STEROID EXCRETION IN ANOREXIA NERVOSA PATIENTS

1979 ◽  
Vol 90 (1) ◽  
pp. 133-138 ◽  
Author(s):  
E. Vanluchene ◽  
W. Aertsens ◽  
D. Vandekerckhove
Keyword(s):  
Anorexia Nervosa ◽  
Urinary Excretion ◽  
Metabolic Abnormalities ◽  
Steroid Excretion

ABSTRACT Seven anorexia nervosa (A. N.) patients had reduced urinary excretion values of tetrahydrocortisone (THE), androsterone (A) and 5α-tetrahydrocortisol (5α-THF). THE to tetrahydrocortisol (THF), A to aetiocholanolone (Ae) and 5α-THF to THF ratios were all significantly reduced. Six A. N. patients had oral metyrapone tests with quantitatively normal but delayed urinary 3α,17α,21-trihydroxy-5β-pregnan-20-one (THS) response. The steroid determinations were done by capillary gaschromatography, which proves to be of value in the study of the above mentioned metabolic abnormalities.

Metabolism of cortisol in anorexia nervosa

1990 ◽  
Vol 122 (6) ◽  
pp. 753-758 ◽  
Author(s):  
H. Vierhapper ◽  
A. Kiss ◽  
P. Nowotny ◽  
S. Wiesnagrotzki ◽  
C. Monder ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Urinary Excretion ◽  
Plasma Concentrations ◽  
Adrenocortical Function ◽  
Acth Stimulation ◽  
Healthy Women ◽  
Rate Limiting Step ◽  
Enhanced Secretion ◽  
Excretion Rates ◽  
Steroid Excretion

Abstract. In patients with anorexia nervosa 24-h mean plasma concentration of cortisol were 0.44± 0.09 μmol/l (normal < 0.28 μmol/l). Following stimulation by ACTH (1–24) urinary excretion rates of cortisol were stimulated from 0.22 ± 0.08 to 4.85 ± 2.78 μmol/24 h. Similarly, plasma concentrations of the glucocorticoid metabolite, tetrahydrocortisone, increased from 23.3 ± 9.0 to 47.3 ± 30.2 nmol/l; urinary excretion rates of tetrahydrocortisone increased from 3.61 ± 0.90 to 8.40 ± 1.72 μmol/24 h. The relative share of the sulphate, glucuronide and free fractions of tetrahydrocortisone in the patients' urine did not indicate any defect in metabolization of this steroid metabolite. Excretion rates of the four glucocorticoid tetrahydro-metabolites, tetrahydrocortisone, allotetrahydrocortisone, tetrahydrocortisol, and allo-tetrahydrocortisol, expressed as percent of total steroid excretion, were similar in patients with anorexia and in healthy women under basal conditions (24 ± 6 vs 23 ± 6%) and during stimulation by ACTH (1–24) (36 ± 10 vs 45 ± 6%). The share of the two androgen metabolites, androsterone and etiocholanolone, was 24 ± 5% of total steroid excretion (basal; healthy women: 27 ± 8%) and 13 ± 2% (ACTH stimulation; healthy women: 12 ± 4%) in patients with anorexia nervosa. Thus, analysis of urinary steroid excretion rates did not indicate a shift in adrenocortical function. The results confirmed enhanced secretion of cortisol in patients with anorexia nervosa under basal conditions and during/following stimulation by ACTH. The ACTH-induced increase in the concentrations of the tetrahydro-glucocorticoid metabolites in urine was less pronounced than that of cortisol. The data strongly suggest a rate-limiting step in the transformation of cortisol into its main metabolites, most likely an impaired reduction of the double bond in positions C4/C5.

ON THE VALUE OF SOME PARAMETERS OF ADRENOCORTICAL GLUCOCORTICOID FUNCTION

1963 ◽  
Vol 44 (4) ◽  
pp. 499-504 ◽  
Author(s):  
M. Van Der Straeten ◽  
A. Vermeulen ◽  
N. Orie ◽  
P. Regniers
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Isotope Dilution ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Steroid Excretion ◽  
Colorimetric Methods

ABSTRACT The authors studied the correlation between cortisol production, as measured by an isotope dilution method, and the urinary excretion of total and free Porter-Silber chromogens, as well as of 17-ketogenic steroids. Although a significant correlation exists between total Porter-Silber chromogens, 17-ketogenic steroid excretion and cortisol production, discrepancies are occasionally observed. Hence, different colorimetric methods should be used to assess the glucocorticoid activity of the adrenal cortex.

