EFFECTS OF OESTROUS CYCLE VARIATIONS AND EXOGENOUS STEROID HORMONES ON THE PRODUCTION AND SECRETION OF CORTICOSTERONE BY THE RAT ADRENAL

1964 ◽  
Vol 45 (4_Suppl) ◽  
pp. S191-S201 ◽  
Author(s):  
Gregory Pincus ◽  
Masanao Hirai
Keyword(s):  
Adrenal Gland ◽  
Statistical Significance ◽  
Male Rats ◽  
Adrenal Vein ◽  
List Type ◽  
Intact Male ◽  
Significant Difference ◽  
The Difference ◽  
Group 5 ◽  
Adrenal Corticosterone

ABSTRACT Results with the adrenal gland: A significant difference (P < 0.01) was found between the elevated production of corticosterone in intact rats during dioestrus and the production at oestrus. At both 10 and 20 days after ovariectomy, the production of corticosterone was decreased as compared with the dioestrous rate. Production of corticosterone in adrenals was increased significantly (P < 0.01) by progesterone injection (500 μg/day for 5 days) and was decreased by oestradiol-17β injections 5 μg/day for 5 days). Corticosterone injection (10 μg/day for 5 days) also significantly (P < 0.01) increased the production of corticosterone in adrenals. Results with adrenal vein blood: Secretion of corticosterone of the intact rat at dioestrus was higher than at oestrus, but the difference was not statistically significant. At 10 and 20 days after ovariectomy, the secretion of corticosterone had decreased from the dioestrous level, but statistical significance was found only at 20 days after ovariectomy. Oestradiol-17β treatment (5 μg/day for 5 days) significantly (P < 0.01) decreased the secretion of corticosterone from the adrenal vein. Progesterone treatment (500 μg/day for 5 days) did not significantly affect the secretion of corticosterone into adrenal vein blood. Also, treatment with corticosterone (10 μg/day for 5 days) did not yield statistically significant changes in the secretion of this compound. Additional results: Nembutal anaesthesia in intact male rats significantly decreased the amount of corticosterone in the adrenal gland (P < 0.05). Ether anaesthesia led to a greater variation in adrenal corticosterone than in nonanaesthetized rats. Ovary weights decreased significantly (P < 0.05) in the progesteroneinjected group (500 μg/day for 5 days); on the other hand, the oestradiol-17β-injected group (5 μg/day for 10 days) exhibited a significant increase of adrenal weight (P < 0.05), and pituitary weight (P < 0.01) and a decrease of ovary weight (P < 0.05).

scholarly journals Cyclic fatigue resistance of 2Shape, Twisted File and EndoSequence Xpress nickel-titanium rotary files at intracanal temperature

2018 ◽  
Vol 12 (4) ◽  
pp. 283-287 ◽  
Author(s):  
Gülşah Uslu ◽  
Taha Özyürek ◽  
Mustafa Gündoğar ◽  
Koray Yılmaz
Keyword(s):  
Fatigue Resistance ◽  
Statistical Significance ◽  
Cyclic Fatigue ◽  
Nickel Titanium ◽  
Bonferroni Correction ◽  
Significant Difference ◽  
Inner Diameter ◽  
The Difference ◽  
Number Of Cycles ◽  
Analyze Data

Background. The aim of this study was to compare the cyclic fatigue resistance of 2Shape, Twisted File (TF) and EndoSequence Xpress (ESX) nickel-titanium rotary files at intracanal temperature (35°C). Methods. Twenty 2Shape TS1 (25/.04), 20 TF (25/.04) and 20 ESX (25/.04) files were tested for cyclic fatigue at intracanal temperature (35°C). All the instruments were rotated in artificial canals which were made of stainless steel with an inner diameter of 1.5 mm, 60° angle of curvature and a radius curvature of 5 mm until fracture occurred; the time to fracture was recorded in seconds using a digital chronometer and the number of cycles to fracture (NCF) for each file was calculated. Kruskal-Wallis test with Bonferroni correction was performed to statistically analyze data using SPSS 21.0. Statistical significance was set at P<0.05. Results. NCF values revealed that the 2Shape had significantly the highest cyclic fatigue resistance, followed by TF and ESX at intracanal temperature (P<0.05). The difference was significant between the TF and ESX groups (P<0.05). There was no significant difference among the 2Shape, TF and ESX files with respect to the lengths of the fractured file fragments (P>.05). Conclusion. Within the limitations of present study, it was concluded that the cyclic fatigue resistance of 2Shape files at the intracanal temperature is higher than that of TF and ESX files.

