THE EFFECT OF EXOGENOUS HUMAN CHORIONIC GONADOTROPHIN ON STEROID EXCRETION IN THE NEWBORN

1969 ◽  
Vol 61 (1) ◽  
pp. 83-88 ◽  
Author(s):  
C. Lauritzen ◽  
C. H. L. Shackleton ◽  
F. L. Mitchell
Keyword(s):  
Urinary Excretion ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Early Infancy ◽  
Before And After ◽  
Steroid Excretion

ABSTRACT The urinary excretion of a range of steroids and steroid-like compounds, including the major compounds with the 3β-hydroxy-Δ5 configuration, have been studied in early infancy before and after the administration of human chorionic gonadotrophin. The only compound which showed any increase in excretion was dehydroepiandrosterone which was increased in four out of seven cases studied.

THE EFFECT OF EXOGENOUS CORTICOTROPHIN ON STEROID EXCRETION IN THE NEWBORN

1968 ◽  
Vol 58 (4) ◽  
pp. 655-663 ◽  
Author(s):  
C. Lauritzen ◽  
C. H. L. Shackleton ◽  
F. L. Mitchell
Keyword(s):  
Urinary Excretion ◽  
In Utero ◽  
Early Infancy ◽  
Average Increase ◽  
Acth Stimulation ◽  
Production Ratio ◽  
Before And After ◽  
The Individual ◽  
Steroid Excretion

ABSTRACT The urinary excretion of the individual 3β-hydroxy-Δ5 steroids together with cortisol and the chromatographic bands of material containing its tetrahydrometabolites, have been studied in early infancy before and after stimulation by exogenous corticotrophin (ACTH). The average increase in the excretion of the Δ5 steroids after stimulation is relatively small (less than 185%) compared with the increase in cortisol and its metabolites (greater than 600%) and it is suggested that ACTH stimulation cannot be solely responsible for the formation of the considerable quantities of Δ5 steroids in early infancy and the high Δ5 steroid/cortisol production ratio in utero.

INTERRELATION BETWEEN HUMAN CHORIONIC GONADOTROPHIN INHIBITORY ACTIVITY IN PLASMA AND URINE AND THE RATE OF URINARY GONADOTROPHIN EXCRETION

1965 ◽  
Vol 33 (2) ◽  
pp. 223-231 ◽  
Author(s):  
I. YAMASHITA ◽  
JANET C. HILLMAN ◽  
M. REISS
Keyword(s):  
Urinary Excretion ◽  
Inhibitory Activity ◽  
Excretion Rate ◽  
Mentally Retarded ◽  
Physical Development ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Urinary Excretion Rate ◽  
Young Males ◽  
Pineal Extracts

SUMMARY The interrelation of urinary and plasma human chorionic gonadotrophin (HCG) inhibitors and the urinary excretion rate of gonadotrophin was studied in ten physically and mentally retarded young males. It was found that the HCG-inhibitory principles had no effect when assayed against the boys' own urinary gonadotrophins. The excretion rate of urinary gonadotrophin was found to be independent of the presence of urinary or plasma HCG-inhibitors, which in turn were not related to the boys' physical development. Certain similarities between the properties of the plasma and urinary HCG-inhibitor and deproteinized pineal extracts are discussed.

A PRELIMINARY INVESTIGATION OF STEROID EXCRETION IN DEPRESSED PATIENTS BEFORE AND AFTER ELECTRO-CONVULSIVE THERAPY

1964 ◽  
Vol 47 (1) ◽  
pp. 58-68 ◽  
Author(s):  
H. C. Ferguson ◽  
A. C. G. Bartram ◽  
H. C. Fowlie ◽  
D. M. Cathro ◽  
K. Birchall ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Normal Values ◽  
Preliminary Investigation ◽  
Depressive Illness ◽  
The Other ◽  
Convulsive Therapy ◽  
Before And After ◽  
The Individual ◽  
Steroid Excretion ◽  
Electro Convulsive Therapy

ABSTRACT Using a method dependent upon paper chromatography, the urinary excretion of the individual corticosteroids and the individual 17-oxosteroids has been studied before and after electro-convulsive therapy in five female patients suffering from a depressive illness. The corticosteroids, which are normally associated with stress, were found to show a fall in excretion from abnormally high levels before treatment to normal levels thereafter. The 11-deoxy-17-oxosteroids, on the other hand, showed a low level of excretion prior to treatment which was followed by a rise to normal values in clinical remission. These findings are discussed.

