RADIOIODINE UPTAKE IN SUBACUTE THYROIDITIS DEVELOPING IN AN ENVIRONMENT OF ENDEMIC GOITRE

1967 ◽  
Vol 56 (4) ◽  
pp. 585-592
Author(s):  
M. Weinstein ◽  
R. J. Soto ◽  
H. Flaster ◽  
A. M. Brunengo ◽  
H. Mendoza ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Buenos Aires ◽  
Endemic Goiter ◽  
Inhibitory Effect ◽  
Subacute Thyroiditis ◽  
Endemic Goitre ◽  
Radioiodine Uptake

ABSTRACT Radioiodine parameters, mainly 131I uptake by the thyroid gland were reviewed in 31 cases of subacute thyroiditis (SAT). Seven cases presented depressed uptake. The remainder had either normal or high uptakes regardless of the phase of the disease during which the measurements were made. Fifteen subjects had lived in endemic goiter areas and 16 were from Buenos Aires where 131I uptakes are high and »subendemic« conditions prevail. It is thought that under these circumstances the inhibitory effect of SAT on 131I uptake as usually seen, does not become evident. PB131I and BE131I were normal in the subjects with normal or high 131I uptakes. It is concluded that radioiodine parameters in an endemic environment do not contribute to the diagnosis of SAT. The pathophysiology of SAT is discussed in the view of the present and related studies.

EPIDEMIC THYROIDITIS

1964 ◽  
Vol 45 (3) ◽  
pp. 381-401 ◽  
Author(s):  
G. Hintze ◽  
P. Fortelius ◽  
J. Railo
Keyword(s):  
Thyroid Gland ◽  
Distribution Pattern ◽  
Needle Biopsy ◽  
Serum Proteins ◽  
Acute Infection ◽  
Thyroid Tissue ◽  
Subacute Thyroiditis ◽  
Present Observation ◽  
Upper Respiratory Tract ◽  
Endemic Goitre

ABSTRACT A type of subacute thyroiditis occurring epidemically in a factory in Helsinki was observed in 44 cases. In every case the thyroiditis followed an acute infection of the upper respiratory tract. The variation in incidence during one and a half years was in good agreement with that of the acute infection. Since Helsinki is in an endemic goitre region, the fact that the disease was of the migrating type was of great diagnostic importance. In all cases but one, the nodules have persisted. One case of asymptomatic thyroiditis was seen. In the majority of the patients the thyroid gland had been carefully palpated before the thyroiditis occurred, and in all cases the condition was followed up by the same investigator. Special attention was paid to changes in the iodine metabolism, the serum cholesterol, the electrophoretic distribution pattern of the serum proteins, and the circulating thyroid auto-antibodies. In many cases needle biopsy of the thyroid gland was performed. Thyroid function invariably returned to normal with time, although one patient remained in a hypothyroid state for about a year. In no cases were thyroid auto-antibodies found. For the beta-globulin fraction, the electrophoretic distribution pattern of the serum proteins gave values which were still not normalized in any case, and only in two cases was the alpha2-fraction normalized. The needle biopsy, when thyroid tissue was obtained, showed almost the same picture as in endemic goitre, but in some specimens nonspecific inflammatory changes were seen. Prednisolone relieved the symptoms, but did not affect the course of the disease. According to the present observation this type of epidemic thyroiditis would seem to represent a form of nonspecific subacute thyroiditis.

SUBACUTE THYROIDITIS

1976 ◽  
Vol 81 (3) ◽  
pp. 707-715 ◽  
Author(s):  
E. G. Lebacq ◽  
G. Therasse ◽  
A. Schmitz ◽  
A. Delannoy ◽  
C. Destailleurs
Keyword(s):  
Thyroid Gland ◽  
Clinical Course ◽  
Subacute Thyroiditis ◽  
Histopathological Study ◽  
Radioiodine Uptake ◽  
Complete Destruction ◽  
Trh Stimulation ◽  
Before And After ◽  
Classical Pattern ◽  
Tsh Levels

ABSTRACT Eleven cases are reported of subacute thyroiditis with histopathological study; there were 9 females and 2 males. Bacteriological studies were inconclusive. Different stages of pathological involvement were observed at the same time in all patients. The clinical course followed the classical pattern in most cases: hyperthyroid-like, hypothyroid-like phase and recovery. Blood TSH assessment before and after TRH stimulation revealed an early phase of depression unresponsive to TRH, followed by high levels with marked stimulation; during the first phase, radioiodine uptake was low, but was enhanced by exogenous TSH administration; accordingly the low uptake seems to be due to low TSH levels and not to complete destruction of the thyroid gland. Failure of TSH levels to rise after TRH stimulation is typical of this stage of the disease. Although the final outcome is not yet predictable in some patients, definitive myxoedema appears to be probable in two cases.

scholarly journals A summary of further researches on the etiology of endemic goitre

1909 ◽  
Vol 81 (545) ◽  
pp. 31-31 ◽  
Keyword(s):  
Thyroid Gland ◽  
Suspended Matter ◽  
Endemic Goitre