scholarly journals Mechanical Thrombectomy in Stroke. Experience from Switching from Stent Retriever Only to Stent Retriever Combined with Aspiration Catheter

2021 ◽  
Vol 10 (9) ◽  
pp. 1802
Author(s):  
Grzegorz Meder ◽  
Paweł Żuchowski ◽  
Wojciech Skura ◽  
Violetta Palacz-Duda ◽  
Milena Świtońska ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Clinical Outcomes ◽  
Mechanical Thrombectomy ◽  
Statistical Significance ◽  
Stent Retriever ◽  
Single Center Experience ◽  
Significant Difference ◽  
First Pass ◽  
Need To Evaluate ◽  
The Difference

Endovascular treatment is a rapidly evolving technique; therefore, there is a constant need to evaluate this method and its modifications. This paper discusses a single-center experience and the results of switching from the stent retriever only (SO) mechanical thrombectomy (MT) to the combined approach (CA), with a stent retriever and aspiration catheters. Methods: The study involved a retrospective analysis of 70 patients undergoing MT with the use of either SO or CA. The primary endpoint was the frequency of perfect reperfusion defined as grade 3 of the modified Thrombolysis in Cerebral Infarction scale (mTICI) after the first pass. The secondary endpoints were the procedure success, defined as mTICI grades 2b-3; time of the procedure; clinical outcome, measured by 90 days’ modified Rankin Scale (mRS) score; Δ NIHSS, defined as the difference between National Institutes of Health Stroke Scale (NIHSS) score at patients’ admission and discharge; and the total number of device passes. Results: Out of the 70 patients included, 33 were treated with SO and 37 with CA. In both groups, a total number of 42 patients received intravenous recombined tissue plasminogen activator (iv-rTPA: 20 patients (60.6%) in the SO group and 22 patients (59.5%) in the CA group (p = 1.000). There was a significant difference between the groups regarding first-pass success rate, with 46% in the CA group and 18% in the SO group, (OR 3.83, 95% CI 1.28 to 11.44, p = 0.016). Complete procedure success tended to be more frequent in the CA group than in the SO group—94.6% vs. 84.8% (OR 3.13, 95% CI 0.56 to 17.34, p = 0.193)—and CA tended to require a lower number of passes than SO (mean 1.76 vs. 2.09 passes per procedure, p = 0.114), yet these differences did not reach statistical significance. Mean duration of the procedure was significantly shorter in the CA group than in the SO group (49 min vs. 64 min, p = 0.017). There was a significant difference in clinical outcomes, with higher Δ NIHSS (9.3 in the CA group vs. 6.7 in the SO group, p = 0.025) after the procedure and 90-day mRS (median 2 in the CA group vs. 4 in the SO group, p = 0.031). Conclusions: Combining stent retrievers with aspiration catheters may offer a beneficial effect on angiographic results and clinical outcomes in stroke patients undergoing endovascular treatment.

Effects of Orthokeratology Lens On Axial Length Elongation in Myopia With Anisometropia Children

2021 ◽  
Author(s):  
Ziyang Chen ◽  
Kai-Ming Chen ◽  
Ying Shi ◽  
Zhao-Da Ye ◽  
Sheng Chen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Axial Length ◽  
Statistical Significance ◽  
Spherical Equivalent ◽  
Significant Difference ◽  
The Mean ◽  
The Difference ◽  
Better Than ◽  
Group 1