EFFECT OF AN ANABOLIC STEROID (METHANDIENONE) ON PITUITARY-ADRENAL FUNCTION IN THE HUMAN

1962 ◽  
Vol 25 (2) ◽  
pp. 199-209 ◽  
Author(s):  
V. WYNN ◽  
J. LANDON ◽  
V. H. T. JAMES
Keyword(s):  
Anorexia Nervosa ◽  
Anabolic Steroid ◽  
Adrenal Glands ◽  
Suppressive Effect ◽  
Adrenal Function ◽  
Endocrine Diseases ◽  
Adrenal Response ◽  
Steroid Excretion ◽  
Urinary Steroid ◽  
Marked Suppression

SUMMARY The effect of methandienone administration on urinary steroid excretion has been studied in subjects with normal pituitary-adrenal function and in patients with various endocrine diseases. In the control subjects, a marked suppression of urinary 17-KS and 17-OHCS excretion occurred, which persisted throughout even prolonged periods of methandienone administration. Upon cessation of methandienone treatment a prompt rise in urinary steroid excretion occurred, on occasions to levels slightly higher than those seen before treatment. Similar results were obtained in subjects with acromegaly and Cushing's syndrome, but in patients with anorexia nervosa and a low basal steroid excretion, the suppressive effect of methandienone was less marked. During treatment with methandienone, pituitary response to metopirone was depressed, but adrenal response to corticotrophin was unaltered. It was concluded that methandienone diminishes the rate of production of adrenocortical steroid by inhibiting corticotrophin production or release. Unlike the inhibition observed during treatment with glucocorticoids, it was not associated with atrophy of the adrenal glands.

A LONGITUDINAL STUDY OF THE URINARY EXCRETION OF INDIVIDUAL STEROIDS IN CHILDREN FROM 3 TO 7 YEARS OLD

1971 ◽  
Vol 68 (1) ◽  
pp. 141-163 ◽  
Author(s):  
D. Gupta ◽  
W. A. Marshall
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Urinary Excretion ◽  
Skeletal Maturity ◽  
Older Children ◽  
Significant Relationships ◽  
The Mean ◽  
Mean Trend ◽  
Steroid Excretion ◽  
Cortisol Metabolites

ABSTRACT A longitudinal study was made of the daily urinary excretion, on or near each birthday, of a number of C19 and C21 steroids in 9 healthy girls and 5 healthy boys aged 3 to 7 years. The amount of androsterone excreted by each individual increased slowly during the period of study but the absolute amounts varied greatly between individuals. The excretion of aetiocholanolone was greater than that of androsterone, contrary to reported findings in older children. Small amounts of DHA were found. Testosterone was found in only about 40% of samples; epitestosterone in 70 % and 11β-OH-androsterone in only 62 %. Cortisol metabolites were excreted in amounts which increased with age and all three metabolites of corticosterone were present in most specimens. 11-Deoxycortisol was found in about 50 % of the samples and THS in 63 %. The mean trend in the ratio of glucuronides to sulphates of the 11-deoxy-17-oxosteroids decreased with increasing age, but the 11-deoxy-11-oxy ratio of 17-oxosteroids increased as did the 5α/5β ratio of the C19 and C21 steroids. No sex differences were observed. The excretion of cortisol metabolites showed a positive correlation with height and weight. 11-Deoxy-17-oxosteroids were positively correlated with the weight. No significant relationships between steroid excretion and skeletal maturity were found.

Pituitary and Adrenal Function in Undernutrition with Mental Illness

1963 ◽  
Vol 109 (461) ◽  
pp. 480-484 ◽  
Author(s):  
V. Marks ◽  
R. G. Bannister
Keyword(s):  
Mental Illness ◽  
Anorexia Nervosa ◽  
Urinary Excretion ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Anterior Pituitary Gland ◽  
Adrenal Function ◽  
Pituitary Function ◽  
Prolonged Starvation

Urinary excretion of adrenal metabolites, especially neutral 17-ketosteroids, is often low in patients with anorexia nervosa (Escamilla, 1949; Bliss and Branch, 1960). This has been taken (Emanuel, 1956; Greenblatt et al., 1951) to provide evidence of adreno-cortical insufficiency secondary to defective pituitary function (Sheldon, 1939; Perloff et al., 1954). According to Perloff et al. (1954) “prolonged starvation may result in functional hypopituitarism, whose differentiation from the syndrome of hypopituitary cachexia due to structural impairment of the anterior pituitary gland is at times extremely difficult, even when the accepted tests for endocrine adequacy are performed”.

