EVALUATION OF THYROID STATUS WITH THE "EFFECTIVE THYROXINE RATIO" (E. T. R.®)

1974 ◽  
Vol 77 (2) ◽  
pp. 250-256 ◽  
Author(s):  
Klaus Kølendorf ◽  
Kaj Siersbæk-Nielsen ◽  
Jens Mølholm Hansen ◽  
Thorkild Friis
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Free Thyroxine ◽  
Normal Range ◽  
High Positive Correlation ◽  
Function Test ◽  
Free Thyroxine Index ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

ABSTRACT A new in vitro thyroid function test, "Effective Thyroxine Ratio" (ETR®) has been tested in 170 patients, and the ETR values in patients with normal and abnormal thyroid function have been compared to the concentration of absolute free thyroxine and free thyroxine index in serum. Among 42 hyperthyroid patients tested with ETR, 13 had values within normal range (30.9 per cent). Three of 18 hypothyroid patients had normal values (16.8 per cent). Eighty-nine per cent of 27 pregnant women and all of 17 patients treated with genuine oestrogens had ETR values within normal range. A high positive correlation was found between values of ETR, absolute free thyroxine in serum (r = 0.62) and free thyroxine index (r = 0.83).

scholarly journals In vitro Thyroid Function Test as a New Indicator of Free Thyroxine

RADIOISOTOPES ◽  
1972 ◽  
Vol 21 (7) ◽  
pp. 415-422
Author(s):  
Hirofumi MORI ◽  
Kin-ichi HISADA ◽  
Atsushi ANDO
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Free Thyroxine ◽  
Function Test

The SimulTRAC FT4/TSH assay evaluated as a first-line thyroid-function test.

1988 ◽  
Vol 34 (7) ◽  
pp. 1488-1491 ◽  
Author(s):  
R K Desai ◽  
W M Deppe ◽  
R J Norman ◽  
T Govender ◽  
S M Joubert
Keyword(s):  
Thyroid Function Test ◽  
Normal Subjects ◽  
Thyroid Status ◽  
First Line ◽  
Dual Isotope ◽  
Function Test ◽  
Clinical Conditions ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
Underlying Pathology

Abstract We evaluated the SimulTRAC FT4 57Co/TSH 125I dual-isotope assay for the simultaneous measurement of free thyroxin (FT4) by radioimmunoassay analog techniques and of thyrotropin (TSH) by immunoradiometry. Inter- and intra-assay CVs were less than 10% over the entire range tested except for 15.9% at the lowest FT4 concentration. Results obtained by the SimulTRAC assay allowed complete differentiation of 85 hyperthyroid patients and 35 hypothyroid patients from normal subjects. However, such estimations of FT4 or TSH concentrations occasionally were misleading for assessing thyroid status in various clinical conditions. We conclude that the SimulTRAC assay has the same inherent disadvantages possessed by FT4 analog and TSH immunoradiometric assays; however, where results of one of the simultaneous assays may be misleading, the results provided by the other may indicate the underlying pathology without requiring an additional assay.

Pictorial reporting of multiple thyroid function results.

1976 ◽  
Vol 22 (10) ◽  
pp. 1562-1566
Author(s):  
R W Pain ◽  
B M Duncan
Keyword(s):  
Thyroid Function ◽  
Reporting System ◽  
Free Thyroxine ◽  
Thyroid Function Tests ◽  
Testing Procedures ◽  
Function Tests ◽  
Free Thyroxine Index ◽  
Total Thyroxine ◽  
Experience Difficulty

Abstract Clinicians experience difficulty in correctly interpreting the results of in vitro thyroid function tests in the presence of abnormalities of thyrobinding proteins or when results are borderline. This difficulty has been largely resolved in our laboratory by three innovations. First, the borderline areas for each of three routine tests of thyroid function (total thyroxine, thyrobinding index, and free thyroxine index) were accurately determined. Second, the results from this routine profile of three tests were displayed pictorially so as to produce patterns characteristic of various diagnostic situations, including euthyroidism in the presence of abnormalities of thyrobinding proteins. Third, interpretive comments and, in the case of borderline patterns, suggested further testing procedures were added to the report. Clinicians find the reporting system helpful and respond when additional tests are suggested. The system, operated manually at first, was later computerized.