Abstract AimTo investigate the effect of orthokeratology (OK) lens on axial length (AL) elongation in myopia with anisometropia children.MethodsThirty-seven unilateral myopia (group 1) and fifty-nine bilateral myopia with anisometropia children were involved in this 1-year retrospective study. And bilateral myopia with anisometropia children were divided into group 2A (diopter of the lower SER eye under − 2.00D) and group 2B(diopter of the lower SER eye is equal or greater than − 2.00D). The change in AL were observed.The datas were analysed using SPSS 21.0.Results(1) In group 1, the mean baseline AL of the H eyes and L eye were 24.70 ± 0.89 mm and 23.55 ± 0.69 mm, respectively. In group 2A, the mean baseline AL of the H eyes and L eyes were 24.61 ± 0.84 mm and 24.00 ± 0.70 mm respectively. In group 2B, the mean baseline AL of the H eyes and L eyes were 25.28 ± 0.72 mm and 24.70 ± 0.74 mm. After 1 year, the change in AL of the L eyes was faster than the H eyes in group 1 and group 2A (all P<0.001).While the AL of the H eyes and L eyes had the same increased rate in group 2B. (2) The effect of controlling AL elongation of H eyes is consistent in three groups (P = 0.559).The effect of controlling AL elongation of L eyes in group 2B was better than that in group 1 and group 2A (P < 0.001). And the difference between group 1 and group 2A has no statistical significance. (3) The AL difference in H eyes and L eyes decreased from baseline 1.16 ± 0.55mm to 0.88 ± 0.68mm after 1 year in group 1.And in group 2A, the AL difference in H eyes and L eyes decreased from baseline 0.61 ± 0.34mm to 0.48 ± 0.28mm. There was statistically significant difference (all P<0.001). In group 2B, the baseline AL difference in H eyes and L eyes has no significant difference from that after 1 year (P = 0.069).ConclusionsMonocular OK lens is effective on suppression AL growth of the myopic eyes and reduce anisometropia value in unilateral myopic children. Binocular OK lenses only reduce anisometropia with the diopter of the low eye under − 2.00D. Binocular OK lenses cannot reduce anisometropia with the diopter of the low eye equal or greater than − 2.00D. Whether OK lens can reduce refractive anisometropia value is related to the spherical equivalent refractive of low refractive eye in bilateral myopia with anisometropia children after 1-year follow-up.

scholarly journals The Effect of Bedside Presentations in the Emergency Department on Patient Satisfaction

2011 ◽  
Vol 3 (4) ◽  
pp. 481-486 ◽  
Author(s):  
Craig I. Schranz ◽  
Robert J. Sobehart ◽  
Kiva Fallgatter ◽  
Robert H. Riffenburgh ◽  
Michael J. Matteucci
Keyword(s):  
Emergency Department ◽  
Patient Satisfaction ◽  
Resident Education ◽  
Statistical Significance ◽  
Future Research ◽  
First Year ◽  
Convenience Sample ◽  
Visual Analog Scales ◽  
Significant Difference ◽  
The Difference

Abstract Background Due to increasing time constraints, the use of bedside presentations in resident education has declined. We examined whether patient satisfaction in the emergency department is affected when first-year residents present at the bedside with attendings. Methods We performed an observational, prospective, nonblinded study in the emergency department of a military teaching hospital. We alternately assigned first-year residents to present a convenience sample of 248 patients to the attending physician at the patient's bedside or away from the patient. We measured patient satisfaction by using the Patient Satisfaction Questionaire-18 (PSQ-18), a validated survey instrument that utilizes a Likert scale, and additional nonvalidated survey questions involving Likert and visual analog scales. Results While the median PSQ-18 score of 74 (95% confidence interval [CI], 72–76) was higher for patient satisfaction when residents made bedside presentations than that for standard presentations, 72 (95% CI, 70–74), the difference did not reach statistical significance (P  =  .33). Conclusion There was no significant difference in overall patient satisfaction between residents' bedside presentations and presentations to attendings away from the patient. Although not significant, the differences noted in PSQ-18 subscales of communication, general satisfaction, and interpersonal manner warrant further investigation. Patients did not appear to be uncomfortable with having their care discussed and with having subsequent resident education at the bedside. Future research on patient satisfaction after implementation of standardized bedside teaching techniques may help further elucidate this relationship.