Steroid and catecholamine studies on pilots during prolonged experiments in a space cabin simulator

1963 ◽  
Vol 18 (6) ◽  
pp. 1257-1262 ◽  
Author(s):  
F. Ulvedal ◽  
W. R. Smith ◽  
B. E. Welch
Keyword(s):  
Urinary Excretion ◽  
Stress Hormones ◽  
Correlation Coefficients ◽  
Ground Level ◽  
Linear Increase ◽  
Significant Trend ◽  
Continuous Linear ◽  
Steroid Excretion ◽  
Medical Examinations ◽  
Level 2

Urinary excretion of 17-hydroxycorticosteroids, corticosterone-like hormones, and catecholamines (epinephrine and norepinephrine) has been investigated on pilots during prolonged experiments in a two-man space cabin simulator. The experimental profiles were: 1) two 17-day experiments at ground level; 2) two 14-day experiments at 27,000 ft; and 3) four experiments at 33,500 ft lasting 17 days. In the latter two groups the atmosphere was essentially 100% O2. The hormone parameters indicate that conditions imposed by the experimental procedures were no more stressful to the subjects than undergoing extensive medical examinations as observed from pre- and postexperimental values. The only significant trend was the continuous linear increase in the excretion of corticosterone-like hormones. There were borderline indications that the excretion of 17-hydroxycorticosteroids and norepinephrine were altitude dependent. Extraordinary occurrences in the simulator were correlated with increased catecholamine and steroid excretion. The correlation coefficients and the analyses of variance for the four hormone parameters were calculated and discussed. endocrinology; sealed environments; stress hormones Submitted on March 26, 1963

Metabolic abnormalities in adolescent patients with anorexia nervosa

1985 ◽  
Vol 6 (3) ◽  
pp. 191-195 ◽  
Author(s):  
Mark R. Milner ◽  
Elizabeth R. McAnarney ◽  
William J. Klish
Keyword(s):  
Anorexia Nervosa ◽  
Metabolic Abnormalities ◽  
Adolescent Patients

STEROID EXCRETION IN IDIOPATHIC HIRSUTISM

1962 ◽  
Vol 24 (4) ◽  
pp. 463-470 ◽  
Author(s):  
V. H. T. JAMES ◽  
W. S. PEART ◽  
S. D. ILES
Keyword(s):  
Urinary Excretion ◽  
Control Subjects ◽  
Urinary Steroids ◽  
Idiopathic Hirsutism ◽  
The Mean ◽  
Steroid Excretion

SUMMARY The excretion of urinary steroids and their response to corticotrophin has been studied in a group of patients with idiopathic hirsutism. The mean resting levels of 17-oxosteroids and 17-hydroxycorticosteroids were higher, and the response to corticotrophin was greater, in the patients as compared to control subjects. Fractionation of 17-oxosteroids in eight patients showed an elevated or abnormally high excretion of steroid metabolites which were presumably being derived from androgen. This appeared to be associated with an adequate production of cortisol, as judged from urinary excretion studies.

scholarly journals Anorexia: Anormal Phobia of Normal Weight

PRILOZI ◽  
2017 ◽  
Vol 38 (2) ◽  
pp. 45-53
Author(s):  
Nada Pop-Jordanova ◽  
Tatjana Zorcec ◽  
Aneta Demerdzieva
Keyword(s):  
Anorexia Nervosa ◽  
Young Patients ◽  
Normal Weight ◽  
Mood Disturbance ◽  
Therapeutic Modality ◽  
Metabolic Abnormalities ◽  
Biological Factors ◽  
Social Psychological ◽  
Oppositional Behavior ◽  
Life Threatening

AbstractAnorexia nervosa is a disorder of feeding behavior associated with distortion of body image, mood disturbance and a wide variety of hormonal and metabolic abnormalities. It is supposed that the disease could be the consequence of a combination of cultural-social, psychological and biological factors.Our study confirmed that anorexia mentalis is a serious, life threatening disorder which in our country appears earlier than it was expected and that is strongly related to environmental factors (family, school, fashion, society).We showed that specific personality traits are characteristic for both, young patients and mothers. Sublimation of emotional stress by exceptional performances, accompanied by food restrictive consumption together with hypersensitivity, oppositional behavior and aggression are specific for this disorder. High levels of self-imposed standards increase the risk for psychological distress, especially for eating disorder symptomatology.Both genders could be involved as patients. Boys must be especially followed for possible psychiatric manifestation.We confirmed that the biofeedback as additional therapeutic modality is very useful.

Exercise in food-restricted rats produces 2DG feeding and metabolic abnormalities similar to anorexia nervosa

1995 ◽  
Vol 57 (1) ◽  
pp. 147-153 ◽  
Author(s):  
Paul F. Aravich ◽  
Eric Z. Stanley ◽  
Lee E. Doerries
Keyword(s):  
Anorexia Nervosa ◽  
Metabolic Abnormalities
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