DEVELOPMENTAL PATTERNS OF PLASMA AND TESTICULAR TESTOSTERONE IN MICE FROM BIRTH TO ADULTHOOD

1978 ◽  
Vol 89 (4) ◽  
pp. 780-788 ◽  
Author(s):  
Ch. Jean-Faucher ◽  
M. Berger ◽  
M. de Turckheim ◽  
G. Veyssiere ◽  
Cl. Jean
Keyword(s):  
Body Weight ◽  
Seminal Vesicle ◽  
Sex Difference ◽  
Plasma Testosterone ◽  
Male Mice ◽  
Developmental Patterns ◽  
Testosterone Levels

ABSTRACT Male mice were raised in cohabitation with females from birth to 90 days. Testosterone was measured every 10 days in plasma and testes. Sex difference in body weight was related to the pre-pubertal increase of testosterone levels in males. The weight of the seminal vesicle was positively correlated with circulating testosterone levels between 1 and 40 days but not between 50 and 90 days Testosterone concentrations in the plasma and testes were high at birth: 630 pg/ml and 58.0 ± 17.7 ng/100 mg; they subsequently decreased during the first days of life and remained low until day 20: 240 ± 110 pg/ml and 0.1 ± 0.03 ng/100 mg. The testosterone levels then increased rapidly between days 20 and 30 and especially between 30 and 40 reaching their maxima: 5770 ± 1720 pg/ml and 123.7 ± 18.3 ng/100 mg testis. This increase was transitory and testosterone levels fell after day 40. By 90 days, the testosterone levels, 440 ± 65 pg/ml and 43.2 ± 5.5 ng/100 mg testis, were comparable to those measured at birth. Plasma testosterone and age were positively correlated between 1 and 40 days, and negatively between 50 and 90 days. The first fertile matings occurred at age 40 days.

EFFECTS OF DENSE HOUSING ON THE GROWTH OF REPRODUCTIVE ORGANS, PLASMA TESTOSTERONE LEVELS AND FERTILITY OF MALE MICE

1981 ◽  
Vol 90 (3) ◽  
pp. 397-402 ◽  
Author(s):  
CH. JEAN-FAUCHER ◽  
M. BERGER ◽  
M. DE TURCKHEIM ◽  
G. VEYSSIERE ◽  
CL. JEAN
Keyword(s):  
Population Size ◽  
Seminal Vesicle ◽  
Reproductive Organs ◽  
Endocrine Function ◽  
Plasma Testosterone ◽  
Male Mice ◽  
Testosterone Levels ◽  
Differential Housing

Male mice were raised in populations of two different sizes from birth to adulthood: six animals (three of each sex) or 30 animals (15 of each sex) being maintained in cages of the same dimensions. Animals were killed every 10 days from weaning to 60 days and at 90 days. Increased population size induced decreased body and seminal vesicle weights; testicular, pituitary and adrenal weights were little affected. Plasma testosterone levels were lowered by increasing population size over the period from weaning to 50 days but they were increased at 60 and 90 days. The age at which first fertile matings occurred was not affected. These results indicate that the endocrine function of the testis, as determined by the measures used here, was specifically affected by this differential housing.

INFLUENCE OF METYRAPONE ON PLASMA CONCENTRATIONS OF TESTOSTERONE AND ANDROSTENEDIONE IN MAN

1971 ◽  
Vol 68 (3) ◽  
pp. 576-584 ◽  
Author(s):  
K. O. Nilsson ◽  
B. Hökfelt
Keyword(s):  
Body Weight ◽  
Male Patient ◽  
Gradual Increase ◽  
Plasma Concentrations ◽  
Plasma Testosterone ◽  
Testosterone Levels ◽  
Basal Plasma ◽  
Normal Males ◽  
A Minor ◽  
Secondary Hypogonadism

ABSTRACT Metyrapone was administered either orally, 750 mg every four h, in a total of six doses, or intravenously 30 mg per kg body weight as a four h infusion. In three males with normal endocrine functions, metyrapone given orally or intravenously induced a fall in plasma testosterone and an elevation of androstenedione within 2–8 h. When metyrapone was administered to a patient given dexamethasone to suppress endogenous ACTH production, the androstenedione levels did not alter whereas the testosterone levels showed a slight, transient decrease. In two normal females metyrapone administration was followed by a marked increase in plasma androstenedione whereas testosterone showed only a minor, gradual increase. In one male patient with Addison's disease the basal plasma testosterone was normal whereas the level of androstenedione was low. Following metyrapone intravenously, there was a slight suppression of plasma testosterone but no change in the androstenedione concentration. In one patient with primary hypogonadism, two with secondary hypogonadism and two with Klinefelter's syndrome the plasma testosterone was low under basal conditions and did not change following metyrapone. Basal plasma androstenedione was within the range for normal males and increased markedly following metyrapone in all the cases.

