ADRENAL ACTIVITY DURING NORMAL GLUCOSE TOLERANCE

1977 ◽  
Vol 84 (1) ◽  
pp. 115-118 ◽  
Author(s):  
Arthur J. Sober ◽  
Henry J. Ruder ◽  
Jonas Sode
Keyword(s):  
Glucose Tolerance ◽  
Plasma Cortisol ◽  
Normal Subjects ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Glucose Ingestion ◽  
Normal Glucose ◽  
Glucose Plasma

ABSTRACT Plasma cortisol was measured by radioimmunoassay during 4 h oral glucose tolerance tests in 8 non-obese normal subjects. Following 100 g of glucose, plasma cortisol concentrations were lower than basal at 15, 30 and 60 min, and declined with a half-time of 70 min. No evidence was obtained that the hyperglycaemia which follows glucose ingestion leads to increased cortisol secretion and that such a mechanism is involved in the stabilization of blood sugar levels during the posthyperglycaemic phase of the normal oral glucose tolerance test. Epinephrine and norepinephrine excretory rates during the hyperglycaemic (0–2 h) and euglycaemic (2–4 h) phases of the test were not significantly different. It is concluded that adrenocortical and adrenomedullary activities are not increased during normal glucose tolerance in man.

Plasma Betatrophin Levels of Subjects Classified with Normal, Impaired, and Diabetic Glucose Tolerance, and Subjects with Impaired Fasting Glucose

2017 ◽  
Vol 49 (06) ◽  
pp. 434-439 ◽  
Author(s):  
Sibel Ozyazgan ◽  
Burak Onal ◽  
Eda Kurtulus ◽  
Hafize Uzun ◽  
Gokhan Akkan ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Glucose Tolerance Test ◽  
Fasting Glucose ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Normal Glucose ◽  
Male Subjects

AbstractThis study was aimed to investigate whether betatrophin shows glucose intolerance or not. To access the plasma betatrophin levels after basal and glucose load, groups were classified as normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetic glucose tolerance (DGT) according to WHO 2012 criteria. An oral glucose tolerance test was performed on age-matched subjects (n=220) with a body mass index (BMI)<27 kg/m2. Subjects were categorized as normoglycemic (n=55), IFG (n=50), IGT (n=60), and DM (n=55) according to the WHO criteria. Baseline betatrophin levels in DGT are significantly higher than in NGT (p<0.005), IFG (p<0.004), and IGT (p<0.001). Male subjects have significantly higher betatrophin levels than female subjects (p<0.01). In DGT, betatrophin of male subjects was found to be significantly higher than the betatrophin of male subjects in NGT (p<0.04), IFG (p<0.01), and IGT (p<0.01). Significant relationship between betatrophin and both ages and HbA1c in all groups were observed. When ages were accepted as an independent factor, significant correlation between betatrophin and ages were found. Betatrophin is increased and associated with age and HbA1c in DGT. Males had higher betatrophin levels compared with females in DGT group. As no obvious betatrophin deficiency to substitute in IFG and IGT individuals were observed, betatrophin levels appeared to be related to the pathogenesis of the diabetic stages rather than prediabetic stages.

Abnormal Regulation of Venous Alanine after Glucose Ingestion in Myotonic Dystrophy

1985 ◽  
Vol 68 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Richard T. Moxley ◽  
William Kingston ◽  
Robert C. Griggs
Keyword(s):  
Amino Acids ◽  
Glucose Tolerance ◽  
Myotonic Dystrophy ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance Testing ◽  
Glucose Ingestion ◽  
Normal Glucose ◽  
Normal Males ◽  
Slight Rise

1. The concentration of amino acids in whole blood was measured before and during standard 5 h oral glucose tolerance testing in six male patients with myotonic dystrophy and five normal males. The plasma levels of insulin and glucose were also determined. 2. From 90 to 240 min after glucose ingestion there was a striking decline in venous alanine concentration in the patients with myotonic dystrophy in contrast to a slight rise in alanine in the normal group. 3. The patients displayed normal glucose tolerance, and there was a sustained fall in the venous concentration of the insulin-sensitive amino acids comparable with that seen in the normal controls. However, the patients showed a threefold increase of plasma insulin after glucose. 4. These data indicate an abnormal regulation of alanine in myotonic dystrophy which may be the result of an alteration in muscle synthesis of this amino acid. This defect in alanine synthesis may be due to a decreased availability of intracellular pyruvate caused by the insulin resistance that exists in these patients.

Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance

2016 ◽  
Vol 29 (2) ◽  
Author(s):  
Eiichiro Satake ◽  
Rie Matsushita ◽  
Kazuteru Kitsuda ◽  
Kohnosuke Ohtaka ◽  
Eiko Nagata ◽  
...  
Keyword(s):  
Early Detection ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Normal Range ◽  
Oral Glucose Tolerance Tests ◽  
Normal Glucose ◽  
Glucose Tolerance Tests ◽  
The Difference

AbstractUrinaryIn Study 1 (328 schoolchildren), fasting and postprandial UMI were measured, with ΔUMI defined as the difference between fasting and postprandial UMI levels. In Study 2, oral glucose tolerance tests and UMI measurements were conducted in 18 children with suspected having diabetes.For Study 1, ΔUMI was observed [−0.65 (−3.9, 1.35) mg/g creatinine]. For Study 2, children with diabetes or impaired glucose tolerance had a significantly higher ΔUMI than children with normal glucose tolerance.These studies demonstrated the normal range of UMI in children and possibility of a novel biomarker for early detection of glucose intolerance in children.

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