EFFECT OF GLUCOCORTICOIDS ON PLASMA TESTOSTERONE IN MEN

1978 ◽  
Vol 89 (1) ◽  
pp. 126-131 ◽  
Author(s):  
G. Schaison ◽  
F. Durand ◽  
I. Mowszowicz
Keyword(s):  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Plasma Testosterone ◽  
Acth Stimulation ◽  
Testosterone Levels ◽  
Before And After ◽  
The Mean ◽  
Normal Men ◽  
Lh Secretion ◽  
Dexamethasone Suppression

ABSTRACT ACTH decreases plasma testosterone levels in men. The aim of this study was to assess the part played by the glucocorticoids in this effect, and the mechanism of their action. Plasma androstenedione, testosterone, cortisol and LH were measured in 8 normal men, before and after the following tests: ACTH stimulation (2 mg im), metyrapone administration (500 mg/every 4 h/6 times) and dexamethasone suppression (8 mg/day/3 days). In addition, androstenedione and testosterone were evaluated under human chorionic gonadotrophin (5000 IU HCG/day/3 days) before and after dexamethasone suppression (8 mg/day/6 days). In all patients, ACTH decreased plasma testosterone from 5.87 ± 1.59 (sd) ng/ml to 3.06 ± 0.8 (sd) ng/ml (P < 0.001). In contrast, after metyrapone, the mean plasma testosterone was increased to 6.98 ± 1.75 (sd) ng/ml. This increase, though not statistically significant, was observed in all patients but one. Both tests resulted in a significant increase of plasma androstenedione (P < 0.01 and P < 0.001, respectively). Dexamethasone suppressed both testosterone and androstenedione levels. None of the three tests had a significant effect on the LH concentration. HCG injection increased the mean plasma testosterone to 11.46 ± 2.80 ng/ml. Dexamethasone significantly depressed (P < 0.01) the testosterone response to HCG. These data are consistent with the following conclusions: 1) The decrease of plasma testosterone levels, observed in men after ACTH administration, is not observed after metyrapone induced ACTH increase. This confirms that it is related to cortisol levels rather than to ACTH itself. 2) Glucocorticoids act directly on testicular biosynthesis since they do not induce any change in LH secretion and since dexamethasone reduces testosterone response to HCG.

VIRILIZING ADRENOCORTICAL ADENOMA RESPONSIVE TO GONADOTROPHIN

1975 ◽  
Vol 78 (1) ◽  
pp. 77-85 ◽  
Author(s):  
M. Blichert-Toft ◽  
H. Vejlsted ◽  
H. Kehlet ◽  
R. Albrechtsen
Keyword(s):  
Young Female ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Adrenocortical Function ◽  
Plasma Testosterone ◽  
Adrenocortical Adenoma ◽  
Androgen Excess ◽  
Pronounced Increase ◽  
Steroid Excretion ◽  
Trophic Hormones

ABSTRACT A virilizing adrenocortical adenoma was demonstrated in a young female. Urinary 17-ketosteroid excretion and subfractions, plasma testosterone level and urinary 17-ketogenic steroid excretion were markedly increased. Dehydroepiandrosterone was the main constituent of the androgen excess. Otherwise the adrenocortical function was found to be normal as evaluated from measurements of cortisol, corticosterone and their metabolites under basal conditions and during dynamic tests. The androgen excess showed an unexpected response to trophic hormones. Human chorionic gonadotrophin stimulation resulted in a pronounced increase in androgen production, whereas no gonadotrophin-dependency could be demonstrated by means of the oestrogen suppression test. Similarly, no corticotrophin-dependency could be demonstrated by corticotrophin stimulation and suppression tests. Removal of the tumour resulted in normalization of the androgen production and no abnormal response upon human chorionic gonadotrophin administration could now be found. The inappropriate response of tumours to trophic hormones is discussed. It is concluded that the reliability of stimulation and suppression tests in determining the site of excessive androgen production should be accepted with reservation.

TESTICULAR FEMINIZATION

1959 ◽  
Vol XXXII (II) ◽  
pp. 222-232 ◽  
Author(s):  
D. Ikkos ◽  
K.-G. Tillinger ◽  
A. Westman
Keyword(s):  
Gonadal Dysgenesis ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Typical Case ◽  
Testicular Feminization ◽  
Intermediate Case ◽  
Histological Picture ◽  
Before And After

ABSTRACT Two cases of »testicular feminization« are described the first a typical case and the second an intermediate case between testicular feminization and gonadal dysgenesis. This second case had an unusual histological picture. A hormonal study including the estimation of urinary oestrone, 17β-oestradiol, oestriol, 17-ketosteroids and 17-hydroxy-corticosteroids before, during and after administration of human chorionic gonadotrophin was carried out in both cases, before and after bilateral gonadectomy. The results obtained indicate that in the first patient the abdominal testicles were the main source of the oestrogens found in the urine.

