SERUM THYROGLOBULIN IN PATIENTS WITH TOXIC AND NON-TOXIC GOITRES COMPARED TO SEX- AND AGE-MATCHED CONTROL SUBJECTS

1979 ◽  
Vol 91 (2) ◽  
pp. 264-270 ◽  
Author(s):  
Ulla Feldt-Rasmussen ◽  
Karine Bech ◽  
John Date
Keyword(s):  
Matched Control ◽  
Diagnostic Value ◽  
Thyroid Disorders ◽  
Serum Thyroglobulin ◽  
Control Subjects ◽  
Distribution Of Values ◽  
Log Normal ◽  
Log Normal Distribution ◽  
Serum Tsh

ABSTRACT To study serum thyroglobulin (Tg) levels in patients with thyroid disorders compared to sex- and age-matched control subjects and to correlate the Tg levels to the thyroid function, 71 patients were investigated before treatment was started. Serum Tg, measured by a double antibody radioimmunoassay, was elevated in all groups with thyroid disorders, as compared to their controls, but the values showed large overlaps between groups. The highest median values were seen in the two groups of patients with toxic goitres (toxic adenoma and Graves' disease). The Tg values in patients with non-toxic goitres (diffuse and nodular) and in controls showed a log normal distribution, whereas the distribution of values from patients with toxic goitres was different. No correlation was found between serum Tg and serum thyroxine, serum triiodothyronine and serum TSH, respectively. It is concluded that determination of serum Tg is of little diagnostic value in thyroid diseases.

Determination of Particle Size of a Dispersed Phase by Small-Angle X-ray Scattering

1989 ◽  
Vol 171 ◽  
Author(s):  
Frank C. Wilson
Keyword(s):  
Particle Size ◽  
High Resolution ◽  
Spherical Particles ◽  
Dispersed Phase ◽  
X Ray ◽  
X Ray Scattering ◽  
Resultant Data ◽  
Log Normal ◽  
Log Normal Distribution

ABSTRACTA method for determining particle diameters up to ca 500 rnm is described. X-ray data are obtained with an ultra-high resolution Bonse-Hart diffractometer and subsequently desmeared. The resultant data, viewed as the invariant argument h l(h), are interpreted as arising from a log-normal distribution of independent spherical particles. The distribution is characterized by its median value and breadth.

scholarly journals Water sensitive papers simulation to assess deposits on targets

2013 ◽  
Vol 44 (2s) ◽  
Author(s):  
Emanuele Cerruto ◽  
Claudia Aglieco
Keyword(s):  
Image Data ◽  
Phytosanitary Treatment ◽  
Processing Software ◽  
Image Processing Software ◽  
Log Normal ◽  
Constant Coefficient Of Variation ◽  
The Impact ◽  
Log Normal Distribution ◽  
Effective Water

Aim of the study is to assess the possibility to use water sensitive papers to estimate, beside the superficial coverage, also the amount of deposit on the target at varying the spray features. To point out the main quantities influencing the deposit, the behaviour of the water sensitive papers was simulated by assuming some simplifying hypotheses: log-normal distribution of the diameter population of the drops and circular spots. Several images (630) of water sensitive papers, sprayed with drops of different mean diameter (from 100 up to 500 μm), constant coefficient of variation (0.50), and theoretical percentage of covered surface ranging from 10 up to 100%, were produced by means of simulation. These images were considered as effective water sensitive paper images and then analysed by means of an image processing software. The correlations between measured and effective values were studied and they allowed for an estimate of deposit and spray features from the image data. This implies that the analysis of the water sensitive paper images allows the determination of more complex parameters such as the unitary deposit and the impact density, all data strictly related to the efficacy of a phytosanitary treatment.

scholarly journals Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jing Hang ◽  
Fan Li ◽  
Xiao-hui Qiao ◽  
Xin-hua Ye ◽  
Ao Li ◽  
...  
Keyword(s):  
Shear Wave ◽  
Diagnostic Performance ◽  
Operating Characteristic ◽  
Thyroid Nodules ◽  
Elasticity Modulus ◽  
Shear Wave Elastography ◽  
Diagnostic Value ◽  
Diagnostic Specificity ◽  
Log Normal ◽  
Log Normal Distribution

