DER GEHALT AN CHORIALEM GONADOTROPIN IM FRUCHTWASSER WÄHREND NORMALER UND PATHOLOGISCHER SCHWANGERSCHAFT

1969 ◽  
Vol 61 (2) ◽  
pp. 369-377 ◽  
Author(s):  
P. Berle
Keyword(s):  
Diabetes Mellitus ◽  
Amniotic Fluid ◽  
Umbilical Artery ◽  
Umbilical Vein ◽  
Substantial Decrease ◽  
Relative Constant

ABSTRACT HCG is measured in the amniotic fluid, in the plasma of the umbilical vein and of the umbilical artery. The values are as 3:1.5:1. From the 9th week of gestation onwards appears a striking rise in the HCG concentration in the amniotic fluid reaching peak values around the 13th week. This peak is followed by a substantial decrease reaching relative constant and low values, which are sustained until the 40th week. The HCG reaches the amniotic fluid by transamnial or transchorial way. Only small amounts come from the foetus. The increased HCG concentration in the amniotic fluid and in the blood of the umbilical vein in severe erythroblastosis and in diabetes mellitus could be caused by an increased production of HCG in the placenta and/or by a decreased inactivation of HCG by means of the foetus.

scholarly journals Retinol transport proteins and concentrations in human amniotic fluid, placenta, and fetal and maternal sera

1985 ◽  
Vol 54 (3) ◽  
pp. 577-583 ◽  
Author(s):  
D. Sklan ◽  
I. Shalit ◽  
N. Lasebnik ◽  
Z. Spirer ◽  
Y. Weisman
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Umbilical Artery ◽  
Protein Complexes ◽  
Binding Protein ◽  
Umbilical Vein ◽  
Retinol Binding Protein ◽  
Human Amniotic Fluid ◽  
Maternal Circulation ◽  
Plasma Retinol

1. The proteins binding retinol, and retinol concentrations, were determined in amniotic fluid, placental cytosol and in the fetal and maternal circulation.2. In non-pregnant women, plasma retinol was almost exclusively found in a transthyretin-retinol-binding-protein complex whereas, in pregnant women, retinol-binding-protein-bound retinol was observed not complexed to transthyretin. This latter fraction increased in concentration with fetal age. These two fractions were the major retinol-protein complexes in amniotic fluid and their relative amounts changed with progress of gestation.3. In fetal blood both of these fractions were again found, with higher proportions of retinol-binding- protein-bound retinol in the umbilical artery than in the umbilical vein.

Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor

2010 ◽  
Vol 121 (3-5) ◽  
pp. 594-610 ◽  
Author(s):  
Martin Hill ◽  
Antonín Pařízek ◽  
Radmila Kancheva ◽  
Michaela Dušková ◽  
Marta Velíková ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Preterm Labor ◽  
Umbilical Artery ◽  
Umbilical Vein

Increase in the concentration of immunoreactive endothelin in human pregnancy

1991 ◽  
Vol 129 (2) ◽  
pp. 301-307 ◽  
Author(s):  
I. Iwata ◽  
T. Takagi ◽  
K. Yamaji ◽  
O. Tanizawa
Keyword(s):  
Detection Limit ◽  
Amniotic Fluid ◽  
Vaginal Delivery ◽  
Umbilical Artery ◽  
Umbilical Vein ◽  
Plasma Concentrations ◽  
Late Pregnancy ◽  
Maternal Plasma ◽  
Fetal Plasma ◽  
The Mean

