SERUM THYROXINE DETERMINATION BY SATURATION ANALYSIS: A NEW METHOD AND STATISTICAL APPROACH

1971 ◽  
Vol 68 (3) ◽  
pp. 431-444 ◽  
Author(s):  
A. Burger ◽  
J. R. Scherrer ◽  
B. Miller ◽  
M. B. Vallotton

ABSTRACT A new method for the measurement of total serum thyroxine (T4) by saturation analysis is presented along with technical details. Its main advantage over previously published methods is its sensitivity of 0.3 picomoles T4 (corresponding to 0.23 ng T4 or 152 pg iodine). It thus allows the measurement of serum thyroxine in very small volumes of human serum (7 μl) and, for the first time, in mouse serum. The use of Sephadex to extract thyroxine from the plasma gives more reproducible results and avoids the need to evaporate the extract to dryness, as in current methods. A high speed digital computer was used for handling data processing. A new statistical algorithm was built into a code called REGSAT which is extensively described. This procedure allowed unskewed predictions of thyroxine levels in the samples and an estimate of the standard curves resolving power.

Geophysics ◽  
1969 ◽  
Vol 34 (3) ◽  
pp. 480-483
Author(s):  
K. Biesheuvel

The following comments on this new method indicate some limitations of the technique as well as a more practical means of solving the equations involved by high‐speed digital computer.


Eng ◽  
2022 ◽  
Vol 3 (1) ◽  
pp. 27-41
Author(s):  
Michael V. Vesnik

The paper formulates the foundations of a recently developed approach, named the method of fundamental components, intended for constructing heuristic solutions in problems of electromagnetic diffraction, for the first time. The difference between the new method and the known heuristic approaches lies in the application of an adjustment procedure that increases the accuracy. The possibility of the mentioned method for obtaining new results is illustrated with the help of the author’s previously published works. The advantages of the new method in constructing high-speed solvers and in the physical interpretation of numerical solutions are shown.


Author(s):  
Zhanfeng Zhao ◽  
Dong Zhang ◽  
Zhiquan Zhou
Keyword(s):  

2018 ◽  
Vol 15 (1) ◽  
pp. 21-33
Author(s):  
Ying Wei ◽  
Yongqiao Liu ◽  
Yifan Hele ◽  
Weiwei Sun ◽  
Yang Wang ◽  
...  

Background: Gentianella acuta (Michx.) Hulten is an important type of medicinal plant found in several Chinese provinces. It has been widely used in folk medicine to treat various illnesses. However, there is not enough detailed information about the chemical constituents of this plant or methods for their content determination. Objective: The focus of this work is the isolation and characterization of the major chemical constituents of Gentianella acuta, and developing an analytical method for their determination. Methods: The components of Gentianella acuta were isolated using (1) ethanol extraction and adsorption on macroporous resin. (2) and ethyl acetate extraction and high speed countercurrent chromatography. A HPLC-DAD method was developed using a C18 column and water-acetonitrile as the mobile phase. Based on compound polarities, both isocratic and gradient elution methods were developed. Results: A total of 29 compounds were isolated from this plant, of which 17 compounds were isolated from this genus for the first time. The main components in this plant were found to be xanthones. The HPLC-DAD method was developed and validated for their determination, and found to show good sensitivity and reliability. Conclusion: The results of this work add to the limited body of work available on this important medicinal plant. The findings will be useful for further investigation and development of Gentianella acuta for its valuable medicinal properties.


1991 ◽  
Vol 148 ◽  
pp. 205-206 ◽  
Author(s):  
A. Krabbe ◽  
J. Storey ◽  
V. Rotaciuc ◽  
S. Drapatz ◽  
R. Genzel

Images with subarcsec spatial resolution in the light of near-infrared atomic (Bry) and molecular hydrogen H2 (S(1) v=1-0) emission lines were obtained for some extended, pointlike objects in the Large Magellanic Cloud (LMC) for the first time. We used the Max-Planck-Institut für extraterrestrische Physik (MPE) near-infrared array spectrometer FAST (image scale 0.8”/pix, spectral resolving power 950) at the ESO/MPI 2.2m telescope, La Silla. We present some results on the 30-Dor complex and N159A5.