Objectives. The present study is aimed at evaluating the diagnostic value of combining shear wave elastography (SWE) parameters and the thyroid imaging reporting and data system (TIRADS) for differentiating between benign and malignant thyroid nodules. Methods. Patients who underwent conventional ultrasonography (US) and SWE before surgery were enrolled in the current study. Each nodule was given a TIRADS risk score. The effectiveness of the SWE parameters was assessed by odds ratios (ORs). The SWE scoring risk stratification was proposed beyond 95% probability, and the desired values were obtained according to the log-normal distribution. The area under the receiver-operating characteristic (AUC) was used to compare the diagnostic performance between TIRADS-alone and TIRADS + SWE. Results. A total of 262 patients with 298 thyroid nodules were enrolled in our study. The pathological analyses were conducted on 121 benign and 177 malignant nodules. The AUC values for TIRADS-alone and TIRADS + SWE were 0.896 (accuracy 83.2%) and 0.917 (accuracy 84.2%), respectively. However, the TIRADS + SWE scores showed a higher specificity (88.4%) and positive predictive value (91.2%) as compared with the TIRADS-alone of 73.6% and 83.2%, respectively. Conclusions. Combining SWE and TIRADS improves the specificity of TIRADS-alone in differentiating between benign and malignant thyroid nodules.

scholarly journals Development of the New Analytic Model for Sand Deposition Particles Downstream of a Fence

Inventions ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 4
Author(s):  
Peyman Razi
Keyword(s):  
Snow Accumulation ◽  
Analytic Model ◽  
Distribution Profile ◽  
Proposed Model ◽  
Simulation Domain ◽  
Discrete Phase ◽  
Sand Particles ◽  
Log Normal ◽  
Log Normal Distribution

Movement of sand particles is a complicated phenomenon that occurs in nature. In this paper, the main goal is to provide an analytic model for the deposition profile of sand particles downstream of a fence. The analytic model was derived with respect to governing equations and shear flows for upstream and downstream regions. In this approach, we obtain a new expression for the downstream velocity of the fence, which allows for the determination of potential areas of deposition particles by assuming a log-normal distribution profile. A discrete-phase flow (DPM) was used to inject particles in the simulation domain. The DPM gives capabilities to capture spatiotemporal velocities components, as we can define the probability of deposition particles in the downstream of the fence. The proposed model was validated with a numerical model and experimental results. The comparison with field data and numerical results shows that the deposition profile is in acceptable agreement. With some assumptions and modifications about the properties of particles, the results of this research can be extended to snow accumulation downstream of a fence.

scholarly journals A note on the relations of certain parameters following a logarithmic transformation

1955 ◽  
Vol 34 (2) ◽  
pp. 289-296 ◽  
Author(s):  
Mary Bagenal
Keyword(s):  
Coefficient Of Variation ◽  
Biological Data ◽  
Logarithmic Transformation ◽  
Confidence Limits ◽  
Formal Relation ◽  
Log Normal ◽  
Constant Coefficient Of Variation ◽  
Log Normal Distribution ◽  
Different Sources

The logarithmic transformation has been used in the statistical analysis of certain marine biological data. Parameters calculated from the transformed distributions have been used in the description of the observations, but it appears that some of the mathematical procedures adopted have not been fully understood.Winsor & Clarke (1940) have analysed data from plankton hauls. The problem considered by them was the determination of the variability in numbers of animals caught by repeated hauls through the same body of water. The raw data were characterized by a constant coefficient of variation, i.e. the variability in catch was proportional to the size of the catch. By transformation from the actual numbers caught to their logarithmic values, it was possible to equalize the variances and to apply the method of analysis of variance to esti-mate the variability due to the different sources. Finally, an estimate of the coefficient of variation was obtained from the logarithmic values. Their method of estimation was quoted by Snedecor (1946, p. 451) and was employed by Barnes & Bagenal (1951) in their study of repeated trawl hauls. Barnes & Bagenal also calculated confidence limits for comparison of observations following the method of Silliman (1946) in his work on pilchard eggs. These methods seem to be based on a misunderstanding of the nature of a trans-formation. The formal relation between the variance of such transformed data and the coefficient of variation of the untransformed data follows from the moments of the ‘log-normal’ distribution, given first by Wicksell (1917). From these moments it will be shown that the method given by Winsor & Clarke is mathematically unsound.