Attitudes towards sex with alcoholics

2011 ◽  
Vol 26 (S2) ◽  
pp. 67-67
Author(s):  
Z.M. Krivokapic ◽  
R.V. Sapic
Keyword(s):  
Sexual Experience ◽  
Social Situation ◽  
Control Group ◽  
List Type ◽  
Homosexual Orientation ◽  
The Social ◽  
Significant Difference ◽  
The Difference ◽  
Attitudes Toward Sex ◽  
The Impact

Attitude is defined as acquired disposition, readiness for a certain way of perception, thinking, emotional reacting and behaving. The formation of social attitudes is greatly in influence by a group (alcoholics group). Drinking alcohol also disrupts higher cognitive processes: abstraction, conceptualization, problem solving and influences on different opinions.Our research concerned the impact of chronic alcohol use and membership to alcoholic group as a framework that influences attitudes towards sexuality. 200 persons were sample in this research: 100 alcohol addicts and 100 persons of the control group. The instrument used in this study was-Scale of attitudes toward sex.Statistically significant difference was found in five attitudes:–Differences in two paragraphs point to some homosexual orientation. We can confidently say that this is a “latent homosexuality in an alcoholic”, it is possible that the difference arises because of the presence of homosexuals in the group of alcoholics, although the subjects did not say to have such orientation.–Some conservatism is present in the attitude drinkers to sexuality of the young, they argue that sexual experience can wait until more mature years.–Extramarital relationships are positively evaluated by the control group, while alcoholics show greater disapproval.–Alcoholics have the attitude that sexual arousal does not come with ease, unlike the control group.–They are more liberal about the social situation of people with HIV (a certain degree of identification with an estimated negative social group).Results showed small difference in attitudes between alcoholics and nonalcoholic.

scholarly journals Circumcision: postoperative complications that required reoperation

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Carolina Talini ◽  
Letícia Alves Antunes ◽  
Bruna Cecília Neves de Carvalho ◽  
Karin Lucilda Schultz ◽  
Maria Helena Camargo Peralta Del Valle ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Surgical Technique ◽  
Medical Records ◽  
Statistical Significance ◽  
Postoperative Outcome ◽  
Conventional Technique ◽  
Significant Difference ◽  
Operative Complications ◽  
Classic Technique ◽  
The Difference

ABSTRACT Objective To evaluate post-operative complications of circumcision requiring surgical reintervention. Methods Retrospective analysis of medical records of patients submitted to circumcision from May 1st, 2015 to May 31st, 2016. Results A total of 2,441 circumcisions were performed; in that, 1,940 using Plastibell and 501 by the classic technique. Complications requiring surgical reintervention were found in 3.27% of patients. When separated by surgical technique, 3.4% of circumcisions using Plastibell device required reoperation, as compared to 3% of conventional technique (p=0.79). Preputial stenosis was most frequently found in classic circumcision, with statistical significance (p<0.001). Bleeding was more frequent when using Plastibell device, but the difference was not statistically different (p=0.37). Patients’ age was also evaluated to investigate if this variable influenced on the postoperative outcome, but no significant difference was found. Conclusion There was no statistically significant difference when comparing complications between the different techniques performed at this hospital. Preputial stenosis was most frequently found in the classic circumcision, while bleeding was more prevalent when using Plastibell device. Patients’ age did not influence in complications.

