Acute suppressive effect of ACTH-induced cortisol secretion on serum prolactin levels in healthy man

1982 ◽  
Vol 99 (3) ◽  
pp. 352-356 ◽  
Author(s):  
P. Bratusch-Marrain ◽  
H. Vierhapper ◽  
W. Waldhäusl ◽  
P. Nowotny
Keyword(s):  
Menstrual Cycle ◽  
Suppressive Effect ◽  
Prolactin Secretion ◽  
Follicular Phase ◽  
Serum Prolactin ◽  
Cortisol Secretion ◽  
Adrenocortical Insufficiency ◽  
Healthy Men ◽  
Healthy Women ◽  
Acute Increase

Abstract. The effect of ACTH on serum prolactin concentrations was studied in 6 healthy women in the follicular phase of the menstrual cycle, in 5 healthy men and in 6 patients (5 males, 1 female) with adrenocortical insufficiency. In healthy women prolactin levels decreased from basal, 14.4 ± 2.1 (SEM) μg/l to 9.4 ± 0.9 μg/l after 30 min and to 8.1 ± 0.7 μg/l after 60 min of iv administration of synthetic ACTH1-24 (0.25 mg). Upon continuous infusion of ACTH1-24 (0.25 mg for 8 h) prolactin fell to 4.4 ± 0.6 μg/l in healthy women and to 4.6 ± 1.5 μg/l (basal: 10.6 ± 1.8 μg/l) in healthy men. In patients with adrenocortical insufficiency prolactin concentrations remained unchanged following an 8 h infusion of ACTH1-24 (before ACTH: 14.5 ± 2.3 μg/l, after ACTH: 16.3 ± 3.1 μg/l). After treatment with dexamethasone (2 mg/day for 3 days) however, prolactin concentrations were suppressed both in healthy women (−52 ± 7%) and men (−25 ± 11%) and in patients with adrenocortical insufficiency (−21 ± 10%). Thus the effect of ACTH on prolactin appeared to be mediated via enhanced cortisol secretion. It is suggested that an acute increase in cortisol levels within the physiological range may modulate prolactin secretion.

SUPPRESSION OF LUTEINIZING HORMONE INDUCED BY ADRENOCORTICOTROPHIN IN HEALTHY WOMEN

1981 ◽  
Vol 91 (3) ◽  
pp. 399-403 ◽  
Author(s):  
H. VIERHAPPER ◽  
W. WALDHÄUSL ◽  
P. NOWOTNY
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Continuous Infusion ◽  
Follicular Phase ◽  
Serum Concentrations ◽  
Adrenocortical Insufficiency ◽  
Healthy Men ◽  
Healthy Women ◽  
Endogenous Cortisol ◽  
Lh Secretion

The effect of ACTH on serum concentrations of LH and FSH was studied in six healthy women in the follicular phase of the menstrual cycle, in six healthy men and in six patients (five men, one woman) with adrenocortical insufficiency. In healthy women the i.v. administration of synthetic 1–24 ACTH (0·25 mg) induced a fall in serum concentrations of LH from 11·1 ± 1·2 (s.d.) to 7·8 ± 0·6 i.u./l (P < 0·005) after 30 min and to 8·2 ± 0·7 i.u./l after 60 min. Upon continuous infusion of 1–24 ACTH (0·25 mg i.v., t = 480 min) LH fell to 6·7 ± 0·9 i.u./l (P < 0·005) in healthy women and to 6·1 ± 3·7 i.u./l (basal, 8·7 ± 3·9 i.u./l) in healthy men. In patients with adrenocortical insufficiency serum concentrations of LH were unchanged by 1–24 ACTH. Serum concentrations of FSH were not altered by 1–24 ACTH in any of the three groups. It is suggested that the effect of ACTH on LH secretion in healthy women is mediated by the acute rise of endogenous cortisol concentrations.

scholarly journals Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers

2013 ◽  
Vol 98 (11) ◽  
pp. 4464-4474 ◽  
Author(s):  
C. N. Jayasena ◽  
A. N. Comninos ◽  
G. M. K. Nijher ◽  
A. Abbara ◽  
A. De Silva ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Reproductive Function ◽  
Reproductive Hormones ◽  
Follicular Phase ◽  
Hypothalamic Amenorrhea ◽  
Healthy Women ◽  
Lh Pulsatility ◽  
Serum Lh ◽  
Healthy Female ◽  
Ultrasound Parameters

