CHARCOAL-DEXTRAN RADIOIMMUNOASSAY OF HUMAN GROWTH HORMONE

1968 ◽  
Vol 57 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Marvin S. Wool ◽  
Herbert A. Selenkow
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Normal Subjects ◽  
Simplified Procedure

ABSTRACT A simplified procedure is described for radioimmunoassay of human growth hormone (HGH) in serum using 125I as a label and dextrancharcoal separation of antibody-bound from unbound HGH. Serum HGH levels were measured fasting and after insulin induced hypoglycaemia in four normal subjects, five patients with hypopituitarism and seven with acromegaly. These values agreed well with similar reports by other investigators.

THE PHARMACOKINETICS, SAFETY AND ENDOCRINE EFFECTS OF AUTHENTIC BIOSYNTHETIC HUMAN GROWTH HORMONE IN NORMAL SUBJECTS

1989 ◽  
Vol 30 (4) ◽  
pp. 335-345 ◽  
Author(s):  
K. Y. HO ◽  
A. J. WEISSBERGER ◽  
M. C. STUART ◽  
R. O. DAY ◽  
L. LAZARUS
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Normal Subjects ◽  
Endocrine Effects

Effects of L-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

1973 ◽  
Vol 4 (5) ◽  
pp. 293-301 ◽  
Author(s):  
Punjab Singh ◽  
D.G. McDevitt ◽  
J. Mackay ◽  
D.R. Hadden
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Normal Subjects ◽  
Tsh Secretion

Dissociation between circulating concentrations of immunoreactive growth hormone releasing factor and growth hormone in normal human subjects

1987 ◽  
Vol 72 (2) ◽  
pp. 181-185 ◽  
Author(s):  
A. M. Sopwith ◽  
Elizabeth S. Penny ◽  
N. Lytras ◽  
G. M. Besser ◽  
Lesley H. Rees
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Subjects ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Human Growth ◽  
Normal Subjects ◽  
Peripheral Circulation ◽  
Growth Hormone Releasing Factor ◽  
Specific Radioimmunoassay

1. Using a highly specific radioimmunoassay we have measured immunoreactive human growth hormone releasing factor (ir-hGRF) concentrations in the peripheral circulation of a total of 12 normal subjects. 2. Neither insulin-induced hypoglycaemia, intravenous arginine nor oral carbohydrate caused any change in venous plasma ir-hGRF concentrations, despite the expected stimulation and suppression respectively of growth hormone secretion. 3. Growth hormone secretion was not increased by oral fat or protein but each of these two foods stimulated ir-hGRF concentrations two- to fourfold. 4. Spontaneous pulses of growth hormone secretion on control days were unaccompanied by any increase in plasma ir-hGRF. 5. The dissociation between peripheral circulating ir-hGRF and growth hormone responses demonstrated under different circumstances suggests that an important source of human growth hormone releasing factor lies outside the hypothalamus and that secretion from this source is unconnected with the normal control of pituitary growth hormone secretion.

Serum concentration of human growth hormone (hGH) after administration of the somatostatin analogue SMS 201-995 in normal subjects

1986 ◽  
Vol 159 (1) ◽  
pp. 93-95 ◽  
Author(s):  
Seiichi Hashida ◽  
Eiji Ishikawa ◽  
Koshi Tanaka ◽  
Naokata Shimizu ◽  
Koji Nakagawa ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Serum Concentration ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Normal Subjects ◽  
Somatostatin Analogue
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