THE RESPONSE OF INHIBIN TO HUMAN CHORIONIC GONADOTROPHIN IS DECREASED IN SENESCENT MEN COMPARED WITH YOUNG MEN

1989 ◽  
Vol 123 (2) ◽  
pp. R9-R11 ◽  
Author(s):  
U. Fingscheidt ◽  
E. Nieschlag
Keyword(s):  
Old Age ◽  
Sertoli Cells ◽  
Young Men ◽  
Serum Testosterone ◽  
Older Men ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Before And After ◽  
Old Men ◽  
Ejaculate Parameters

ABSTRACT Inhibin and testosterone were measured in the serum of young and old men with proven fertility before and after stimulation with human chorionic gonadotrophin (hCG) in order to characterize endocrinological changes in senescence further. While there was a significant increase of both hormones in all young men, there was a decreased response of serum testosterone and an insignificant increase in inhibin in the older men. Although basal hormone levels and ejaculate parameters were not different, hCG stimulation revealed that there were decreased secretory capacities of Leydig as well as of Sertoli cells in old age.

Miscarriage Prevention Tea Affects Plasma β-Endorphin Concentrations in Women with Early Threatened Abortions

1999 ◽  
Vol 27 (02) ◽  
pp. 277-282 ◽  
Author(s):  
Fei Sun ◽  
Dun Qing Yan ◽  
Gong Li Zhang ◽  
Jin Yu ◽  
En Nian Xiao
Keyword(s):  
Successful Treatment ◽  
Plasma Concentrations ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Psychological Consultation ◽  
Normal Ranges ◽  
Before And After ◽  
History Of ◽  
Recurrent Abortions ◽  
Gonadotrophin Releasing Hormone

Twenty threatened abortive patients in the 7-8th week of gestation were treated with a classical miscarriage prevention tea (Shou-Tai-Tang) combined with psychological consultation. All of the patients had a history of unexplained recurrent abortions. This treatment succeeded in sixteen out of 20 patients. The plasma concentrations of ß-endorphin (ß-EP), gonadotrophin releasing hormone (GnRH), human chorionic gonadotrophin (hCG), and progesterone (P4) were measured by radioimmunoassay before and after treatment. Comparied to control subjects, ß-EP levels were significantly higher, while GnRH, hCG, and P4 were lower than before treatment. Concentrations of these peptides/hormones returned to normal ranges after successful treatment.

URINARY EXCRETION OF ANDROST-16-EN-3α-OL LEVELS IN NORMAL SUBJECTS, AND EFFECTS OF TREATMENT WITH TROPHIC HORMONES

1962 ◽  
Vol 24 (4) ◽  
pp. 435-444 ◽  
Author(s):  
B. W. L. BROOKSBANK
Keyword(s):  
Menstrual Cycle ◽  
Urinary Excretion ◽  
Small Proportion ◽  
Intramuscular Injection ◽  
Human Subjects ◽  
Normal Subjects ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Normal Human ◽  
The Mean

SUMMARY Data are presented on the urinary excretion of androst-16-en-3α-ol by normal human subjects over the age span 4–86 years. The figures range from < 100 to 2630 μg./24 hr. in males, and < 100 to 1100 μg./24 hr. in females, the mean for men of 16–45 years being nearly three times that for women of the same age. The effect on urinary androstenol and 17-oxosteroids of human chorionic gonadotrophin (HCG) and of corticotrophin (ACTH) have been compared in three normal young men and two women. Marked elevation of androstenol excretion occurred after ACTH in both sexes, while HCG administration resulted in an increased urinary output of androstenol and 17-oxosteroids only in two of the men and not in the women tested in either phase of the menstrual cycle. Intramuscular injection of androstenol itself (20 mg.) resulted in increased levels of androstenol in the urine equivalent only to a very small proportion of the injected dose. The metabolic origin of androstenol is discussed in the light of the results presented and of those of other investigators. It seems likely that androstenol arises not primarily from testosterone but mainly from an adrenal precursor.

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