THE UPTAKE OF 131I TRIIODOTHYRONINE BY RESIN. AN IN VITRO TEST OF THYROID FUNCTION

1961 ◽  
Vol 37 (4) ◽  
pp. 607-615 ◽  
Author(s):  
M. G. Woldring ◽  
A. Bakker ◽  
H. Doorenbos
Keyword(s):  
Thyroid Function ◽  
Plasma Sample ◽  
In Vitro Test ◽  
Red Cell ◽  
Normal Range ◽  
Cell Substrate ◽  
Vitro Test ◽  
Uptake Test ◽  
Hyperthyroid Patients

ABSTRACT A technique is described, which resembles the in vitro red cell triiodothyronine uptake test for the investigation of thyroid function, but which requires only 0.5 ml of plasma. The uptake of radio-triiodothyronine is measured by a method in which resin replaces the erythrocytes. Thus the variable of the red cell substrate is excluded. By means of the resin technique described, an uptake of 14–27 % was found in a group of 130 euthyroid subjects. Fourteen plasma samples from hyperthyroid patients were investigated, which showed an uptake range of 25–40 % (one plasma sample from this group had an uptake of 25.8, i. e. within the normal range). In one case of hypothyroidism, an uptake of 10.7 % was found. It is not yet possible to state the level of uptake below which the diagnosis of hypothyroidism should be considered. The effect of different factors like the quantity of resin, incubationtemperature and incubation-time, pH and others have been investigated. The results are discussed.

scholarly journals An in vitro Thyroid Function Test by Res-O-Mat T4 Kit

RADIOISOTOPES ◽  
1971 ◽  
Vol 20 (9) ◽  
pp. 445-451
Author(s):  
Yoshio YONAHARA ◽  
Yoshiko TAKAHARA ◽  
Hiroshi KIRIMURA ◽  
Ichiro KURAMITSU
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Function Test

scholarly journals An in vitro Thyroid Function Test by Res-O-Mat T3 Kit

RADIOISOTOPES ◽  
1970 ◽  
Vol 19 (3) ◽  
pp. 142-148
Author(s):  
Yoshio YONAHARA ◽  
Yoshiko TAKAHARA ◽  
Hiroshi KIRIMURA ◽  
Masafumi KAWATO ◽  
Ichiro KURAMITSU
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Function Test

THE "EFFECTIVE THYROXINE RATIO" – NEW IN VITRO TEST OF THYROID FUNCTION AND ITS CORRELATION WITH FREE THYROXINE

1974 ◽  
Vol 76 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Janusz Nauman ◽  
Alicja Nauman
Keyword(s):  
Pregnant Women ◽  
Normal Subjects ◽  
Free Thyroxine ◽  
In Vitro Test ◽  
High Reproducibility ◽  
Vitro Test ◽  
The Mean ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

ABSTRACT The effective thyroxine ratio (ETR) and absolute concentration of free thyroxine (AFT4) were estimated in the sera of 31 normal subjects, 27 hyperthyroid patients, 12 hypothyroid patients and 21 euthyroid pregnant women. The mean ETR value in the controls was 1.0 ± 0.18, in the hyperthyroid patients 1.31 ± 0.25, in the hypothyroid patients 0.71 ± 0.21 and in normal pregnant women 0.99 ± 0.24. The mean AFT4 in the normal subjects was 3.0 ± 0.53 ng/100 ml, in the hyperthyroid patients 9.49 ± 2.44 ng/ 100 ml, in the hypothyroid patients 0.58 ± 0.15 ng/100 ml and in the pregnant women 2.84 ± 0.63 ng/100 ml, respectively. High reproducibility of ETR and a significant positive correlation between ETR and AFT4 with r = 0.96 suggest that ETR might be a suitable in vitro test for routine clinical evaluation of the thyrometabolic state.

scholarly journals Fundamental and Clinical Evaluation of the Effective Thyroxine Ratio by Res-O-Mat ETR Test A New in vitro Thyroid Function Test

1972 ◽  
Vol 48 (9) ◽  
pp. 685-697,635
Author(s):  
Toru MORI ◽  
Tadako KOUSAKA ◽  
Satoshi HAMADA ◽  
Yosuke TAKEDA ◽  
Katsuji IKEKUBO ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Clinical Evaluation ◽  
Thyroid Function Test ◽  
Function Test
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