Background: Kisspeptin is a critical hypothalamic regulator of reproductive function. Chronic kisspeptin administration causes profound tachyphylaxis in male monkeys and in women with functional hypothalamic amenorrhea. The pharmacological effects of chronic kisspeptin exposure in healthy women with normal menstrual cycles have not been studied previously. Aim: Our aim was to determine the effects of follicular-phase kisspeptin-54 treatment on menstrual cyclicity in healthy women. Methods: We performed a prospective, single-blinded, 1-way crossover study. Healthy women received twice-daily sc injections of kisspeptin (6.4 nmol/kg) or 0.9% saline during menstrual days 7–14 (n = 5 per treatment arm). Serial assessments of basal reproductive hormones, ultrasound parameters, LH pulsatility, and acute sensitivity to GnRH and kisspeptin-54 injection were performed. Results: Menstrual cyclicity persisted in all women after follicular-phase kisspeptin-54 treatment. Chronic exposure to kisspeptin-54 did not abolish acute stimulation of LH after injection of kisspeptin-54 or GnRH. In addition, kisspeptin-54 treatment was associated with a shorter mean length of the menstrual cycle (mean length of menstrual cycle was 28.6 ± 1.4 days with saline vs 26.8 ± 3.1 days with kisspeptin, P &lt; .01), earlier onset of highest recorded serum LH (mean menstrual day of highest LH was 15.2 ± 1.3 with saline vs 13.0 ± 1.9 with kisspeptin, P &lt; .05), and earlier onset of the luteal phase (mean menstrual day of progesterone increase was 18.0 ± 2.1 with saline vs 15.8 ± 0.9 with kisspeptin, P &lt; .05). Conclusion: Our data suggest that 1 week of exogenous kisspeptin-54 does not abolish menstrual cyclicity in healthy women. Further work is needed to determine whether kisspeptin could be used to treat certain anovulatory disorders.

The effect of oxytocin administration upon the pulsatile secretion of luteinizing hormone in humans

1989 ◽  
Vol 121 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Janet A. Amico ◽  
Donald W. Richardson ◽  
Stephen J. Winters
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
The Other ◽  
Healthy Men ◽  
Pulsatile Secretion ◽  
Oxytocin Infusion ◽  
Double Blinded ◽  
Lh Secretion ◽  
Synthetic Oxytocin

Abstract. The effect of iv administration of synthetic oxytocin upon the pulsatile pattern of LH secretion was studied in 5 healthy men and 10 healthy women. Five of the women were studied in the follicular phase of a menstrual cycle and the other 5 were studied in the luteal phase of a cycle. Synthetic oxytocin in 0.9% saline or saline alone was administered via continuous iv infusion for 8 h on 2 consecutive days. Infusions were administered using a double-blinded and radomized schedule. The rate of the oxytocin infusion commenced at 1 mU/min and was increased 1 mU/min every 40 min to a final rate of 12 mU/min. The plasma oxytocin concentration during oxytocin infusion ranged from 2–70 fmol/l. Blood for LH determination was sampled every 20 min in the 5 follicular phase women and every 10 min in the 5 men and 5 luteal phase women. The detect algorithm was used to analyze LH pulsatile secretion. Oxytocin infusion was without significant effect on mean LH, number of LH pulses, or area under the LH curve in men or women studied for the period of observation. Thus it is unlikely that increases in plasma oxytocin regulate the pulsatile secretion of LH in humans.

scholarly journals The Effects of Estrogen and Progesterone Hormones on Active Hip Joint Position Sense in Healthy Women in Different Phases of a Menstrual Cycle

2021 ◽  
Author(s):  
Maliheh Mosavi Ghomi ◽  
Mehrdad Shariati ◽  
Mokhtar Mokhtari ◽  
Fatemeh Ramezani Nowrozani
Keyword(s):  
Menstrual Cycle ◽  
Hip Joint ◽  
Position Sense ◽  
Joint Position Sense ◽  
Follicular Phase ◽  
Joint Position ◽  
Activity Increase ◽  
Healthy Women ◽  
Significant Difference ◽  
The Brain