Evaluation of survival by ADCC status: Subgroup analysis of SB3 (Trastuzumab Biosimilar) and reference trastuzumab in patients with HER2-positive early breast cancer at three-year follow-up.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 580-580 ◽  
Author(s):  
Xavier Pivot ◽  
Mark D. Pegram ◽  
Javier Cortes ◽  
Diana Lüftner ◽  
Gary H. Lyman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Statistical Significance ◽  
Phase Iii ◽  
Breast Cancer Patients ◽  
Her2 Positive ◽  
Follow Up Study ◽  
Significant Difference ◽  
The Difference

580 Background: SB3 is an approved biosimilar of reference trastuzumab (TRZ). At additional 2-year follow-up after completing neoadjuvant and adjuvant treatment, there was a difference in event-free survival (EFS), but no difference in overall survival (OS) between SB3 and TRZ. Upon monitoring quality attributes of TRZ, a marked downward shift in antibody-dependent cell-mediated cytotoxicity activities (ADCC) was observed in TRZ lots with expiry dates from Aug 2018 to Dec 2019. Some of the lots were used in the Phase III study. This is a post-hoc analysis of EFS and OS by ADCC status from a 3-year follow-up to investigate the difference in EFS between SB3 and TRZ. Methods: After completion of neoadjuvant and adjuvant therapy in patients with HER2 positive early breast cancer, patients from selected countries participated in a 5-year follow-up study (NCT02771795). Within the TRZ group, patients exposed to at least one shifted ADCC lot and those never exposed to shifted ADCC lot during neoadjuvant period were considered as “Exposed” and “Unexposed,” respectively. EFS and OS after 3-year follow-up was analyzed by ADCC status in the long-term follow-up set. Results: 367 patients (SB3, N = 186; TRZ, N = 181) were enrolled in the follow-up study. Within TRZ, 55 patients were Unexposed and 126 patients were Exposed. At a median follow-up duration of 40.8 months in SB3 and 40.5 months in TRZ, 3-year EFS rates were 92.5% in SB3, 94.5% in Unexposed, and 82.5% in Exposed and OS rates were 97.0%, 100%, and 90.6%, respectively. Exposed was associated with decreased EFS compared to Unexposed (HR 0.14, 95% CI 0.04-0.51, p= 0.003). There was a trend of decreased OS in Exposed compared to Unexposed, however, there was no significant difference (HR 0.14, 95% CI 0.02-1.15, p= 0.068). Between SB3 and Unexposed, no difference was observed in EFS (HR 1.06, 95% CI 0.33-3.44, p= 0.923), or OS (HR 0.54, 95% CI 0.05-5.44, p= 0.600). Conclusions: Within the TRZ group, Exposed showed significantly lower EFS compared to Unexposed, and a similar trend was observed in OS with no statistical significance. Between SB3 and Unexposed, no significant difference in EFS or OS was observed. Clinical trial information: NCT02771795.

scholarly journals Psychological factors of delinquent adolescent girls and suicide attempters

Medicina ◽  
2008 ◽  
Vol 44 (2) ◽  
pp. 147
Author(s):  
Virginija Ribakovienë ◽  
Virginija Adomaitienë ◽  
Diana Danytë ◽  
Rûta Kalkytë
Keyword(s):  
Adolescent Girls ◽  
Externalizing Behavior ◽  
Statistical Significance ◽  
Delinquent Behavior ◽  
Social Competency ◽  
Suicide Attempters ◽  
Delinquent Girls ◽  
Significant Difference ◽  
Social Difficulties ◽  
The Difference

The aim of this study was to study and compare externalizing and internalizing difficulties, clinical problems of adolescent girls who attempted a suicide and delinquent girls. A total of 100 adolescent girls aged 11–18 years have participated in this study: 50 of them were suicide attempters, and the other 50 girls had problems of delinquent behavior. In this study, the questionnaire ASEBA YSR 11–18 was used. To compare averages, Student’s t and Mann-Whitney’s U tests were applied with a 0.05 level of statistical significance. For adolescent girls who attempted a suicide, more prominent internal difficulties were identified. They were more depressive/anxious, presented more somatic complains, and were more closed/anxious. Those girls felt more anxiety and presented more affective problems. The difference in the average scores of scales of the both groups was statistically significant (P<0.05). Externalizing problems of adolescent suicide attempters did not significantly differ from ones of the girls with delinquent behavior. The average scores of scales on braking of rules and aggression were not significantly different. Girls with delinquent behavior had a higher social competency, and the girls who attempted a suicide more often presented significant social difficulties, though there was no statistically significant difference in the scores on the activity competence scale. Conclusions. The adolescent girls who attempted a suicide have more evident internal difficulties than delinquent girls do, though externalizing behavior difficulties of the suicide attempters are similar to those of girls with delinquent behavior. The girls who attempted a suicide experience more social difficulties, and their social competency is lower when comparing to delinquent girls of the same age.