ABSTRACT Maternal plasma concentrations of immunoreactive endothelin (ir-ET) during pregnancy, labour and after birth were measured by radioimmunoassay. Concentrations of ir-ET in the umbilical artery, umbilical vein, amniotic fluid and neonatal urine were also examined. The mean (± s.e.m.) plasma ir-ET concentration in early pregnancy (4–7 weeks) was 13·7±0·5 pmol/l, which was significantly higher than that in non-pregnant women (5·9±0·3 pmol/l). During pregnancy, plasma ir-ET concentrations gradually decreased to a minimum of 11·5±0·4 pmol/l in weeks 20–23, and then increased again towards term (12·5±0·4 pmol/l after 36 weeks of pregnancy). In women undergoing vaginal delivery, the mean plasma ir-ET concentration (17·1±0·7 pmol/l) increased significantly, compared with that in late pregnancy. After delivery, the plasma ir-ET concentration decreased abruptly to 4·0±0·2 pmol/l on the first day. Plasma ir-ET concentrations in umbilical vessels were significantly higher than those in maternal plasma. In addition, concentrations in the umbilical artery were significantly higher than those in the umbilical vein in cases of vaginal delivery. Concentrations of ir-ET in amniotic fluid were much higher than those in maternal or fetal plasma. ir-ET concentrations in neonatal urine on day 1 after birth were below the detection limit (< 0·1 pmol/l) by radioimmunoassay in 70% of the cases examined but on day 5 after birth ir-ET was present at measurable concentrations in all cases. It is suggested that endothelin may act as a circulating hormone during pregnancy and labour in both maternal and fetal circulations. Journal of Endocrinology (1991) 129, 301–307

Semiquantitative Assessment of Amniotic Fluid Among Individuals With and Without Diabetes Mellitus

2021 ◽  
Author(s):  
Matthew J. Bicocca ◽  
Emma J. Qureshey ◽  
Suneet P. Chauhan ◽  
Edgar Hernandez‐Andrade ◽  
Baha M. Sibai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Amniotic Fluid ◽  
Semiquantitative Assessment

scholarly journals Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women´s Weight: Possible Impact on Feto-Placental Vascular Function

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 506 ◽  
Author(s):  
Susana Contreras-Duarte ◽  
Lorena Carvajal ◽  
María Jesús Garchitorena ◽  
Mario Subiabre ◽  
Bárbara Fuenzalida ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vascular Function ◽  
Plasma Cholesterol ◽  
Umbilical Vein ◽  
Maternal Plasma ◽  
Maternal Weight ◽  
Cholesterol Levels ◽  
The Impact

Gestational diabetes mellitus (GDM) associates with fetal endothelial dysfunction (ED), which occurs independently of adequate glycemic control. Scarce information exists about the impact of different GDM therapeutic schemes on maternal dyslipidemia and obesity and their contribution to the development of fetal-ED. The aim of this study was to evaluate the effect of GDM-treatments on lipid levels in nonobese (N) and obese (O) pregnant women and the effect of maternal cholesterol levels in GDM-associated ED in the umbilical vein (UV). O-GDM women treated with diet showed decreased total cholesterol (TC) and low-density lipoproteins (LDL) levels with respect to N-GDM ones. Moreover, O-GDM women treated with diet in addition to insulin showed higher TC and LDL levels than N-GDM women. The maximum relaxation to calcitonin gene-related peptide of the UV rings was lower in the N-GDM group compared to the N one, and increased maternal levels of TC were associated with even lower dilation in the N-GDM group. We conclude that GDM-treatments modulate the TC and LDL levels depending on maternal weight. Additionally, increased TC levels worsen the GDM-associated ED of UV rings. This study suggests that it could be relevant to consider a specific GDM-treatment according to weight in order to prevent fetal-ED, as well as to consider the possible effects of maternal lipids during pregnancy.