2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Erik Buhmann ◽  
Sascha Diefenbacher ◽  
Engin Eren ◽  
Frank Gaede ◽  
Gregor Kasieczka ◽  
...  

AbstractAccurate simulation of physical processes is crucial for the success of modern particle physics. However, simulating the development and interaction of particle showers with calorimeter detectors is a time consuming process and drives the computing needs of large experiments at the LHC and future colliders. Recently, generative machine learning models based on deep neural networks have shown promise in speeding up this task by several orders of magnitude. We investigate the use of a new architecture—the Bounded Information Bottleneck Autoencoder—for modelling electromagnetic showers in the central region of the Silicon-Tungsten calorimeter of the proposed International Large Detector. Combined with a novel second post-processing network, this approach achieves an accurate simulation of differential distributions including for the first time the shape of the minimum-ionizing-particle peak compared to a full Geant4 simulation for a high-granularity calorimeter with 27k simulated channels. The results are validated by comparing to established architectures. Our results further strengthen the case of using generative networks for fast simulation and demonstrate that physically relevant differential distributions can be described with high accuracy.


2021 ◽  
Vol 11 (13) ◽  
pp. 5787
Author(s):  
Toan-Thang Vu ◽  
Thanh-Tung Vu ◽  
Van-Doanh Tran ◽  
Thanh-Dong Nguyen ◽  
Ngoc-Tam Bui

The measurement speed and measurement accuracy of a displacement measuring interferometer are key parameters. To verify these parameters, a fast and high-accuracy motion is required. However, the displacement induced by a mechanical actuator generates disadvantageous features, such as slow motion, hysteresis, distortion, and vibration. This paper proposes a new method for a nonmechanical high-speed motion using an electro-optic modulator (EOM). The method is based on the principle that all displacement measuring interferometers measure the phase change to calculate the displacement. This means that the EOM can be used to accurately generate phase change rather than a mechanical actuator. The proposed method is then validated by placing the EOM into an arm of a frequency modulation interferometer. By using two lock-in amplifiers, the phase change in an EOM and, hence, the corresponding virtual displacement could be measured by the interferometer. The measurement showed that the system could achieve a displacement at 20 kHz, a speed of 6.08 mm/s, and a displacement noise level < 100 pm//√Hz above 2 kHz. The proposed virtual displacement can be applied to determine both the measurement speed and accuracy of displacement measuring interferometers, such as homodyne interferometers, heterodyne interferometers, and frequency modulated interferometers.


Author(s):  
Scott M Croom ◽  
Matt S Owers ◽  
Nicholas Scott ◽  
Henry Poetrodjojo ◽  
Brent Groves ◽  
...  

Abstract We have entered a new era where integral-field spectroscopic surveys of galaxies are sufficiently large to adequately sample large-scale structure over a cosmologically significant volume. This was the primary design goal of the SAMI Galaxy Survey. Here, in Data Release 3 (DR3), we release data for the full sample of 3068 unique galaxies observed. This includes the SAMI cluster sample of 888 unique galaxies for the first time. For each galaxy, there are two primary spectral cubes covering the blue (370–570 nm) and red (630–740 nm) optical wavelength ranges at spectral resolving power of R = 1808 and 4304 respectively. For each primary cube, we also provide three spatially binned spectral cubes and a set of standardized aperture spectra. For each galaxy, we include complete 2D maps from parameterized fitting to the emission-line and absorption-line spectral data. These maps provide information on the gas ionization and kinematics, stellar kinematics and populations, and more. All data are available online through Australian Astronomical Optics (AAO) Data Central.


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