OESTROGEN – ANTI-OESTROGEN INTERACTION: EFFECT OF U11100A, MRL-41 (CLOMIPHENE) AND U11555A ON OESTROGEN INDUCED UTERINE GLYCOGEN AND PROTEIN SYNTHESIS IN THE RAT DURING DELAYED IMPLANTATION

1969 ◽  
Vol 62 (3) ◽  
pp. 489-497 ◽  
Author(s):  
Suresh Mohla ◽  
M. R. N. Prasad
Keyword(s):  
Protein Synthesis ◽  
Comparative Study ◽  
Interaction Effect ◽  
Mode Of Action ◽  
Biochemical Changes ◽  
Delayed Implantation ◽  
Receptor Sites ◽  
Made In

ABSTRACT A comparative study of three non-steroidal anti-oestrogens (a dihydronaphthalene, UlllOOA; a diphenylindene derivative, U-11555A and MRL-41 (clomiphene) was made in order to study their mode of action and their interaction with oestrogen induced biochemical changes in the uterus. Pretreatment with UlllOOA, clomiphene or U11555A effectively blocked the oestrogen induced increase in uterine glycogen and protein synthesis. However, all the three compounds tested were found to be uterotrophic; clomiphene also increased uterine glycogen while U11555A showed a transient oestrogenic action in increasing uterine protein. Clomiphene and U11100A have been shown to inhibit the uptake of oestrogen at the receptor sites. Our results may be interpreted as indicating that pretreatment with these compounds (U11100A, clomiphene or U11555A) blocked the uterine receptor sites in such a manner so as to render ineffective the action of oestrogen administered subsequently.

On white marble half-lotus meditation statues carved in Wuding Era of the Eastern Wei Dynasty

2019 ◽  
Vol 19 (1) ◽  
pp. 182-194
Author(s):  
Hyun-Sook So
Keyword(s):  
New York ◽  
Comparative Study ◽  
Metropolitan Museum ◽  
White Marble ◽  
City Area ◽  
Metropolitan Museum Of Art ◽  
Right Hand ◽  
Second Year ◽  
Made In ◽  
Wei Dynasty

Abstract In 2012, large amounts of white marble Buddhist statues of the Eastern Wei and Northern Qi Dynasties were unearthed from the Buddhist sculpture hoard at Bei Wuzhuang in Ye City Site. This paper makes a comparative study on a bodhisattva statue in meditation seated in half-lotus posture (resting right ankle on the knee of pendent left leg and holding right hand upward) among them and another sculpture of the same type and made in the same period unearthed at the Xiude Monastery site in Dingzhou; from the double-tree, stupa and coiling dragon designs shown by them, this paper explores the commonalities and differences of the Buddhist arts in these two areas. Moreover, this paper reveals that this motif emerged earlier in the Ye City area than in the Dingzhou area, and diffused to the latter after it became popular in the Ye City area. By these conclusions, this paper infers that the white marble meditating statue seated in half-lotus position with the date of the second year of Wuding Era (544 CE) in the collection of the Metropolitan Museum of Art in New York, USA was produced in Ye City area.

scholarly journals A comparative study of Pleurosigma subrectum and P. acus (Bacillariophyta)

Phytotaxa ◽  
2015 ◽  
Vol 207 (3) ◽  
pp. 273
Author(s):  
FRITHJOF A.S. STERRENBURG ◽  
STUART R. STIDOLPH ◽  
EUGENIA A. SAR ◽  
Ines Sunesen
Keyword(s):  
Comparative Study ◽  
Original Data ◽  
Type Material ◽  
Diatom Species ◽  
Morphological Differences ◽  
Sem Investigation ◽  
Made In

In continuation of an earlier paper on Pleurosigma species with an (almost) non-sigmoid valve and raphe sternum, a comparative study was made in LM and SEM of Pleurosigma subrectum and P. acus. For P. subrectum, slides and a subsample of the type material were examined. For P. acus no unmounted material permitting SEM investigation is extant; a sample containing specimens fully matching the type in LM was therefore used as epitype material for SEM. The original data on striation of P. acus are emended. No morphological differences indicating separate specific status of these two taxa were observed and P. acus is therefore here designated a heterotypic synonym of P. subrectum. From the data now available, this is a very widely distributed species. The study demonstrates the indispensable role of collections for investigations on the diversity and distribution of diatom species.

