PEPTIDASES IN THE RAT HYPOTHALAMUS INACTIVATING THYROTROPHIN-RELEASING HORMONE (TRH)

1975 ◽  
Vol 79 (1) ◽  
pp. 209-216 ◽  
Author(s):  
E. C. Griffiths ◽  
K. C. Hooper ◽  
S. L. Jeffcoate ◽  
N. White
Keyword(s):  
Anterior Pituitary ◽  
Female Rats ◽  
Peptidase Activity ◽  
Thyrotrophin Releasing Hormone ◽  
Male And Female ◽  
Releasing Hormone ◽  
Rat Hypothalamus ◽  
Male And Female Rats ◽  
Specific Radioimmunoassay ◽  
The Brain

ABSTRACT Peptidases capable of inactivating thyrotrophin-releasing hormone (TRH) have been demonstrated in the hypothalamus. With the development of a specific radioimmunoassay for TRH, this method was used to further study the enzymes acting on the releasing hormone. Whole hypothalamic homogenates from male and female rats inactivated TRH, with greater peptidase activity being found in the female animals. Separation of the homogenates into particulate (microsomal and mitochondrial) and supernatant (soluble/cytoplasmic) fractions showed approximately the same amounts of enzyme activity in both fractions, while dialysis of the fractions slightly reduced the TRH peptidase activity present, suggesting that a diffusible co-factor might be partially involved in the releasing hormone's degradation. These results confirm the presence of TRH-inactivating peptidases in the rat hypothalamus and suggest that the enzymes may be involved in some way in the mechanisms by which the brain controls thyrotrophin release by the anterior pituitary.

Regulation of Pro-Gonadotropin-Releasing Hormone Gene Expression by Sex Steroids in The Brain of Male and Female Rats

1989 ◽  
Vol 3 (11) ◽  
pp. 1748-1756 ◽  
Author(s):  
Daniel Toranzo ◽  
Eric Dupont ◽  
Jacques Simard ◽  
Claude Labrie ◽  
Jacques Couet ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sex Steroids ◽  
Gonadotropin Releasing Hormone ◽  
Female Rats ◽  
Male And Female ◽  
Releasing Hormone ◽  
Male And Female Rats ◽  
The Brain

CELLULAR LOCALIZATION OF A PROLACTIN-LIKE ANTIGEN IN THE RAT BRAIN

1979 ◽  
Vol 83 (2) ◽  
pp. 261-NP ◽  
Author(s):  
G. TOUBEAU ◽  
J. DESCLIN ◽  
M. PARMENTIER ◽  
J. L. PASTEELS
Keyword(s):  
Rat Brain ◽  
Cellular Localization ◽  
Female Rats ◽  
Nerve Fibres ◽  
Male And Female ◽  
Immunoreactive Material ◽  
Paraventricular Nuclei ◽  
Male And Female Rats ◽  
The Brain

The distribution of immunoreactive neurones and fibres was studied in rat brain using an antiserum to rat prolactin. Neurones containing the immunoreactive material were localized in the arcuate, ventromedial, premamillary, supraoptic and paraventricular nuclei of the hypothalamus. Immunoreactive nerve fibres were widely distributed within the brain. No differences were observed in labelling between male and female rats, or as a consequence of hypophysectomy.

A model for the study of sexual function in anesthetized male and female rats

1991 ◽  
Vol 261 (5) ◽  
pp. R1276-R1285 ◽  
Author(s):  
K. E. McKenna ◽  
S. K. Chung ◽  
K. T. McVary
Keyword(s):  
Sexual Function ◽  
Penile Erection ◽  
Neural Mechanisms ◽  
Female Rats ◽  
Descending Inhibition ◽  
Male And Female ◽  
Uterine Contractions ◽  
Male And Female Rats ◽  
Rhythmic Contractions ◽  
The Brain

A preparation for the study of sexual function in anesthetized spinal male and female rats is discussed. Urethral stimulation in males elicited penile erection, ejaculation, and rhythmic contractions of the striated perineal muscles. In females, vaginal and uterine contractions and rhythmic contractions of the perineal muscles were elicited. These responses show many similarities to responses seen during sexual climax in unanesthetized humans and animals. This response, which we refer to as the urethrogenital reflex, is unaffected in either sex by gonadectomy. We determined that the urethrogenital reflex is produced by a spinal pattern generator and is under tonic descending inhibition from the brain stem. We conclude that this preparation may be a valuable model for experimental study of the neural mechanisms of sexual function in both sexes.

Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats

1988 ◽  
Vol 439 (1-2) ◽  
pp. 322-329 ◽  
Author(s):  
Gennaro Schettini ◽  
Tullio Florio ◽  
Olimpia Meucci ◽  
Elisa Landolfi ◽  
Gaetano Lombardi ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Anterior Pituitary ◽  
Female Rats ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Male And Female ◽  
Male And Female Rats ◽  
Pituitary Adenylate Cyclase
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