EFFECT OF THYROTROPHIN RELEASING HORMONE AND THYROID-STIMULATING HORMONE ON SERUM PROTEIN-BOUND 131I

1972 ◽  
Vol 70 (3) ◽  
pp. 454-462 ◽  
Author(s):  
Egil Haug ◽  
Harald Frey ◽  
Terje Sand
Keyword(s):  
Oral Dose ◽  
Thyroid Stimulating Hormone ◽  
Significant Rise ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Thyrotrophin Releasing Hormone ◽  
Peak Response ◽  
Releasing Hormone ◽  
Clear Dose Response ◽  
The Mean

ABSTRACT Seventeen subjects without any clinical or laboratory evidence of thyroidal or pituitary disease were given 1.0 mg thyrotrophin-releasing hormone (TRH) as a rapid iv injection 48 hours after an oral dose of 50 μCi 131I-. In all subjects there was a clear rise in serum PB131I. The elevation in the mean serum PB131I was significant (P<0.01) one hour after TRH, and the mean peak response was noted at 4 hours. It is suggested that this elevation in serum PB131I following TRH administration reflects the effect of the TSH released. In order to find the most suitable method of administration, 1.0 mg TRH was given iv, im, or as a 1 hour infusion. The maximal responses seemed to be independent of the mode of administration. Six subjects were given 3.0 mg TRH iv and 4 others 6.0 mg TRH iv. It was not possible to demonstrate a clear dose-response relationship. In five subjects the serum PB127I and the serum PB131I were measured at the same times following administration of TRH. This showed that the serum PB131I was a more sensitive index of TSH release than the serum PB127I. Twenty-four hours after the TRH injection the same subjects were given 5 IU TSH as a rapid iv or im injection. All subjects responded with a significant rise in serum PB131I. In the subjects who did not respond to TRH the response to TSH allows the differentiation between pituitary and thyroid disease.

Thyroid-Stimulating Hormone and Prolactin Responses to Thyrotropin-Releasing Hormone in Common Migraine

Cephalalgia ◽  
1987 ◽  
Vol 7 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Giovanni Murialdo ◽  
Paola Masturzo ◽  
Ugo Filippi ◽  
Diego De Palma ◽  
Daniela Balbi ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Dose Response ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Healthy Controls ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Releasing Hormone ◽  
The One ◽  
Stimulating Hormone

Intravenous administration of 50 μg or 200 μg thyrotropin-releasing hormone (TRH) to men with common migraine elicited blunted prolactin (PRL) responses, when compared with healthy controls. The thyroid-stimulating hormone (TSH) response was enhanced after 50 μg TRH in the migraineurs, but not after 200 μg. The physiologic TSH dose-response relationship was abolished in migraine sufferers. The data may be interpreted in the light of dopaminergic and noradrenergic supersensitivity, for PRL and TSH, respectively. The TSH response in migraine differs from the one that occurs in depression.

SERUM THYROTROPHIN AND THE RESPONSE TO THYROTROPHIN RELEASING HORMONE IN SYMPTOMLESS AUTOIMMUNE THYROIDITIS AND IN BORDERLINE AND OVERT HYPOTHYROIDISM

1974 ◽  
Vol 75 (2) ◽  
pp. 274-285 ◽  
Author(s):  
A. Gordin ◽  
P. Saarinen ◽  
R. Pelkonen ◽  
B.-A. Lamberg
Keyword(s):  
Autoimmune Thyroiditis ◽  
Elevated Serum ◽  
Mean Value ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Mean ◽  
The Individual ◽  
Serum Tsh

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

RESPONSE OF NORMAL, HYPOTHYROID AND HYPOTHALAMO-PITUITARY INSUFFICIENT CHILDREN TO SYNTHETIC THYROTROPHIN-RELEASING HORMONE

1971 ◽  
Vol 51 (3) ◽  
pp. 483-488 ◽  
Author(s):  
G. MILHAUD ◽  
P. RIVAILLE ◽  
M. S. MOUKHTAR ◽  
E. BINET ◽  
J. C. JOB
Keyword(s):  
Time Course ◽  
Solid Phase ◽  
Thyroid Stimulating Hormone ◽  
Normal Children ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Tsh Secretion ◽  
Course Changes ◽  
Serum Tsh ◽  
Tsh Deficiency

SUMMARY Thyrotrophin-releasing hormone (TRH) was synthesized by the solid phase technique, administered to 13 children, and the time-course changes in the serum level of thyroid-stimulating hormone (TSH) assessed. In eight normal children, peak levels of TSH occurred 20 min after the injection, and circulating TSH remained significantly raised for 60 min. In three hypothyroid children, the increase in serum TSH was much greater than in normal children, suggesting the existence of large pituitary TSH stores. In two hypopituitary children with TSH deficiency, TSH reserves seemed normal. One of these patients had a craniopharyngioma; after operation, the increase in serum TSH was reduced. These results show that assay of serum TSH after administration of synthetic TRH provides a test which distinguishes pituitary from hypothalamic defects affecting TSH secretion.

