Treatment of anorchia with oral testosterone undecanoate: pharmacodynamics and clinical effectiveness

1980 ◽  
Vol 95 (2) ◽  
pp. 244-250 ◽  
Author(s):  
J. Weil ◽  
F. Bidlingmaier ◽  
O. Butenandt ◽  
W. G. Sippell ◽  
W. Baumgartner ◽  
...  
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Sexual Maturation ◽  
Peak Level ◽  
Clinical Effectiveness ◽  
Bone Age ◽  
Plasma Testosterone ◽  
Testosterone Undecanoate ◽  
Axillary Hair ◽  
Specific Radio

Abstract. The pharmacodynamics of plasma testosterone (T) and androstenedione (A) levels were studied in ten hypogonadal boys after oral administration of testosterone undecanoate (TU). Plasma T and A levels were measured by specific radio-immunoassays. Six hours after a single dose of 120 mg TU, there was a significant increase (P < 0.005) in plasma T and A with a median T peak level of 940 ng/100 ml. Furthermore, twelve agonadal boys treated with a mean dose of 60 mg TU/day were examined over a period of 18–24 months. During this therapy, plasma T and A levels were significantly higher than before (P < 0.005), whereas plasma levels of LH and FSH did not decrease significantly. With the exception of one anorchic boy, all patients showed signs of sexual maturation, such as growth of pubic and axillary hair, and steady development of bone age during oral TU treatment.

PLASMA TESTOSTERONE IN MALE PUBERTY

1974 ◽  
Vol 75 (1) ◽  
pp. 181-194 ◽  
Author(s):  
D. Knorr ◽  
F. Bidlingmaier ◽  
O. Butenandt ◽  
H. Fendel ◽  
R. Ehrt-Wehle
Keyword(s):  
Bone Age ◽  
Pubic Hair ◽  
Cross Sectional Study ◽  
Growth Spurt ◽  
Plasma Testosterone ◽  
Gas Liquid Chromatography ◽  
Cross Sectional ◽  
Sexual Characteristics ◽  
Testicular Size ◽  
Axillary Hair

ABSTRACT Plasma testosterone was investigated by gas-liquid chromatography with an electron capture detector in a cross-sectional study in childhood and during puberty in 214 boys. The testosterone values were correlated with sexual characteristics such as axillary hair, pubic hair, testicular size and bone age. In 22 individuals during puberty a longitudinal study was started, indicating a very steep increase of plasma testosterone between 40 and 240 ng/100 ml. This stage is mostly passed through very rapidly within 10 months. Plasma testosterone, growth velocity and weight gain were correlated in two boys during puberty. The peak of growth spurt occurs between 50 and 170 ng of plasma testosterone.

PLASMA ANDROGEN LEVELS IN MEN AFTER ORAL ADMINISTRATION OF TESTOSTERONE OR TESTOSTERONE UNDECANOATE

1975 ◽  
Vol 79 (2) ◽  
pp. 366-374 ◽  
Author(s):  
E. Nieschlag ◽  
J. Mauss ◽  
A. Coert ◽  
P. Kićović
Keyword(s):  
Oral Administration ◽  
Thin Layer ◽  
Free Testosterone ◽  
Peripheral Circulation ◽  
Plasma Testosterone ◽  
Testosterone Undecanoate ◽  
Striking Increase ◽  
Layer Chromatography ◽  
Effective Medication ◽  
Androgen Levels

ABSTRACT Plasma testosterone and androstenedione levels in men were measured after oral administration of free testosterone and testosterone undecanoate. Both androgens were determined by simultaneous, specific radioimmunoassays after separation and isolation by thin layer chromatography. While free unesterified testosterone had no effect on plasma androgen levels, a striking increase of both testosterone and androstenedione levels was noted after administration of testosterone undecanoate, which is otherwise only achieved by parenteral testosterone application. This effect of testosterone undecanoate is probably due to absorption via the lymph rather than via the portal vessels so that peripheral circulation is reached before metabolism in the liver. Testosterone undecanoate promises to be an effective medication for oral androgen replacement.

scholarly journals The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration

1994 ◽  
Vol 33 (2) ◽  
pp. 289-297 ◽  
Author(s):  
K. W. T. Tsang ◽  
P. Roberts ◽  
R. C. Read ◽  
F. Kees ◽  
R. Wilson ◽  
...  
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dose Oral ◽  
Hydroxy Metabolite

Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans

1986 ◽  
Vol 11 (3) ◽  
pp. 171-174 ◽  
Author(s):  
S. R. Bareggi ◽  
R. Pirola ◽  
S. eva ◽  
L. Zecca
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dose Oral

EFFECT OF ETHINYLOESTRADIOL ON PLASMA TESTOSTERONE LEVELS AND URINARY TESTOSTERONE EXCRETION IN MAN

1965 ◽  
Vol 50 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Enrico Forchielli ◽  
Govind S. Rao ◽  
Inder R. Sarda ◽  
Norman B. Gibree ◽  
Peter E. Pochi ◽  
...  
Keyword(s):  
Oral Administration ◽  
Plasma Testosterone ◽  
Testosterone Levels ◽  
The Mean ◽  
Normal Men ◽  
Daily Oral Administration

ABSTRACT The daily oral administration of one mg of ethinyloestradiol to normal men decreased the mean plasma testosterone from 0.84 ± 0.07 μg per 100 ml to 0.20 ± 0.04 in 21 trials and decreased the urinary testosterone from 63 ± 1.1 μg per day to 8 ± 0.3 in 16 trials.

