EFFECTS OF ADMINISTRATION OF METOPIRON AND OF DELIVERY ON HUMAN PLASMA CORTICOTROPHIN

1965 ◽  
Vol 48 (4) ◽  
pp. 581-586
Author(s):  
Tore H:son Holmdahl
Keyword(s):  
Human Plasma ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Normal Subjects ◽  
Pituitary Tumour ◽  
Plasma Acth ◽  
Normal Delivery ◽  
Do So

ABSTRACT The ACTH activity of human peripheral blood was assayed during two types of stimuli: 1) administration of SU-4885 (Metopiron® CIBA), 2) normal delivery. Metopiron produced an increase of plasma ACTH activity in 3 normal subjects but failed to do so in 1 case of pituitary tumour. Of the 7 cases of normal delivery studied, 4 showed a significant increase in plasma ACTH activity at the time of delivery.

scholarly journals Immune reactions in human filariasis

1978 ◽  
Vol 8 (2) ◽  
pp. 228-232 ◽  
Author(s):  
D Subrahmanyam ◽  
K Mehta ◽  
D S Nelson ◽  
Y V Rao ◽  
C K Rao
Keyword(s):  
Immunoglobulin G ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Wuchereria Bancrofti ◽  
Normal Subjects ◽  
Peripheral Blood Leukocytes ◽  
51Cr Release ◽  
Blood Leukocytes ◽  
Release Studies

Sera from cases of elephantiasis due to Wuchereria bancrofti infection promoted an intense adhesion of peripheral blood leukocytes to W. bancrofti microfilariae in vitro. A similar adhesion was also seen using sera from some normal persons living for several years in areas where filariasis is endemic. No such adhesion was evident with sera from microfilaria carriers or from normal subjects from nonendemic areas. The adhesion was complement independent and was associated with the immunoglobulin G fraction of serum. 51Cr release studies suggested the occurrence of cell-mediated cytotoxicity to W. bancrofti microfilariae in the presence of elephantiasis serum. Microfilariae of Litomosoides carinii could be isolated free of blood cells, from the blood of infected rats. In the presence of serum, or its immunoglobulin G fraction, from patients with elephantiasis, L. carinii microfilariae adhered to human peripheral blood leukocytes or rat spleen cells.

scholarly journals Human monoclonal anti-keyhole limpet hemocyanin antibody-secreting hybridoma produced from peripheral blood B lymphocytes of a keyhole limpet hemocyanin-immune individual.

1982 ◽  
Vol 155 (1) ◽  
pp. 333-338 ◽  
Author(s):  
H C Lane ◽  
J H Shelhamer ◽  
H S Mostowski ◽  
A S Fauci
Keyword(s):  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Keyhole Limpet Hemocyanin ◽  
Normal Subjects ◽  
Peripheral Blood Lymphocytes ◽  
Human Monoclonal Antibodies ◽  
Blood Lymphocytes ◽  
Predetermined Specificity ◽  
Culture Supernatants ◽  
Mouse Myeloma

A human IgMk monoclonal antibody, 2F7, of predetermined specificity, has been produced by the fusion of human peripheral blood lymphocytes with the nonsecreting mouse myeloma line SP-1. The heterohybridoma has remained stable for over 8 mo, with culture supernatants containing up to 30 micrograms/ml of specific IgM. The antibody has been shown to be capable of inducing a blastogenic response in the absence of antigen in the peripheral blood lymphocytes of normal subjects immune to the antigen. The ability to choose an antigen, immunize a human subject to that antigen, and then use the peripheral blood lymphocytes from that subject to produce antigen-specific human monoclonal antibodies should be of great value in a wide variety of investigative, diagnostic, and therapeutic endeavors.U

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