EFFECT OF EPINEPHRINE ON GLUCOSE METABOLISM IN NOVIKOFF ASCITES HEPATOMA CELLS

1969 ◽  
Vol 61 (2) ◽  
pp. 209-218
Author(s):  
V. N. Nigam
Keyword(s):  
Lactic Acid ◽  
Glucose Metabolism ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Glycogen Synthesis ◽  
Neoplastic Transformation ◽  
Tumour Cells ◽  
Small Extent ◽  
Ascites Hepatoma ◽  
Stimulation Of

ABSTRACT No major effects of epinephrine on glycogen synthesis and glycolysis by intact Novikoff ascites-hepatoma were noted. However, at 2 × 10−5 m epinephrine concentration glycogen synthesis from glucose was slightly enhanced and lactic acid production was slightly decreased. These effects were attributed to a stimulation of UDPglucose-α-glucan glucosyltransferase and an inhibition of phosphofructokinase. Breakdown of glycogen deposited by the tumour cells was also inhibited to a small extent by epinephrine. The pattern of epinephrine action on glucose metabolism of tumour cells suggests that loss as well as modification of the receptor (of epinephrine) occurs during neoplastic transformation of liver.

Stimulation of Lactic Acid Production in Vitro from Prepubertal Rat Ovaries by Gonadotropins and Their Subunits1

Endocrinology ◽  
1973 ◽  
Vol 92 (4) ◽  
pp. 1022-1027 ◽  
Author(s):  
SUSAN WALKER FARMER ◽  
M. R. SAIRAM ◽  
HAROLD PAPKOFF
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Stimulation Of

scholarly journals Hyperthermia, Na+K+ATPase and lactic acid production in some human tumour cells

1984 ◽  
Vol 49 (4) ◽  
pp. 437-445 ◽  
Author(s):  
R H Burdon ◽  
S M Kerr ◽  
C M Cutmore ◽  
J Munro ◽  
V Gill
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Tumour Cells ◽  
Human Tumour ◽  
Human Tumour Cells

Effect of cadmium on the growth of Lactobacillus lactis, L. helveticus and Streptococcus thermophilus in milk

1984 ◽  
Vol 51 (4) ◽  
pp. 591-596 ◽  
Author(s):  
Hannu Korkeala ◽  
Stefan Soback ◽  
Jorma Hirn
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Skim Milk ◽  
Streptococcus Thermophilus ◽  
Inhibitory Effect ◽  
Inhibition Of Growth ◽  
Lactobacillus Lactis ◽  
Stimulation Of ◽  
Slight Inhibition

SummaryThe viable counts, pH and production of lactic acid were determined for Lactobacillus lactis, L. helveticus and Streptococcus thermophilus after 0, 5 and 24 h anaerobic incubation at 44 °C in skim milk containing 0, 3, 5 or 7μg cadmium (Cd)/l. In skim milk containing 7μg Cd/l, a noticeable decrease in lactic acid production and inhibition of the decrease in pH was observed for all three strains after 24 h, although there was only a slight inhibition of growth. With 3 and 5μg Cd/l, there was only a slight inhibition in the decrease in pH. In addition, with 3 μg Cd/l some evidence of stimulation of lactic acid production was found. The inhibitory effect of low Cd concentrations on lactic acid bacteria may give rise to problems in the dairy industry.

