IMPAIRMENT OF INDUCTION OF GLYCOLYTIC ENZYMES AND DEVELOPMENT OF INSULIN RESISTANCE IN RATS AS A RESULT OF CONTINUOUS INSULIN TREATMENT

1974 ◽  
Vol 76 (2) ◽  
pp. 319-331 ◽  
Author(s):  
R. I. Salganik ◽  
N. P. Mertvetsov ◽  
O. E. Gordienko ◽  
V. N. Chesnokov ◽  
L. A. Semenova
Keyword(s):  
Blood Sugar ◽  
Pyruvate Kinase ◽  
Rna Synthesis ◽  
Insulin Treatment ◽  
Insulin Injection ◽  
Liver Cells ◽  
Immunoreactive Insulin ◽  
Electron Microscopic ◽  
Microscopic Studies

ABSTRACT It has been established that the administration of insulin to rats for 10 days results in a considerable increase of RNA synthesis as well as in the activity of hexokinase and pyruvate kinase in liver cells. Electron microscopic studies have shown that on the 6th day of insulin treatment the size of hepatocytes nucleoli and the number of free ribosomes increase. Moreover on the 10th day of treatment the glycogen content is changed in the liver cells. Following long-term insulin treatment (16–20 days) the liver cells lose their capacity to respond by enhanced RNA synthesis and by the induction of hexokinase and pyruvate kinase. It has also been demonstrated that insulin administration for 10–15 days significantly decreases blood sugar. However, continuous insulin treatment (up to 25-27 days) elevates blood sugar to values surpassing even the normal value on day 27 of treatment. The administration of insulin to rats for 25–27 days leads to a decreased tolerance to glucose load. The content of immunoreactive insulin in the blood plasma increases considerably on day 10 of insulin injection and continues to rise more sharply on subsequent days of treatment.

scholarly journals Long-term Fate of Lung Autografts Charged with Providing Total Pulmonary Function I. Light and Electron Microscopic Studies

1979 ◽  
Vol 190 (5) ◽  
pp. 648-653 ◽  
Author(s):  
FRANK J. VEITH ◽  
CHERYL M. MONTEFUSCO ◽  
SIGURD BLUMCKE ◽  
JACK W. C. HAGSTROM
Keyword(s):  
Pulmonary Function ◽  
Electron Microscopic ◽  
Microscopic Studies

Electron Microscopic Studies in Long-Term Surviving Canine Pulmonary Autotransplants1

2015 ◽  
pp. 210-217
Author(s):  
N. Lempert ◽  
J. Fulfs ◽  
R. Abraham ◽  
F. Coulston ◽  
D. A. Blumenstock
Keyword(s):  
Electron Microscopic ◽  
Microscopic Studies

scholarly journals Changing of polyethylene film structure during long-term aging

2020 ◽  
Vol 21 (1) ◽  
pp. 157-166
Author(s):  
B. P. Yatsyshyn ◽  
N. I. Domantsevich
Keyword(s):  
Surface Structure ◽  
Structure Formation ◽  
Film Structure ◽  
Electron Microscopic ◽  
Polyethylene Films ◽  
Organic Mineral ◽  
Microscopic Studies ◽  
Characteristic Features ◽  
Mineral Fillers

The study of surface structure of polyethylene films after their manufacture and later 7 years of closed storage were carried out. Electron-microscopic studies have revealed the features of the structure formation and aging processes, depending on the amount of organic and organic-mineral fillers, as well as the characteristic features of the destruction of the polymer material matrix.

scholarly journals Vapor Permeability of Thin-Film Composite Materials Based |on Polyethylene

2019 ◽  
Vol 20 (3) ◽  
pp. 291-299
Author(s):  
N. Domantsevich ◽  
B. Yatsyshyn
Keyword(s):  
Water Vapor Permeability ◽  
Storage Conditions ◽  
Vapor Permeability ◽  
Electron Microscopic ◽  
Polyethylene Matrix ◽  
Subsequent Aging ◽  
Organic Mineral ◽  
Microscopic Studies ◽  
Mineral Fillers

The study of the vapor permeability and surface structure of polyethylene films modified with organic filler (casein) and mixed organic-mineral fillers stored under closed storage conditions have been shown. Changes in diffusion characteristics are shown depending on the type and amount of filler in long-term (up to 7 years) studies. It was established that the injection into the polyethylene matrix of fillers and additives significantly changes the structure formation with long-term aging. Water vapor permeability of polyethylene film modified by fillers increases along the subsequent aging. However, the deviation of characteristics at 7 years of storage does not exceed the value of WVTR = 0.6 mg·m-2·s-1, even taking into account the small thickness of the samples, which in most cases the long-term use of such a product is permissible. Electron microscopic studies of modified films have been carried out.

Light and electron microscopic studies of phrenic nerves after long-term electrical stimulation

1983 ◽  
Vol 58 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Jung H. Kim ◽  
Elias E. Manuelidis ◽  
William W. L. Glenn ◽  
Yoshitaka Fukuda ◽  
Douglas S. Cole ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Morphological Changes ◽  
Electron Microscopic ◽  
Content Type ◽  
Bipolar Electrodes ◽  
Microscopic Studies ◽  
Phrenic Nerves ◽  
Focal Demyelination ◽  
Real Area

✓ Light and electron microscopic evaluations were carried out on canine phrenic nerves subjected to long-term electrical stimulation. A total of 34 stimulated and 19 control nerves were studied by light microscopy, and 10 stimulated and five control nerves were evaluated by electron microscopy. Except in a few cases in which a higher current was used, the current used for stimulation was between 1 and 2 mA. The pulse width was 150 µsec. The typical charge per pulse was 0.22 µC and charge density per pulse 1.125 µC/sq cm of real area. The total number of days of electrical stimulation in individual phrenic nerves ranged from 4 to 374. No morphological changes in the phrenic nerve that could be attributed to the electrical stimulation were observed by light or electron microscopic study. There were, however, two phrenic nerves cuffed with bipolar electrodes which showed focal demyelination at the electrode level, but these changes were caused by factors other than the electrical stimulation. The results of the studies have direct clinical implications to long-term stimulation of phrenic nerves.

Sign in / Sign up

Export Citation Format

Share Document