A comparative study of teleconsultations versus face-to-face consultations

2001 ◽  
Vol 7 (5) ◽  
pp. 257-265 ◽  
Author(s):  
E J Nordal ◽  
D Moseng ◽  
B Kvammen ◽  
M-L Løchen
Keyword(s):  
General Practitioner ◽  
Comparative Study ◽  
Complete Agreement ◽  
Patient Relationship ◽  
Doctor Patient Relationship ◽  
Partial Agreement ◽  
Face To Face ◽  
High Degree ◽  
Made In

We compared the diagnoses made by one dermatologist via telemedicine with those of another dermatologist made in a face-to-face consultation. The patients first underwent a teledermatology consultation and then a face-to-face consultation. A general practitioner was present with the patient in the videoconference studio. Videoconferencing equipment connected at 384 kbit/s was used. The doctor-patient relationship and the satisfaction of the patients and dermatologists in the two settings were assessed, as well as technical conditions during the videoconferences. There were 121 patients, with a mean age of 40 years (range 17-82 years). There was a high degree of concordance between the two sets of diagnoses, with 72% complete agreement and 14% partial agreement between the two dermatologists. A total of 116 patients (96% of those included) completed a questionnaire. Both the patients and the dermatologists were in general satisfied with the videoconferences. Videoconferencing with a participating general practitioner may be useful in dermatology, but the technique should be used only for selected patients.

Comparative study of some applications made in the Vue.js and React.js frameworks

2021 ◽  
Author(s):  
Cornelia Mihaela Novac ◽  
Ovidiu Constantin Novac ◽  
Raluca Marina Sferle ◽  
Mircea Ioan Gordan ◽  
Gyongyi Bujdoso ◽  
...  
Keyword(s):  
Comparative Study ◽  
Made In

The initial synthesis of haemoglobin in de-embryonated chick blastoderms.

Development ◽  
1964 ◽  
Vol 12 (4) ◽  
pp. 609-619
Author(s):  
Anna Hell
Keyword(s):  
Protein Synthesis ◽  
Deoxyribonucleic Acid ◽  
Primitive Streak ◽  
Specific Protein ◽  
In Vitro System ◽  
Embryonic Tissues ◽  
Different Types ◽  
Excellent Tool ◽  
Made In

Enormous progress has been made in the last few years towards the elucidation of the mechanism of protein synthesis, and great interest is centred on the steps leading to cellular differentiation and specific protein synthesis. We know that genetic information is passed on from one generation of cells to the next by deoxyribonucleic acid (DNA), and that this material directs all protein synthesis by the intermediary of the different types of ribonucleic acid (RNA). A simple in vitro system described by O'Brien (1959) seemed to offer an excellent tool for the study of the differentiation of the blood islands, and the initial formation of a well-known protein, haemoglobin (Hb), in chick embryonic tissues. After de-embryonation, chick blastoderms, from the stage of primitive streak onwards, can be cultured in vitro on a saline agar medium supplemented with glucose.

Processing of the precursor to a chloroplast ribosomal protein made in the cytosol occurs in two steps, one of which depends on a protein made in the chloroplast

1985 ◽  
Vol 5 (5) ◽  
pp. 1093-1099
Author(s):  
R J Schmidt ◽  
N W Gillham ◽  
J E Boynton
Keyword(s):  
Molecular Weight ◽  
Protein Synthesis ◽  
Ribosomal Protein ◽  
Apparent Molecular Weight ◽  
Protein L ◽  
Mature Form ◽  
Chloroplast Protein Synthesis ◽  
Made In

In pulse-chase experiments in which log-phase cells of Chlamydomonas reinhardtii were labeled in vivo for 5 min with H2(35)SO4, fluorographs of immunoprecipitates from whole cell extracts revealed that chloroplast ribosomal proteins L-2, L-6, L-21, and L-29, which are made in the cytosol and imported, appeared in their mature forms. However, in the case of chloroplast ribosomal protein L-18, which is also made in the cytoplasm and imported, a prominent precursor with an apparent molecular weight of 17,000 was found at the end of a 5-min pulse. This precursor was processed to its mature size (apparent molecular weight of 15,500) within the first 5 min of the subsequent chase. As determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the precursor to L-18 formed in vivo was 1.5 kilodaltons smaller than the primary product detected in translations of Chlamydomonas polyadenylated RNA in vitro. Upon a 10-min incubation with a postribosomal supernatant from Chlamydomonas, the 18,500-dalton precursor detected in vitro could be partially converted into a polypeptide that comigrated with the 17,000-dalton precursor detected in extracts of cells labeled in vivo. Under conditions in which the total amounts of chloroplast proteins had been reduced and cells were made to synthesize ribosomes rapidly, the apparent half-life of the 17,000-dalton precursor was extended over that seen in log-phase cells. When chloroplast protein synthesis was inhibited with lincomycin for 3 h before labeling under these conditions, the 17,000-dalton L-18 precursor but not the mature form was found, and the precursor was slowly degraded during a 60-min chase. When cells were placed in the dark for 3 h before labeling, processing of this precursor to the mature form appeared unaffected, but the chloroplast-synthesized ribosomal protein L-26 was detected, indicating that chloroplast protein synthesis was still occurring. We interpret these results to indicate that the maturation of protein L-18 in vivo involves at least two processing steps, one of which depends on a protein made on chloroplast ribosomes.

