Glucose tolerance, growth hormone and somatomedin levels in osteosarcoma patients

1980 ◽  
Vol 94 (4) ◽  
pp. 517-522 ◽  
Author(s):  
U. Adamson ◽  
L.-Å. Broström ◽  
S. Efendić ◽  
K. Hall
Keyword(s):  
Growth Hormone ◽  
Glucose Tolerance ◽  
Insulin Response ◽  
Plasma Growth Hormone ◽  
Intravenous Glucose ◽  
Insulin Response To Glucose ◽  
The Mean ◽  
The Individual ◽  
And Control ◽  
Mean Glucose

Abstract. Intravenous glucose tolerance, insulin response to glucose, the sensitivity of the periphery to insulin as well as growth hormone and somatomedin levels were determined in osteosarcoma patients and control subjects matched by age, sex, weight and length. The insulin response to glucose and the peripheral sensitivity to insulin were evaluated by using the individual blood glucose and plasma insulin curves for parameter identification in a mathematical model. The mean glucose tolerance was significantly decreased in the patients, most likely due to decreased peripheral insulin sensitivity. Plasma growth hormone levels were normal in all patients which was also the case with somatomedin levels determined by both radioreceptor- and radioimmunoassay.

METABOLISM OF [2-14C] PYRUVATE IN NORMAL, ACROMEGALIC AND HGH-TREATED HUMAN SUBJECTS

1970 ◽  
Vol 65 (1) ◽  
pp. 155-169 ◽  
Author(s):  
W. W. Shreeve ◽  
E. Cerasi ◽  
R. Luft
Keyword(s):  
Glucose Tolerance ◽  
Marked Reduction ◽  
Human Subjects ◽  
Insulin Response ◽  
Human Growth ◽  
Pyruvate Oxidation ◽  
High Insulin ◽  
Low Glucose ◽  
Insulin Response To Glucose ◽  
The Mean

ABSTRACT In 4 studies on 3 acromegalic patients, who had normal iv glucose tolerance and high insulin response to infused glucose (Al), the oxidation to 14CO2 of [2-14C] pyruvate (injected intravenously in trace amount after overnight fast) was not different from that in 9 studies of 9 nonacromegalic »high insulin responders« (Ni). In 4 studies on 3 other acromegalic patients, who had low glucose tolerance and less insulin response to glucose (A2), the formation of 14CO2 was reduced to ½–⅔ that of Al or N1 and was about proportionate to the reduction in glucose tolerance. In A2 the 14CO2 formation was slightly lower than the mean for 10 studies with 7 non-acromegalic subjects, who were »low insulin responders« with normal or low glucose tolerance (N2). Among non-acromegalics expiration of 14CO2 was significantly lower in N2 than in N1. Among 4 non-acromegalic subjects treated with human growth hormone for 3–4 days one had a marked reduction in pyruvate oxidation, while all had a decrease in glucose tolerance. Analysis of 14C in blood glucose at 60 minutes after injection of [2-14C]pyruvate suggested that slightly more total 14C-glucose was present in A2 than N1 without any differences between A2 and N2 or N1 and N2. Two out of 4 studies in A1 showed lower than normal amounts of 14Cglucose. No change in 14C-glucose occurred after administration of HGH. The findings suggest that impairment of pyruvate oxidation accompanies a lowered glucose tolerance in acromegalics with a diabetic tendency. Changes in gluconeogenesis from pyruvate appear to be minimal.

GLUCOSE TOLERANCE AND INSULIN RESPONSE DURING DAILY CONTINUOUS LOW-DOSE ORAL CONTRACEPTIVE TREATMENT

1969 ◽  
Vol 62 (2) ◽  
pp. 242-250 ◽  
Author(s):  
U. Larsson-Cohn ◽  
B. Tengström ◽  
L. Wide
Keyword(s):  
Glucose Tolerance ◽  
Blood Glucose Concentration ◽  
Fasting Blood Glucose ◽  
Insulin Response ◽  
Continuous Treatment ◽  
Intravenous Glucose ◽  
Dose Oral ◽  
Glucose Tolerance Tests ◽  
Insulin Response To Glucose ◽  
Intravenous Glucose Tolerance Tests

ABSTRACT Intravenous glucose tolerance tests and insulin determinations were performed on 37 women at different stages of the menstrual cycle and after one, three and twelve months of daily continuous treatment with 0.5 mg of norethindrone or 0.5 mg of chlormadinone acetate. The fasting blood glucose concentration, the k-values (percentage disappearance rate of glucose per minute) and the insulin response to glucose administration were compared. No statistically significant differences were found between the values obtained on two occasions before treatment, and during treatment.

STUDIES ON THE PATHOGENESIS OF DIABETES IN ACROMEGALY

1967 ◽  
Vol 56 (4) ◽  
pp. 593-607 ◽  
Author(s):  
Rolf Luft ◽  
Erol Cerasi ◽  
Carl Axel Hamberger
Keyword(s):  
Glucose Tolerance ◽  
Insulin Response ◽  
Normal Glucose Tolerance ◽  
Glucose Infusion ◽  
Intravenous Glucose ◽  
Highly Active ◽  
Normal Glucose ◽  
Insulin Response To Glucose ◽  
Active Acromegaly ◽  
Plasma Insulin Response

ABSTRACT Plasma insulin response to glucose infusion was found to be markedly increased in 20 patients with active acromegaly and with normal intravenous glucose tolerance. The insulin response was more pronounced in patients with highly active acromegaly than in those showing moderately active disease. In five patients with active acromegaly and with decreased glucose tolerance the insulin response was delayed and smaller than normal, i. e. similar to that seen in diabetic subjects without acromegaly. After successful treatment of the acromegaly insulin response to glucose infusion was normalized in the patients with normal glucose tolerance. In those with decreased glucose tolerance the diabetic type of insulin response remained unchanged even when the glucose tolerance was normalized. It is suggested that diabetes in connection with acromegaly develops only in prediabetic individuals, i.e. subjects with decreased insulin response to hyperglycaemia, who are unable to overcome the diabetogenic effect of growth hormone by compensatory hyperinsulinism.

