OESTRIOL-3-GLUCOSIDURONATE, A MAJOR URINARY METABOLITE OF OESTRIOL AND OESTRIOL-16(17?)-GLUCOSIDURONATE

1965 ◽  
Vol 50 (2) ◽  
pp. 261-272 ◽  
Author(s):  
U. Goebelsmann ◽  
K. Sjöberg ◽  
N. Wiqvist ◽  
E. Diczfalusy
Keyword(s):  
Pregnant Woman ◽  
Radioactive Material ◽  
Urinary Metabolite ◽  
Major Urinary Metabolite

ABSTRACT Oestriol-16-14C (OE3-16-14C) was administered to a non-pregnant woman and oestriol-16-14C-16(17?)-glucosiduronate (OE3-16-14C-16(17?)Gl) to a pregnant woman and the urinary oestriol conjugates were isolated and identified. More than 85 per cent of the radioactive material administered to the two subjects was excreted in the urine within 96 hours. In both cases more than 16 per cent of the administered radioactive material was isolated and identified as oestriol-16-14C-3-glucosiduronate (OE3-16-14C-3Gl) and more than-70 per cent as OE3-16-14C-16(17?)Gl. It is concluded that oestriol-3-glucosiduronate is a major urinary metabolite of both oestriol and oestriol-16(17?)-glucosiduronate.

scholarly journals Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 768 ◽  
Author(s):  
Hironori Kawamoto ◽  
Hiromichi Hara ◽  
Jun Araya ◽  
Akihiro Ichikawa ◽  
Yu Fujita ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cancer Progression ◽  
Stage Iv ◽  
Staging System ◽  
Tnm Staging ◽  
Tumor Burden ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
Major Urinary Metabolite ◽  
Embryonic Antigen

Background: Prostaglandin E2 (PGE2) is metabolized to prostaglandin E-major urinary metabolite (PGE-MUM). Enhanced cyclooxygenase-2 (COX-2) expression demonstrated in lung adenocarcinoma indicates increased PGE-MUM levels in patients with lung adenocarcinoma. Objectives: We aimed to elucidate the clinical usefulness of measuring PGE-MUM as an indicator of tumor burden in patients with lung adenocarcinoma. Methods: PGE-MUM was measured by a radioimmunoassay in control healthy volunteers (n = 124) and patients with lung adenocarcinoma (n = 54). Associations between PGE-MUM levels and clinical characteristics of the patients (including lung cancer stage and TNM factors (T: Tumor, N: Node, M: Metastasis) were examined. Results: PGE-MUM levels were significantly elevated in patients with lung adenocarcinoma. A PGE-MUM level of 14.9 μg/g∙Cr showed 70.4% sensitivity and 67.7% specificity for the diagnosis of lung adenocarcinoma. PGE-MUM levels tended to be positively correlated with cancer progression as determined by the TNM staging system. Advanced stage (stage III, stage IV, and recurrence) was significantly associated with high PGE-MUM levels by logistic regression analysis. No apparent correlation was demonstrated between PGE-MUM and carcinoma embryonic antigen (CEA) levels. Conclusions: PGE-MUM can be a promising biomarker reflecting the systemic tumor burden of lung adenocarcinoma.

Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity

2017 ◽  
Vol 64 (6) ◽  
pp. 955-961 ◽  
Author(s):  
Shin-ichiro Hagiwara ◽  
Isao Okayasu ◽  
Mutsunori Fujiwara ◽  
Masaaki Matsuura ◽  
Hiromitsu Ohnishi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
Major Urinary Metabolite

scholarly journals Identification of the Major Urinary Metabolite of the Highly Reactive Cyclopentenone Isoprostane 15-A2t-Isoprostanein Vivo

2005 ◽  
Vol 280 (26) ◽  
pp. 25178-25184 ◽  
Author(s):  
Ginger L. Milne ◽  
Ling Gao ◽  
Alessio Porta ◽  
Giuseppe Zanoni ◽  
Giovanni Vidari ◽  
...  
Keyword(s):  
Urinary Metabolite ◽  
Major Urinary Metabolite

Metabolism in vivo of dioxane: identification of p-dioxane-2-one as the major urinary metabolite

1977 ◽  
Vol 26 (16) ◽  
pp. 1535-1538 ◽  
Author(s):  
Yin-tak Woo ◽  
Joseph C. Arcos ◽  
Mary F. Argus ◽  
Gary W. Griffin ◽  
Kazvyoshi Nishiyama
Keyword(s):  
Urinary Metabolite ◽  
Major Urinary Metabolite

Facile method for preparation of 2,3-dinor-6-keto PGF1α, the major urinary metabolite of prostacyclin

1988 ◽  
Vol 36 (4) ◽  
pp. 421-430 ◽  
Author(s):  
M. Balazy ◽  
E.P. Brass ◽  
J.G. Gerber ◽  
A.S. Nies
Keyword(s):  
Urinary Metabolite ◽  
Major Urinary Metabolite

Quantification of the Major Urinary Metabolite of 15-F2t-Isoprostane (8-iso-PGF2α) by a Stable Isotope Dilution Mass Spectrometric Assay

1999 ◽  
Vol 269 (2) ◽  
pp. 326-331 ◽  
Author(s):  
Jason D. Morrow ◽  
William E. Zackert ◽  
James P. Yang ◽  
Eric H. Kurhts ◽  
Denis Callewaert ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Isotope Dilution ◽  
Mass Spectrometric ◽  
Urinary Metabolite ◽  
Stable Isotope Dilution ◽  
Major Urinary Metabolite
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