Luteinizing hormone responses to luteinizing hormone releasing hormone (LHRH) in acute mania and the effects of lithium on LHRH and thyrotrophin releasing hormone tests in volunteers

1989 ◽  
Vol 19 (1) ◽  
pp. 69-77 ◽  
Author(s):  
R. Hunter ◽  
J. E. Christie ◽  
L. J. Whalley ◽  
J. Bennie ◽  
S. Carroll ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Thyroid Stimulating Hormone ◽  
Thyrotrophin Releasing Hormone ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Trh Stimulation ◽  
The Status ◽  
Hormone Responses ◽  
Independent Features ◽  
Stimulating Hormone

SynopsisThe endocrine responses to Luteinizing Hormone Releasing Hormone (LHRH) of eight drug-free males with mania were determined. Basal levels of Luteinizing Hormone (LH) and the plasma levels following injection of LHRH were elevated in patients compared with controls; Follicle Stimulating Hormone (FSH) and testosterone were not different. Elevated levels of LH have been described previously in recovered manic patients and have been suggested to be state-independent features of mania. In order to clarify the status of this finding, the effects of lithium administration upon hormone responses to LHRH in six male volunteers were also investigated, together with the effects upon Thyrotrophin Releasing Hormone (TRH) stimulation of Thyroid Stimulating Hormone (TSH) and prolactin release. Lithium increased the basal levels of LH and levels after injection of LHRH without effect upon FSH and testosterone. Lithium also increased basal and TRH stimulated release of TSH and basal prolactin levels. Lithium was without effect upon prolactin responses to TRH. The results are discussed in relation to current information on the mechanism of lithium's action. The implications for neuroendocrine work on recovered patients taking lithium are also explored.

Physiological roles of thyrotrophin-releasing hormone and vasoactive intestinal peptide on the pulsatile secretory patterns of prolactin in pituitary-grafted female rats

1994 ◽  
Vol 142 (3) ◽  
pp. 581-586 ◽  
Author(s):  
A Lafuente ◽  
J Marcó ◽  
A I Esquifino
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Prolactin Secretion ◽  
Female Rats ◽  
Thyrotrophin Releasing Hormone ◽  
Mean Values ◽  
Pulsatile Secretion ◽  
Releasing Hormone ◽  
Absolute Amplitude ◽  
The Mean ◽  
The Absolute

Abstract Much is known about the fact that thyrotrophin-releasing hormone (TRH) and vasoactive intestinal peptide (VIP) stimulate prolactin secretion but areas of uncertainty remain. This work was undertaken to describe the effects of TRH and VIP on the pulsatile secretion pattern of prolactin, in adult sham-operated and pituitary-grafted hyperprolactinaemic female rats. Two pulses of TRH (1 μg/rat) or one pulse of VIP (20 μg/rat) were given 60 or 120 min after the period of blood sampling. Pituitary grafting increased the mean values of prolactin, absolute amplitude and duration of the peaks and decreased their frequency, compared with control animals. In sham-operated rats, TRH elevated prolactin levels by increasing the absolute and relative amplitudes and duration of the pulses, along with a decrease in their frequency. No priming effects of TRH were observed in this study. Hyperprolactinaemia blunted TRH effects on the pulsatile secretion pattern of prolactin. In sham-operated rats, VIP administration increased the absolute and relative amplitudes of the prolactin peaks. None of the other parameters studied were changed. In pituitary-grafted animals, VIP administration increased the absolute and relative amplitudes of the prolactin peaks but to a lesser extent compared with controls. These data suggest that TRH and VIP affect prolactin pulsatility differentially. The effects of TRH and VIP were blunted to some extent by exposure to previously elevated circulating prolactin levels. Journal of Endocrinology (1994) 142, 581–586

scholarly journals Outbreak of trichinellosis in Cáceres, Spain, December 2001–February 2002

2002 ◽  
Vol 7 (10) ◽  
pp. 136-138 ◽  
Author(s):  
M Cortés-Blanco ◽  
A García-Cabañas ◽  
F Guerra-Peguero ◽  
J- M Ramos-Aceitero ◽  
D Herrera-Guibert ◽  
...  
Keyword(s):  
Incubation Period ◽  
Dose Response ◽  
Attack Rate ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Domestic Pig ◽  
Trichinella Britovi ◽  
The Mean ◽  
Cooked Meat

An outbreak of trichinellosis by T. britovi occured in Cáceres, Spain, between 18 December 2001 and 11 February 2002, following the consumption of insufficiently cooked meat from a domestic pig. Among the 56 people exposed, 26 cases of trichinellosis were diagnosed, of which 17 serologically confirmed. The mean incubation period was 23.5 days (3–45). Among the foodstuffs suspected, salami-type sausages were associated with an attack rate of 93.3% (14/15), and a dose-response relationship was observed. Trichinella britovi is essentially a sylvatic species, but this study suggests a change in the epidemiology of trichinellosis.

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