Determination of particle size distribution in an Fe2O3-based catalyst using magnetometry and x-ray diffraction

1992 ◽  
Vol 7 (7) ◽  
pp. 1856-1860 ◽  
Author(s):  
Manjula M. Ibrahim ◽  
Jianmin Zhao ◽  
Mohindar S. Seehra
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Line Broadening ◽  
X Ray Diffraction ◽  
X Ray ◽  
Mössbauer Measurements ◽  
Log Normal ◽  
Log Normal Distribution

In this paper, the techniques of SQUID magnetometry and line broadening in x-ray diffraction are employed for determining an important parameter for catalysts, viz. the particle size distribution. Magnetization versus temperature (5 K–400 K) and magnetization versus field (up to 55 kOe) data are reported for an α–Fe2O3 based catalyst. After determining the region of superparamagnetism, the distribution function f(r) is determined assuming a log normal distribution and Langevin paramagnetism of superparamagnetic particles. The distribution is found to be fairly symmetric with center near 65 Å and range of 35 to 115 Å. From line-broadening of Bragg peaks in x-ray diffraction, particle radii varying between 75 Å and 110 Å are obtained. These results are compared with the reported Mössbauer measurements of Huffman et al. on the same sample.

Is Quantitative Determination of Fibrin(ogen) Degradation Products and Thrombin-Antithrombin III Complexes Useful to Diagnose Deep Venous Thrombosis in Outpatients?

1989 ◽  
Vol 62 (04) ◽  
pp. 1043-1045 ◽  
Author(s):  
Paul F M M van Bergen ◽  
Eduard A R Knot ◽  
Jan J C Jonker ◽  
Auke C de Boer ◽  
Moniek P M de Maat
Keyword(s):  
Quantitative Determination ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Antithrombin Iii ◽  
Degradation Products ◽  
Family Doctor ◽  
Diagnostic Value ◽  
Impedance Plethysmography ◽  
Fibrin Degradation Products

SummaryWe studied the diagnostic value of recently introduced ELISA’s for the determination of thrombin-antithrombin III (TAT) complexes, fibrin degradation products (FbDP), fibrinogen degradation products (FgDP) and total degradation products (TDP) for deep venous thrombosis (DVT) in plasma of 239 consecutive outpatients, suspected for DVT by their family doctor. DVT was confirmed by impedance plethysmography in 60 patients. Using the 95th percentile range of 42 healthy volunteers the sensitivity for the detection of DVT was: 37% for TAT, 95% for TDP, 92% for FbDP and 90% for FgDP. Specificity was: 88% for TAT, 16% for TDP, 20% for FbDP and 25% for FgDP.We conclude that these assays are of little value in the diagnosis of DVT in outpatients.

GASCHROMATOGRAPHIC DETERMINATION OF STEROIDS IN THE URINE OF PATIENTS WITH CUSHING'S SYNDROME

1971 ◽  
Vol 67 (2) ◽  
pp. 303-315 ◽  
Author(s):  
A. J. Moolenaar ◽  
A. P. van Seters
Keyword(s):  
Liquid Chromatography ◽  
Cushing’S Syndrome ◽  
Normal Subjects ◽  
Diagnostic Value ◽  
Cushing's Syndrome ◽  
Gas Liquid Chromatography ◽  
Obese Subjects

ABSTRACT The 17-oxosteroids were estimated in the urine of 27 patients with Cushing's syndrome by gas-liquid chromatography (G. L. C.). The values of the various steroid fractions are compared with those of normal subjects, patients with thyrotoxicosis and obese subjects. The effect of the age of the patients on the diagnostic value of the invidual 17-oxosteroids and their ratios is discussed.

scholarly journals A Universal Model for the Log-Normal Distribution of Elasticity in Polymeric Gels and Its Relevance to Mechanical Signature of Biological Tissues

Biology ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 64
Author(s):  
Arnaud Millet
Keyword(s):  
Elastic Modulus ◽  
Normal Distribution ◽  
Biological Tissues ◽  
Force Microscopy ◽  
Polymeric Gels ◽  
Atomic Force ◽  
Clear Explanation ◽  
Log Normal ◽  
Log Normal Distribution

The mechanosensitivity of cells has recently been identified as a process that could greatly influence a cell’s fate. To understand the interaction between cells and their surrounding extracellular matrix, the characterization of the mechanical properties of natural polymeric gels is needed. Atomic force microscopy (AFM) is one of the leading tools used to characterize mechanically biological tissues. It appears that the elasticity (elastic modulus) values obtained by AFM presents a log-normal distribution. Despite its ubiquity, the log-normal distribution concerning the elastic modulus of biological tissues does not have a clear explanation. In this paper, we propose a physical mechanism based on the weak universality of critical exponents in the percolation process leading to gelation. Following this, we discuss the relevance of this model for mechanical signatures of biological tissues.

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