THE EFFECTS OF CLOMIPHENE ON ENDOCRINE FUNCTION IN MALE PATIENTS WITH ADRENOCORTICAL INSUFFICIENCY AND FOLLOWING CASTRATION

1968 ◽  
Vol 58 (1) ◽  
pp. 38-48 ◽  
Author(s):  
R. A. Harkness ◽  
E. T. Bell ◽  
J. A. Loraine ◽  
A. A. A. Ismail ◽  
W. I. Morse
Keyword(s):  
Follicle Stimulating Hormone ◽  
Endocrine Function ◽  
Adrenocortical Insufficiency ◽  
Marked Rise ◽  
Testosterone Levels ◽  
Main Effect ◽  
Male Patients ◽  
Stimulating Hormone

ABSTRACT The effect of clomiphene administration on steroid and gonadotrophin output has been studied in three male patients with adrenocortical insufficiency and in three castrate men. In the patients with adrenocortical insufficiency the main effect of clomiphene was to produce a marked increase in the output of urinary testosterone and of its metabolites, androsterone and aetiocholanolone. It is concluded that this effect results from testicular stimulation. In the castrate males clomiphene caused a less marked rise in the excretion of dehydroepiandrosterone (DHA), androsterone and aetiocholanolone, presumably indicating adrenocortical stimulation. Testosterone levels may have fallen slightly during the administration of the compound. Little or no effect on the output of »total gonadotrophic activity« or of follicle-stimulating hormone (FSH) was produced by clomiphene.

EFFECTS OF FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE ON PLASMA TESTOSTERONE LEVELS IN HYPOPHYSECTOMIZED AND IN INTACT IMMATURE AND ADULT MALE RATS

1974 ◽  
Vol 61 (2) ◽  
pp. 193-198 ◽  
Author(s):  
S. EL SAFOURY ◽  
A. BARTKE
Keyword(s):  
Luteinizing Hormone ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Adult Rats ◽  
Testosterone Levels ◽  
Hypophysectomized Rats ◽  
Stimulating Hormone

SUMMARY The effects of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on plasma testosterone levels were examined in hypophysectomized and in intact immature and adult male rats. The animals were injected with saline, LH, FSH, or both gonadotrophins twice daily for 3·5 days and were killed 3 h after the last injection. Plasma testosterone levels were measured by radioimmunoassay. In immature hypophysectomized rats, plasma testosterone levels were not changed by treatment with LH, FSH or LH plus FSH. The weight of the testes and of the seminal vesicles was increased only in animals injected with both LH and FSH. In adult hypophysectomized rats, LH caused the expected increase in plasma testosterone levels, while FSH injected alone had no effect. Plasma testosterone levels in rats treated with 5 μg LH and 20 μg FSH were significantly greater than those in animals given 5 μg LH alone. However, the same dose of FSH did not potentiate the action of 25 μg LH on plasma testosterone levels. In adult hypophysectomized rats the weight of testes was not affected by any of the treatments. The weight of the seminal vesicles was increased by the higher dose of LH and addition of FSH caused no further increase. In intact immature and adult rats plasma testosterone levels and the weight of testes were not changed by any of the treatments. Seminal vesicle weight was increased only in adult rats treated with the higher dose of LH together with FSH. The results demonstrate that FSH potentiates the action of low doses of LH on plasma testosterone levels in adult hypophysectomized rats and suggest that FSH may be involved in the regulation of androgen secretion by the rat testis.

scholarly journals Prognostic Value of Follicle-Stimulating Hormone Levels in Predicting Survival in Men With Idiopathic Pulmonary Arterial Hypertension

2022 ◽  
Vol 16 (1) ◽  
pp. 155798832110670
Author(s):  
Qian Wang ◽  
Yuan-Yuan Sun ◽  
Yu-Xia Huang ◽  
Lan Wang ◽  
Yu-Qing Miao ◽  
...  
Keyword(s):  
Survival Rate ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Cox Regression ◽  
Follicle Stimulating Hormone ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
World Health ◽  
Pulmonary Arterial ◽  
Male Patients ◽  
Stimulating Hormone