Transient impairment or delay of urinary trihydroxypregnanone (THS) response to metyrapone in boys with delayed adolescence and in patients with isolated growth hormone deficiency

1982 ◽  
Vol 99 (2) ◽  
pp. 166-173 ◽  
Author(s):  
M. Zachmann ◽  
D. Tassinari ◽  
W. Sorgo ◽  
G. U. Exner ◽  
B. Kempken ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Single Dose ◽  
Growth Hormone Deficiency ◽  
Bone Age ◽  
Urine Samples ◽  
Hormone Deficiency ◽  
Cortisol Response ◽  
Transient Impairment ◽  
Group A ◽  
Group B

Abstract. Twentythree boys with delayed adolescence (age 15.7 ± 2.0, bone age 12.4 ± 2.1 years) were studied. Their cortisol response to insulin was normal. After oral metyrapone (500 mg/m2 by mouth) one to three consecutive 12 h urine samples were collected for analysis of THS. Thirtyseven tests with 37 first, 21 second, and 11 third samples were carried out. The results could be divided into two main groups: 25 tests (group A) were subnormal in the first sample, 12 of them with a very weak (40 ± 8 μg/m2/12 h) and 13 with an insufficient (191 ± 16 μg/m2/12 h) THS response. Values in the second and third sample were higher, indicating a dealyed response. In 12 tests (group B), the results were normal (1016 ± 143 μg/m2/12 h) in the first and lower in the second and third samples. In three patients with repeated tests, there was improvement with increasing bone age. The THS-responses to metyrapone did not correlate with those of growth hormone, gonadotrophins, and TSH to stimuli. It is concluded that the THS-response to a single dose of metyrapone may be temporarily insufficient or delayed in delayed adolescence. We interpret this finding as showing transiently reduced or slow hypothalamic responsiveness.

scholarly journals Sexual maturation in Atlantic salmon male parr may be triggered both in early spring and late summer under standard farming conditions

2021 ◽  
Author(s):  
Elia Ciani ◽  
Kristine von Krogh ◽  
Rasoul Nourizadeh-Lillabadi ◽  
Ian Mayer ◽  
Romain Fontaine ◽  
...  
Keyword(s):  
Atlantic Salmon ◽  
Sexual Maturation ◽  
Late Summer ◽  
Early Spring ◽  
Plasma Testosterone ◽  
Farmed Salmon ◽  
Early Maturing ◽  
Advanced Stages ◽  
One Year ◽  
Immature Fish

AbstractMale Atlantic salmon (Salmo salar) display different sexual strategies, maturing either as parr during the freshwater phase (as sneaky spawners), or as post smolts following one or several years at sea. First sexual maturation (puberty) occurs at different times depending on environmental and genetic factors. To improve our knowledge on the timing (age and season) of first sexual maturation in Atlantic salmon male parr, we investigated pubertal activation in second generation farmed salmon from the Norwegian river Figgjo, reared under natural conditions of photoperiod and water temperature. Histological analysis, in combination with morphometric measurements, plasma androgen levels and pituitary gonadotropin gene expression analysis revealed that, as previously reported, some male parr initiated early sexual maturation in spring at one year of age. Interestingly, some male parr were observed to initiate sexual maturation already in autumn, six months after hatching (under-yearlings), much earlier than reported in previous studies. One-year old maturing males showed a low induction in gonadotropin levels, while under-yearling maturing males displayed a significant increase in fshb transcripts as compared to immature fish. Plasma testosterone, detectable also in immature males, increased constantly during testes development, while 11-ketotestosterone, undetectable in immature and early maturing males, increased during more advanced stages of maturation. A mild feminization of the testes (ovotestes) was detected in a subset of samples. This study brings new knowledge on the little investigated field of sexually maturing under-yearlings in Atlantic salmon. This is also the first study comparing the physiology of under-yearling vs one-year old maturing male parr, thus bringing new insights to the remarkable plasticity of Atlantic salmon puberty.

Toxicoklnetic of bifenox in goats after single dose oral administration

1998 ◽  
Vol 95 ◽  
pp. 143
Author(s):  
T.K. Mandal ◽  
S. Roy ◽  
A.K. Chakraborty ◽  
A. Bhattacharyya ◽  
A. Chowdhury
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dose Oral

Serum Levels of Potassium Penicillin V following Oral Administration to Febrile and Afebrile Children

PEDIATRICS ◽  
1963 ◽  
Vol 32 (5) ◽  
pp. 919-922
Author(s):  
F. WHITEHOUSE ◽  
S. A. OBENG ◽  
A. R. PEQUET ◽  
J. K. CHAMNESS ◽  
J. K. JENDER ◽  
...  
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Age Groups ◽  
Serum Levels ◽  
High Serum ◽  
Penicillin V ◽  
Potassium Penicillin

A single dose of 200-400,000 units of oral potassium penicillin V is absorbed rapidly in fasting febrile children and infants to produce high serum levels. These levels are similar to those of afebrile children in the same age groups. From this standpoint, therapy of acutely ill febrile children with oral potassium penicillin V in reliable when penicillin is indicated.

Brompheniramine and Chlorpheniramine Pharmacokinetics Following Single-Dose Oral Administration in Children Aged 2 to 17 Years

2017 ◽  
Vol 58 (4) ◽  
pp. 494-503 ◽  
Author(s):  
Sudam Pathirana ◽  
Shyamalie Jayawardena ◽  
Suzanne Meeves ◽  
Gary A. Thompson
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dose Oral
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