Introduction: The proprioceptive system is a sensory system based on an individual’s knowledge of his or her body. This knowledge is transmitted to the brain through inputs received from joints, muscles, tendons, and ligaments. As a result, these inputs inadvertently inform the brain of the state of the body’s muscles. Numerous factors can affect this system. This study aimed to investigate the effect of estrogen and progesterone hormones on understanding and recognizing the proprioceptive sense of hip joint in healthy women during the menstrual cycle. Materials and Methods: In this quasi-experimental study, 15 healthy women participated voluntarily. They had regular menstrual cycles without any history of disease and drug use. The concentration of estrogen and progesterone during a cycle in the follicular (4-6 days), ovulation, and luteal phases were evaluated to detect their effects on the sense of perception and cognition of the proprioceptive joint in the two movements of abduction and flexion by the target angle reconstruction method (30°). Results: The errors of active joint position sense were reduced in abduction and flexion during ovular and luteal phases compared to the follicular phase. However, in the flexion direction of hip movement, there was a significant difference in absolute error during hormonal changes in the menstrual cycle (P=0.000). Conclusion: The results showed that due to more involvement of motor control of hip muscles joint by motor neuron activity (increase release of estrogen hormone), all errors reduced in ovular and luteal phases compared to the follicular phase. The flexion movement is more disturbed, and due to more flexibility in this direction, absolute errors are significantly reduced. This reduction of errors in ovular and luteal phases compared to the regular stage of hormone release (follicular phase) may cause some rigidity in the hip joint and an increase of trauma  in external mechanical forces. This study’s findings showed that the lowest proprioception sensation is in the follicular phase. Decreasing the concentration of sex hormones in this phase is likely to reduce the sense of recognition of the joint, thus increasing the likelihood of injury in this phase. Findings from this study showed that the lowest proprioceptic sensation is in  the follicular phase. The results of this study showed that the least sense is Prvpryvsptyk in Fazfvlykvlar.

Influence of the menstrual cycle on nonlinear properties of heart rate variability in young women

2009 ◽  
Vol 297 (2) ◽  
pp. H765-H774 ◽  
Author(s):  
Xiaopeng Bai ◽  
Jingxiu Li ◽  
Lingqi Zhou ◽  
Xueqi Li
Keyword(s):  
Heart Rate ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Thyroid Stimulating Hormone ◽  
Follicular Phase ◽  
Ovarian Hormone ◽  
Free Triiodothyronine ◽  
Complexity Measures ◽  
Nonlinear Properties ◽  
Healthy Women

This study was designed to assess the changes in nonlinear properties of heart rate (HR) variability (HRV) during the menstrual cycle by means of complexity measures, including sample entropy (SampEn) and correlation dimension (CD), and explore probable physiological interpretations for them. In 16 healthy women (mean age: 23.8 ± 2.7 yr), complexity measures along with the spectral components of HRV (sympathovagal markers) were analyzed over 1,500 R-R intervals recorded during both the follicular phase ( day 11.9 ± 1.4) and the luteal phase ( day 22.0 ± 1.4) of each woman's menstrual cycle. Simultaneously, serum ovarian hormone (estradiol-17 and progesterone) and thyroid-related hormone [free triiodothyronine, free thyroxine (T4), and thyroid-stimulating hormone] concentrations were measured. With regard to HRV measures, SampEn, CD, and high-frequency (HF) components decreased from the follicular phase to the luteal phase, whereas normalized low-frequency (LF) components and the LF-to-HF ratio as well as resting HR increased. In regard to hormone levels, whereas progesterone was increased, the other hormone concentrations were unchanged. Furthermore, across the menstrual cycle, both SampEn and CD were well correlated with the spectral indexes and free T4 concentrations, and SampEn also showed significant correlations with the ratio of estradiol-17 to progesterone concentrations. These results suggest that the nonlinear properties in HRV are altered during the regular menstrual cycle and that the autonomic nervous system, ovarian hormone balance, and free T4 may be involved in nonlinear HR control in healthy women. All of these factors may enrich the physiological meanings of complexity measures.

scholarly journals The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans

2011 ◽  
Vol 96 (12) ◽  
pp. E1963-E1972 ◽  
Author(s):  
Channa N. Jayasena ◽  
Gurjinder M. K. Nijher ◽  
Alexander N. Comninos ◽  
Ali Abbara ◽  
Adam Januszewki ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Menstrual Cycle ◽  
Reproductive Hormones ◽  
Follicular Phase ◽  
Reproductive Hormone ◽  
Hormone Release ◽  
Men And Women ◽  
Healthy Men ◽  
Gonadotropin Release ◽  
Serum Lh

