BONE MINERALIZATION AND BONE MINERAL CONTENT IN PRIMARY HYPERPARATHYROIDISM

1977 ◽  
Vol 84 (2) ◽  
pp. 314-319 ◽  
Author(s):  
Lars Tougaard ◽  
Christian Hau ◽  
Paul Rødbro ◽  
Jørn Ditzel
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Mineralization ◽  
Elevated Serum ◽  
Photon Absorptiometry ◽  
Mean Values ◽  
Bone Biopsies ◽  
The Mean

ABSTRACT The degree of bone mineralization and the bone mineral content (BMC) was evaluated in 6 patients with primary hyperparathyroidism. The degree of bone mineralization was estimated as the phosphorus/hydroxyproline ratio (P/Hypro) in bone biopsies; BMC was estimated by photon absorptiometry on both forearms. The mean values of both parameters were significantly lower than normal (P < 0.001 for P/Hypro; P < 0.02 for BMC). As no significant correlation was found between P/Hypro and BMC in hyperparathyroidism, the findings of low values of P/Hypro and of BMC in patients with elevated serum calcium point to primary hyperparathyroidism.

Persistence of Diminished Bone Mineral Content Following Renal Transplantation in Childhood

PEDIATRICS ◽  
1984 ◽  
Vol 73 (4) ◽  
pp. 459-466
Author(s):  
Russell W. Chesney ◽  
Philip G. Rose ◽  
Richard B. Mazess
Keyword(s):  
Renal Transplantation ◽  
Serum Creatinine ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Strongly Correlated ◽  
Photon Absorptiometry ◽  
Prednisone Dose ◽  
Daily Prednisone ◽  
Control Volumes

Bone mineral content (BMC) was measured in the nondominant arm of 18 children (aged 37/12 to 17½ years) for a total 783 months after renal transplantation. Using photon absorptiometry, 89 measurements were made; 17 of the 18 patients had a functioning graft and one patient died. Significant demineralization, a BMC greater than -2 SD below appropriate control volumes, was found in 11 of 18 patients (62%) and 55 of 89 measurements (61%). Bone loss was progressive; among the 16 patients followed for more than 6 months, ten showed a decline of more than 0.5 SD in BMC, five had no change, and only one showed improvement. No relationship was found between BMC and the use of furosemide, type of transplant (15 living, seven cadaver), prior renal disease (six with glomerulonephritis, 11 tubulointerstitial), need for a second graft (five patients), chronic anticonvulsant therapy, or serum calcium and phosphate values. BMC was slightly correlated (P &lt; .05) with alkaline phosphatase values. BMC was more strongly correlated with serum creatinine (y = -0.48x + 1.25, r = -.042, P &lt; .001) and prednisone dose (mg/kg/d) (y = -0.65x + 0.481, r = -.543, P &lt; .001) in an inverse relationship. Patients whose serum creatinine value was less than 1 mg/dL had a BMC of -0.71 ± 0.34 SD; those with serum creatinine value greater than 2 mg/dL had BMC of -3.32 ± 0.31 SD, different at P &lt; .001. Patients receiving daily prednisone therapy had a significantly lower BMC than those receiving alternate-day therapy (-3.11 ± 1.23 SD v -1.72 ± 1.29 SD, P &lt; .005).

62 Growth Performance and Mineral Status of 6 Kg Piglets Fed Reduced Levels of Dietary Calcium

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 42-42
Author(s):  
Laura A Merriman ◽  
Craig Wyatt ◽  
Marie-Pierre Létourneau-Montminy ◽  
Xaviere Rousseau ◽  
Dan Bussières
Keyword(s):  
Bone Mineral Content ◽  
Growth Performance ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Mineralization ◽  
Phase 1 ◽  
Short Term ◽  
Plasma Parameters ◽  
Dietary Treatments ◽  
The Impact

Abstract Imbalances between calcium (Ca) and phosphorus (P) impair growth performance and bone mineralization. However, reducing dietary limestone may change the buffering capacity of feed in early nursery piglets, which may help prevent post-weaning diarrhea. An experiment was conducted to evaluate the impact of reducing Ca post weaning compared to recommendations outlined by NRC (2012) or a low P diet. Dietary treatments consisted of 1) Low Ca (LCa; Phase 1, 0.51% Ca and 0.47% STTD P), 2) NRC recommendations (NRC; Phase 1, 0.85% Ca and 0.42% STTD P), and 3) a recommendation lower in phosphorus (LP; Phase 1, 0.65% Ca and 0.36% STTD P). Each diet was fed over 4 phases. Piglets (n = 953; 276/275 Fast X PIC 800 genetics) were blocked by room, sex, and initial BW (6 kg). Feed intake and pig weights were recorded weekly. At 12 d and 41 d, blood was collected and Dual-X ray (DXA) measurements were taken using 8 piglets per treatment. Fecal scores were evaluated during wk 4 and 5. Data were analyzed using MIXED procedure of SAS (SAS Inst. Inc., Cary, NC). There were no differences observed in mortality, overall growth performance, plasma Ca and P, and scour scores at either time point. At 12 d, the bone mineral content was reduced (P = 0.001) in LP pigs compared to LCa and NRC. At 41 d, bone mineral content was reduced in NRC in comparison to LCa while LP was intermediate (P = 0.001). Plasma parameters showed an increased magnesium (Mg) and Ca:Mg in LCa (P &lt; 0.01) that can be related to bone resorption to face Ca hypocalcemia. Pigs were healthy with no enteric challenges, limiting the ability to observe a benefit in fecal scores. In conclusion, piglets can maintain growth and bone mineralization through a short-term limestone removal program.

Sign in / Sign up

Export Citation Format

Share Document