UMBILICAL VESSEL ANGIOCARDIOGRAPHY IN THE NEWBORN INFANT

PEDIATRICS ◽  
1963 ◽  
Vol 31 (6) ◽  
pp. 946-951
Author(s):  
Samuel O. Sapin ◽  
Leonard M. Linde ◽  
George C. Emmanouilides
Keyword(s):  
Newborn Infant ◽  
Umbilical Artery ◽  
Umbilical Vein ◽  
Newborn Infants ◽  
Umbilical Vessel ◽  
Accurate Interpretation ◽  
Sick Newborn

Angiocardiography from an umbilical vessel approach was performed in 10 critically sick newborn infants. The umbilical vein route was successfully employed up to the eighth day of life, while the umbilical artery was safely used as late as age 5 days. This approach has advantages over other methods of catheterization and angiocardiography. Angiocardiographic quality was satisfactory for accurate interpretation.

scholarly journals Downregulation of the Netrin-1 Receptor UNC5b Underlies Increased Placental Angiogenesis in Human Gestational Diabetes Mellitus

2019 ◽  
Vol 20 (6) ◽  
pp. 1408 ◽  
Author(s):  
Catalina Prieto ◽  
Bárbara Casas ◽  
Paulina Falcón ◽  
Andrea Villanueva ◽  
Pablo Lois ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Molecular Mechanisms ◽  
Umbilical Vein ◽  
Trophic Factors ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Placental Angiogenesis

Gestational diabetes mellitus (GDM) is a common metabolic disorder, defined by high blood glucose levels during pregnancy, which affects foetal and post-natal development. However, the cellular and molecular mechanisms of this detrimental condition are still poorly understood. A dysregulation in circulating angiogenic trophic factors, due to a dysfunction of the feto-placental unit, has been proposed to underlie GDM. But even the detailed study of canonical pro-angiogenic factors like vascular endothelial growth factor (VEGF) or basic Fibroblast Growth Factor (bFGF) has not been able to fully explain this detrimental condition during pregnancy. Netrins are non-canonical angiogenic ligands produced by the stroma have shown to be important in placental angiogenesis. In order to address the potential role of Netrin signalling in GDM, we tested the effect of Netrin-1, the most investigated member of the family, produced by Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSC), on Human Umbilical Vein Endothelial Cells (HUVEC) angiogenesis. WJ-MSC and HUVEC primary cell cultures from either healthy or GDM pregnancies were exposed to physiological (5 mM) or high (25 mM) d-glucose. Our results reveal that Netrin-1 is secreted by WJ-MSC from healthy and GDM and both expression and secretion of the ligand do not change with distinct experimental glucose conditions. Noteworthy, the expression of its anti-angiogenic receptor UNC5b is reduced in GDM HUVEC compared with its expression in healthy HUVEC, accounting for an increased Netrin-1 signalling in these cells. Consistently, in healthy HUVEC, UNC5b overexpression induces cell retraction of the sprouting phenotype.

Alterations in oxytocin prohormone processing during early development in the fetal sheep

1992 ◽  
Vol 263 (3) ◽  
pp. R738-R740 ◽  
Author(s):  
M. Morris ◽  
M. Castro ◽  
J. C. Rose
Keyword(s):  
Fetal Development ◽  
Plasma Levels ◽  
Umbilical Artery ◽  
Umbilical Vein ◽  
Late Gestation ◽  
Developmental Changes ◽  
Fetal Sheep ◽  
Fetal Plasma ◽  
Prohormone Processing ◽  
Specific Antisera

Oxytocin (OT) prohormone processing was studied in fetal sheep. Using specific antisera that recognize the amidated and the COOH-terminal extended forms of OT, we measured arterial and venous levels of the OT peptides in fetal sheep plasma at 94 and 138 days of gestation. Plasma levels of the COOH-terminal extended forms, OT-X, were highest early in development, 35.7 +/- 9.8 vs. 14.3 +/- 5.7 pg/ml (94 vs. 138 days). The ratio of the plasma peptides, OT-X to OT, was higher in the young fetus (35 +/- 11.6 vs. 3.1 +/- 1.3, 94 vs. 138 days). There were also developmental changes in the umbilical artery-umbilical vein differences, with positive values noted in late gestation. These results demonstrate that the changes in the processing of the OT precursor that occur during fetal development are reflected by alterations in the relative amounts of prohormone and amidated hormone found in fetal plasma.

Sign in / Sign up

Export Citation Format

Share Document