Adrenarche is dissociated from gonadarche – studies in patients with Turner's syndrome

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S232-S240 ◽  
Author(s):  
W.M. TELLER ◽  
J. HOMOKI ◽  
S. WUDY ◽  
J.H.M. SCHLICKENRIEDER
Keyword(s):  
Gonadal Dysgenesis ◽  
Capillary Column ◽  
Development Stage ◽  
Breast Development ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Clinical Onset ◽  
Steroid Profiles ◽  
Capillary Column Gas Chromatography ◽  
Urinary Steroid

ABSTRACT Twenty-two patients with gonadal dysgenesis (14 45,XO; median age 13.6 years; 8 mosaics, median age 12.3 years) were studied regarding their clinical onset of adrenarche (pubarche) and breast development. The latter was considered evidence of gonadarche. 1/22 showed breast development, stage 2; 9/22 had pubarche, stage 2-4. The 24 -urinary excretion of androsterone, etiocholanolone, dehydroepiandrosterone, 16α- and 16β-dehydroepiandrosterone was studied in these patients by urinary capillary column gas chromatography profiling. The urinary steroid profiles of twenty-one healthy, normal girls (median age 10.4 years) served as controls. Dehydroepiandrosterone and its 16-hydroxylated derivatives were excreted in significantly greater amounts by the patients with Turner's syndrome as compared to normal girls. These findings support the hypothesis, that adrenarche is independent of gonadarche and proceeds even in instances of gonadal dysgenesis.

scholarly journals Turner's Syndrome: Approach to Diagnosis and Treatment

2018 ◽  
Vol 13 (3) ◽  
pp. 61-62
Author(s):  
Sadhana Sah ◽  
Ganesh Dangal ◽  
Aruna Karki ◽  
Hema Pradhan ◽  
Ranjana Shrestha ◽  
...  
Keyword(s):  
Short Stature ◽  
Estrogen Therapy ◽  
Tanner Stage ◽  
Breast Development ◽  
Primary Amenorrhea ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Secondary Sexual Characteristics ◽  
Karyotypic Abnormality ◽  
Sexual Characteristics

Turner's syndrome is the most common karyotypic abnormality causing gonadal failure and primary amenorrhea. It is characterized by short stature and absence of secondary sexual characteristics. It is diagnosed by increased plasma FSH and LH level with low level of estrogen i.e. hypergonadotrophic hypogonadism. Ultrasound abdomen reveals streak ovaries and atrophic uterus. Karyotype confirms the diagnosis of Turner's syndrome (45XO). We present here a 15 years girl who presented with primary amenorrhea with short stature with breast development corresponds to Tanner stage I. Her FSH was raised. Ultrasound abdomen showed uterine agenesis and streak ovaries. Karyotype showed 45XO which confirmed the diagnosis of Turner's syndrome. She is now on estrogen therapy and her height has increased and breast development corresponds to Tanner stage II. Keywords: hypergonadotrophic hypogonadism, primary amenorrhea, Turner's syndrome

CHROMOSOME COMPLEMENT IN GONADAL DYSGENESIS (TURNER'S SYNDROME)

The Lancet ◽  
1959 ◽  
Vol 273 (7078) ◽  
pp. 886 ◽  
Author(s):  
M. Fraccaro ◽  
K. Kaijser ◽  
J. Lindsten
Keyword(s):  
Gonadal Dysgenesis ◽  
Chromosome Complement ◽  
Turner's Syndrome ◽  
Turner’S Syndrome

Turner's syndrome (gonadal dysgenesis)

1973 ◽  
Vol 8 (2) ◽  
pp. 239
Author(s):  
Mazloum Z. Osman ◽  
Bertram R. Girdany
Keyword(s):  
Gonadal Dysgenesis ◽  
Turner's Syndrome ◽  
Turner’S Syndrome

scholarly journals DERMATOGLYPHIC ANALYSIS IN TURNER’S SYNDROME

2020 ◽  
Vol 09 (02) ◽  
pp. 04-09 ◽  
Author(s):  
Aytakin Hasanova
Keyword(s):  
Congenital Malformation ◽  
Gonadal Dysgenesis ◽  
Turner's Syndrome ◽  
Turner’S Syndrome

The palm- and finger-prints of 10 patients suspected to have Tumers syn¬drome were analysed. The results were compared to the dermatoglyphic patterns characteristic of Turner’s syndrome found in the literature. In 3 cases a dermatoglyphic picture corresponding to that of the literature was observed. In one case a perfect analysis could not be performed because of a congenital malformation of one of the hands. In 4 cases no perfect correspondence was found. With the aid of dermatoglyphic examinations the possibility of Turner’s syndrome was excluded in 2 cases. In these 2 cases the karyotypes did not prove to be X monosomy either. The method is believed to be useful for dif-ferential diagnosis of gonadal dysgenesis.

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