The object of the research was to determine by experiment on man whether goitre was caused by matter held in suspension in goitre-producing waters; and to ascertain, as far as possible, the nature of the suspended ingredient which had been surmised to be responsible for the production of the disease. Thirteen individuals, including myself, were given suspended matter, which had been removed by filtration from goitre-producing water, every morning before the first meal of the day. I and three others developed enlargements of the thyroid gland. The experiment was repeated in the case of eight individuals who were given the same suspended matter, which had previously been boiled for 10 minutes; in no case did any enlargement of the thyroid gland occur.

scholarly journals An unusual case of struma ovarii

2021 ◽  
Vol 2021 ◽  
Author(s):  
Viktoria F Koehler ◽  
Patrick Keller ◽  
Elisa Waldmann ◽  
Nathalie Schwenk ◽  
Carolin Kitzberger ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Adnexal Mass ◽  
Thyroid Tissue ◽  
Reference Interval ◽  
Struma Ovarii ◽  
Radioiodine Uptake ◽  
Diagnostic Pitfalls ◽  
Biochemical Features

Introduction Struma ovarii is a teratoma of the ovaries predominantly composed of thyroid tissue. Hyperthyroidism associated with struma ovarii is rare, occurring in approximately 8% of cases. Due to the rarity of struma ovarii, available data are limited to case reports and small case series. Methods and results We report on a 61-year-old female patient with known Hashimoto’s thyroiditis on levothyroxine replacement therapy for years with transition to clinical and biochemical hyperthyroidism despite antithyroid medication with carbimazole (10 mg/day), new diagnosis of urothelial carcinoma and an adnexal mass suspicious of ovarian cancer. The patient underwent resection of the adnexal mass and histopathology revealed a mature teratoma predominantly composed of thyroid tissue showing high levels of sodium iodide symporter protein expression. Following struma ovarii resection and disappearance of autonomous production of thyroid hormones, the patient developed hypothyroidism with severely decreased thyroid hormone levels fT4 and fT3 (fT4 0.4 ng/dL, reference interval 0.9–1.7 and fT3 < 1.0 pg/mL, reference interval 2.0–4.4). This has previously been masked by continued thyroid-stimulating hormone suppression due to long-term hyperthyroidism pre-surgery indicating secondary hypothyroidism, in addition to primary hypothyroidism based on the known co-existing chronic lymphocytic thyroiditis of the orthotopic thyroid gland. Levothyroxine administration was started immediately restoring euthyroidism. Conclusion This case illustrates possible diagnostic pitfalls in a patient with two concurrent causes of abnormal thyroid function. Learning points Struma ovarii is an ovarian tumor containing either entirely or predominantly thyroid tissue and accounts for approximately 5% of all ovarian teratomas. In rare cases, both benign and malignant struma ovarii can secrete thyroid hormones, causing clinical and biochemical features of hyperthyroidism. Biochemical features of patients with struma ovarii and hyperthyroidism are similar to those of patients with primary hyperthyroidism. In such cases, thyroid scintigraphy should reveal low or absent radioiodine uptake in the thyroid gland, but the presence of radioiodine uptake in the pelvis in a whole body radioiodine scintigraphy. We give advice on possible diagnostic pitfalls in a case with two simultaneous causes of abnormal thyroid function due to the co-existence of struma ovarii.

scholarly journals SUB-ACUTE THYROIDITIS: ESR AS DIAGNOSTIC MARKER AND OPTIMUM DURATION OF PREDNISOLONE THERAPY

1969 ◽  
Vol 5 (1) ◽  
pp. 582-585
Author(s):  
ASADULLAH ◽  
MAHID IQBAL ◽  
IZAZ UR RAHMAN ◽  
S.M.NAEEM ◽  
IQBAL AHMAD
Keyword(s):  
Thyroid Gland ◽  
Steroid Therapy ◽  
Subacute Thyroiditis ◽  
Blood Picture ◽  
High Grade Fever ◽  
Prednisolone Therapy ◽  
History Of ◽  
De Quervain ◽  
De Quervain Thyroiditis ◽  
Acute Thyroiditis

