PARTIAL SOMATOTROPHIN INSUFFICIENCY IN CUSHING'S SYNDROME

1969 ◽  
Vol 60 (1) ◽  
pp. 121-129 ◽  
Author(s):  
G. Strauch ◽  
E. Modigliani ◽  
P. Luton ◽  
H. Bricaire
Keyword(s):  
Growth Hormone ◽  
Cushing’S Syndrome ◽  
Selective Inhibition ◽  
Cushing's Syndrome ◽  
Glucose Load ◽  
Plasma Growth Hormone ◽  
Arginine Infusion ◽  
Hormone Levels

ABSTRACT Plasma growth hormone levels were studied in 15 patients with Cushing's syndrome using several stimuli. All tests except one, were performed before treatment. No change occurred in 6 patients during acute hypoglycaemia and in 11 out of 13 after a glucose load. Arginine given intravenously to 11 subjects elicited a rise in 7 out of 8 females and 1 out of 3 males. From patients who responded to arginine infusion, 6 were insensitive to one or two of the above mentioned stimuli. A selective inhibition of the releasing mechanisms might account for the partial somatotrophin insufficiency found in Cushing's syndrome.

CHANGES IN PLASMA GROWTH HORMONE LEVELS IN RETARDED CHILDREN

2008 ◽  
Vol 12 (3-4) ◽  
pp. 294-306
Author(s):  
J. HILLMAN ◽  
J. HAMMOND ◽  
J. SOKOLA ◽  
M. REISS
Keyword(s):  
Growth Hormone ◽  
Plasma Growth Hormone ◽  
Hormone Levels

scholarly journals Dopamine agonist-responsive Cushing’s disease

2019 ◽  
Vol 12 (2) ◽  
pp. bcr-2018-228045
Author(s):  
Gurpreet Anand ◽  
Andrea Bink ◽  
Felix Beuschlein ◽  
Christoph Schmid
Keyword(s):  
Growth Hormone ◽  
Dopamine Agonist ◽  
Cushing’S Syndrome ◽  
Tumour Size ◽  
Hypogonadotropic Hypogonadism ◽  
Immunohistochemical Analysis ◽  
Cushing's Syndrome ◽  
Central Hypothyroidism ◽  
Mri Scans

A 47-year-old Caucasian man was referred to our clinic with a severe clinical and biochemical phenotype of endogenous hypercortisolism for further evaluation and treatment. In addition to confirming adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome, we found left temporal hemianopsia, massively increased prolactin, increased growth hormone/insulin-like growth factor 1 values, hypogonadotropic hypogonadism and central hypothyroidism. As the cause of these abnormalities we revealed an invasive macroadenoma of the pituitary secreting ACTH, prolactin and growth hormone, resulting not only in a clinically predominant picture of Cushing’s syndrome but also causing hypogonadotropic hypogonadism and central hypothyroidism. The patient responded surprisingly well to dopamine agonist treatment leading not only to normalisation of prolactin levels but also to clinical and biochemical remission of Cushing’s syndrome. Tumour size decreased successively in follow-up MRI scans. Despite lacking immunohistochemical analysis of tumour tissue, we assume plurihormonal secretion of ACTH, prolactin and growth hormone from pituitary macroadenoma, which fortunately responded well to dopamine agonist treatment.

scholarly journals Normalisation of plasma growth hormone levels improved cardiac dysfunction due to acromegalic cardiomyopathy with severe fibrosis

2010 ◽  
Vol 2010 (oct18 2) ◽  
pp. bcr1220092559-bcr1220092559 ◽  
Author(s):  
F. Yokota ◽  
H. Arima ◽  
M. Hirano ◽  
T. Uchikawa ◽  
Y. Inden ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cardiac Dysfunction ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
Acromegalic Cardiomyopathy ◽  
Severe Fibrosis

Pituitary and Plasma Growth Hormone Levels in Bulls from Birth to One Year of Age

1970 ◽  
Vol 31 (2) ◽  
pp. 358-363 ◽  
Author(s):  
R. W. Purchas ◽  
K. L. Macmillan ◽  
H. D. Hafs
Keyword(s):  
Growth Hormone ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
One Year

Sustained exercise augments long-term starvation increases in plasma growth hormone in the steelhead trout, Salmo gairdneri

1988 ◽  
Vol 66 (4) ◽  
pp. 853-855 ◽  
Author(s):  
Bruce A. Barrett ◽  
Brian A. McKeown
Keyword(s):  
Growth Hormone ◽  
Salmo Gairdneri ◽  
Steelhead Trout ◽  
Hormone Concentration ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
Significant Difference ◽  
Normal Feeding ◽  
Stored Reserves

During the increased locomotor activity of migration many salmonids do not actively feed and it is likely that metabolic alterations occur to facilitate the mobilization of stored reserves. The present laboratory study was designed to simulate the occurrence of exercise and starvation as natural parameters of migration and to assess the effects of such parameters on levels of plasma growth hormone, which might indicate alterations in metabolism during migration. Juvenile steelhead trout, Salmo gairdneri, were starved for a 30-day period. Starved individuals exhibited a marked increase in plasma growth hormone concentration (38.6 ± 6.7 ng/mL) compared with control individuals held on a normal feeding regime (6.4 ± 1.84 ng/mL). A subgroup of fish from the starved group were exercised by being forced to swim at 1.5 body lengths/s for a 24-h period. Exercised individuals exhibited plasma growth hormone levels in excess of 140 ng/mL. There was no significant difference between the plasma growth hormone levels of unexercised starved fish and exercised fed fish.

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