Syndrome of inappropriate ADH secretion concealed by hypokalaemia due to ectopic ACTH production

1981 ◽  
Vol 96 (2) ◽  
pp. 182-187 ◽  
Author(s):  
R. J. M. Corrall ◽  
B. M. Frier ◽  
J. G. Ratcliffe ◽  
J. Podmore ◽  
W. Ramsay ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Renal Function ◽  
Cell Carcinoma ◽  
Large Fraction ◽  
Plasma Acth ◽  
Ectopic Acth ◽  
Ectopic Secretion ◽  
Ectopic Acth Production ◽  
Oat Cell Carcinoma ◽  
Corticosteroid Secretion

Abstract. A case is described of a patient with an oat cell carcinoma of the bronchus with moderately elevated levels of plasma corticotrophin (ACTH) and antidiuretic hormone (ADH). Ectopic secretion of ACTH induced severe hypokalaemia and concealed the effects of concomitant ADH secretion on renal function. Normal renal responsiveness was restored following correction of hypokalaemia. The hypokalaemia was associated with evidence of a marked increase in corticosteroid secretion but plasma ACTH concentrations did not show a proportionate elevation. Chromatographic studies on tumour extracts suggest that the presence of a large fraction of high molecular weight ACTH in plasma could explain this discrepancy.

scholarly journals Diabetic ketoalkalosis due to ectopic ACTH production from an oat cell carcinoma.

1981 ◽  
Vol 57 (669) ◽  
pp. 455-456 ◽  
Author(s):  
D. W. Pearson ◽  
J. A. Thomson ◽  
A. C. Kennedy ◽  
P. G. Toner ◽  
J. G. Ratcliffe
Keyword(s):  
Cell Carcinoma ◽  
Ectopic Acth ◽  
Ectopic Acth Production ◽  
Oat Cell Carcinoma

scholarly journals A Case of the Oat-cell Carcinoma of the Lung with Ectopic ACTH Production Proved by the High Level of ACTH in Tumor Cells in Pleural Fluid

Haigan ◽  
1978 ◽  
Vol 18 (4) ◽  
pp. 393-400
Author(s):  
San-e Ishikawa ◽  
Yutaka Johshita ◽  
Toshimitsu Suzuki ◽  
Tatsuo Arai ◽  
Toshikazu Saito ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Tumor Cells ◽  
Pleural Fluid ◽  
Ectopic Acth ◽  
Ectopic Acth Production ◽  
Oat Cell Carcinoma ◽  
High Level

Large fraction irradiation with or without misonidazole in advanced non-oat cell carcinoma of the lung: A phase III randomized trial of the RTOG

1987 ◽  
Vol 13 (6) ◽  
pp. 861-867 ◽  
Author(s):  
Joseph R. Simpson ◽  
Madeline Bauer ◽  
Todd H. Wasserman ◽  
Carlos A. Perez ◽  
Bahman Emami ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Cell Carcinoma ◽  
Large Fraction ◽  
Phase Iii ◽  
Oat Cell Carcinoma

Ectopic ACTH, prostatic oat cell carcinoma, and marked hypernatremia

Cancer ◽  
1977 ◽  
Vol 40 (2) ◽  
pp. 773-778 ◽  
Author(s):  
Robert E. Wenk ◽  
Belur S. Bhagavan ◽  
Robert Levy ◽  
Dennis Miller ◽  
William Weisburger
Keyword(s):  
Cell Carcinoma ◽  
Ectopic Acth ◽  
Oat Cell Carcinoma

scholarly journals Octreotide-Sensitive Ectopic ACTH Production by Islet Cell Carcinoma with Multiple Liver Metastases

2003 ◽  
Vol 50 (2) ◽  
pp. 135-143 ◽  
Author(s):  
MASARU DOI ◽  
TAIHEI IMAI ◽  
MASAYOSHI SHICHIRI ◽  
TOHRU TATENO ◽  
NOZOMI FUKAI ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Cell Carcinoma ◽  
Islet Cell ◽  
Ectopic Acth ◽  
Islet Cell Carcinoma ◽  
Ectopic Acth Production ◽  
Multiple Liver Metastases

Ectopic Secretion of Calcitonin by Oat-Cell Carcinoma

1974 ◽  
Vol 290 (20) ◽  
pp. 1122-1124 ◽  
Author(s):  
Omega L. Silva ◽  
Kenneth L. Becker ◽  
Aron Primack ◽  
John Doppman ◽  
Richard H. Snider
Keyword(s):  
Cell Carcinoma ◽  
Ectopic Secretion ◽  
Oat Cell Carcinoma

Adrenocorticotropin Production by a Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 462-463
Author(s):  
K.S. McCarty ◽  
N.R. Wallace ◽  
W. Litaker ◽  
S. Wells ◽  
G. Eisenbarth
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Small Cell ◽  
Hormone Production ◽  
Carcinoma Of The Breast ◽  
Ectopic Acth ◽  
Ultrastructural Studies ◽  
Subcutaneous Metastases ◽  
Ectopic Acth Production ◽  
The Right ◽  
Pituitary Carcinomas

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.

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