EFFECT OF CORTICOSTEROIDS ON URINARY 5β AND 5α C19 STEROIDS IN MAN

1964 ◽  
Vol 46 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Hildegard Wilson ◽  
Steven Schenker
Keyword(s):  
Testosterone Propionate ◽  
Periodic Fever ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Dexamethasone Therapy ◽  
Normal Women ◽  
Normal Men ◽  
Short Time

ABSTRACT A high proportion of urinary C19 5β to 5α steroid metabolites has been found on administration of glucocorticoids in a number of instances. During long term treatment with prednisone or dexamethasone, 100 mg testosterone propionate was administered to 3 patients. The ratios of the resulting metabolites etiocholanolone (E, 5β) to androsterone (A, 5α) were 2.7, 3.3 and 2.1, compared to 1.3 and 0.9 after withdrawal of corticoids from the first 2 patients. In 3 normal men, ratios of endogenously derived E and A while receiving corticoids, compared to control ratios were 2.3 to 1.0, 2.2 to 0.6 and 1.2 to 0.9. Ratios in normal women rose from 1.1 to 2.2 and 2.4 to 4.3 on receiving dexamethasone. Not all subjects gave the expected response. In 3 of these the dosage of corticoid was either low or given for a short time. The ratio of C19O3 metabolites of administered 11β-hydroxy-androst-4-ene-3,17-dione was also changed in favour of the 5β products during corticoid treatment. In a man with periodic fever the high E/A ratios observed were probably related to dexamethasone therapy rather than to the disease.

scholarly journals Possibilities of Digitalization and Service Design in the Development of Patient Adherence

2021 ◽  
Author(s):  
Diána Nagy
Keyword(s):  
Patient Adherence ◽  
Service Design ◽  
Rapid Onset ◽  
Term Treatment ◽  
Number Of Patients ◽  
Long Term Treatment ◽  
Therapeutic Services ◽  
Effective Use ◽  
Short Time

In parallel with the development of modern health systems and the growth of the welfare state, diseases have shifted towards chronic diseases. Today, instead of rapid-onset infections, most resources are focused on the long-term treatment of mostly lifelong chronic conditions. The condition for the effective use of therapies is to take the specified dose with the prescribed frequency and for the required period of time. If these parameters are met, we can talk about patient collaboration or adherence. For certain diseases and treatments, adherence is critically low. In the case of complex preparations to be taken several times a day, or diseases that do not cause serious, noticeable complaints, the initial number of patients treated is reduced to a fraction within a short time. As a result, economic harm is perceived not only by the patient but also by all those involved in the health care system, including pharmaceutical companies. However, the factors influencing patient collaboration vary widely. In order to achieve high adherence, the goal is to develop health services that coordinate the actors involved, the infrastructure, the communication, the material components to improve the user experience. As a user-centered methodology, service design can play a prominent role in the design of therapeutic services, contributing to the reduction of uncertainties in innovation processes. In my study, I assess the digital toolkit of patient education in Hungarian society. The aim is to explore digital tools and technologies that can contribute to the development of health awareness and education so that both science and the pharmaceutical and technology companies that exploit it can apply the results of research.

Clinical evaluation of long-term treatment with levo-norgestrel and testosterone enanthate in normal men

Contraception ◽  
1980 ◽  
Vol 21 (6) ◽  
pp. 631-640 ◽  
Author(s):  
Marie Foegh ◽  
Keith Nicol ◽  
Ivan Bruunshuus Petersen ◽  
Geert Schou
Keyword(s):  
Clinical Evaluation ◽  
Term Treatment ◽  
Testosterone Enanthate ◽  
Long Term Treatment ◽  
Normal Men

Hypnotherapy is effective in the long-term treatment of functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A115-A115 ◽  
Author(s):  
E CALVERT ◽  
L HOUGHTON ◽  
P COOPER ◽  
P WHORWELL
Keyword(s):  
Functional Dyspepsia ◽  
Term Treatment ◽  
Long Term Treatment

1608: Long-Term Treatment with High Doses of Sildenafil Does Not Up-Regulate the Levels of Phosphodiesterase 5 (Pde5) in the Rat Penis

2004 ◽  
Vol 171 (4S) ◽  
pp. 424-424 ◽  
Author(s):  
Monica G. Ferrini ◽  
Eliane G. Valente ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Term Treatment ◽  
Long Term Treatment ◽  
High Doses ◽  
Phosphodiesterase 5

Long-Term Treatment Outcomes for Heroin Dependence: The 11-Year Follow-Up of the ATOS Study

2013 ◽  
Author(s):  
Christina Marel ◽  
Maree Teesson ◽  
Shane Darke ◽  
Katherine Mills ◽  
Joanne Ross ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Term Treatment ◽  
Heroin Dependence ◽  
Long Term Treatment
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