Abstract Background: Kisspeptin peptides are critical in human reproductive physiology and are potential therapies for infertility. Kisspeptin-10 stimulates gonadotropin release in both male and female rodents. However, few studies have investigated the effects of kisspeptin-10 on gonadotropin release in humans, and none have investigated the effect in women. If kisspeptin is to be useful for treating reproductive disease, its effects in both men and women must be established. Aim: To compare the effects of kisspeptin-10 administration on reproductive hormone release in healthy men and women. Methods: Intravenous bolus kisspeptin-10 was administered to men and women (n = 4–5 per group). Subcutaneous bolus and iv infusion of kisspeptin-10 was also administered to female women (n = 4–5 per group). Circulating reproductive hormones were measured. Results: In healthy men, serum LH and FSH were elevated after iv bolus kisspeptin-10, at doses as low as 0.3 and 1.0 nmol/kg, respectively. In healthy women during the follicular phase of the menstrual cycle, no alterations in serum gonadotropins were observed after iv bolus, sc bolus, or iv infusion of kisspeptin-10 at maximal doses of 10 nmol/kg, 32 nmol/kg, and 720pmol/kg/min, respectively. In women during the preovulatory phase, serum LH and FSH were elevated after iv bolus kisspeptin-10 (10 nmol/kg). Conclusion: Kisspeptin-10 stimulates gonadotropin release in men as well as women during the preovulatory phase of menstrual cycle but fails to stimulate gonadotropin release in women during the follicular phase. The sexual dimorphism of the responsiveness of healthy men and women to kisspeptin-10 administration has important clinical implications for the potential of kisspeptin-10 to treat disorders of reproduction.

Impaired pituitary response to bromocriptine suppression: reversal after bromocriptine plus tamoxifen

1982 ◽  
Vol 101 (4) ◽  
pp. 491-500 ◽  
Author(s):  
Wernfrid Völker ◽  
Werner G. Gehring ◽  
Renate Berning ◽  
Rüdiger C. Schmidt ◽  
Jörg Schneider ◽  
...  
Keyword(s):  
Side Effects ◽  
Combined Therapy ◽  
Suppressive Effect ◽  
Prolactin Secretion ◽  
Serum Prolactin ◽  
Incomplete Resection ◽  
Receptor Sites ◽  
Competitive Inhibitors ◽  
Marked Suppression

Abstract. This study was designed to clarify whether previously resistant cases of adenomatous hyperprolactinaemia to bromocriptine might be improved by additive tamoxifen therapy. Ten hyperprolactinaemic women under bromocriptine (2.5–10 mg) with hypophyseal tumours of different extent were treated with a combined therapy of bromocriptine and tamoxifen (10–20 mg). Two of them had undergone incomplete resection of chromophobe adenomata. The others refused surgery or irradiation. Two other women without basal therapy because of side effects from bromocriptine, received the combined therapy from the beginning of the study. In 6 out of 10 women the addition of tamoxifen resulted in a marked suppression of prolactin serum values. Amenorrhoea and glactorrhoea ceased in 4 of them. One woman conceived. One reported a marked improvement of libido. One stated that side effects under bromocriptine disappeared through the addition of tamoxifen. The 2 women who previously were suffering from side effects were able to take bromocriptine when tamoxifen was added. Four patients were non-responders. Serum prolactin remained unchanged as well as the clinical follow-up. The effectiveness of the combined therapy was not related to the extent of the tumour or to the clinical or biochemical baseline date. We conclude that the suppressive effect of bromocriptine on prolactin secretion is enhanced by the addition of tamoxifen in most cases of adenomatous hyperprolactinaemia. Side effects of bromocriptine are considerably reduced. Anti-oestrogens are competitive inhibitors of the binding of oestradiol to the receptor. Oestrogen play an important role in the development of prolactin secreting adenomata. Our finding of responders and non-responders to tamoxifen suggests that the anti-oestrogen competes for greater or lesser concentrations of receptor sites in prolactinomata.

Urinary polyamine excretion during the menstrual cycle.