scholarly journals Sex differences in Alzheimer’s-related Tau biomarkers and a mediating effect of testosterone

2020 ◽  
Author(s):  
Erin Sundermann ◽  
Matthew S. Panizzon ◽  
Xu Chen ◽  
Murray Andrews ◽  
Douglas Galasko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Differences ◽  
Sex Difference ◽  
Mediating Effect ◽  
Interactive Effects ◽  
Plasma Testosterone ◽  
Testosterone Levels ◽  
Before And After

Abstract Women show greater pathological Tau biomarkers than men along the Alzheimer’s disease (AD) continuum, particularly among apolipoprotein ε-E4 (APOE4) carriers; however, the reason for this sex difference in unknown. Sex differences often indicate an underlying role of sex hormones. We examined whether testosterone levels might influence this sex difference and the modifying role of APOE4 status. Analyses included 172 participants (25 cognitively normal, 97 mild cognitive impairment, 50 AD participants) from the Alzheimer’s Disease Neuroimaging Initiative (34% female, 54% APOE4+, aged 55–90). We examined the separate and interactive effects of plasma testosterone levels and APOE4 on cerebrospinal fluid phosphorylated-tau181 (p-Tau) levels in the overall sample, and the sex difference in p-Tau levels before and after adjusting for testosterone. A significant APOE4-by-testosterone interaction revealed that lower testosterone levels related to higher p-Tau levels among APOE4 carriers regardless of sex. As expected, women had higher p-Tau levels than men among APOE4 carriers only, yet this difference was eliminated upon adjustment for testosterone. Results suggest that testosterone is protective against p-Tau particularly among APOE4 carriers. The lower testosterone levels that typically characterize women may predispose them to pathological Tau, particularly among female APOE4 carriers.

scholarly journals Brain aromatase activity and plasma testosterone levels are elevated in aggressive male mice during early ontogeny

1994 ◽  
Vol 82 (1-2) ◽  
pp. 185-192 ◽  
Author(s):  
J.C. Compaan ◽  
J.B. Hutchison ◽  
A. Wozniak ◽  
A.J.H. de Ruiter ◽  
J.M. Koolhaas
Keyword(s):  
Early Ontogeny ◽  
Plasma Testosterone ◽  
Aromatase Activity ◽  
Male Mice ◽  
Testosterone Levels ◽  
Brain Aromatase ◽  
Aggressive Male

INCREASED SENSITIVITY OF SEMINAL VESICLES TO TESTOSTERONE IN A MOUSE STRAIN WITH LOW PLASMA TESTOSTERONE LEVELS

1974 ◽  
Vol 60 (1) ◽  
pp. 145-148 ◽  
Author(s):  
A. BARTKE
Keyword(s):  
Testosterone Propionate ◽  
Seminal Vesicles ◽  
Plasma Testosterone ◽  
Testicular Function ◽  
Androgen Deficiency ◽  
Male Mice ◽  
Testosterone Levels ◽  
Sex Drive ◽  
Testicular Weight ◽  
Increased Sensitivity

SUMMARY In male mice of the C57BL/10J (C57) strain the testicular weight, sex drive and aggression are low compared with a number of other strains, indicating androgen deficiency. In contrast, DBA/2J (DBA) males were 'normal' in all studied parameters of testicular function. The weight of the seminal vesicles is similar in both strains. Plasma testosterone levels, and the responsiveness of the seminal vesicles to injected testosterone propionate in C57 and DBA animals were compared. Plasma testosterone levels were 1·3 ± 0·4 ng/ml in C57 and 4·6 ± 1·0 ng/ml in DBA mice. The increase in weight of the seminal vesicles after administration of testosterone propionate to castrated male mice was, however, considerably greater in C57 than in DBA mice. In order to restore the weight of the seminal vesicles to normal it was necessary to administer twice as much testosterone propionate to DBA than to C57 males.

EFFECTS OF AN INTRAVENOUS INJECTION OF TETRACOSACTID ON PLASMA CORTICOSTEROID AND TESTOSTERONE LEVELS IN UNSTRESSED MALE RABBITS

1979 ◽  
Vol 91 (3) ◽  
pp. 511-518 ◽  
Author(s):  
K. W. Faulborn ◽  
M. Fenske ◽  
L. Pitzel ◽  
A. König
Keyword(s):  
Body Weight ◽  
Intravenous Injection ◽  
Plasma Levels ◽  
Plasma Testosterone ◽  
Rapid Rise ◽  
Testosterone Concentration ◽  
Testosterone Levels ◽  
Blood Withdrawal ◽  
Basal Plasma ◽  
Pre Treatment