scholarly journals Addressing Poverty in Sudan and Malaysia: A Story of Success and Constraints

2016 ◽  
Vol 9 (2) ◽  
pp. 206
Author(s):  
Hillo Abdelatti ◽  
Yasin Elhadary ◽  
Narimah Samat
Keyword(s):  
Comparative Study ◽  
World Bank ◽  
Poverty Line ◽  
Decision Makers ◽  
The Political ◽  
Political Will ◽  
Muslim Countries ◽  
National Governments ◽  
Desk Review ◽  
Made In

Sudan and Malaysia have shown some socio-economic similarities especially when it comes to the issue of addressing poverty. After independence, almost half of the entire population of both countries were living under poverty line. The successive national governments in both countries have embarked on eliminating the extreme poverty. The aim of this paper is to highlight the policies and programmes adopted and implemented by policymakers in both countries in addressing poverty. The overall objective is to uncover the secret of the success and constraints faced both countries in addressing poverty. To achieve such objective, the paper based mainly on a desk review of recent documents and review of some recent researches' result. The paper has come out with that the similarities between both countries manifested itself in that both are classified as Muslim countries, have an agricultural background, inherited the same legacy as been colonized by British, their communities consist of various ethnic groups and minorities with sharp spatial and ethnic inequalities in income and social class. Despite these, Malaysia has succeeded in reducing poverty from over fifty 52.4% in 1970 to around one per cent 1.2 % in 2015, while less progress has been made in side of Sudan. Moreover, unlike Sudan, Malaysia has managed to achieve the MDGs goals in halving a head before the time determined, while Sudan has long way and it seems impossible to fulfil such objective even after 2015. Our findings have shown that, formulated home-grown policies, rejecting imposed policies by international institutions (World Bank), availability and accessibility of up to date poverty data, ability to implement policies and above all the political will are the main drivers behind the secret of success in the side of Malaysia and vice versa for Sudan. Sudan like other countries has to follow the Malaysia model if the decision makers are serious in eliminating poverty. This paper may contribute to the on-going discussion on poverty and open rooms for more comparative study between nations. Comparative study will help the planners in formulating rational policy, benefitting from exchanging ideas and learning from each.

scholarly journals The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes

1988 ◽  
Vol 254 (1) ◽  
pp. 39-44 ◽  
Author(s):  
R Hertz ◽  
J Bar−Tana
Keyword(s):  
Protein Synthesis ◽  
Carboxylic Acids ◽  
Mode Of Action ◽  
Biological Effects ◽  
Rat Hepatocytes ◽  
Protein Adducts ◽  
Cultured Rat Hepatocytes ◽  
Acylated Proteins ◽  
Dose Dependent ◽  
Protein Acylation

Three xenobiotic amphipathic carboxylates, namely MEDICA 16, nafenopin and bezafibrate, which differ remarkably in their hydrophobic backbones, were found to acylate membrane and cytosolic liver proteins in cultured rat hepatocytes. The acylation patterns observed were time- and dose-dependent, and the acylated residue consisted of the original xenobiotic. The acylation patterns generated by the three xenobiotic carboxylates included common proteins which were acylated by the three xenobiotics (e.g. proteins of 32, 52, 56 and 72 kDa) as well as unique proteins which were specifically acylated by the respective xenobiotics. The acylation of liver proteins by either MEDICA 16 or nafenopin remained unaffected under conditions where protein synthesis was completely inhibited by cycloheximide. Protein acylation thus offers a common mode of action of xenobiotic amphipathic carboxylates, which may, however, result in diverse xenobiotyl-protein adducts. The xenobiotyl-acylated proteins might be involved in triggering some of the biological effects exerted by xenobiotic amphipathic carboxylates employed as hypolipidaemic effectors, peroxisomal proliferators or preadipocyte convertors.

Sign in / Sign up

Export Citation Format

Share Document