THE EFFECT OF INSULIN ON THE UPTAKE OF MONOSACCHARIDES BY THE RAT LENS

1961 ◽  
Vol 22 (4) ◽  
pp. 361-369 ◽  
Author(s):  
RUTH LEVARI ◽  
W. KORNBLUETH ◽  
E. WERTHEIMER
Keyword(s):  
Lactic Acid ◽  
Glucose Uptake ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Bicarbonate Buffer ◽  
Total Uptake ◽  
Order Of Magnitude ◽  
Normal Rat ◽  
Stimulation Of

SUMMARY 1. A direct stimulatory effect of insulin, in vitro, on the uptake of galactose, glucosamine and some pentoses by the intact lens, has been established. Stimulation of glucose uptake is perceptible only under certain conditions, and was more pronounced in a medium of bicarbonate buffer than in phosphate. 2. Insulin increased lactic acid production from glucose and from galactose. 3. Chronic diabetes decreased galactose uptake. Insulin, in vitro, restored the uptake to the level of that of normal rat lenses. 4. Phloridzin was found to cancel the effect of insulin. 5. The increase in uptake by insulin was of the same order of magnitude for glucose and galactose, irrespective of the total uptake. The decrease in uptake due to diabetes was quantitatively the same as the increase by insulin in normal rat lenses. The effect of insulin on lactic acid production was identical for both hexoses. 6. The possible existence of two pathways of glucose uptake in the rat lens is discussed.

EFFETCS OF LH AND HCG ON THE METABOLISM OF THE PREPUBERTAL RAT OVARY: STIMULATION OF AMINO ACID TRANSPORT, PROTEIN SYNTHESIS, AND GLYCOLYSIS

1975 ◽  
Vol 78 (1) ◽  
pp. 122-134 ◽  
Author(s):  
Lars Nilsson ◽  
Gunnar Selstam
Keyword(s):  
Body Weight ◽  
Lactic Acid ◽  
Amino Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Amino Acid Uptake ◽  
Time Interval ◽  
Acid Uptake ◽  
Rat Ovary ◽  
Stimulation Of

ABSTRACT It has earlier been reported from this laboratory that FSH can stimulate amino acid uptake, protein synthesis and glycolysis in the isolated prepubertal rat ovary. In the present investigation the effects of LH and HCG were studied. The hormones were injected to prepubertal female rats, and the ovaries were extirpated for incubation in Krebs bicarbonate buffer 120 min later. Injection of 1 μg/100 g body weight of a bovine LH preparation (NIH-LH-B8) produced a significant increase in the in vitro uptake of [14C]α-amino-isobutyric acid ([14C]AIB) and [3H]leucine as well as of the incorporation of radioactivity into the ovarian protein. Higher doses (10 and 100 μg) of NIH-LH-B8 gave only minor further increases. Lactic acid production during the incubation period was also measured as a determination of the rate of glycolysis. Lactic acid production was stimulated by the LH injections with a clear dose-response between 0.1 and 10 μg/100 g body weight. The effects of LH were also investigated with shorter intervals between the injection of the hormone and the extirpation of the ovaries. While lactic acid production was maximally stimulated at a time interval of 30 min (the shortest time interval studied), 60 min was necessary for the stimulation of amino acid uptake and amino acid incorporation into protein. Injections of HCG mimicked the effects of LH on all parameters studied.

Influence of fasting and refeeding on response of adipose tissue to insulin

1963 ◽  
Vol 205 (2) ◽  
pp. 222-224 ◽  
Author(s):  
Richard O. Moore
Keyword(s):  
Adipose Tissue ◽  
Lactic Acid ◽  
Glucose Metabolism ◽  
Gas Exchange ◽  
Glucose Uptake ◽  
Acid Production ◽  
Lactic Acid Production ◽  
The Other ◽  
Fasting And Refeeding

The glucose uptake, lactic acid production, and net gas exchange has been measured in adipose tissue from fed, fasted, or fasted and refed rats with and without insulin addition in vitro. Unstimulated adipose tissue from fasted and from fasted and refed rats showed a decreased capacity to take up glucose in vitro and a more negative net gas exchange than similar tissue from fed control animals. Insulin added in vitro increased the glucose uptake and CO2 excess in adipose tissue from fed, fasted, and refed rats, but the response with tissue from refed rats was several times that of the other groups. It is concluded that insulin is required for the marked increase in glucose metabolism associated with the refeeding regimen.

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