BACKGROUND: Thyroiditis is an inflammation of the thyroid gland that can arise due to a variety ofcauses. Subacute thyroiditis or de Quervain thyroiditis is comparatively uncommon with recurrence rateof 5% patients over a 20-year period. It usually presents in the form of epidemics and mostly hasoverlapping symptoms, which leads to misdiagnosis.OBJECTIVE: To study sub-acute thyroiditis with the risks and benefits of treatment and consequencesof non treatment.PATIENTS AND METHODS: The study was conducted on seventy (70) patients who visited forconsultancy during April 2014 to May 2015. Their mean age was 37 years, having 28 male 42 females.Those who presented with symptoms of pain in front of neck, unilateral or bilateral, periodic generalizedbody aches, without having history of high grade fever, were included in the study after taking theirconsent. ESR, TFTs and complete blood picture of those having mildly enlarged or not palpable,painful and tender thyroid were done and recorded. They were divided into various groups for steroidtherapy. The patients were selected randomly.RESULTS: All the seventy patients having symptoms, suggestive of thyrioditis had markedly raisedESR with normal TFTs range and rest of the blood picture, were put on 40-45mg/day with tapering dosefor two to six weeks. Those who were put on six weeks steroid therapy had no recurrence, where asthose with duration less than six weeks time suffered from recurrence of symptoms.CONCLUSION: Subacute thyroditis presented with generalized bodyach and tender thyroid gland withraised ESR, when treated with 40-45mg/day prednisolone therapy for six weeks responded significantly.KEY WORDS: Thyroiditis, Subacute thyroiditis, Erythrocyte sedimentation rate, Steroid therapy.

Management of nontoxic multinodular goitre

2011 ◽  
pp. 589-595
Author(s):  
Wilmar M. Wiersinga
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Adult Population ◽  
Normal Serum ◽  
Endemic Goitre ◽  
Disease Entity ◽  
Multinodular Goitre ◽  
Free Triiodothyronine ◽  
Serum Free ◽  
The Uk

Goitres can be classified according to thyroid function into toxic goitres, hypothyroid goitres, and euthyroid or nontoxic goitres (see Chapter 3.5.1). The most prevalent causes of nontoxic goitre are endemic (iodine-deficient) goitre and sporadic nontoxic goitre (diffuse or nodular). The disease entity of sporadic nontoxic goitre is defined as a benign enlargement of the thyroid gland of unknown cause, in euthyroid patients (normal serum free thyroxine (T4) and free triiodothyronine (T3) concentrations) living in an area without endemic goitre. The diagnosis is by exclusion. The prevalence of sporadic nontoxic goitre (also called simple goitre) in the adult population is high, 3.2% in the UK (see Chapter 3.1.7), and it is more common in women (5.3%) than in men (0.8%). This chapter deals predominantly with sporadic nontoxic multinodular goitre.

scholarly journals A Case of Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and Normal Radioiodine Uptake

1993 ◽  
Vol 69 (9) ◽  
pp. 997-1002
Author(s):  
Toshihiko HISAOKA ◽  
Naoko MOMOTANI ◽  
Hiroshi YOSHIMURA ◽  
Naofumi ISHIKAWA ◽  
Kunihiko ITO ◽  
...  
Keyword(s):  
Subacute Thyroiditis ◽  
Thyrotropin Receptor ◽  
Radioiodine Uptake ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

Somatostatin Receptor Expression in the Thyroid Demonstrated with 111In-Octreotide Scintigraphy

1995 ◽  
Vol 34 (03) ◽  
pp. 100-103 ◽  
Author(s):  
U. Schrell ◽  
M. Buchfelder ◽  
J. Hensen ◽  
J. Wendler ◽  
M. Gramatzki ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Disease ◽  
Endemic Goiter ◽  
Somatostatin Receptor ◽  
Receptor Expression ◽  
Graves Disease ◽  
Tumor Localization ◽  
Thyroid Autonomy ◽  
Thyroid Uptake ◽  
Octreotide Scintigraphy

SummaryNeuroendocrine tumors with somatostatin receptor expression may be localized by 111ln-octreotide scintigraphy. This study examines those thyroid conditions where 111 ln-octreotide uptake could be observed also in the thyroid gland. 26 consecutive patients who underwent 111 ln-octreotide scintigraphy for tumor localization were additionally examined for thyroid disease by sonography and 99mTc-pertechnetate scintigraphy. 12 of these patients had no significant thyroid uptake and had an euthyroid normal-sized thyroid gland. 14 patiens with 111ln thyroid uptakes had endemic goiters, two of them with thyroid autonomy and one with Graves’ disease. Thus, 111 ln-octreotide thyroid uptake was predominantly seen in patients with endemic goiter with or without thyroid autonomy.

scholarly journals A summary of further experimental researches on the etiology of endemic goitre. (Second series.)

1911 ◽  
Vol 83 (564) ◽  
pp. 335-337 ◽  
Keyword(s):  
Thyroid Gland ◽  
Suspended Matter ◽  
Royal Society ◽  
Intestinal Tract ◽  
Living Organism ◽  
Causal Factor ◽  
Endemic Goitre ◽  
Experimental Researches ◽  
Disease Present

The object of the research was to test by further experimentation on man the accuracy of the results communicated to the Royal Society on November 26, 1908. These results afforded evidence that goitre was due to a living organism of disease present in the water of goitrous localities, that the causal factor of the disease was destroyed by boiling, and that it inhabited, in all probability, the intestinal tract of man. I. Twenty-three individuals, of the average age of 22, consumed the suspended matter of goitre-producing water for periods of from 30 to 55 days. Of these, six showed an increase in size of the thyroid gland which persisted in a more or less well-marked manner up to the end of the experiments. Three others showed a thyroid hypertrophy of a transitory character.

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