab tests. Except for case 2, the other patients’ severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) nucleic acid tests were negative. But their anti-SARS-COV-2 nucleocapsid antibody showed a dynamic trend, consistent with the process of virus infection and clearance. A growing number of asymptomatic or covert cases need more attention. Lack of surveillance may lead to another outbreak. We hope to demonstrate our cases to attract the attention of governments or health authorities that covert cases should be the focus as well.

scholarly journals Vasitis: clinical and ultrasound confusion with inguinal hernia clarified by computed tomography

2013 ◽  
Vol 5 (4) ◽  
pp. 74
Author(s):  
Kathleen Eddy ◽  
Bruce Piercy ◽  
Richard Eddy
Keyword(s):  
Computed Tomography ◽  
Inguinal Hernia ◽  
Spermatic Cord ◽  
Vas Deferens ◽  
The Other ◽  
Other Hand ◽  
Ultrasound Computed Tomography ◽  
Ultrasound Findings ◽  
Duplex Doppler

Vasitis or inflammation of the vas deferens is a rarely describedcondition categorized by Chan & Schlegel1 as either generallyasymptomatic vasitis nodosa or the acutely painful infectious vasitis.Clinically, infectious vasitis presents with nonspecific symptomsof localized pain and swelling that can be confused with other,more common conditions such as epididymitis, orchitis, testiculartorsion, and inguinal hernia. Ultrasound with duplex Doppler scanningcan be used to exclude epididymitis, orchitis, and testiculartorsion. On the other hand, while inguinal hernia is difficult todifferentiate from vasitis using ultrasound, computed tomography(CT) is diagnostic. We describe 2 cases of vasitis with clinicaland ultrasound findings that initially were interpreted as inguinalhernias. In both patients, CT was diagnostic for vasitis showing anedematous spermatic cord and no hernia. Urine cultures in bothpatients were negative, but the symptoms resolved with antibiotictreatment.

Spinal Epidural Compression Secondary to Osteoblastic Metastatic Vertebral Expansion

Neurosurgery ◽  
1988 ◽  
Vol 23 (5) ◽  
pp. 662-665 ◽  
Author(s):  
Alan Hirschfeld ◽  
William Beutler ◽  
Juliet Seigle ◽  
Herbert Manz
Keyword(s):  
Computed Tomography ◽  
Radiation Therapy ◽  
Spinal Canal ◽  
Surgical Decompression ◽  
The Other ◽  
Precise Nature ◽  
Osteoblastic Metastasis ◽  
Neurological Improvement ◽  
Epidural Compression ◽  
Spinal Epidural

Abstract We present two cases in which spinal epidural compression was caused by the expansion of bony elements into the spinal canal as a result of osteoblastic metastases. The precise nature of the compression was appreciated only on computed tomography. One patient had immediate and sustained neurological improvement after laminectomy. The other benefited temporarily, but widespread involvement of his spine ultimately led to paraplegia despite two more decompressive procedures. We think that bony expansion of the spine secondary to osteoblastic metastasis is not reversible with radiation therapy alone and is, therefore, an absolute indication for surgical decompression.

SPECT Scan in Somatization Disorder Patients: An Exploratory Study of Eleven Cases

2001 ◽  
Vol 35 (3) ◽  
pp. 359-363 ◽  
Author(s):  
Javier Garcia-Campayo ◽  
Concepcion Sanz-Carrillo ◽  
Teresa Baringo ◽  
Concepción Ceballos
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Spect Imaging ◽  
The Other ◽  
University Hospital ◽  
Somatization Disorder ◽  
Emission Computed Tomography ◽  
Axis I ◽  
Pain Symptoms

