DECREASED ARGININE-INDUCED HGH RESPONSE DURING L-DOPA THERAPY IN PARKINSONIAN PATIENTS

1974 ◽  
Vol 77 (4) ◽  
pp. 686-690 ◽  
Author(s):  
S. E. Johnson ◽  
N. Norman ◽  
O. Sjaastad
Keyword(s):  
Parkinson’S Disease ◽  
Growth Hormone ◽  
Parkinson's Disease ◽  
Growth Hormone Response ◽  
Hormone Response ◽  
Significant Lowering

ABSTRACT A study has been carried out in 8 patients with Parkinson's disease in order to measure the growth hormone response to arginine before treatment with L-DOPA and during such treatment. A significant lowering of the HGH response was found during treatment.

GROWTH-HORMONE RESPONSE IN PARKINSON'S DISEASE

The Lancet ◽  
1976 ◽  
Vol 307 (7957) ◽  
pp. 483-484 ◽  
Author(s):  
J.D. Parkes ◽  
A.G. Debono ◽  
C.D. Marsden
Keyword(s):  
Parkinson’S Disease ◽  
Growth Hormone ◽  
Parkinson's Disease ◽  
Growth Hormone Response ◽  
Hormone Response

Psychotic and Depressive Symptoms in Parkinson's Disease a Study of the Growth Hormone Response to Apomorphine

1995 ◽  
Vol 167 (4) ◽  
pp. 522-526 ◽  
Author(s):  
John D. C. Mellers ◽  
Niall P. Quinn ◽  
Maria A. Ron
Keyword(s):  
Parkinson’S Disease ◽  
Growth Hormone ◽  
Parkinson's Disease ◽  
Depressive Symptomatology ◽  
Past History ◽  
Visual Hallucinations ◽  
Hormone Response ◽  
Receptor Sensitivity ◽  
Dopaminergic Mechanisms ◽  
History Of

BackgroundThe growth hormone (GH) response to apomorphine, thought to reflect central dopaminergic receptor sensitivity, has been reported as enhanced in acute schizophrenia. We investigated this response in relation to the psychotic episodes associated with Parkinson's disease (PD).MethodThe GH response to apomorphine was measured in three groups of patients with Parkinson's disease: those currently psychotic (n = 9), those with a past history of psychosis (n = 7) and those who had never been psychotic (n = 8).ResultsApomorphine-induced GH response was not related to psychosis but was unexpectedly associated with measures of depression.ConclusionsVisual hallucinations were a prominent feature in the psychotic patients and the atypical nature of these psychoses might explain why we found no evidence of dopaminergic sensitivity. Serotonergic dysfunction would be in keeping with this. Dopaminergic mechanisms may contribute to the minor depressive symptomatology seen in PD.

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