The objective of the study was to assess the association between changes in plasma follicle-stimulating hormone (FSH) and the potential effect on idiopathic pulmonary arterial hypertension (IPAH) in male patients. A total of 116 male patients with IPAH and 53 healthy controls were included from XX Hospital. Plasma FSH concentration was assessed in all participants. Receiver operating characteristic curves were used to assess the mortality risk. Kaplan–Meier curve and Cox regression analyses were used to predict the value of FSH on the survival rate of male IPAH patients. The plasma FSH concentration in the IPAH group was significantly higher than that in the control group ( p = .017). Nonsurvivors had significantly higher levels of FSH than survivors ( p < .0001). FSH levels were positively correlated with World Health Organization Functional Class, mean pulmonary artery pressure, and pulmonary vascular resistance (PVR; p = .023, p < .0001, and p < .0001, respectively) and negatively correlated with 6-min walk distance (6MWD) and cardiac output (CO; p = .004 and p = .010). Cox regression model analysis showed that the levels of FSH were also the independent factors of mortality in male IPAH patients ( p < .0001). The IPAH patients with higher FSH levels had higher PVR, lower 6MWD, CO, and a lower survival rate ( p = .042, p = .003, p = .029, and p < .0001, respectively). Therefore, we identified that increased FSH levels were associated with disease severity in male patients with IPAH and independently predicted risk of disease and poor survival rate.

scholarly journals Study of the Protective Effects of Quince (Cydonia Oblonga) Leaf Extract on Fertility Alterations and Gonadal Dysfunction Induced by Monosodium Glutamate in Adult Male Wistar Rats

2015 ◽  
Vol 22 (4) ◽  
pp. 375-384 ◽  
Author(s):  
Davoud Kianifard ◽  
Gholamreza Vafaei Saiah ◽  
Farhad Rezaee
Keyword(s):  
Leaf Extract ◽  
Body Weight Gain ◽  
Monosodium Glutamate ◽  
Follicle Stimulating Hormone ◽  
Protective Effects ◽  
Epididymal Sperm ◽  
Testosterone Levels ◽  
Gonadal Dysfunction ◽  
Testicular Weight ◽  
Stimulating Hormone

AbstractBackground and Aims: Starting from the cytotoxic effects of monosodium glutamate (MSG), the aim of this study was to evaluate the protective effects of quince leaf extract as natural antioxidant on the reproductive dysfunction induced by monosodium glutamate in rats. Material and methods: Monosodium glutamate was administrated with a dose of 30 and 60 mg/kg and quince leaf extract was administrated with a dose of 500 mg/kg. At the end of study, body and testicular weight measurement, hormonal and epididymal sperm analysis were performed. Results: Follicle stimulating hormone (FSH) and testosterone levels were reduced after administration of monosodium glutamate. The levels of luteinizing hormone (LH) exhibited no significant changes. Treatment with quince leaf extract led to improvement in follicle stimulating hormone and testosterone levels. Epididymal sperm population was reduced after administration of monosodium glutamate and treatment with quince leaf extract. The increased sperm motility rate induced by monosodium glutamate was reduced after treatment with quince leaf extract. Administration of monosodium glutamate led to more body weight gain in comparison to combined administration monosodium glutamate and quince leaf extract. Conclusions: The quince leaf extract can be effective in reduction of functional alterations of reproductive system induced by monosodium glutamate.

Effect of exposure to long days on the secretion of oestradiol, oestrone, progesterone, testosterone, androstenedione, cortisol and follicle-stimulating hormone in intact and spayed ferrets

1983 ◽  
Vol 99 (3) ◽  
pp. 361-368 ◽  
Author(s):  
B. T. Donovan ◽  
Christine Matson ◽  
M. J. Kilpatrick
Keyword(s):  
Follicle Stimulating Hormone ◽  
Blood Levels ◽  
Gonadal Steroid ◽  
Intact Female ◽  
Testosterone Levels ◽  
Additional Group ◽  
Plasma Oestradiol ◽  
Stimulating Hormone

The changes in concentration of plasma oestradiol, oestrone, progesterone, androstenedione, testosterone, cortisol and FSH were followed in intact female ferrets brought into oestrus by extension of the photoperiod from 8 to 16 h daily. An additional group of spayed females was similarly exposed to the extended photoperiod. There was no change in the blood oestrone, androstenedione and testosterone levels in the spayed females; the concentration of oestradiol, progesterone and FSH fell, while that of cortisol rose after 6 weeks. The intact females showed no change in plasma oestrone and cortisol concentrations, a rise in plasma oestradiol associated with the onset of oestrus, and falls in the blood levels of testosterone, androstenedione, progesterone and FSH. These results indicate that the changes in plasma gonadal steroid levels after extension of the photoperiod differ markedly from those in rodents or ruminants.

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