Objective: There are no previous studies using single photon emission computed tomography (SPECT) scans in somatization disorder (SD) patients. The aim of this paper is to assess SPECT imaging abnormalities in SD patients and study any relation to laterality. Method: Eleven SD patients from the Somatization Disorder Unit of Miguel Servet University Hospital, Zaragoza, Spain, not fulfilling criteria for any other psychiatric disorder and showing normal computed tomography (CT) and magnetic resonance imaging (MRI) images were studied with SPECT. Patients with DSM-IV axis I comorbidity were ruled out because it has been demonstrated that SPECT scans can show abnormalities in patients with depression and anxiety disorders. The technique used for SPECT was 99mTc-D,1,hexamethylpropyleneamide- oxime (99mTc-HMPAO) in four patients and 99mTc-bicisate in the other seven. The SPECT scans were evaluated without knowledge of clinical data and entirely by visual inspection. Results: Seven out of 11 (63.6%) SD patients showed hypoperfusion in SPECT imaging. In four cases there was hypoperfusion in the non-dominant hemisphere and the predominance of pain symptoms took place in the contralateral hemibody. In the other three patients hypoperfusion was bilateral. The anatomical regions affected were cerebellum (four cases), frontal and prefrontal areas (three cases), temporoparietal areas (two cases) and the complete hemisphere (one case). Conclusions: A proportion of SD patients may present hypoperfusion in SPECT images, uni- or bilaterally, in different brain areas. Possible aetiological explanations for this finding are discussed. Controlled studies are necessary to confirm or refute this hypothesis.

THE EFFECT OF EXOGENOUS PROGESTAGEN ON THE LEVELS OF FREE OESTROGEN IN THE OVARIAN VEIN PLASMA OF THE EWE

1970 ◽  
Vol 48 (4) ◽  
pp. 485-496 ◽  
Author(s):  
J. F. SMITH ◽  
T. J. ROBINSON
Keyword(s):  
Plasma Levels ◽  
Similar Pattern ◽  
Peak Level ◽  
The Other ◽  
Ovarian Vein ◽  
Active Ovary ◽  
The Mean ◽  
Significant Change

SUMMARY The levels of free oestrogen (oestrone and oestradiol-17β) in plasma in the ovarian vein were determined in three groups, each of 27 ewes, at nine intervals at about the time of oestrus. One group had a normal oestrus while the other two had been treated for 16 days with intravaginal sponges containing either 10 or 30 mg of a synthetic progestagen (Cronolone, Searle). In untreated ewes, the mean level (corrected) of oestradiol-17β in plasma from the active ovary rose from 25·3 ng/100 ml at −48 h to a peak of 91·6 ng/100 ml at 0 h (onset of oestrus) and then fell. There was evidence of biphasic production. The mean level of oestrone was relatively high (13·0 ng/100 ml) at −48 h; it fell to 2·0 ng/100 ml between −36 and −24 h and then rose again to 9·4 ng/100 ml at + 12 h. There was no significant change, with time, in the plasma levels of either oestrogen from the non-active ovary. The total amounts of oestradiol-17β and of oestrone produced from both ovaries at an oestrous period were estimated to average 9·7 and 2·4 μg. In treated ewes, a similar pattern of production of oestradiol-17β was shown by the ewes treated with 30 mg Cronolone. That of ewes treated with 10 mg differed (P < 0·01). Peak level was reached at an earlier stage, relative to the onset of oestrus, and it declined more rapidly, the total amount of oestrogen produced (oestrone + oestradiol-17β) was less (10 mg Cronolone, 8·6 μg; 30 mg Cronolone, 12·1 μg; normal oestrus, 12·1 μg), and there was no biphasic production.

scholarly journals The plasma microRNA levels and their relationship with the general health and functional status in female patients with fibromyalgia syndrome

2021 ◽  
Vol 36 (4) ◽  
pp. 482-492
Author(s):  
Erbil Akaslan ◽  
Orhan Güvener ◽  
Ayşegül Görür ◽  
Didem Havva Çelikcan ◽  
Lülüfer Tamer ◽  
...  
Keyword(s):  
Plasma Level ◽  
Functional Status ◽  
Plasma Levels ◽  
General Health ◽  
Fibromyalgia Syndrome ◽  
Subscale Score ◽  
Female Patients ◽  
Mental Symptom ◽  
Sf 36 ◽  
Plasma Microrna