scholarly journals MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO-1 Pathway While Reducing Oxidative Damage in Male Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Kazim Sahin ◽  
Mehmet Tuzcu ◽  
Cemal Orhan ◽  
Hasan Gencoglu ◽  
Nurhan Sahin ◽  
...  
Keyword(s):  
Sexual Function ◽  
Treated Group ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Mucuna Pruriens ◽  
Tribulus Terrestris ◽  
Sexual Hormones ◽  
Significant Difference ◽  
Group 5

Mucuna pruriens, Ashwagandha, and Tribulus terrestris are known as the enhancers for sexual health, functional activities, vitality, and longevity. These herbs had been widely used in the Ayurveda medicine as aphrodisiacs through the ages, and their efficacy was also verified separately in our previous publication. Therefore, the aim of this study was to determine the effects of Mucuna, Ashwagandha, and Tribulus complexes on sexual function in rats. Twenty-eight male rats allocated to four groups as follows: (i) negative control (C); (ii) positive control or sildenafil citrate treated group (5 mg/kg) (S); (iii) MAT1 (combination of 10 mg Mucuna (M) + 10 mg Ashwagandha (A) + 10 mg Tribulus (T)/kg BW); (iv) MAT 2 (20 mg Mucuna + 20 mg Ashwagandha + 20 mg Tribulus/kg BW). There was no significant difference found between the MAT1 and MAT2 groups while they showed significantly increased testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels when compared to the negative control. Significant increases in Nrf2/HO1 levels and decreases in NF-κB were detected in MAT groups similar to the decrease in serum and testis malondialdehyde (MDA) levels as compared to both controls. The sperm motility, count, and rate also significantly improved in both MAT groups, while ALT, AST, creatinine, ALP, and urea levels did not change in any of the groups. Oral consumption of MATs combination in male rats resulted in inhibition of NF-κB and MDA and also increased sex hormones with Nrf2-mediated HO-1 induction. MAT combinations may improve sexual functions by increasing levels of sexual hormones and regulation of NF-κB and Nrf2/HO-1 signaling pathways.

scholarly journals Stimulantia Effect Of Single Bulb Garlic Extract (Allium Sativum Var.Solo Garlic) in Swiss Webster Mice

2020 ◽  
Vol 17 (2) ◽  
pp. 107-115
Author(s):  
Ika Buana Januarti
Keyword(s):  
Ethanolic Extract ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Stimulant Effect ◽  
Swimming Time ◽  
Significant Difference ◽  
Garlic Bulb ◽  
The Difference ◽  
Group 5

Stimulant is an agent that stimulates the central nervous system thereby increasing physical and mental abilities and minimizing fatigue. The use of synthetic caffeine stimulants of 10 mg / kg BW is known to have side effects of increasing total cholesterol and increasing LDL, therefore alternative stimulants from natural ingredients are needed. Natural materials that have been studied contain flavonoids and phenolic as a stimulant compound is a single garlic bulbs. The purpose of this study was to determine the stimulant effect of a single garlic bulbs ethanolic extract on mice from the difference in swimming time. The research experimental used Pre test and Post test control design. Sample of this research used mice which were divided into 6 groups. Group 1 pretest dose 5 g / kgBB, group 2 (negative control), group 3 (caffeine), group 4 extract dose 5g / kgBB, group 5 dose 10g / kgBB and group 6 dose 20g / kgBB. Data was analyze using one way Anova continued with Post Hoc test. The group of single garlic bulb ethanolic extract dose 20 g / kgBB had the highest stimulant effect with 222,722 minutes fatigue time difference and statistically have significant difference (p <0.05) than the negative control group. Group of single garlic bulb extract can influence the time of fatigue of mice by extending the swimming time of mice so that it has a longer fatigue time which means it has a stimulant effect

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