1978 ◽  
Vol 24 (5) ◽  
pp. 769-771 ◽  
Author(s):  
S Osterberg ◽  
S Rosén ◽  
O Heby
Keyword(s):  
Menstrual Cycle ◽  
Thin Layer ◽  
Follicular Phase ◽  
Chromatographic Technique ◽  
Healthy Women ◽  
Early Follicular Phase ◽  
Urinary Polyamines

Abstract Urinary polyamines were measured by a fluorometric thin-layer chromatographic technique in samples collected daily throughout a single menstrual cycle by each of 13 healthy women. Polyamine excretion fluctuated considerably, but excretion of putrescine, spermidine, and spermine combined was consistently greatest during menstruation, sometimes extending into the early follicular phase of the cycle. Enhanced excretion of polyamines was also noticed in many individuals at the approximate time of ovulation.

Menstrual Cycle Modulation of Benzodiazepines Effects in Healthy Women

2009 ◽  
Author(s):  
Shanna Babalonis ◽  
Joshua A. Lile ◽  
Catherine A. Martin ◽  
Thomas H. Kelly
Keyword(s):  
Menstrual Cycle ◽  
Healthy Women

EVALUATION OF CHANGES IN CARDIORESPIRATORY FUNCTIONS DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE IN YOUNG WOMEN

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shehnaz Shaikh
Keyword(s):  
Menstrual Cycle ◽  
Sample Size ◽  
Young Women ◽  
Luteal Phase ◽  
Uterine Wall ◽  
Normal Weight ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Granulose Cells ◽  
Efficiency Test

Introduction: Menstrual cycle or menstruation involved discharge of sanguinous fluid and a sloughing of uterine wall. In women menstruation occurs at regular intervals on an average of 28 days, although most women gave a history of regular intervals of 28 to 30 days. About 10% -15% of women showed cycle at the precise 28 ± 2 days intervals when menstrual calendar was utilized. Normally in young women in different phases of ovarian cycles the plasma levels of estrogen vary. Ovulation occurs in the first 12-13th day of menstrual cycle, which is termed estrogen surge and second occurs in mid-luteal phase. During mid cycle or follicular phase of menstrual cycle the plasma concentration of progesterone is very low about 0.9 ng/mL. its level starts rising owing to secretion from the granulose cells. During luteal phase progesterone level reaches its peak value of 18 ng/mL and its level fall to a minimum value toward the end of the cycle. Estrogen affects local and systemic vasodilation. The menstrual cycle envelops two fundamental stages, the follicular stage (FP) and the luteal stage (LP). The follicular stage can part advance into two substages; the early FP, which is characterised with moo concentrations of both the key hormones estrogen and progesterone; and the mid FP where estrogen is tall autonomously from progesterone. The LP is epitomized by tall concentration of both estrogen and progesterone. These two fundamental stages are isolated by a soak surge in luteinizing hormone activating ovulation. These recurrent changes are said to be frequency unsurprising while long time. Aim: The main aim of this study is to evaluate the Cardiorespiratory functions changes during different Phases of Menstrual Cycle.   Material and methods: In this study, 20 with normal weight, 20 with obese and 20 with overage were included and taken them as a sample size. In this study all the young women those were recruited as a sample size are unmarried, undergraduate female student with the between the age group of 18-22years, having regular 28+6 days menstrual cycle for at least last 6months prior to this study. For the collection of data all the participants were instructed to attend the physiology lab department during each of three different phases. Day-2 during menstrual phase, Day-7, during follicular phase and Day-22 during luteal phase and the following parameters were recorded as Anthropometric measurements, measuring of pulse rate and blood pressure and cardiac efficiency test. Result: In general, work out proficiency changed essentially amid the distinctive stages of the menstrual cycle with the most elevated amid luteal stage and least amid menstrualo stage. There was no critical contrast in impact test amid menstrual stage, follicular stage and luteal stage of menstrual cycle among three bunches of people. Conclusion: We have watched noteworthy increment in cardiac and respiratory proficiency within the luteal stage of the menstrual cycle in ordinary weight people. Lower wellness levels were watched in overweight and stout females. In this manner hone of customary work out and admissions of solid slim down which offer assistance in lessening the weight and in turn the BMI will offer assistance in improving the physical wellness of the people. Keywords: Cardiorespiratory, Menstrual cycle, expiratory blast test

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