ABSTRACT Administration of tetracosactid into male rabbits, fitted with permanently indwelling jugular catheters, resulted in a rapid rise of plasma corticosteroids and plasma testosterone. Corticosteroid concentrations were significantly elevated at 40 and 60 min and testosterone concentrations 20 min after the iv injection of tetracosactid (2.5, 5.0, and 10.0 μg/kg body weight), in comparison to pre-treatment levels. Corticosteroid values in plasma were elevated as long as 120 min after tetracosactid injection. In contrast, testosterone levels were lower at 60–120 min after tetracosactid injection than corresponding pre-treatment values. However, these differences were not significant. At the doses used no tetracosactiddose-dependent corticosteroid or testosterone release could be found; apparently, testosterone release is only dependent upon basal plasma levels but not upon the dose of tetracosactid applied. From these studies it is concluded that tetracosactid may bring about an increase or decrease of testosterone concentration in plasma in the buck depending upon the length of time elapsing between injection of tetracosactid and blood withdrawal.

THE EXCRETION OF INDIVIDUAL ADRENOCORTICAL STEROIDS DURING NORMAL CHILDHOOD AND ADOLESCENCE

1975 ◽  
Vol 79 (3) ◽  
pp. 551-567 ◽  
Author(s):  
D. C. L. Savage ◽  
Constance C. Forsyth ◽  
Eileen McCafferty ◽  
Jenny Cameron
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Chromatographic Method ◽  
Clinical Signs ◽  
High Plasma ◽  
Plasma Testosterone ◽  
Childhood And Adolescence ◽  
Testosterone Levels ◽  
The Individual ◽  
Specific Paper

ABSTRACT The excretion of 7 individual 17-oxosteroids and 7 individual corticosteroids in 24 h urine samples from 62 normal infants, children and adolescents, based on an accurate and specific paper chromatographic method for their separation and quantitation, is reported. The excretion of the 11-deoxy-17-oxosteroids gradually increases from 7 years of age and the increase becomes more rapid 2 or 3 years before the clinical signs of puberty appear. The rise continues throughout puberty and beyond it until the adult level is reached. The increase far exceeds that which would be accounted for by the growth of the individual. The increase in the excretion of the 11-oxy-17-oxosteroids with age is much more gradual. Androgens favour the formation of 5α metabolites and the 5α:5β ratio of the total 5α 17-oxosteroids and the total 5β 17-oxosteroids shows a statistically significant increase with age. In addition, a relatively high 5α:5β ratio is noted in male infants, which is likely to be related to their relatively high plasma testosterone levels. The excretion of the 17-hydroxycorticosteroids and the α-ketolic metabolites of cortisol gradually rises with age and correlates with body weight. The α-ketolic metabolites of corticosterone are relatively high in infancy, but after the age of 4 years their excretion also correlates with body weight. An increase in the 5α:5β ratio of allo-THF to THF is noted at puberty similar to that found with the 5α:5β ratios of the 17-oxosteroids.

scholarly journals Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2135
Author(s):  
Roger Grífols ◽  
Carolina Zamora ◽  
Iván Ortega-Saez ◽  
Garikoitz Azkona
Keyword(s):  
Social Isolation ◽  
Plasma Levels ◽  
Agonistic Behavior ◽  
Plasma Testosterone ◽  
Male Mice ◽  
Laboratory Mice ◽  
Testosterone Levels ◽  
Behavioral Abnormalities ◽  
Group Members

Rearing laboratory mice in groups is important since social isolation after weaning induces brain alterations, which entails behavioral abnormalities in adulthood. Age is an important factor when grouping males of different litters due to inter-male aggressiveness. The aim of this study was to determine whether newly weaned mice could safely be grouped with late juvenile or early and late pubescent mice, and whether cage cleaning, the number of the hosting group members and testosterone plasma levels have any influence. Newly weaned C57BL/6J, CD1, and SCID Beige male mice were systematically grouped with same strain late juvenile, early or late pubescent male mice in clean or dirty cages of 1, 2 or 3 hosting members. We also analyzed plasma testosterone levels at different postnatal days. Our result showed that only strain and hosting male’s age influence agonistic behavior toward newly weaned mice. Thus, in order not to house a recently weaned male alone, we would recommend grouping it with late juvenile same strain mice in all studied strains. In the same way, CD1 and SCID Beige pubescent mice will admit a newly weaned mouse in their group. However, we would not recommend grouping newly weaned and pubescent C57BL/6J males.

Strange females increase plasma testosterone levels in male mice

Science ◽  
1975 ◽  
Vol 189 (4208) ◽  
pp. 1104-1106 ◽  
Author(s):  
F Macrides ◽  
A Bartke ◽  
S Dalterio
Keyword(s):  
Plasma Testosterone ◽  
Male Mice ◽  
Testosterone Levels
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