OBESITY AS AN ADDITIONAL FACTOR IN THE PATHOGENESIS OF DIABETES

1968 ◽  
Vol 59 (2) ◽  
pp. 344-352 ◽  
Author(s):  
Rolf Luft ◽  
Erol Cerasi ◽  
Bo Andersson
Keyword(s):  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Peripheral Resistance ◽  
Insulin Response ◽  
Intravenous Glucose ◽  
Endogenous Insulin ◽  
Intravenous Glucose Tolerance ◽  
Obese Subjects ◽  
Insulin Response To Glucose ◽  
Plasma Insulin Response

ABSTRACT Plasma insulin response to glucose infusion was measured in obese subjects with normal and decreased intravenous glucose tolerance. In obese non-diabetic subjects there was insulin hyperresponsiveness to glucose accompanied by peripheral resistance to endogenous insulin. In the obese diabetic subjects insulin response was of the type seen in non-obese diabetics; in no such instance could insulin hyperresponsiveness to glucose be obtained. It is suggested that obesity precipitates diabetes only in subjects with preexisting impairment of insulin response, i. e. in prediabetics. Subjects with unimpaired insulin secreting capacity would overcome the diabetogenic effect of obesity by compensatory hyperinsulinism.

Metabolic effects of physical training in ovariectomized and hyperestrogenic rats

2001 ◽  
Vol 90 (1) ◽  
pp. 235-241 ◽  
Author(s):  
Martin G. Latour ◽  
Motoo Shinoda ◽  
Jean-Marc Lavoie
Keyword(s):  
Glucose Tolerance ◽  
Physical Training ◽  
Training Session ◽  
Insulin Response ◽  
Metabolic Effects ◽  
Experimental Conditions ◽  
Intravenous Glucose ◽  
Positive Effects ◽  
Ovx Rats ◽  
The Mean

This study was undertaken to evaluate the effects of regular endurance-type exercise on glucose tolerance and glucose-stimulated insulin response (GSIR) in ovariectomized (OVX) rats with and without estrogen replacement. To do that, OVX Sprague-Dawley rats were compared with an OVX estradiol-treated group (OVXE2) and a sham-operated (Sham) group. Each of these groups was subdivided into a sedentary and a treadmill-trained (8 wk) group. Intravenous glucose tolerance tests (0.5 g/kg) were conducted in all rats 48 h after the last training session. Plasma levels of 17β-estradiol and the uterus weight were significantly ( P < 0.05) lower in OVX compared with results in Sham and significantly ( P< 0.01) higher in OVXE2 (hyperestrogenic) compared with results in Sham. Body weights were significantly ( P < 0.01) different among groups, in the following decreasing order: OVX, Sham, and OVXE2. The average daily food intake was significantly ( P < 0.01) increased in OVX rats compared with Sham, whereas estradiol treatment diminished this effect ( P< 0.01). Exercise training was found to alter none of the above-mentioned variables in all three experimental conditions. Although the mean integrated area under the glucose and insulin curves was not affected by OVX, training induced a significant ( P < 0.01) reduction in the mean integrated area under the insulin curve in all three experimental conditions. It is concluded that the positive effects of physical training on improving GSIR in OVX and hyperestrogenic animals are similar to what has been found in Sham.

GLUCOSE DISAPPEARANCE RATE IN SYMPTOMATIC NEONATAL HYPOGLYCEMIA

PEDIATRICS ◽  
1973 ◽  
Vol 52 (1) ◽  
pp. 75-82
Author(s):  
Rosita S. Pildes ◽  
Daksha A. Patel ◽  
Menachem Nitzan
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Newborn Infants ◽  
Glucose Disposal ◽  
Disappearance Rate ◽  
Neonatal Hypoglycemia ◽  
Plasma Growth Hormone ◽  
Intravenous Glucose ◽  
Glucose Disappearance

The present study was undertaken to determine the rate of glucose disposal in the pathogenesis of symptomatic neonatal hypoglycemia. Intravenous glucose (1 gm/kg) was injected rapidly into 11 hypoglycemic and eight control newborn infants. The percentage (mean ± SEM) disappearance rate per minute (Kt) was significantly higher (p &lt; 0.001) in the hypoglycemic newborn infants compared with that of the controls (2.8 ± 0.1 versus 1.2 ± 0.1, respectively). Baseline plasma insulin concentrations were significantly higher (p &lt; 0.01) in the hypoglycemic (16.8 ± 3.9µU/ml) than those of the controls (3.5 ± 1.0µU/ml). Baseline plasma growth hormone values in the hypoglycemic newborns were 16.6 ± 5.7 mµg/ml. Growth hormorne values rose in the hypoglycemic to 36 ± 10 mµg/ml at 10 minutes and to 64 ± 13 mµg/ml by 60 minutes.

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