Objectives: The aim of this study was to identify the plasma level of micro-ribonucleic acid (microRNA) expressions and the relationship between plasma microRNA levels with the general health and functional status in female patients with fibromyalgia syndrome (FMS). Patients and methods: Thirty-five female patients (mean age: 42.0±11.8 years; range, 21 to 62 years) diagnosed as FMS and 35 sex-and age-matched healthy controls (mean age: 43.7±8.8 years; range, 21 to 56 years) were enrolled in the study. MicroRNA measurements of the participants in plasma were carried out by using the quantitative polymerase chain reaction (qPCR). A total of 11 plasma levels of microRNA expressions were examined in both groups. The general health and functional status of the patients and controls were assessed by the Fibromyalgia Impact Questionnaire (FIQ) and the Short Form-36 (SF-36) scale. Results: No significant difference was observed between the plasma levels of microRNA expressions in patients with FMS and healthy controls. The plasma level of miR-320a expression was found to be negatively correlated with the total FIQ score in female patients with FMS (p=0.05, r=-0.34). Negative correlations were also detected between the plasma level of miR-320a and miR-320b expressions and the subscale score of SF-36 physical function in female patients with FMS (p=0.01, r=-0.43 and p=0.01, r=-0.43, respectively). A strong positive correlation was found between miR-142-3p and the subscale score of SF-36 mental symptom score in female patients with FMS (p<0.001, r=1.00). Conclusion: The expression levels of microRNAs in plasma between female patients with FMS and controls were not significantly different. Only plasma levels of miR-320a, miR-320b, and miR-142-3p expressions were associated with the general health, functional status, and mental symptom score in female patients with FMS.

scholarly journals Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Report of 2 Cases and Literature Review

2021 ◽  
Vol 1 (1) ◽  
pp. 36-40
Author(s):  
Xiangting Xie ◽  
◽  
Ying Zhang ◽  
Xiaoyan Tan ◽  
Yun Luo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Relevant Literature ◽  
Complete Resection ◽  
The Other ◽  
Malignant Lymphomas ◽  
Chest Computed Tomography ◽  
Pulmonary Malt Lymphoma

Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is indolent and progresses more slowly than other malignant lymphomas. The clinical features are not specific and the diagnosis can often be difficult. Here, we present two rare cases of pulmonary MALT lymphoma. Both patients were incidentally found lesions in the lungs with chest computed tomography during physical examination. They were finally diagnosed by pathological biopsy. One received complete resection, the other was treated with chemotherapy. There were no recurrence in the two patients during follow-up. We also review relevant literature to provide a better recognition of this disease.

EFFECTS OF CONTINUOUS DAILY ADMINISTRATION OF 0.5 mg OF CHLORMADINONE ACETATE ON THE PLASMA LEVELS OF PROGESTERONE AND ON THE URINARY EXCRETION OF LUTEINIZING HORMONE AND TOTAL OESTROGENS

1970 ◽  
Vol 63 (4) ◽  
pp. 705-716 ◽  
Author(s):  
U. Larsson-Cohn ◽  
E. D. B. Johansson ◽  
L. Wide ◽  
C. Gemzell
Keyword(s):  
Luteinizing Hormone ◽  
Plasma Level ◽  
Urinary Excretion ◽  
Corpus Luteum ◽  
Plasma Levels ◽  
Chlormadinone Acetate ◽  
The Mean ◽  
Low Levels ◽  
The Difference ◽  
All Treatment

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of luteinizing hormone (LH) and total oestrogens were performed in 6 subjects during one control cycle, immediately followed by three cycles of daily treatment with 0.5 mg of chlormadinone acetate continuously. The control cycles were ovulatory according to the parameters investigated. Two of the women showed a normal LH excretion pattern in all treatment cycles. The four other subjects also had periodical variations in the LH excretion but no distinct midcycle peaks occurred. The mean oestrogen excretion was increased in all three treatment cycles but the difference was satistically significant only in the last two cycles. Compared with the treatment cycles, the sum of progesterone values was significantly decreased in the first two cycles. Chlormadinone acetate in this dose had no thermogenic effect. Three of the subjects showed bleeding irregularities which had no clear connection with the hormone variations measured in the study. It is suggested that the low levels of progesterone might be due to a defective corpus luteum function.

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